iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pte-104021

Ensembl Protein ID

EFQ95139

UniProt Accession

E3RGL3; E3RGL3_PYRTT

Genbank Protein ID

EFQ95139.1

Protein Name

PAB-dependent poly(A)-specific ribonuclease subunit PAN2; PAB1P-dependent poly(A)-nuclease; PAN deadenylation complex catalytic subunit 2

Genbank Nucleotide ID

GL532912

Gene Name

PAN2; PTT_06948

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
PTT_06948	EFQ95139	EFQ95139

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.20e-11	43.7	491	816

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs..........gyeqqDa 92
           Gl+ +    Y N +LQ   ++p +r+l l+++ + +  e       +ll++l  l+  l k    + + +++lk+++ +++ +s                 
   Q: 491  GLETHITNSYANPLLQLFRFTPLIRNLALQHTASPCLFE------SCLLCELGFLIDMLEKAAGLNCQASNFLKTFSGLSNAVSlnlleefapnVALTSMI 585
           677777778*********************777777665......69999999999999999999999999999999999887755554444433333344 PP
   S: 93   qEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke.....slq 188
           q + +flld+++ee+                      ++  +   ++s ++++++ q + +++c +c+n++ r  +++  +l  p k+ +k++     +++
   Q: 586  QNLNRFLLDKVSEEF----------------------RQMLPGHTGPSAMDQVLETQARASMRCAQCNNETIRGGKNFVNELVYPAKHVMKNTriprpTFS 664
           566666666666666......................445688999*******************************999999999998877788888999 PP
   S: 189  dcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeq..ksrekinkkvefpleLdlsp.fcts.......peekqkekkkYe 279
           ++L++ ++++  +   + +c+kc+++q+++++ +++++P vL+l+    s + +   ++++ + ++v   + +d  + fc +        ++++++ + Ye
   Q: 665  QILKASVERQDQT---RGWCTKCNRYQQMVQRKTIQSVPGVLMLNAAIQSHEAKLlwSMPNWLPQEVG--IIVDQGQfFCFEgqdlklhLQRGVHQITVYE 760
           9998777776655...37**************************987774444331133333334433..334444533333222222233344459**** PP
   S: 280  Liavv..vHsGslssGHYvayvkn........ekgkWllfdDskVtevkeeevlee 325
           L+++v  + sG++++ H va ++          +++W lf+D  V+++++ee l++
   Q: 761  LVGIVadINSGEHQKPHLVATINTgpssreedAEDRWHLFNDFLVRPIPKEEALRF 816
           *****555789*************888877655666*************9999876 PP

Organism

Pyrenophora teres

Functional Description
(View)

Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein PAB1, which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.

Protein Sequence
(Fasta)

MEADWDELAI VQLPPPGPHL PAVPISTFAF DTTQELLWTG NNHGRVTSFY GPHLERYTAF 60
RGHAPPDGPV KQFLFTEKGI ISISKQSVHY SHRRGLTQWH LTNPEFKDLK CMNFTSKGTR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAGGCCG ACTGGGATGA GGTATAGCTA GCTCTTCTCT TTTGCTTGTC CTGCAAGCAT 60
TGTCGCAGCC CTCAACACTG CAAGCGCATA GCGACTGACT GCTGCACAGC TAGCCATCGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0269--Exonuclease
KW-0378--Hydrolase
KW-0507--mRNA processing
KW-0540--Nuclease
KW-1185--Reference proteome

Interpro

IPR013520--Exonuclease_RNaseT/DNA_pol3
IPR030843--PAN2
IPR028881--PAN2_dom
IPR012337--RNaseH-like_dom
IPR028889--USP_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR017986--WD40_repeat_dom

PROSITE

PS50235--USP_3

Pfam

PF00929--RNase_T
PF13423--UCH_1

SMART

SM00479--EXOIII

Gene Ontology

GO:0031251--C:PAN complex
GO:0003676--F:nucleic acid binding
GO:0004535--F:poly(A)-specific ribonuclease activity
GO:0006397--P:mRNA processing
GO:0000289--P:nuclear-transcribed mRNA poly(A) tail shortening

KEGG

pte:PTT_06948

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001273	Ailuropoda melanoleuca	31.94	5.00e-159	553.00
IUUC-Apl-003500	Anas platyrhynchos	31.22	7.00e-90	323.00
IUUC-Aca-004930	Anolis carolinensis	31.07	2.00e-96	345.00
IUUC-Acl-008214	Aspergillus clavatus	52.09	0.00e+00	1222.00
IUUC-Afu-009112	Aspergillus fumigatus	52.09	0.00e+00	1199.00
IUUC-Ang-009531	Aspergillus niger	52.11	0.00e+00	1177.00
IUUC-Ame-011259	Astyanax mexicanus	29.74	1.00e-88	320.00
IUUC-Bta-012371	Bos taurus	32.29	3.00e-160	558.00
IUUC-Bci-013684	Botrytis cinerea	48.39	0.00e+00	1074.00
IUUC-Cja-019297	Callithrix jacchus	31.63	4.00e-154	537.00
IUUC-Cfa-020489	Canis familiaris	31.94	7.00e-158	550.00
IUUC-Cpo-022392	Cavia porcellus	31.92	8.00e-159	553.00
IUUC-Csa-023220	Chlorocebus sabaeus	32.12	1.00e-157	549.00
IUUC-Csv-025841	Ciona savignyi	27.63	7.00e-65	241.00
IUUC-Cgl-026534	Colletotrichum gloeosporioides	53.56	0.00e+00	1217.00
IUUC-Cne-026932	Cryptococcus neoformans	34.35	3.00e-163	567.00
IUUC-Dre-028482	Danio rerio	28.89	6.00e-85	307.00
IUUC-Dno-029398	Dasypus novemcinctus	31.06	2.00e-92	332.00
IUUC-Dor-030307	Dipodomys ordii	31.94	3.00e-93	335.00
IUUC-Dme-032111	Drosophila melanogaster	28.51	8.00e-81	293.00
IUUC-Eca-033985	Equus caballus	32.03	2.00e-159	555.00
IUUC-Eeu-034928	Erinaceus europaeus	30.43	2.00e-42	166.00
IUUC-Fca-035587	Felis catus	32.38	3.00e-162	564.00
IUUC-Fal-037587	Ficedula albicollis	32.53	1.00e-159	555.00
IUUC-Fso-038133	Fusarium solani	47.61	0.00e+00	1033.00
IUUC-Gmo-039076	Gadus morhua	28.91	2.00e-85	309.00
IUUC-Ggr-039957	Gaeumannomyces graminis	47.85	0.00e+00	1032.00
IUUC-Gga-040948	Gallus gallus	32.18	8.00e-158	549.00
IUUC-Gac-042396	Gasterosteus aculeatus	30.68	6.00e-90	324.00
IUUC-Ggo-045412	Gorilla gorilla	31.86	6.00e-157	546.00
IUUC-Hsa-046076	Homo sapiens	31.86	8.00e-157	546.00
IUUC-Itr-048143	Ictidomys tridecemlineatus	31.05	8.00e-87	313.00
IUUC-Kpa-049178	Komagataella pastoris	33.63	2.00e-178	618.00
IUUC-Lch-050279	Latimeria chalumnae	41.23	1.00e-67	249.00
IUUC-Loc-052872	Lepisosteus oculatus	30.95	6.00e-91	327.00
IUUC-Lma-052986	Leptosphaeria maculans	88.69	0.00e+00	2104.00
IUUC-Laf-054181	Loxodonta africana	30.82	3.00e-88	318.00
IUUC-Mcc-054812	Macaca mulatta	31.97	4.00e-158	550.00
IUUC-Meu-056325	Macropus eugenii	30.82	7.00e-91	327.00
IUUC-Mor-057246	Magnaporthe oryzae	44.04	0.00e+00	895.00
IUUC-Mpo-057464	Magnaporthe poae	48.95	0.00e+00	1056.00
