iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fal-037417

Ensembl Protein ID

ENSFALP00000012614.1

UniProt Accession

U3KC60; U3KC60_FICAL

Genbank Protein ID

ENSFALP00000012614

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGTO01011732

Gene Name

PRPF19

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFALG00000012084.1	ENSFALT00000012664.1	ENSFALP00000012614.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	4.80e-16	58.3	3	64
E3 adaptor/Cullin RING/DCX/DWD	1.80e-32	109.7	390	423
UBD/Beta-Prp	1.20e-54	185.2	231	461

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 6    flCpIslelMrdPvvlp.sGitydrssIekwlasggktcPvtrqplteedlvPnltlrrliqa 67
           ++C+Is+e++++P+v+p s+++y+r+ Iek++a++g+ +Pv++qpl+ee+l++ ++ + +  +
   Q: 3    LICSISNEVPEHPCVSPvSNHVYERRLIEKYIAENGT-DPVNNQPLSEEQLIDIKVAHPIRPK 64
           79**********************************9.***************9998877665 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sdtllvsGsdDgtikvWDlrt 32
           gH++++t++af  ++ +l++++dD ++k+WDlr+
   Q: 390  GHSGPITSIAFseNGYYLATAADDSSVKLWDLRK 423
           8**********976699**************986 PP

UBD/Beta-Prp

   S: 19   spdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgd 107
             d++ ++tg++d+ ++v+d ++++ l++l+gh+++vt+v f+p++++  ++s D+ti++w++ + +cv+++++he sv+ ls++++gd
   Q: 231  PSDTNKILTGGADKNVIVFDKSSEQILATLKGHTKKVTSVVFHPSQELVFSASPDATIRIWSVPNASCVQVVRAHEGSVTGLSLHATGD 319
           568899*********************************************************************************** PP
   S: 108  klvsGshdrtirvwdletgqclee.tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkel 195
           +l+s s+d++    d++tg +l + t++    + +c+++hpdg ++ +G+ D+++++Wdlk  + +  + g h ++++s++f++ng +l
   Q: 320  YLLSSSDDQYWAFSDIQTGRVLTKvTDESSGCALTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPG-HSGPITSIAFSENGYYL 407
           **********************997777777799************************************9.***************** PP
   S: 196  vsgsldgtvklwdlqtgecvrtlnghtd.nvksvrfspnderlvsgssDgsiri 248
           +++++d++vklwdl++ +  +tl+  ++  vks+ f++ +++l+ g+ D +i+i
   Q: 408  ATAADDSSVKLWDLRKLKNFKTLQLDNNfEVKSLIFDQSGTYLALGGTDVQIYI 461
           ***************999999999866527*******************99987 PP

Organism

Ficedula albicollis

Protein Sequence
(Fasta)

MALICSISNE VPEHPCVSPV SNHVYERRLI EKYIAENGTD PVNNQPLSEE QLIDIKVAHP 60
IRPKPPSATS IPAILKALQD EWDAVMLHSF TLRQQLQTTR QELSHALYQH DAACRVIARL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGGGGGGGG GGGGGGGGGG GGGGGGGGGG GGGGGGGGGG GGGGGGGGGG GGGGGGGGGG 60
GGGGGGGGGG GGGGGGGGGG GGGGGGGGGG CGGGAGCGCT TCCGGTTCCG GCGGCGGCGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR013915--Pre-mRNA_splic_Prp19
IPR000772--Ricin_B_lectin
IPR003613--Ubox_domain
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50231--RICIN_B_LECTIN
PS51698--U_BOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08606--Prp19
PF04564--U-box
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00504--Ubox
SM00320--WD40

Gene Ontology

GO:0071013--C:catalytic step 2 spliceosome
GO:0005737--C:cytoplasm
GO:0005662--C:DNA replication factor A complex
GO:0005811--C:lipid particle
GO:0016020--C:membrane
GO:0016607--C:nuclear speck
GO:0000974--C:Prp19 complex
GO:0035861--C:site of double-strand break
GO:0034450--F:ubiquitin-ubiquitin ligase activity
GO:0034613--P:cellular protein localization
GO:0006303--P:double-strand break repair via nonhomologous end joining
GO:0008610--P:lipid biosynthetic process
GO:0045665--P:negative regulation of neuron differentiation
GO:0048711--P:positive regulation of astrocyte differentiation
GO:0048026--P:positive regulation of mRNA splicing, via spliceosome
GO:0010498--P:proteasomal protein catabolic process
GO:0070534--P:protein K63-linked ubiquitination
GO:0072422--P:signal transduction involved in DNA damage checkpoint
GO:0000245--P:spliceosomal complex assembly
GO:0000244--P:spliceosomal tri-snRNP complex assembly

KEGG

fab:101815719

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000488	Aegilops tauschii	39.69	6.00e-98	352.00
IUUC-Aml-001230	Ailuropoda melanoleuca	94.19	0.00e+00	945.00
IUUC-Atr-002594	Amborella trichopoda	44.23	5.00e-119	421.00
IUUC-Apl-003686	Anas platyrhynchos	89.49	0.00e+00	744.00
IUUC-Aca-005272	Anolis carolinensis	97.02	0.00e+00	998.00
IUUC-Aly-005586	Arabidopsis lyrata	44.32	4.00e-119	421.00
IUUC-Ath-007696	Arabidopsis thaliana	44.19	2.00e-115	409.00
IUUC-Acl-008335	Aspergillus clavatus	35.08	8.00e-70	257.00
IUUC-Afl-008527	Aspergillus flavus	38.61	6.00e-75	274.00
IUUC-Afu-008957	Aspergillus fumigatus	38.99	8.00e-82	297.00
IUUC-Ani-009280	Aspergillus nidulans	37.70	1.00e-67	250.00
IUUC-Ang-009746	Aspergillus niger	36.92	3.00e-68	252.00
IUUC-Aor-009905	Aspergillus oryzae	38.40	1.00e-78	286.00
IUUC-Ate-010412	Aspergillus terreus	38.40	1.00e-67	250.00
IUUC-Ame-011561	Astyanax mexicanus	84.17	1.00e-109	389.00
IUUC-Bgr-012283	Blumeria graminis	33.40	5.00e-59	221.00
IUUC-Bta-013242	Bos taurus	97.42	0.00e+00	1000.00
IUUC-Bci-013901	Botrytis cinerea	34.59	3.00e-67	248.00
IUUC-Bdi-014277	Brachypodium distachyon	44.81	6.00e-125	440.00
IUUC-Bol-016207	Brassica oleracea	45.54	1.00e-118	419.00
IUUC-Bra-017902	Brassica rapa	43.93	3.00e-117	415.00
IUUC-Cel-018271	Caenorhabditis elegans	50.99	7.00e-152	530.00
IUUC-Cja-019879	Callithrix jacchus	96.83	0.00e+00	992.00
IUUC-Cfa-020175	Canis familiaris	97.42	0.00e+00	1001.00
IUUC-Cpo-022379	Cavia porcellus	97.02	0.00e+00	998.00
IUUC-Cre-022993	Chlamydomonas reinhardtii	40.55	5.00e-99	354.00
IUUC-Csa-023500	Chlorocebus sabaeus	97.22	0.00e+00	999.00
IUUC-Cho-025065	Choloepus hoffmanni	84.57	6.00e-145	506.00
IUUC-Cin-025699	Ciona intestinalis	68.12	4.00e-175	607.00
IUUC-Csv-026128	Ciona savignyi	65.37	0.00e+00	674.00
IUUC-Cgl-026507	Colletotrichum gloeosporioides	33.79	3.00e-67	248.00
IUUC-Cne-026860	Cryptococcus neoformans	37.77	2.00e-95	342.00
IUUC-Dre-028187	Danio rerio	83.17	0.00e+00	857.00
IUUC-Dno-029453	Dasypus novemcinctus	97.02	0.00e+00	997.00
IUUC-Dor-030150	Dipodomys ordii	95.80	6.00e-125	440.00
IUUC-Dse-031220	Dothistroma septosporum	32.70	2.00e-59	222.00
IUUC-Dme-031906	Drosophila melanogaster	65.94	0.00e+00	667.00
IUUC-Ete-033035	Echinops telfairi	84.52	0.00e+00	846.00
IUUC-Eca-033478	Equus caballus	97.22	0.00e+00	998.00
IUUC-Eeu-034974	Erinaceus europaeus	98.48	0.00e+00	677.00
IUUC-Fca-036194	Felis catus	96.81	0.00e+00	990.00
IUUC-Fox-037922	Fusarium oxysporum	34.74	6.00e-66	244.00
IUUC-Fso-038256	Fusarium solani	33.87	3.00e-66	245.00
IUUC-Gmo-038713	Gadus morhua	84.95	0.00e+00	872.00
IUUC-Ggr-039854	Gaeumannomyces graminis	32.82	1.00e-55	210.00
IUUC-Gga-041143	Gallus gallus	99.01	0.00e+00	1012.00
