iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ssc-116263

Ensembl Protein ID

ENSSSCP00000006323.2

UniProt Accession

F1RSN0; F1RSN0_PIG

Genbank Protein ID

ENSSSCP00000006323

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

FP085492

Gene Name

SHARPIN

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSSCG00000005914.2	ENSSSCT00000006494.2	ENSSSCP00000006323.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/ZnF/NZF	4.00e-13	48.9	342	369
ULD/UDP/UBQ/UBQ_Other	2.40e-13	50.0	221	282

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/ZnF/NZF

   S: 2    eaqWaCsaCTflNePeavkCemCsrpRg 29
           +++W+C++CTf+N+P++++CemCs++R+
   Q: 342  QPGWSCPSCTFINAPSRPGCEMCSTQRP 369
           689************************8 PP

ULD/UDP/UBQ/UBQ_Other

   S: 2    qvtvksldgs.eltlkvnpsdtVaeLKekiekklgippeqqrLiykGkiL.eddktLadyglk 62
           qvtv+++ +s + +l+v+p++t+  L+e++++++g+pp+ qr+++ G++L  + ++La+yg++
   Q: 221  QVTVEDAASSaHVSLQVHPHCTIRALQEQVFSEFGFPPAVQRWVI-GRCLcAPECSLASYGVR 282
           89*******************************************.**************995 PP

Organism

Sus scrofa

Protein Sequence
(Fasta)

MAPPAGGAAA SSDSGSPAVL LAVHAAVRPL GAGPDAEAQL RRLQLSADPE RPGRFRLELL 60
GAGHGAVGLE WPLESVYYTV RGPSQHELQP PPGGPGTLGL HFTDPQEAQR WAALVRSATM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTCGGACCGG AGATGGCTCC TCCAGCGGGC GGCGCGGCCG CCTCCTCGGA CTCGGGCTCG 60
CCGGCGGTGC TCTTGGCCGT GCACGCCGCG GTGAGGCCGC TGGGCGCGGG GCCGGACGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome

Interpro

IPR031912--Sharpin_PH
IPR029071--Ubiquitin-rel_dom
IPR001876--Znf_RanBP2

PROSITE

PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2

Pfam

PF16764--Sharpin_PH
PF00641--zf-RanBP

SMART

SM00547--ZnF_RBZ

Gene Ontology

GO:0005829--C:cytosol
GO:0071797--C:LUBAC complex
GO:0043130--F:ubiquitin binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0030262--P:apoptotic nuclear changes
GO:0031424--P:keratinization
GO:0007005--P:mitochondrion organization
GO:0050728--P:negative regulation of inflammatory response
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0097039--P:protein linear polyubiquitination
GO:2000348--P:regulation of CD40 signaling pathway
GO:0010803--P:regulation of tumor necrosis factor-mediated signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001223	Ailuropoda melanoleuca	83.85	8.00e-131	459.00
IUUC-Apl-004151	Anas platyrhynchos	65.96	4.00e-17	78.60
IUUC-Bta-012948	Bos taurus	83.21	1.00e-150	526.00
IUUC-Cja-019031	Callithrix jacchus	76.32	2.00e-122	431.00
IUUC-Cfa-020863	Canis familiaris	77.08	1.00e-120	426.00
IUUC-Cpo-022499	Cavia porcellus	72.19	2.00e-118	418.00
IUUC-Csa-023641	Chlorocebus sabaeus	75.96	4.00e-119	421.00
IUUC-Cne-026853	Cryptococcus neoformans	52.17	1.00e-02	34.70
IUUC-Dno-029459	Dasypus novemcinctus	56.82	5.00e-63	234.00
IUUC-Dor-030914	Dipodomys ordii	59.37	1.00e-75	276.00
IUUC-Ete-032940	Echinops telfairi	71.11	6.00e-106	377.00
IUUC-Eca-033537	Equus caballus	83.09	3.00e-136	478.00
IUUC-Eeu-035176	Erinaceus europaeus	71.28	8.00e-70	256.00
IUUC-Fca-035971	Felis catus	77.00	1.00e-128	452.00
IUUC-Fal-037440	Ficedula albicollis	45.45	1.00e-10	57.40
IUUC-Gmo-039219	Gadus morhua	39.43	3.00e-53	201.00
IUUC-Gga-040198	Gallus gallus	45.29	2.00e-30	125.00
IUUC-Gac-041562	Gasterosteus aculeatus	38.42	8.00e-37	147.00
IUUC-Ggo-044678	Gorilla gorilla	75.82	7.00e-121	426.00
IUUC-Hsa-046578	Homo sapiens	77.44	2.00e-125	441.00
IUUC-Itr-047913	Ictidomys tridecemlineatus	72.88	1.00e-125	442.00
IUUC-Lch-050269	Latimeria chalumnae	36.18	3.00e-53	202.00
IUUC-Mcc-055686	Macaca mulatta	70.41	2.00e-117	414.00
IUUC-Meu-055912	Macropus eugenii	51.80	3.00e-59	221.00
IUUC-Mmr-060584	Microcebus murinus	74.18	8.00e-130	456.00
IUUC-Mdo-062191	Monodelphis domestica	56.38	4.00e-81	294.00
IUUC-Mmu-063740	Mus musculus	69.70	3.00e-104	371.00
IUUC-Mpu-066878	Mustela putorius furo	72.68	9.00e-116	409.00
IUUC-Mlu-067878	Myotis lucifugus	81.10	4.00e-132	464.00
IUUC-Nle-069748	Nomascus leucogenys	76.36	5.00e-118	416.00
IUUC-Ont-072270	Oreochromis niloticus	39.83	4.00e-52	198.00
IUUC-Oba-075102	Oryza barthii	42.22	4.00e-04	38.50
IUUC-Obr-076087	Oryza brachyantha	58.33	2.00e-04	38.90
IUUC-Ogl-077291	Oryza glaberrima	42.22	4.00e-04	38.50
IUUC-Oin-079800	Oryza indica	44.68	1.00e-04	40.40
IUUC-Ome-081262	Oryza meridionalis	42.22	7.00e-04	37.70
IUUC-Oni-082829	Oryza nivara	44.68	1.00e-04	40.40
IUUC-Opu-083275	Oryza punctata	40.91	2.00e-03	37.00
IUUC-Oga-088300	Otolemur garnettii	73.92	8.00e-134	469.00
IUUC-Oar-089549	Ovis aries	82.96	4.00e-154	537.00
IUUC-Ptr-090961	Pan troglodytes	77.26	8.00e-115	406.00
IUUC-Pan-092687	Papio anubis	77.53	1.00e-123	436.00
IUUC-Pno-095076	Phaeosphaeria nodorum	30.77	2.00e-03	35.00
IUUC-Pab-097872	Pongo abelii	74.40	2.00e-117	415.00
IUUC-Pca-100363	Procavia capensis	69.44	5.00e-74	271.00
IUUC-Ppe-101337	Prunus persica	48.00	2.00e-03	36.60
IUUC-Pva-102595	Pteropus vampyrus	81.23	1.00e-117	416.00
IUUC-Pyt-104442	Pyrenophora triticirepentis	29.23	2.00e-03	35.00
IUUC-Rno-105856	Rattus norvegicus	68.93	5.00e-96	344.00
IUUC-Sha-106838	Sarcophilus harrisii	54.87	4.00e-76	278.00
IUUC-Ssl-108588	Sclerotinia sclerotiorum	39.13	1.00e-03	37.40
IUUC-Sly-111366	Solanum lycopersicum	50.00	3.00e-05	42.00
IUUC-Sar-113611	Sorex araneus	66.32	1.00e-26	113.00
IUUC-Tru-118089	Takifugu rubripes	41.48	2.00e-58	219.00
IUUC-Tni-120004	Tetraodon nigroviridis	42.31	1.00e-49	190.00
IUUC-Tbe-127471	Tupaia belangeri	66.37	2.00e-95	342.00
IUUC-Ttr-128534	Tursiops truncatus	81.85	2.00e-104	371.00
IUUC-Vda-130005	Verticillium dahliae	38.89	1.80e-02	33.50

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence