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Tag Content
UUCD2 ID IUUC-Mga-059699
UUCD1 version UUC-MeG-00159
Ensembl Protein ID ENSMGAP00000002933.2
UniProt Accession G1MW43; G1MW43_MELGA
Protein Name E3 ubiquitin-protein ligase RNF168; RING finger protein 168; RING-type E3 ubiquitin transferase RNF168
Gene Name RNF168
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMGAG00000003252.2 ENSMGAT00000003623.2 ENSMGAP00000002933.2
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/RING 2.70e-06 27.6 16 55
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
    C iC+e f + p++lpC+H+++ +C+ +++ + CP Cr
   Q: 16 CQICMEIFVE-PVTLPCNHTICNSCFqLT------VENASLCCPFCR 55
    9********9.9**************444......5**********8 PP
   

Organism Meleagris gallopavo
Functional Description
(View)

Functional Description



     E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively).
E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively).
Protein Sequence
(Fasta)
MSKKSEAPLS LDDCLCQICM EIFVEPVTLP CNHTICNSCF QLTVENASLC CPFCRRRVSS 60
WARYNARRNT LINWELWEKI QKKYPKECER RINGQDLEEL VFVPHPQHQL SKPGELRQEY 120
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Protein Fasta Sequence



>IUUC-Mga-059699|E3,RING|Meleagris gallopavo
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGTCAAAGA AATCGGAGGC TCCCCTTTCC TTAGATGACT GCCTCTGCCA GATCTGCATG 60
GAGATCTTTG TGGAGCCCGT GACGCTGCCG TGCAACCATA CCATCTGTAA TTCTTGTTTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Mga-059699|E3,RING|Meleagris gallopavo
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR034725--RNF168
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

SMART

SM00184--RING

Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0043234--C:protein complex
GO:0035861--C:site of double-strand break
GO:0000151--C:ubiquitin ligase complex
GO:0031491--F:nucleosome binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006302--P:double-strand break repair
GO:0070535--P:histone H2A K63-linked ubiquitination
GO:0035518--P:histone H2A monoubiquitination
GO:0036351--P:histone H2A-K13 ubiquitination
GO:0036352--P:histone H2A-K15 ubiquitination
GO:0034244--P:negative regulation of transcription elongation from RNA polymerase II promoter
GO:0045739--P:positive regulation of DNA repair
GO:0010212--P:response to ionizing radiation
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000755 Aegilops tauschii 35.53 9.00e-10 57.80
IUUC-Aml-001573 Ailuropoda melanoleuca 41.39 7.00e-84 304.00
IUUC-Atr-002992 Amborella trichopoda 36.47 1.00e-09 57.00
IUUC-Apl-003963 Anas platyrhynchos 77.67 0.00e+00 679.00
IUUC-Aca-004420 Anolis carolinensis 47.22 6.00e-88 317.00
IUUC-Ath-007019 Arabidopsis thaliana 37.18 1.00e-08 55.50
IUUC-Ame-011521 Astyanax mexicanus 55.80 5.00e-44 171.00
IUUC-Bta-013002 Bos taurus 40.00 7.00e-75 274.00
IUUC-Cja-019945 Callithrix jacchus 39.83 3.00e-77 282.00
IUUC-Cfa-020533 Canis familiaris 38.74 2.00e-77 283.00
IUUC-Cpo-021643 Cavia porcellus 36.44 2.00e-54 206.00
IUUC-Csa-023638 Chlorocebus sabaeus 41.89 2.00e-77 283.00
IUUC-Cho-024319 Choloepus hoffmanni 40.30 2.00e-74 272.00
IUUC-Cin-025679 Ciona intestinalis 36.36 1.00e-22 99.80
IUUC-Csv-026052 Ciona savignyi 34.72 3.00e-23 101.00
IUUC-Dre-028519 Danio rerio 54.17 4.00e-40 158.00
IUUC-Dno-029294 Dasypus novemcinctus 39.90 3.00e-79 288.00
IUUC-Ete-032714 Echinops telfairi 63.25 1.00e-40 160.00
IUUC-Eca-033343 Equus caballus 43.98 3.00e-80 291.00
IUUC-Fca-036251 Felis catus 41.92 2.00e-81 296.00
IUUC-Fal-037048 Ficedula albicollis 66.55 7.00e-179 619.00
IUUC-Gmo-039400 Gadus morhua 49.58 9.00e-36 141.00
IUUC-Gga-040444 Gallus gallus 88.02 0.00e+00 968.00
IUUC-Gac-041735 Gasterosteus aculeatus 48.89 8.00e-41 159.00
IUUC-Gma-044332 Glycine max 36.25 2.00e-11 63.20
IUUC-Ggo-044940 Gorilla gorilla 32.09 6.00e-28 118.00
IUUC-Hsa-046424 Homo sapiens 39.77 6.00e-75 274.00
IUUC-Itr-048965 Ictidomys tridecemlineatus 41.56 2.00e-69 256.00
IUUC-Lch-050649 Latimeria chalumnae 40.08 1.00e-60 226.00
IUUC-Loc-051847 Lepisosteus oculatus 38.76 1.00e-52 200.00
IUUC-Laf-053938 Loxodonta africana 40.63 5.00e-81 294.00
IUUC-Mcc-055360 Macaca mulatta 39.93 5.00e-74 271.00
IUUC-Meu-056684 Macropus eugenii 40.07 5.00e-70 258.00
IUUC-Mtr-058007 Medicago truncatula 36.84 7.00e-11 61.20
IUUC-Mmr-060779 Microcebus murinus 41.03 2.00e-83 303.00
IUUC-Mdo-062225 Monodelphis domestica 43.10 1.00e-79 290.00
IUUC-Mmu-064239 Mus musculus 38.29 7.00e-64 237.00
IUUC-Mpu-066141 Mustela putorius furo 43.51 4.00e-92 331.00
IUUC-Mlu-067945 Myotis lucifugus 43.10 2.00e-76 279.00
IUUC-Nle-069769 Nomascus leucogenys 49.82 8.00e-52 197.00
IUUC-Opr-070905 Ochotona princeps 34.50 9.00e-49 187.00
IUUC-Ont-071477 Oreochromis niloticus 52.38 7.00e-39 154.00
IUUC-Oan-073587 Ornithorhynchus anatinus 69.29 1.00e-50 191.00
IUUC-Ocu-073832 Oryctolagus cuniculus 39.09 5.00e-68 251.00
IUUC-Obr-076219 Oryza brachyantha 35.53 1.00e-09 56.60
IUUC-Ogl-077658 Oryza glaberrima 36.84 1.00e-09 57.00
IUUC-Oin-079383 Oryza indica 36.84 1.00e-09 57.40
IUUC-Ome-081482 Oryza meridionalis 36.84 1.00e-09 57.40
IUUC-Oni-083025 Oryza nivara 36.84 1.00e-09 57.40
IUUC-Opu-083547 Oryza punctata 36.11 4.00e-09 55.50
IUUC-Osa-085978 Oryza sativa 36.84 1.00e-09 57.40
IUUC-Ola-086478 Oryzias latipes 53.60 1.00e-37 147.00
IUUC-Oga-088318 Otolemur garnettii 40.54 3.00e-75 275.00
IUUC-Oar-089647 Ovis aries 39.12 4.00e-75 275.00
IUUC-Ptr-090516 Pan troglodytes 39.77 2.00e-76 279.00
IUUC-Pan-092302 Papio anubis 39.26 7.00e-71 261.00
IUUC-Psi-093604 Pelodiscus sinensis 52.36 4.00e-129 454.00
IUUC-Pfo-096441 Poecilia formosa 55.71 1.00e-45 176.00
IUUC-Pab-097729 Pongo abelii 39.56 3.00e-73 269.00
IUUC-Pca-100552 Procavia capensis 68.00 2.00e-40 159.00
IUUC-Pva-102780 Pteropus vampyrus 38.91 1.00e-72 266.00
IUUC-Rno-105461 Rattus norvegicus 39.24 3.00e-74 272.00
IUUC-Sha-106809 Sarcophilus harrisii 43.70 2.00e-79 289.00
IUUC-Sly-111317 Solanum lycopersicum 40.79 9.00e-13 67.40
IUUC-Stu-112446 Solanum tuberosum 37.80 2.00e-12 66.20
IUUC-Sar-113579 Sorex araneus 40.45 5.00e-63 234.00
IUUC-Sbi-113834 Sorghum bicolor 38.16 2.00e-10 59.70
IUUC-Tgu-117187 Taeniopygia guttata 88.08 2.00e-85 307.00
IUUC-Tru-118182 Takifugu rubripes 53.15 9.00e-37 147.00
IUUC-Tni-120205 Tetraodon nigroviridis 56.52 5.00e-46 177.00
IUUC-Tca-121416 Theobroma cacao 36.25 4.00e-11 62.00
IUUC-Tvi-122557 Trichoderma virens 39.19 1.00e-05 44.30
IUUC-Tae-123092 Triticum aestivum 35.53 1.00e-09 57.80
IUUC-Tur-126688 Triticum urartu 34.21 8.00e-10 57.40
IUUC-Tbe-127622 Tupaia belangeri 42.06 6.00e-85 307.00
IUUC-Ttr-128988 Tursiops truncatus 39.77 3.00e-75 275.00
IUUC-Vpa-130302 Vicugna pacos 65.08 1.00e-46 180.00
IUUC-Vvi-131424 Vitis vinifera 35.53 4.00e-09 55.10
IUUC-Xtr-132196 Xenopus tropicalis 37.42 4.00e-67 248.00
Created Date 25-Jun-2017

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