IUUC-Gac-042129	Gasterosteus aculeatus	84.55	0.00e+00	890.00
IUUC-Gma-044273	Glycine max	45.09	5.00e-122	431.00
IUUC-Ggo-045262	Gorilla gorilla	97.22	0.00e+00	999.00
IUUC-Hsa-046036	Homo sapiens	97.22	0.00e+00	999.00
IUUC-Hvu-047442	Hordeum vulgare	43.89	5.00e-69	253.00
IUUC-Itr-048169	Ictidomys tridecemlineatus	96.83	0.00e+00	962.00
IUUC-Lch-050105	Latimeria chalumnae	89.29	0.00e+00	934.00
IUUC-Lpe-050976	Leersia perrieri	44.62	1.00e-120	426.00
IUUC-Loc-052042	Lepisosteus oculatus	73.77	0.00e+00	661.00
IUUC-Lma-053143	Leptosphaeria maculans	35.01	8.00e-66	245.00
IUUC-Laf-053451	Loxodonta africana	93.67	0.00e+00	986.00
IUUC-Mcc-055786	Macaca mulatta	97.22	0.00e+00	999.00
IUUC-Meu-056161	Macropus eugenii	96.27	7.00e-138	483.00
IUUC-Mor-057215	Magnaporthe oryzae	32.68	2.00e-57	216.00
IUUC-Mpo-057419	Magnaporthe poae	31.48	1.00e-51	197.00
IUUC-Mtr-057756	Medicago truncatula	44.66	2.00e-117	416.00
IUUC-Mla-059085	Melampsora laricipopulina	38.05	3.00e-86	311.00
IUUC-Mga-060158	Meleagris gallopavo	91.78	0.00e+00	896.00
IUUC-Mvi-060441	Microbotryum violaceum	38.10	2.00e-79	289.00
IUUC-Mmr-061085	Microcebus murinus	97.22	0.00e+00	999.00
IUUC-Mdo-061804	Monodelphis domestica	97.22	0.00e+00	998.00
IUUC-Mmu-063608	Mus musculus	93.50	0.00e+00	985.00
IUUC-Mac-064972	Musa acuminata	44.42	1.00e-117	416.00
IUUC-Mpu-065700	Mustela putorius furo	97.42	0.00e+00	1000.00
IUUC-Mlu-068223	Myotis lucifugus	93.45	0.00e+00	979.00
IUUC-Nfi-068504	Neosartorya fischeri	38.26	4.00e-81	295.00
IUUC-Ncr-068729	Neurospora crassa	36.69	3.00e-65	242.00
IUUC-Nle-069754	Nomascus leucogenys	97.22	0.00e+00	999.00
IUUC-Opr-070621	Ochotona princeps	93.16	0.00e+00	934.00
IUUC-Ont-071377	Oreochromis niloticus	84.75	0.00e+00	869.00
IUUC-Oan-073498	Ornithorhynchus anatinus	71.38	1.00e-120	425.00
IUUC-Ocu-074182	Oryctolagus cuniculus	93.33	0.00e+00	986.00
IUUC-Oba-075509	Oryza barthii	44.53	9.00e-123	433.00
IUUC-Obr-076480	Oryza brachyantha	45.11	4.00e-124	437.00
IUUC-Ogl-077052	Oryza glaberrima	44.53	1.00e-122	433.00
IUUC-Ogu-078919	Oryza glumaepatula	44.53	9.00e-123	433.00
IUUC-Oin-079357	Oryza indica	43.82	5.00e-116	410.00
IUUC-Olo-080376	Oryza longistaminata	43.94	3.00e-111	395.00
IUUC-Ome-081973	Oryza meridionalis	43.85	1.00e-110	393.00
IUUC-Oni-082849	Oryza nivara	44.72	2.00e-123	436.00
IUUC-Opu-083243	Oryza punctata	44.34	5.00e-122	431.00
IUUC-Oru-084613	Oryza rufipogon	44.42	4.00e-123	434.00
IUUC-Osa-085407	Oryza sativa	44.51	3.00e-122	431.00
IUUC-Ola-086566	Oryzias latipes	83.53	0.00e+00	857.00
IUUC-Olu-087757	Ostreococcus lucimarinus	39.52	1.00e-94	340.00
IUUC-Oga-089010	Otolemur garnettii	92.70	0.00e+00	946.00
IUUC-Oar-089638	Ovis aries	97.42	0.00e+00	1000.00
IUUC-Ptr-091141	Pan troglodytes	97.22	0.00e+00	999.00
IUUC-Pan-092662	Papio anubis	97.22	0.00e+00	999.00
IUUC-Psi-093777	Pelodiscus sinensis	96.90	0.00e+00	818.00
IUUC-Pno-095115	Phaeosphaeria nodorum	35.86	1.00e-67	250.00
IUUC-Ppa-095841	Physcomitrella patens	45.02	4.00e-122	431.00
IUUC-Pfo-096390	Poecilia formosa	83.76	0.00e+00	865.00
IUUC-Pab-098250	Pongo abelii	95.46	0.00e+00	931.00
IUUC-Pop-099854	Populus trichocarpa	44.98	8.00e-121	427.00
IUUC-Pca-100553	Procavia capensis	97.02	0.00e+00	991.00
IUUC-Ppe-101383	Prunus persica	43.63	9.00e-114	403.00
IUUC-Pva-102189	Pteropus vampyrus	97.62	0.00e+00	1001.00
IUUC-Pgr-103304	Puccinia graminis	37.19	2.00e-84	305.00
IUUC-Ptt-103984	Puccinia triticina	37.50	2.00e-89	322.00
IUUC-Pte-104385	Pyrenophora teres	33.54	7.00e-71	261.00
IUUC-Pyt-104697	Pyrenophora triticirepentis	33.97	1.00e-71	263.00
IUUC-Rno-105581	Rattus norvegicus	97.02	0.00e+00	997.00
IUUC-Sha-107071	Sarcophilus harrisii	93.16	0.00e+00	984.00
IUUC-Sja-107697	Schizosaccharomyces japonicus	31.38	1.00e-36	147.00
IUUC-Spo-108315	Schizosaccharomyces pombe	32.63	7.00e-46	177.00
IUUC-Ssl-108628	Sclerotinia sclerotiorum	35.82	1.00e-66	246.00
IUUC-Smo-109648	Selaginella moellendorffii	45.35	2.00e-122	432.00
IUUC-Sit-109873	Setaria italica	44.15	4.00e-121	428.00
IUUC-Sly-111673	Solanum lycopersicum	45.16	4.00e-114	404.00
IUUC-Stu-112125	Solanum tuberosum	44.77	8.00e-113	400.00
IUUC-Sbi-114696	Sorghum bicolor	42.54	2.00e-109	389.00
IUUC-Sre-115134	Sporisorium reilianum	32.48	4.00e-72	265.00
IUUC-Ssc-116260	Sus scrofa	97.22	0.00e+00	998.00
IUUC-Tgu-116533	Taeniopygia guttata	99.60	0.00e+00	1016.00
IUUC-Tru-117800	Takifugu rubripes	83.37	0.00e+00	885.00
IUUC-Tsy-118980	Tarsius syrichta	91.63	0.00e+00	905.00
IUUC-Tni-120334	Tetraodon nigroviridis	68.32	0.00e+00	706.00
IUUC-Tca-121807	Theobroma cacao	44.68	3.00e-121	428.00
IUUC-Tre-121920	Trichoderma reesei	33.62	9.00e-65	240.00
IUUC-Tvi-122294	Trichoderma virens	33.26	8.00e-57	214.00
IUUC-Tae-125713	Triticum aestivum	45.00	2.00e-125	442.00
IUUC-Tur-126664	Triticum urartu	40.49	4.00e-115	408.00
IUUC-Tme-127026	Tuber melanosporum	34.69	2.00e-69	256.00
IUUC-Tbe-127582	Tupaia belangeri	98.18	0.00e+00	674.00
IUUC-Ttr-128313	Tursiops truncatus	97.22	0.00e+00	993.00
IUUC-Uma-129626	Ustilago maydis	33.33	9.00e-74	270.00
IUUC-Vda-129699	Verticillium dahliae	35.98	5.00e-70	258.00
IUUC-Vpa-130593	Vicugna pacos	96.70	0.00e+00	887.00
IUUC-Vvi-131668	Vitis vinifera	44.21	5.00e-120	424.00
IUUC-Xtr-132186	Xenopus tropicalis	86.33	0.00e+00	776.00
IUUC-Xma-133212	Xiphophorus maculatus	83.76	0.00e+00	864.00
IUUC-Yli-134607	Yarrowia lipolytica	56.82	2.00e-41	160.00
IUUC-Zma-135662	Zea mays	44.81	5.00e-123	434.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence