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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045781
Ensembl Protein ID ENSP00000273666.6
UniProt Accession Q9Y2K9; Q4G1B4; Q6PIC3; STB5L_HUMAN
Genbank Protein ID BAA76850.1; AAH22029.1; AAH37531.1
Protein Name Syntaxin-binding protein 5-like; Lethal(2) giant larvae protein homolog 4; Tomosyn-2
Genbank Nucleotide ID AB023223; BC022029; BC037531
Gene Name STXBP5L; KIAA1006; LLGL4
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000145087.12 ENST00000273666.10 ENSP00000273666.6
ENSG00000145087.12 ENST00000471454.5 ENSP00000420019.1
ENSG00000145087.12 ENST00000461772.5 ENSP00000420642.1
ENSG00000145087.12 ENST00000472879.5 ENSP00000419627.1
ENSG00000145087.12 ENST00000497029.5 ENSP00000420287.1
ENSG00000145087.12 ENST00000492541.5 ENSP00000420666.1
ENSG00000145087.12 ENST00000471262.1 ENSP00000420167.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
AREsitecircBasecircRNADbCircNet
miRTarBasemicroRNATRANSFACTargetScan
RepTarmiRNAMapSomamiRmiRcode
RAID2
Protein-protein Interaction
iRefIndexMenthaInWeb_IM
Disease-associated Variation
ClinVarGWASdbOMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMUniProt
BioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 3.00e-14 54.2 113 144
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 5    svtclaf..sdtllvsGsdDgtikvWDlrtgv 34
            v  l+f  +++ lvs+s D t+++W+lr+ +
   Q: 113  AVLQLQFliNEGALVSASSDDTLHLWNLRQKR 144
           4888999999999***************9865 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     May play a role in vesicle trafficking and exocytosis.
 May play a role in vesicle trafficking and exocytosis.
Protein Sequence
(Fasta)
MKKFNFRKVL DGLTASSPGS GSSSGSNSGG GAGSGSVHPA GTAGVLREEI QETLTSEYFQ 60
ICKTVRHGFP HQPTALAFDP VQKILAIGTR TGAIRILGRP GVDCYCQHES GAAVLQLQFL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045781|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GACGTCCCCG GGCACCCCGC CCCCTTCACC TCCCAGCTTT GCCGGGGAAG AAGCAGGGCG 60
GGGCAAGCTA GGGGCCGGCC CGGGGGCGGG GCCTGCCTCC CACGGCGGGA GGGCGGAGCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045781|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-1003--Cell membrane
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0268--Exocytosis
KW-0472--Membrane
KW-0488--Methylation
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat
Interpro

IPR000664--Lethal2_giant
IPR013905--Lgl_C_dom
IPR013577--LLGL2
IPR001388--Synaptobrevin
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS50892--V_SNARE
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF08596--Lgl_C
PF08366--LLGL
PF00400--WD40
PRINTS

PR00962--LETHAL2GIANT
SMART

SM00320--WD40
Gene Ontology

GO:0005737--C:cytoplasm
GO:0016021--C:integral component of membrane
GO:0005886--C:plasma membrane
GO:0005096--F:GTPase activator activity
GO:0017137--F:Rab GTPase binding
GO:0019905--F:syntaxin binding
GO:0006887--P:exocytosis
GO:0042593--P:glucose homeostasis
GO:0046676--P:negative regulation of insulin secretion
GO:0050714--P:positive regulation of protein secretion
GO:0015031--P:protein transport
GO:0017157--P:regulation of exocytosis
GO:0050708--P:regulation of protein secretion
KEGG hsa:9515
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000919 Aegilops tauschii 19.29 4.00e-20 94.40
IUUC-Atr-002583 Amborella trichopoda 26.50 8.00e-22 99.80
IUUC-Apl-003824 Anas platyrhynchos 81.15 0.00e+00 1754.00
IUUC-Aca-004971 Anolis carolinensis 78.87 0.00e+00 1695.00
IUUC-Acl-008044 Aspergillus clavatus 20.50 4.00e-15 77.40
IUUC-Afl-008612 Aspergillus flavus 20.94 4.00e-14 74.30
IUUC-Afu-008901 Aspergillus fumigatus 22.02 4.00e-16 80.90
IUUC-Ani-009223 Aspergillus nidulans 23.43 1.00e-17 85.50
IUUC-Ang-009861 Aspergillus niger 21.26 8.00e-16 79.70
IUUC-Aor-010078 Aspergillus oryzae 20.94 4.00e-14 74.30
IUUC-Bgr-012214 Blumeria graminis 23.86 2.00e-10 61.60
IUUC-Bta-013516 Bos taurus 97.39 0.00e+00 2226.00
IUUC-Bdi-015011 Brachypodium distachyon 20.53 2.00e-19 92.00
IUUC-Bol-015788 Brassica oleracea 22.70 3.00e-24 107.00
IUUC-Bra-017845 Brassica rapa 22.70 2.00e-24 108.00
IUUC-Cja-019607 Callithrix jacchus 98.79 0.00e+00 2015.00
IUUC-Cfa-020684 Canis familiaris 97.13 0.00e+00 2231.00
IUUC-Cpo-021931 Cavia porcellus 91.74 0.00e+00 2032.00
IUUC-Csa-024071 Chlorocebus sabaeus 99.58 0.00e+00 2357.00
IUUC-Cho-025086 Choloepus hoffmanni 89.88 0.00e+00 2033.00
IUUC-Dre-028232 Danio rerio 70.08 0.00e+00 1558.00
IUUC-Dno-029242 Dasypus novemcinctus 96.63 0.00e+00 2237.00
IUUC-Dor-030660 Dipodomys ordii 89.71 0.00e+00 2052.00
IUUC-Dse-031263 Dothistroma septosporum 24.55 4.00e-13 70.50
IUUC-Ete-033006 Echinops telfairi 81.51 0.00e+00 1253.00
IUUC-Eeu-034943 Erinaceus europaeus 97.77 0.00e+00 845.00
IUUC-Fca-036345 Felis catus 92.83 0.00e+00 1505.00
IUUC-Fal-036915 Ficedula albicollis 84.97 0.00e+00 2039.00
IUUC-Gga-040529 Gallus gallus 87.35 0.00e+00 2061.00
IUUC-Gac-042416 Gasterosteus aculeatus 70.98 0.00e+00 1606.00
IUUC-Gma-043398 Glycine max 24.01 5.00e-23 103.00
IUUC-Ggo-044575 Gorilla gorilla 99.75 0.00e+00 2385.00
IUUC-Hvu-047650 Hordeum vulgare 20.18 1.00e-20 95.50
IUUC-Lch-050258 Latimeria chalumnae 82.71 0.00e+00 1545.00
IUUC-Lpe-051115 Leersia perrieri 20.50 2.00e-19 91.70
IUUC-Loc-051905 Lepisosteus oculatus 77.85 0.00e+00 1324.00
IUUC-Lma-053029 Leptosphaeria maculans 23.74 9.00e-18 86.30
IUUC-Laf-053669 Loxodonta africana 94.01 0.00e+00 2180.00
IUUC-Mcc-055188 Macaca mulatta 99.41 0.00e+00 2355.00
IUUC-Meu-056246 Macropus eugenii 78.96 0.00e+00 1158.00
IUUC-Mmr-061273 Microcebus murinus 90.36 0.00e+00 2167.00
IUUC-Mdo-062223 Monodelphis domestica 93.41 0.00e+00 1979.00
IUUC-Mmu-063800 Mus musculus 95.19 0.00e+00 2269.00
IUUC-Mac-065436 Musa acuminata 29.23 3.00e-13 71.20
IUUC-Mlu-067278 Myotis lucifugus 96.12 0.00e+00 2268.00
IUUC-Nfi-068318 Neosartorya fischeri 21.58 4.00e-16 80.50
IUUC-Nle-069733 Nomascus leucogenys 99.58 0.00e+00 2380.00
IUUC-Opr-070840 Ochotona princeps 81.64 0.00e+00 1236.00
IUUC-Ocu-074214 Oryctolagus cuniculus 97.64 0.00e+00 2277.00
IUUC-Oin-079192 Oryza indica 19.96 6.00e-18 87.00
IUUC-Oru-084893 Oryza rufipogon 20.68 2.00e-16 81.30
IUUC-Ola-087301 Oryzias latipes 73.61 0.00e+00 1565.00
IUUC-Oga-089148 Otolemur garnettii 95.95 0.00e+00 2256.00
IUUC-Oar-090261 Ovis aries 97.19 0.00e+00 2190.00
IUUC-Ptr-090697 Pan troglodytes 100.00 0.00e+00 2388.00
IUUC-Pan-092899 Papio anubis 99.41 0.00e+00 2347.00
IUUC-Psi-093249 Pelodiscus sinensis 86.40 0.00e+00 1982.00
IUUC-Pab-097774 Pongo abelii 94.25 0.00e+00 1763.00
IUUC-Pop-099413 Populus trichocarpa 21.61 8.00e-17 83.20
IUUC-Ppe-101236 Prunus persica 21.85 4.00e-19 90.90
IUUC-Pva-102704 Pteropus vampyrus 86.00 0.00e+00 1924.00
IUUC-Pte-104412 Pyrenophora teres 24.22 3.00e-18 87.80
IUUC-Pyt-104770 Pyrenophora triticirepentis 24.22 6.00e-18 86.70
IUUC-Rno-105297 Rattus norvegicus 96.24 0.00e+00 2132.00
IUUC-Sha-107086 Sarcophilus harrisii 88.08 0.00e+00 1895.00
IUUC-Sly-111338 Solanum lycopersicum 27.52 3.00e-21 95.90
IUUC-Stu-112417 Solanum tuberosum 28.29 1.00e-21 97.80
IUUC-Tgu-117382 Taeniopygia guttata 85.92 0.00e+00 1767.00
IUUC-Tru-118317 Takifugu rubripes 73.51 0.00e+00 1630.00
IUUC-Tsy-119322 Tarsius syrichta 91.88 0.00e+00 1405.00
IUUC-Tca-121778 Theobroma cacao 21.19 6.00e-22 100.00
IUUC-Tre-122192 Trichoderma reesei 22.97 3.00e-18 87.80
IUUC-Tae-125452 Triticum aestivum 20.49 2.00e-20 95.10
IUUC-Tur-126560 Triticum urartu 20.40 8.00e-18 86.30
IUUC-Ttr-129239 Tursiops truncatus 96.59 0.00e+00 2177.00
IUUC-Vpa-130524 Vicugna pacos 91.15 0.00e+00 2028.00
IUUC-Xtr-132634 Xenopus tropicalis 76.47 0.00e+00 1815.00
IUUC-Xma-133316 Xiphophorus maculatus 67.56 0.00e+00 1633.00
Created Date 25-Jun-2017

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