iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oga-088226

Ensembl Protein ID

ENSOGAP00000017541.1

UniProt Accession

H0XN50; H0XN50_OTOGA

Genbank Protein ID

ENSOGAP00000017541

Protein Name

PAB-dependent poly(A)-specific ribonuclease subunit PAN2; Inactive ubiquitin carboxyl-terminal hydrolase 52; PAB1P-dependent poly(A)-nuclease; PAN deadenylation complex catalytic subunit 2

Genbank Nucleotide ID

AAQR03076904

Gene Name

PAN2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000030620.1	ENSOGAT00000030978.1	ENSOGAP00000017541.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	6.50e-21	74.9	525	916

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 9    tCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs............ 85
             Y+N+++Q+L++++++r+l+ +   + +++      + +l+++l  lf+ l  s+    + +++l+a++++ e               
   Q: 525  NAYCNCMIQVLYFLEPVRCLIQN---HLCQK------EFCLACELGFLFHMLDLSRGDPCQGNNFLRAFRTIPEASAlgliladsdeas 604
           56*********************...55654......57*************9****************99999865766666666665 PP
   S: 86   ..gyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldl 172
             g+     q   +f+l ql++++           +e +  ++ + a  +  ++++s+i +lF  ++++   c +c+++++r+++ l +
   Q: 605  gkGNLARLIQRWNRFILTQLHQDM-----------QELEVPQAYRGAGGSFCSSGDSVIGQLFSCEMENCSLC-RCGSETVRTSSTLLF 681
           555556666667777777777777...........2333334556678899*****************99999.8************** PP
   S: 173  slpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdl 261
           +l+ p++++ k+ ++ ++L+     e+ +   + +c++c+k+q + ++  +++lP++L+++    s +e+   r  ++ ++ f+  + +
   Q: 682  TLSYPDDKTGKNYDFAHVLKRSICLEQNT---QAWCDNCEKYQPTIQTRNIRHLPDILVINCEVNSSKEADFWR--MQAEFAFK--VAV 763
           *******************9888766665...69***************************9999666654443..55555555..666 PP
   S: 262  spfcts........................peekqke.................................................... 274
           +++  +                        p     +                                                    
   Q: 764  KKHGGEisknkefaladwkelgspegvlvcP-----Sieelkniwlpfsirmkmtknkgldvcnwtdgdellslaawvppsqwgparae 847
           6666663334444444555555555555550.....05555555555555555555555566666666666666666666666666666 PP
   S: 275  ....kkkYeLiavvvHsG.slssGHYvayvkn...........ekgkWllfdDskVtevkeeevleetg 327
                + Y+L+a vvH   s  +G  va++k            ++++W+lf+D  +++++++e +++  
   Q: 848  eehgVYVYDLMATVVHILdSRTGGSLVAHIKVgetyhqrkegvTHQQWYLFNDFLIEPIDKHEAVQFDM 916
           66669*************9*************999988877777888************9999888654 PP

Organism

Otolemur garnettii

Functional Description
(View)

Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.

Protein Sequence
(Fasta)

MNFEGLDPGL AEYAPAMHSA LDPVLDAHLN PSLLQNVELD PEGVALEALP VQESVHIMEG 60
VYSELHSVVA EVGVPVSVSH FDLHEEMLWV GSHGGHATSF FGPALERYSS FQVNGSDDIR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAACTTTG AGGGTCTAGA TCCTGGACTG GCAGAGTATG CCCCTGCCAT GCATTCTGCC 60
TTGGACCCTG TCCTGGATGC CCACCTGAAC CCAAGTCTGC TACAGAATGT GGAGCTGGAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0269--Exonuclease
KW-0378--Hydrolase
KW-0507--mRNA processing
KW-0540--Nuclease
KW-0539--Nucleus
KW-1185--Reference proteome

Interpro

IPR013520--Exonuclease_RNaseT/DNA_pol3
IPR030843--PAN2
IPR028881--PAN2_dom
IPR012337--RNaseH-like_dom
IPR028889--USP_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR017986--WD40_repeat_dom