IUUC-Mla-058911	Melampsora laricipopulina	39.67	6.00e-121	427.00
IUUC-Mga-059335	Meleagris gallopavo	32.39	8.00e-156	543.00
IUUC-Mvi-060461	Microbotryum violaceum	34.49	5.00e-172	597.00
IUUC-Mmr-060636	Microcebus murinus	32.11	5.00e-156	543.00
IUUC-Mmu-063503	Mus musculus	31.92	6.00e-161	560.00
IUUC-Mpu-066670	Mustela putorius furo	32.11	2.00e-160	558.00
IUUC-Mlu-068119	Myotis lucifugus	32.06	4.00e-162	563.00
IUUC-Nfi-068398	Neosartorya fischeri	52.40	0.00e+00	1227.00
IUUC-Ncr-068927	Neurospora crassa	46.28	0.00e+00	970.00
IUUC-Nle-069651	Nomascus leucogenys	31.17	4.00e-148	517.00
IUUC-Opr-070614	Ochotona princeps	32.03	5.00e-156	543.00
IUUC-Ont-072433	Oreochromis niloticus	32.13	1.00e-157	548.00
IUUC-Oan-073283	Ornithorhynchus anatinus	38.53	2.00e-59	222.00
IUUC-Ocu-074401	Oryctolagus cuniculus	30.95	8.00e-93	333.00
IUUC-Ola-087522	Oryzias latipes	31.50	1.00e-156	546.00
IUUC-Oga-088226	Otolemur garnettii	30.87	5.00e-94	337.00
IUUC-Oar-089241	Ovis aries	32.28	2.00e-160	558.00
IUUC-Pan-092297	Papio anubis	32.04	4.00e-145	507.00
IUUC-Psi-094043	Pelodiscus sinensis	30.81	2.00e-89	322.00
IUUC-Pma-094394	Petromyzon marinus	31.86	7.00e-145	506.00
IUUC-Pno-095053	Phaeosphaeria nodorum	88.85	0.00e+00	1903.00
IUUC-Ppa-095188	Physcomitrella patens	27.93	3.00e-116	411.00
IUUC-Pfo-097517	Poecilia formosa	31.90	2.00e-158	551.00
IUUC-Pca-100471	Procavia capensis	32.15	4.00e-156	543.00
IUUC-Pva-102805	Pteropus vampyrus	32.43	6.00e-92	330.00
IUUC-Pyt-104682	Pyrenophora triticirepentis	99.03	0.00e+00	2265.00
IUUC-Rno-105471	Rattus norvegicus	31.97	2.00e-162	565.00
IUUC-Sce-106235	Saccharomyces cerevisiae	31.13	3.00e-145	508.00
IUUC-Sha-106883	Sarcophilus harrisii	30.54	5.00e-84	304.00
IUUC-Spo-108169	Schizosaccharomyces pombe	38.31	0.00e+00	696.00
IUUC-Sar-113323	Sorex araneus	33.08	5.00e-124	437.00
IUUC-Sre-115075	Sporisorium reilianum	42.03	4.00e-61	228.00
IUUC-Ssc-116363	Sus scrofa	30.87	2.00e-93	335.00
IUUC-Tru-118427	Takifugu rubripes	30.63	3.00e-94	338.00
IUUC-Tni-120218	Tetraodon nigroviridis	31.04	5.00e-95	341.00
IUUC-Tre-122177	Trichoderma reesei	53.10	0.00e+00	1190.00
IUUC-Tme-127176	Tuber melanosporum	45.82	0.00e+00	912.00
IUUC-Tbe-127641	Tupaia belangeri	32.95	5.00e-29	121.00
IUUC-Ttr-128888	Tursiops truncatus	33.29	5.00e-104	370.00
IUUC-Uma-129361	Ustilago maydis	43.19	3.00e-63	235.00
IUUC-Xtr-132811	Xenopus tropicalis	29.90	1.00e-83	303.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence