iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-054570

UUCD1 version

UUC-LoA-01093

Ensembl Protein ID

ENSLAFP00000012771.3

UniProt Accession

G3TES3; G3TES3_LOXAF

Protein Name

Uncharacterized protein

Gene Name

USP37

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000015247.3	ENSLAFT00000015248.3	ENSLAFP00000012771.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.50e-87	294.3	343	953

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw..kskkkavsprellkalkkeaeefsgy 87
           +G++NlgNtCYmN++LQ+L+++++++++ll+   + ++++  k p ++ll+ +++l+ +    +s++k+   +++++a++++ae+fsgy
   Q: 343  QGFSNLGNTCYMNAILQSLFSLQSFANDLLK---QGIPWK--KIPLNALLRRFAHLLVKKDicNSETKKDLLKKVKNAISATAERFSGY 426
           69*****************************...*****9..578888888888888666577************************** PP
   S: 88   eqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpv 176
           +q+Da+Efl+++ldql+e+++k  nk++++e    +++++d+   + ++ +++++ ++++++++++i+c++c+++  ++e+f+dls+++
   Q: 427  MQNDAHEFLSQCLDQLKEDMEK-LNKTWKTEPVPGEENSPDI---SATRVYTCPVITNLEFEVQHSIICKACGEIIPKREQFNDLSIDL 511
           ********************55.9999999999998899999...7999**************************************** PP
   S: 177  pgkeetkke.slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspf 264
           p++++  ++ s+qd+L+ f+++eele    y+cekc +k+ a  ++k+++lP+vLilhLkR+sf+ + + ++ki ++v +p+ L+ls++
   Q: 512  PRRKKPLPPrSIQDSLDLFFRAEELE----YSCEKCGGKC-ALVRHKFNRLPRVLILHLKRYSFNVALSLNNKIGQQVIIPRYLTLSSH 595
           *999886545***************9....*********9.89999******************************************* PP
   S: 265  cts...................................................................................... 267
           ct+                                                                                      
   Q: 596  CTEttkpplnlgwsahmtvsrplkasqmvnscitspstpskkftfkskssslalcldsdsedelkrsvalsqrlcevsggeqqqedlek 684
           ***99999999999999999999999999999999999999999999999999999999999999999999999999988888888888 PP
   S: 268  ......................................................................................... 267
                                                                                                    
   Q: 685  dsklcrlepdkselensgfdgmseeelvaavleiskretspslshedddkptsspdtgfaeddiqempenpepvetekpkavtepdpas 773
           88888888888888888888888888888888888877777777777777777777777777777777777777666666666666666 PP
   S: 268  ................peekqke.................................................................. 274
                           p     e                                                                  
   Q: 774  fteitkdcdenkenktP-----Egsqgevdwlqqydmerereeqelqqalaqslqeqeaweqkedddikratelslqefnssfldslgs 857
           66666666655555550.....0555555555555555555566666666666666777777777777777777788888888888888 PP
   S: 275  ...............................kkkYeLiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetgsta 330
                                          +++Y+Li+vv+H G ++ssGHY+++v++ k++ W++++D +V++++e++v++++++++
   Q: 858  dedsgnedvldmeyteaeaeelkrnaetgnlPHSYRLISVVSHIGsTSSSGHYISDVYDIKKQaWFTYNDLEVSKIQEASVQSDRDRSG 946
           8888888888888888888889999999999****************************99999************************* PP
   S: 331  YvlfYkr 337
           Y++fY++
   Q: 947  YIFFYMH 953
           *****98 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

MSPLKIHGPI RIRSMQTGIT KWKEGSFEIV EKENKVSLVV HYNTGGIPRI FQLTHNIKNV 60
VLRPSGAKQS RLMLTLQDNS FLSIDKVPSK DAEEMRLFLD AVHQNRLHAA MKPQGSGSFG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCTCCTC TGAAGATACA TGGTCCTATC AGAATTCGCA GTATGCAGAC TGGGATTACA 60
AAGTGGAAAG AAGGATCCTT TGAAATTGTG GAAAAAGAGA ATAAAGTCAG CCTAGTGGTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR003903--UIM_dom
IPR032069--USP37-like_PH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50330--UIM
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH
PF16674--UCH_N
PF02809--UIM

SMART

SM00726--UIM

Gene Ontology

GO:0005634--C:nucleus
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0000082--P:G1/S transition of mitotic cell cycle
GO:0035871--P:protein K11-linked deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0006275--P:regulation of DNA replication
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001400	Ailuropoda melanoleuca	95.82	0.00e+00	1769.00
IUUC-Apl-004033	Anas platyrhynchos	77.68	0.00e+00	1454.00
IUUC-Aca-005370	Anolis carolinensis	70.90	0.00e+00	1342.00
IUUC-Ame-011884	Astyanax mexicanus	57.91	0.00e+00	992.00
IUUC-Bta-012725	Bos taurus	94.10	0.00e+00	1721.00
IUUC-Cja-019939	Callithrix jacchus	93.08	0.00e+00	1672.00
IUUC-Cfa-020835	Canis familiaris	95.62	0.00e+00	1810.00
IUUC-Cpo-022067	Cavia porcellus	90.96	0.00e+00	1555.00
IUUC-Cre-022867	Chlamydomonas reinhardtii	30.04	2.00e-24	107.00
IUUC-Csa-023085	Chlorocebus sabaeus	93.29	0.00e+00	1744.00
IUUC-Cho-024390	Choloepus hoffmanni	86.87	3.00e-169	589.00
IUUC-Cin-025496	Ciona intestinalis	38.04	2.00e-43	170.00
IUUC-Csv-025812	Ciona savignyi	36.15	4.00e-42	166.00
IUUC-Dre-028255	Danio rerio	57.41	0.00e+00	952.00
IUUC-Dno-028986	Dasypus novemcinctus	94.39	0.00e+00	1716.00
IUUC-Dor-031062	Dipodomys ordii	77.12	0.00e+00	882.00
IUUC-Ete-032359	Echinops telfairi	84.38	0.00e+00	850.00
IUUC-Eca-033964	Equus caballus	94.20	0.00e+00	1746.00
IUUC-Eeu-034492	Erinaceus europaeus	85.90	0.00e+00	837.00
IUUC-Fca-036359	Felis catus	94.80	0.00e+00	1754.00
IUUC-Fal-037640	Ficedula albicollis	77.98	0.00e+00	1426.00
IUUC-Gmo-039600	Gadus morhua	54.55	0.00e+00	938.00
IUUC-Gga-040126	Gallus gallus	77.37	0.00e+00	1393.00
IUUC-Gac-041557	Gasterosteus aculeatus	53.65	0.00e+00	907.00
IUUC-Ggo-045571	Gorilla gorilla	87.98	0.00e+00	1506.00
IUUC-Hsa-046043	Homo sapiens	92.26	0.00e+00	1692.00
IUUC-Itr-048207	Ictidomys tridecemlineatus	91.55	0.00e+00	1688.00
IUUC-Lch-050357	Latimeria chalumnae	64.34	0.00e+00	1045.00
IUUC-Loc-052849	Lepisosteus oculatus	60.69	0.00e+00	996.00
IUUC-Mcc-054989	Macaca mulatta	92.63	0.00e+00	1610.00
IUUC-Meu-056273	Macropus eugenii	76.42	1.00e-93	337.00
IUUC-Mga-059814	Meleagris gallopavo	75.86	0.00e+00	1396.00
IUUC-Mmr-061726	Microcebus murinus	92.88	0.00e+00	1733.00
IUUC-Mdo-062974	Monodelphis domestica	84.33	0.00e+00	1569.00
IUUC-Mmu-064069	Mus musculus	88.61	0.00e+00	1607.00
IUUC-Mpu-066008	Mustela putorius furo	94.40	0.00e+00	1714.00
IUUC-Nle-069259	Nomascus leucogenys	93.29	0.00e+00	1697.00
IUUC-Opr-070882	Ochotona princeps	97.66	1.00e-118	421.00
IUUC-Ont-072441	Oreochromis niloticus	54.45	0.00e+00	926.00
IUUC-Oan-073151	Ornithorhynchus anatinus	76.62	2.00e-123	434.00
IUUC-Ocu-074879	Oryctolagus cuniculus	92.07	0.00e+00	1696.00
IUUC-Ola-087007	Oryzias latipes	53.45	0.00e+00	881.00
IUUC-Oga-088385	Otolemur garnettii	91.90	0.00e+00	1717.00
IUUC-Oar-090305	Ovis aries	94.20	0.00e+00	1749.00
IUUC-Ptr-091299	Pan troglodytes	92.98	0.00e+00	1700.00
IUUC-Pan-091996	Papio anubis	93.51	0.00e+00	1690.00
IUUC-Psi-093176	Pelodiscus sinensis	78.93	0.00e+00	1454.00
IUUC-Pma-094331	Petromyzon marinus	48.67	0.00e+00	763.00
IUUC-Pfo-096503	Poecilia formosa	55.89	0.00e+00	914.00
IUUC-Pab-098543	Pongo abelii	91.85	0.00e+00	903.00
IUUC-Pca-101099	Procavia capensis	91.41	0.00e+00	1366.00
IUUC-Pva-103163	Pteropus vampyrus	87.69	0.00e+00	1615.00
IUUC-Rno-105766	Rattus norvegicus	89.62	0.00e+00	1622.00
IUUC-Sha-106610	Sarcophilus harrisii	80.58	0.00e+00	1467.00
IUUC-Sar-113256	Sorex araneus	90.48	1.00e-113	404.00
IUUC-Ssc-116353	Sus scrofa	93.81	0.00e+00	1691.00
IUUC-Tgu-116971	Taeniopygia guttata	77.47	0.00e+00	1396.00
IUUC-Tru-117932	Takifugu rubripes	46.64	7.00e-139	488.00
IUUC-Tsy-119185	Tarsius syrichta	87.88	0.00e+00	1111.00
IUUC-Tni-119842	Tetraodon nigroviridis	60.44	2.00e-113	403.00
IUUC-Tbe-127281	Tupaia belangeri	82.09	0.00e+00	657.00
IUUC-Ttr-128177	Tursiops truncatus	94.96	0.00e+00	1360.00
IUUC-Vpa-130031	Vicugna pacos	94.50	0.00e+00	1788.00
IUUC-Xtr-132949	Xenopus tropicalis	64.92	0.00e+00	1160.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence