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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046188
Ensembl Protein ID ENSP00000391901.2
UniProt Accession O43189; B1AZX2; B1AZX3; O60929; Q5SU07; Q5SU08; Q96KM7; PHF1_HUMAN
Genbank Protein ID AAC52062.1; AAC13273.1; CAI18271.1; CAI18272.1; CAA16158.1; CAA16159.1; CAC38366.1; CAC38367.1; CAM26298.1; CAM26299.1; EAX03729.1; EAX03730.1; AAH08834.1
Protein Name PHD finger protein 1; Polycomb-like protein 1
Genbank Nucleotide ID AF029678; AF052205; AL662799; AL662799; AL021366; AL021366; AL050332; AL050332; BX088650; BX088650; CH471081; CH471081; BC008834
Gene Name PHF1; PCL1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000225553.7 ENST00000495185.5 ENSP00000433516.1
ENSG00000225553.7 ENST00000454914.6 ENSP00000407295.2
ENSG00000225553.7 ENST00000427869.6 ENSP00000391901.2
ENSG00000225553.7 ENST00000475137.5 ENSP00000434774.1
ENSG00000225553.7 ENST00000419154.5 ENSP00000413510.1
ENSG00000225553.7 ENST00000423868.1 ENSP00000399226.1
Annotation
mRNA Expression
ArrayExpress
DNA & RNA Element
CircNet
Protein-protein Interaction
IIDiRefIndexPINAMentha
InWeb_IM
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProt
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/PHD 1.60e-09 39.4 89 140
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/PHD
   S: 3    vClvCgeggedek.slveCekCrewfHpaClklsveeelpnsek.wiCpkCr 52
            C vC++++      lv CekCr+++H++C+ + +  + +++ + w C++C 
   Q: 89   LCCVCRSETVVPGnRLVSCEKCRHAYHQDCHVPRAPAPGEGEGTsWVCRQCV 140
           588***999876459*******************66666655558******7 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Involved in DNA damage response and is recruited at double-strand breaks (DSBs). Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex: it is however unclear whether recruitment of the PRC2 complex to H3K36me3 leads to enhance or inhibit H3K27me3 methylation mediated by the PRC2 complex. According to some reports, PRC2 recruitment by PHF1 promotes H3K27me3 and subsequent gene silencing by inducing spreading of PRC2 and H3K27me3 into H3K36me3 loci (PubMed:18285464 and PubMed:23273982). According to another report, PHF1 recruits the PRC2 complex at double-strand breaks (DSBs) and inhibits the activity of PRC2 (PubMed:23142980). Regulates p53/TP53 stability and prolonges its turnover: may act by specifically binding to a methylated from of p53/TP53.
 Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Involved in DNA damage response and is recruited at double-strand breaks (DSBs). Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex: it is however unclear whether recruitment of the PRC2 complex to H3K36me3 leads to enhance or inhibit H3K27me3 methylation mediated by the PRC2 complex. According to some reports, PRC2 recruitment by PHF1 promotes H3K27me3 and subsequent gene silencing by inducing spreading of PRC2 and H3K27me3 into H3K36me3 loci (PubMed:18285464 and PubMed:23273982). According to another report, PHF1 recruits the PRC2 complex at double-strand breaks (DSBs) and inhibits the activity of PRC2 (PubMed:23142980). Regulates p53/TP53 stability and prolonges its turnover: may act by specifically binding to a methylated from of p53/TP53.
Protein Sequence
(Fasta)
MAQPPRLSRS GASSLWDPAS PAPTSGPRPR LWEGQDVLAR WTDGLLYLGT IKKVDSAREV 60
CLVQFEDDSQ FLVLWKDISP AALPGEELLC CVCRSETVVP GNRLVSCEKC RHAYHQDCHV 120
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Protein Fasta Sequence


>IUUC-Hsa-046188|E3,PHD|Homo sapiens
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Nucleotide Sequence
(Fasta)
AAGCACGGGG CGGGACGTCC ACGGGAAGCG GCGCGCACGC CCGCCGACTC CCTCGCGCCA 60
ACCGCCGACG GCCGCCGCCC GGTGAAGGAG GGGCTCAGTC CTCCCAGGTG CCGCGCGCAG 120
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Nucleotide Fasta Sequence


>IUUC-Hsa-046188|E3,PHD|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0160--Chromosomal rearrangement
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0227--DNA damage
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR025894--Mtf2_C_dom
IPR031202--PHF1
IPR002999--Tudor
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF14061--Mtf2_C
PF00628--PHD
SMART

SM00249--PHD
SM00333--TUDOR
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005815--C:microtubule organizing center
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0035861--C:site of double-strand break
GO:0003682--F:chromatin binding
GO:0035064--F:methylated histone binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0008270--F:zinc ion binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0016569--P:covalent chromatin modification
GO:0045814--P:negative regulation of gene expression, epigenetic
GO:0061086--P:negative regulation of histone H3-K27 methylation
GO:0061087--P:positive regulation of histone H3-K27 methylation
GO:0006351--P:transcription, DNA-templated
KEGG hsa:5252
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001720 Ailuropoda melanoleuca 97.53 0.00e+00 933.00
IUUC-Bta-012536 Bos taurus 96.83 0.00e+00 889.00
IUUC-Cja-019049 Callithrix jacchus 98.77 0.00e+00 926.00
IUUC-Cfa-021211 Canis familiaris 97.35 0.00e+00 929.00
IUUC-Cpo-021980 Cavia porcellus 94.73 0.00e+00 919.00
IUUC-Csa-023154 Chlorocebus sabaeus 98.94 0.00e+00 951.00
IUUC-Dor-030431 Dipodomys ordii 95.95 0.00e+00 883.00
IUUC-Ete-032589 Echinops telfairi 89.01 0.00e+00 902.00
IUUC-Eca-034315 Equus caballus 97.71 0.00e+00 961.00
IUUC-Ggo-044966 Gorilla gorilla 99.65 0.00e+00 953.00
IUUC-Itr-048249 Ictidomys tridecemlineatus 96.83 0.00e+00 926.00
IUUC-Laf-053729 Loxodonta africana 92.48 0.00e+00 871.00
IUUC-Mcc-055486 Macaca mulatta 98.94 0.00e+00 951.00
IUUC-Meu-055933 Macropus eugenii 93.73 0.00e+00 682.00
IUUC-Mmr-061114 Microcebus murinus 95.95 0.00e+00 940.00
IUUC-Mdo-062033 Monodelphis domestica 84.56 0.00e+00 793.00
IUUC-Mpu-065725 Mustela putorius furo 97.35 0.00e+00 946.00
IUUC-Mlu-067243 Myotis lucifugus 94.36 0.00e+00 920.00
IUUC-Nle-069759 Nomascus leucogenys 99.12 0.00e+00 924.00
IUUC-Ocu-073930 Oryctolagus cuniculus 97.71 0.00e+00 922.00
IUUC-Oga-088161 Otolemur garnettii 95.24 0.00e+00 920.00
IUUC-Oar-089582 Ovis aries 96.48 0.00e+00 882.00
IUUC-Ptr-090810 Pan troglodytes 99.29 0.00e+00 970.00
IUUC-Pan-091980 Papio anubis 98.94 0.00e+00 951.00
IUUC-Pab-098556 Pongo abelii 99.29 0.00e+00 927.00
IUUC-Pca-100360 Procavia capensis 95.82 0.00e+00 828.00
IUUC-Pva-102900 Pteropus vampyrus 97.00 0.00e+00 911.00
IUUC-Rno-105536 Rattus norvegicus 93.12 0.00e+00 921.00
IUUC-Ssc-116070 Sus scrofa 95.41 0.00e+00 871.00
IUUC-Tsy-119247 Tarsius syrichta 99.37 0.00e+00 640.00
Created Date 25-Jun-2017

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