PROSITE

PS50235--USP_3

Pfam

PF00929--RNase_T
PF13423--UCH_1

SMART

SM00479--EXOIII

Gene Ontology

GO:0005634--C:nucleus
GO:0000932--C:P-body
GO:0031251--C:PAN complex
GO:0003676--F:nucleic acid binding
GO:0004535--F:poly(A)-specific ribonuclease activity
GO:0006397--P:mRNA processing
GO:0000289--P:nuclear-transcribed mRNA poly(A) tail shortening
GO:0010606--P:positive regulation of cytoplasmic mRNA processing body assembly

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001273	Ailuropoda melanoleuca	96.45	0.00e+00	2321.00
IUUC-Apl-003500	Anas platyrhynchos	83.77	0.00e+00	1871.00
IUUC-Aca-004930	Anolis carolinensis	83.62	0.00e+00	2036.00
IUUC-Acl-008214	Aspergillus clavatus	31.10	3.00e-156	546.00
IUUC-Afu-009112	Aspergillus fumigatus	31.42	3.00e-147	516.00
IUUC-Ang-009531	Aspergillus niger	30.86	7.00e-150	525.00
IUUC-Ame-011259	Astyanax mexicanus	75.14	0.00e+00	1843.00
IUUC-Bta-012371	Bos taurus	96.69	0.00e+00	2325.00
IUUC-Bci-013684	Botrytis cinerea	43.35	2.00e-72	267.00
IUUC-Cja-019297	Callithrix jacchus	94.73	0.00e+00	2278.00
IUUC-Cfa-020489	Canis familiaris	96.36	0.00e+00	2311.00
IUUC-Cpo-022392	Cavia porcellus	95.21	0.00e+00	2314.00
IUUC-Csa-023220	Chlorocebus sabaeus	96.86	0.00e+00	2333.00
IUUC-Csv-025841	Ciona savignyi	45.38	0.00e+00	898.00
IUUC-Cgl-026534	Colletotrichum gloeosporioides	29.57	1.00e-89	324.00
IUUC-Cne-026932	Cryptococcus neoformans	42.94	4.00e-73	270.00
IUUC-Dre-028482	Danio rerio	73.08	0.00e+00	1793.00
IUUC-Dno-029398	Dasypus novemcinctus	96.03	0.00e+00	2305.00
IUUC-Dor-030307	Dipodomys ordii	88.46	0.00e+00	1295.00
IUUC-Dme-032111	Drosophila melanogaster	41.08	0.00e+00	881.00
IUUC-Eca-033985	Equus caballus	96.94	0.00e+00	2331.00
IUUC-Eeu-034928	Erinaceus europaeus	83.81	0.00e+00	772.00
IUUC-Fca-035587	Felis catus	96.53	0.00e+00	2343.00
IUUC-Fal-037587	Ficedula albicollis	83.99	0.00e+00	2004.00
IUUC-Fso-038133	Fusarium solani	42.29	2.00e-77	284.00
IUUC-Gmo-039076	Gadus morhua	72.71	0.00e+00	1755.00
IUUC-Ggr-039957	Gaeumannomyces graminis	32.09	2.00e-140	493.00
IUUC-Gga-040948	Gallus gallus	84.56	0.00e+00	2051.00
IUUC-Gac-042396	Gasterosteus aculeatus	73.39	0.00e+00	1805.00
IUUC-Ggo-045412	Gorilla gorilla	97.03	0.00e+00	2338.00
IUUC-Hsa-046076	Homo sapiens	97.03	0.00e+00	2341.00
IUUC-Itr-048143	Ictidomys tridecemlineatus	90.33	0.00e+00	2121.00
IUUC-Kpa-049178	Komagataella pastoris	40.48	7.00e-67	249.00
IUUC-Lch-050279	Latimeria chalumnae	72.40	0.00e+00	1722.00
IUUC-Loc-052872	Lepisosteus oculatus	75.84	0.00e+00	1839.00
IUUC-Lma-052986	Leptosphaeria maculans	31.13	6.00e-93	335.00
IUUC-Laf-054181	Loxodonta africana	95.77	0.00e+00	2321.00
IUUC-Mcc-054812	Macaca mulatta	97.35	0.00e+00	2337.00
IUUC-Meu-056325	Macropus eugenii	91.17	0.00e+00	2195.00
IUUC-Mor-057246	Magnaporthe oryzae	27.13	7.00e-67	249.00
IUUC-Mpo-057464	Magnaporthe poae	31.76	3.00e-143	503.00
IUUC-Mla-058911	Melampsora laricipopulina	40.77	1.00e-69	258.00
IUUC-Mga-059335	Meleagris gallopavo	84.96	0.00e+00	2000.00
IUUC-Mvi-060461	Microbotryum violaceum	33.45	5.00e-145	508.00
IUUC-Mmr-060636	Microcebus murinus	97.68	0.00e+00	2340.00
IUUC-Mmu-063503	Mus musculus	95.69	0.00e+00	2305.00
IUUC-Mpu-066670	Mustela putorius furo	97.02	0.00e+00	2330.00
IUUC-Mlu-068119	Myotis lucifugus	95.94	0.00e+00	2364.00
IUUC-Nfi-068398	Neosartorya fischeri	32.09	2.00e-157	550.00
IUUC-Ncr-068927	Neurospora crassa	30.09	5.00e-131	462.00
IUUC-Nle-069651	Nomascus leucogenys	93.08	0.00e+00	2234.00
IUUC-Opr-070614	Ochotona princeps	95.47	0.00e+00	2272.00
IUUC-Ont-072433	Oreochromis niloticus	74.49	0.00e+00	1855.00
IUUC-Oan-073283	Ornithorhynchus anatinus	74.55	0.00e+00	1437.00
IUUC-Ocu-074401	Oryctolagus cuniculus	97.02	0.00e+00	2342.00
IUUC-Ola-087522	Oryzias latipes	73.37	0.00e+00	1798.00
IUUC-Oar-089241	Ovis aries	96.29	0.00e+00	2343.00
IUUC-Pan-092297	Papio anubis	97.38	0.00e+00	2089.00
IUUC-Psi-094043	Pelodiscus sinensis	81.12	0.00e+00	1919.00
IUUC-Pma-094394	Petromyzon marinus	68.69	0.00e+00	1566.00
IUUC-Pno-095053	Phaeosphaeria nodorum	31.03	1.00e-80	295.00
IUUC-Ppa-095188	Physcomitrella patens	32.87	1.00e-159	557.00
IUUC-Pfo-097517	Poecilia formosa	74.35	0.00e+00	1855.00
IUUC-Pca-100471	Procavia capensis	95.96	0.00e+00	2172.00
IUUC-Pva-102805	Pteropus vampyrus	92.06	0.00e+00	1819.00
IUUC-Pte-104021	Pyrenophora teres	30.79	2.00e-95	343.00
IUUC-Pyt-104682	Pyrenophora triticirepentis	30.50	5.00e-94	339.00
IUUC-Rno-105471	Rattus norvegicus	94.78	0.00e+00	2289.00
IUUC-Sce-106235	Saccharomyces cerevisiae	33.71	7.00e-61	229.00
IUUC-Sha-106883	Sarcophilus harrisii	91.06	0.00e+00	2046.00
IUUC-Spo-108169	Schizosaccharomyces pombe	44.22	3.00e-74	273.00
IUUC-Sar-113323	Sorex araneus	94.56	0.00e+00	1702.00
IUUC-Sre-115075	Sporisorium reilianum	37.90	7.00e-61	229.00
IUUC-Ssc-116363	Sus scrofa	97.10	0.00e+00	2370.00
IUUC-Tru-118427	Takifugu rubripes	74.25	0.00e+00	1873.00
IUUC-Tni-120218	Tetraodon nigroviridis	74.23	0.00e+00	1874.00
IUUC-Tre-122177	Trichoderma reesei	31.44	1.00e-151	530.00
IUUC-Tme-127176	Tuber melanosporum	31.76	4.00e-142	499.00
IUUC-Tbe-127641	Tupaia belangeri	87.63	0.00e+00	800.00
IUUC-Ttr-128888	Tursiops truncatus	95.13	0.00e+00	1464.00
IUUC-Uma-129361	Ustilago maydis	38.42	2.00e-63	238.00
IUUC-Xtr-132811	Xenopus tropicalis	78.65	0.00e+00	1896.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence