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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046800
Ensembl Protein ID ENSP00000399518.1
UniProt Accession Q01826; B3KXF1; C9JTR6; Q59EQ0; SATB1_HUMAN
Genbank Protein ID AAA60304.1; BAG54463.1; BAD92998.1; EAW64291.1; AAH01744.1
Protein Name DNA-binding protein SATB1; Special AT-rich sequence-binding protein 1
Genbank Nucleotide ID M97287; AK127242; AB209761; AC139618; BC001744
Gene Name SATB1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000182568.16 ENST00000338745.10 ENSP00000341024.5
ENSG00000182568.16 ENST00000417717.6 ENSP00000399518.1
ENSG00000182568.16 ENST00000491519.4 ENSP00000479866.1
ENSG00000182568.16 ENST00000452260.6 ENSP00000406727.2
ENSG00000182568.16 ENST00000493952.2 ENSP00000453908.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtBioGRID
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
ULD/UDP/UBQ/UBQ_Other 1.40e-10 42.5 76 162
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   ULD/UDP/UBQ/UBQ_Other
   S: 1    vqvtvksldgs.eltlkvnpsd.tVaeLKeki.....ekk.lgip.peqqrLiykGkiL...eddktLady.glkdgstihllekksg 75
           v+++v++++++ e+++k ++++ +V+++K+++     e++ l+++ +++++ + kG i+   +++++L+++ +++d++++++l+++++
   Q: 76   VFCVVEHYENAiEYDCK-EEHAeFVLVRKDMLfnqliEMAlLSLGySHSSAAQAKGLIQvgkWNPVPLSYVtDAPDATVADMLQDVYH 162
           689**************.77777*******99999998888*********************************************98 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma (By similarity). Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes (e.g. PML at the MHC-I locus) and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes. Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis. Interacts with the unique region (UR) of cytomegalovirus (CMV). Alu-like motifs and SATB1-binding sites provide a unique chromatin context which seems preferentially targeted by the HIV-1 integration machinery. Moreover, HIV-1 Tat may overcome SATB1-mediated repression of IL2 and IL2RA (interleukin) in T-cells by binding to the same domain than HDAC1. Delineates specific epigenetic modifications at target gene loci, directly up-regulating metastasis-associated genes while down-regulating tumor-suppressor genes. Reprograms chromatin organization and the transcription profiles of breast tumors to promote growth and metastasis.
 Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma (By similarity). Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes (e.g. PML at the MHC-I locus) and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes. Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis. Interacts with the unique region (UR) of cytomegalovirus (CMV). Alu-like motifs and SATB1-binding sites provide a unique chromatin context which seems preferentially targeted by the HIV-1 integration machinery. Moreover, HIV-1 Tat may overcome SATB1-mediated repression of IL2 and IL2RA (interleukin) in T-cells by binding to the same domain than HDAC1. Delineates specific epigenetic modifications at target gene loci, directly up-regulating metastasis-associated genes while down-regulating tumor-suppressor genes. Reprograms chromatin organization and the transcription profiles of breast tumors to promote growth and metastasis.
Protein Sequence
(Fasta)
MDHLNEATQG KEHSEMSNNV SDPKGPPAKI ARLEQNGSPL GRGRLGSTGA KMQGVPLKHS 60
GHLMKTNLRK GTMLPVFCVV EHYENAIEYD CKEEHAEFVL VRKDMLFNQL IEMALLSLGY 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046800|ULD,UBQ_Other|Homo sapiens
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Nucleotide Sequence
(Fasta)
AAACAACAAG CAACAAGAGG AAGCCGCAGG CGACAAGAGG AGGAGTGCGC GTGTTGGGGG 60
CCCCCGGAGA GGTGAGGGGG CAGGGTTGGC GGGCGACGAG AACCGCGCCG CGCACCCCAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046800|ULD,UBQ_Other|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0160--Chromosomal rearrangement
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0371--Homeobox
KW-0945--Host-virus interaction
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
Interpro

IPR003350--CUT_dom
IPR032355--CUTL
IPR009057--Homeobox-like
IPR001356--Homeobox_dom
IPR010982--Lambda_DNA-bd_dom
IPR032392--ULD
PROSITE

PS51042--CUT
PS50071--HOMEOBOX_2
Pfam

PF02376--CUT
PF16557--CUTL
PF00046--Homeobox
PF16534--ULD
SMART

SM01109--CUT
SM00389--HOX
Gene Ontology

GO:0016604--C:nuclear body
GO:0005720--C:nuclear heterochromatin
GO:0016363--C:nuclear matrix
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0016605--C:PML body
GO:0003682--F:chromatin binding
GO:0003690--F:double-stranded DNA binding
GO:0000977--F:RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001227--F:transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0050798--P:activated T cell proliferation
GO:0043367--P:CD4-positive, alpha-beta T cell differentiation
GO:0043374--P:CD8-positive, alpha-beta T cell differentiation
GO:0006325--P:chromatin organization
GO:0006338--P:chromatin remodeling
GO:0008544--P:epidermis development
GO:0097194--P:execution phase of apoptosis
GO:0016571--P:histone methylation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0060004--P:reflex
GO:0006351--P:transcription, DNA-templated
GO:0016032--P:viral process
KEGG hsa:6304
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001269 Ailuropoda melanoleuca 99.36 0.00e+00 1288.00
IUUC-Apl-003442 Anas platyrhynchos 98.15 0.00e+00 1212.00
IUUC-Aca-004969 Anolis carolinensis 88.74 0.00e+00 1392.00
IUUC-Ame-010811 Astyanax mexicanus 76.79 0.00e+00 990.00
IUUC-Bta-012461 Bos taurus 99.32 0.00e+00 1213.00
IUUC-Cel-018701 Caenorhabditis elegans 34.00 2.00e-10 60.80
IUUC-Cja-020003 Callithrix jacchus 97.37 0.00e+00 1499.00
IUUC-Cfa-020082 Canis familiaris 99.20 0.00e+00 1287.00
IUUC-Cpo-021601 Cavia porcellus 99.66 0.00e+00 1226.00
IUUC-Csa-023306 Chlorocebus sabaeus 100.00 0.00e+00 1231.00
IUUC-Cho-025063 Choloepus hoffmanni 92.95 0.00e+00 986.00
IUUC-Dre-028396 Danio rerio 72.56 0.00e+00 901.00
IUUC-Dno-029755 Dasypus novemcinctus 88.56 0.00e+00 1340.00
IUUC-Dor-030766 Dipodomys ordii 99.23 0.00e+00 1219.00
IUUC-Ete-032547 Echinops telfairi 90.80 4.00e-134 472.00
IUUC-Eca-033394 Equus caballus 94.02 0.00e+00 1435.00
IUUC-Eeu-034706 Erinaceus europaeus 93.78 0.00e+00 1333.00
IUUC-Fca-036482 Felis catus 94.24 0.00e+00 1136.00
IUUC-Fal-037384 Ficedula albicollis 98.64 0.00e+00 1212.00
IUUC-Fso-038109 Fusarium solani 37.29 4.70e-02 33.90
IUUC-Gmo-038956 Gadus morhua 75.64 0.00e+00 684.00
IUUC-Ggr-039906 Gaeumannomyces graminis 33.33 8.00e-03 31.60
IUUC-Gga-040653 Gallus gallus 90.44 0.00e+00 1435.00
IUUC-Gac-041928 Gasterosteus aculeatus 78.74 0.00e+00 707.00
IUUC-Ggo-044842 Gorilla gorilla 98.49 0.00e+00 1513.00
IUUC-Lch-050515 Latimeria chalumnae 84.03 0.00e+00 1322.00
IUUC-Loc-052600 Lepisosteus oculatus 75.18 0.00e+00 1216.00
IUUC-Laf-054011 Loxodonta africana 98.62 0.00e+00 1489.00
IUUC-Mga-059444 Meleagris gallopavo 97.66 0.00e+00 1206.00
IUUC-Mmr-061285 Microcebus murinus 99.37 0.00e+00 1493.00
IUUC-Mdo-062444 Monodelphis domestica 96.23 0.00e+00 1501.00
IUUC-Mmu-063758 Mus musculus 99.49 0.00e+00 1228.00
IUUC-Mpu-066758 Mustela putorius furo 96.73 0.00e+00 1483.00
IUUC-Mlu-067012 Myotis lucifugus 98.99 0.00e+00 1216.00
IUUC-Nle-069511 Nomascus leucogenys 99.75 0.00e+00 1496.00
IUUC-Opr-070880 Ochotona princeps 81.13 0.00e+00 1170.00
IUUC-Ont-072450 Oreochromis niloticus 73.78 0.00e+00 913.00
IUUC-Oan-073212 Ornithorhynchus anatinus 97.40 4.00e-87 313.00
IUUC-Ocu-074585 Oryctolagus cuniculus 98.74 0.00e+00 1509.00
IUUC-Oba-075370 Oryza barthii 36.96 1.00e-03 36.60
IUUC-Olo-080429 Oryza longistaminata 32.61 1.60e-02 33.90
IUUC-Ome-081450 Oryza meridionalis 34.78 7.00e-03 35.00
IUUC-Oni-082089 Oryza nivara 24.66 3.40e-02 32.00
IUUC-Ola-087463 Oryzias latipes 64.72 0.00e+00 699.00
IUUC-Oga-089020 Otolemur garnettii 98.99 0.00e+00 1490.00
IUUC-Oar-090026 Ovis aries 87.13 0.00e+00 1370.00
IUUC-Ptr-090639 Pan troglodytes 100.00 0.00e+00 1230.00
IUUC-Pan-092418 Papio anubis 100.00 0.00e+00 1136.00
IUUC-Psi-093141 Pelodiscus sinensis 97.62 0.00e+00 1024.00
IUUC-Ppa-095438 Physcomitrella patens 26.88 3.00e-02 33.10
IUUC-Pfo-096325 Poecilia formosa 80.43 0.00e+00 906.00
IUUC-Pab-098180 Pongo abelii 100.00 0.00e+00 1230.00
IUUC-Pca-100487 Procavia capensis 96.92 0.00e+00 1459.00
IUUC-Pva-102302 Pteropus vampyrus 91.30 0.00e+00 1168.00
IUUC-Rno-105734 Rattus norvegicus 99.32 0.00e+00 1225.00
IUUC-Sha-106963 Sarcophilus harrisii 95.72 0.00e+00 1498.00
IUUC-Sar-113384 Sorex araneus 99.49 0.00e+00 1227.00
IUUC-Ssc-115971 Sus scrofa 99.32 0.00e+00 1216.00
IUUC-Tgu-117121 Taeniopygia guttata 94.47 0.00e+00 1498.00
IUUC-Tru-118767 Takifugu rubripes 64.64 0.00e+00 711.00
IUUC-Tni-120223 Tetraodon nigroviridis 75.87 0.00e+00 888.00
IUUC-Ttr-128230 Tursiops truncatus 95.47 0.00e+00 1477.00
IUUC-Vpa-130676 Vicugna pacos 91.24 0.00e+00 968.00
IUUC-Xtr-132122 Xenopus tropicalis 88.32 0.00e+00 1068.00
Created Date 25-Jun-2017

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