iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pab-097872

Ensembl Protein ID

ENSPPYP00000021267.1

UniProt Accession

H2PRF7; H2PRF7_PONAB

Genbank Protein ID

ENSPPYP00000021267

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ABGA01291831

Gene Name

SHARPIN

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPPYG00000018962.1	ENSPPYT00000022115.1	ENSPPYP00000021267.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
ULD/UDP/UBQ/UBQ_Other	5.30e-12	45.5	239	291

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UDP/UBQ/UBQ_Other

   S: 12   eltlkvnpsdtVaeLKekiekklgippeqqrLiykGkiL.eddktLadyglkdg 64
           +  l+v+p++tVa L+e+++++lg+pp+ qr+++ G++L  + ++La+yg++++
   Q: 239  HVALQVHPHCTVAALQEQVFSELGFPPAVQRWVI-GRCLcVPERSLASYGVRQD 291
           556779****************************.**************99754 PP

Organism

Pongo abelii

Protein Sequence
(Fasta)

MAPPAGGAAA AASDLGSAAV LLAVHAAVRP LGAGPDAEAQ LRKLQLSADP ERPGRFRLEL 60
LGAGPGAVNL EWPLESVSYT IRGPTQHELQ PPPGGPGTLS LHFLNPQEAQ RWAVLVRGAT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGCCGC CAGCGGGCGG GGCGGCGGCG GCGGCCTCGG ATTTGGGGTC GGCCGCAGTG 60
CTCTTGGCTG TGCACGCCGC GGTGAGGCCG CTGGGCGCCG GGCCAGACGC CGAGGCACAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR031912--Sharpin_PH
IPR029071--Ubiquitin-rel_dom

Pfam

PF16764--Sharpin_PH

Gene Ontology

GO:0005829--C:cytosol
GO:0071797--C:LUBAC complex
GO:0030262--P:apoptotic nuclear changes
GO:0031424--P:keratinization
GO:0007005--P:mitochondrion organization
GO:0050728--P:negative regulation of inflammatory response
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0097039--P:protein linear polyubiquitination
GO:2000348--P:regulation of CD40 signaling pathway
GO:0010803--P:regulation of tumor necrosis factor-mediated signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000111	Aegilops tauschii	38.24	1.80e-02	33.10
IUUC-Aml-001223	Ailuropoda melanoleuca	81.91	3.00e-115	408.00
IUUC-Apl-004151	Anas platyrhynchos	68.09	4.00e-18	82.40
IUUC-Ang-009713	Aspergillus niger	33.33	8.00e-03	34.70
IUUC-Bta-012948	Bos taurus	80.60	3.00e-121	427.00
IUUC-Cel-018155	Caenorhabditis elegans	36.54	6.40e-02	29.30
IUUC-Cja-019031	Callithrix jacchus	87.31	2.00e-121	428.00
IUUC-Cfa-020863	Canis familiaris	75.66	6.00e-91	327.00
IUUC-Cpo-022499	Cavia porcellus	77.30	9.00e-114	403.00
IUUC-Csa-023641	Chlorocebus sabaeus	93.36	8.00e-137	479.00
IUUC-Dno-029459	Dasypus novemcinctus	65.18	4.00e-58	218.00
IUUC-Dor-030914	Dipodomys ordii	64.21	6.00e-102	363.00
IUUC-Ete-032940	Echinops telfairi	70.86	2.00e-114	405.00
IUUC-Eca-033537	Equus caballus	80.00	2.00e-117	415.00
IUUC-Eeu-035176	Erinaceus europaeus	67.57	6.00e-78	284.00
IUUC-Fca-035971	Felis catus	79.79	4.00e-107	381.00
IUUC-Gmo-039219	Gadus morhua	40.21	1.00e-39	157.00
IUUC-Ggo-044678	Gorilla gorilla	93.71	4.00e-145	507.00
IUUC-Hsa-046578	Homo sapiens	96.32	2.00e-150	525.00
IUUC-Itr-047913	Ictidomys tridecemlineatus	71.64	4.00e-113	400.00
IUUC-Mcc-055686	Macaca mulatta	93.93	1.00e-131	462.00
IUUC-Meu-055912	Macropus eugenii	52.00	2.00e-59	222.00
IUUC-Mmr-060584	Microcebus murinus	82.18	7.00e-121	426.00
IUUC-Mdo-062191	Monodelphis domestica	53.87	1.00e-66	246.00
IUUC-Mmu-063740	Mus musculus	71.05	4.00e-95	341.00
IUUC-Mpu-066878	Mustela putorius furo	75.58	4.00e-107	380.00
IUUC-Mlu-067878	Myotis lucifugus	79.61	8.00e-115	406.00
IUUC-Nle-069748	Nomascus leucogenys	96.05	3.00e-152	530.00
IUUC-Ont-072270	Oreochromis niloticus	38.99	2.00e-39	155.00
IUUC-Oga-088300	Otolemur garnettii	81.21	2.00e-126	445.00
IUUC-Oar-089549	Ovis aries	79.93	1.00e-122	432.00
IUUC-Ptr-090961	Pan troglodytes	96.66	3.00e-151	527.00
IUUC-Pan-092687	Papio anubis	94.33	5.00e-142	497.00
IUUC-Pfo-096865	Poecilia formosa	37.28	8.00e-29	121.00
IUUC-Pca-100363	Procavia capensis	69.06	7.00e-78	284.00
IUUC-Pva-102595	Pteropus vampyrus	77.96	2.00e-136	478.00
IUUC-Rno-105856	Rattus norvegicus	72.48	1.00e-97	349.00
IUUC-Sha-106838	Sarcophilus harrisii	56.60	1.00e-54	206.00
IUUC-Sar-113611	Sorex araneus	67.18	2.00e-36	145.00
IUUC-Ssc-116263	Sus scrofa	74.40	4.00e-117	414.00
IUUC-Tru-118089	Takifugu rubripes	41.33	2.00e-44	172.00
IUUC-Tni-120004	Tetraodon nigroviridis	41.33	2.00e-33	136.00
IUUC-Tbe-127471	Tupaia belangeri	71.09	2.00e-121	428.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence