• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Details
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046867
UUCD1 version UUC-HoS-00071
Ensembl Protein ID ENSP00000380256.4
UniProt Accession P41002; B2R8H3; Q96EG9; CCNF_HUMAN
Genbank Protein ID AAB60342.1; CAA85308.1; BAG36170.1; AAH12349.1
Protein Name Cyclin-F; F-box only protein 1
Genbank Nucleotide ID U17105; Z36714; AK313371; AC106820
Gene Name CCNF; FBX1; FBXO1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000162063.12 ENST00000293968.11 ENSP00000293968.7
ENSG00000162063.12 ENST00000397066.8 ENSP00000380256.4
ENSG00000162063.12 ENST00000564236.1 ENSP00000457587.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
BioGRIDmUbiSiDa
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box F-box 20596027
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication.
 Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication.
Protein Sequence
(Fasta)
MGSGGVVHCR CAKCFCYPTK RRIRRRPRNL TILSLPEDVL FHILKWLSVE DILAVRAVHS 60
QLKDLVDNHA SVWACASFQE LWPSPGNLKL FERAAEKGNF EAAVKLGIAY LYNEGLSVSD 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046867|E3,F-box|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CTGCGCCTGC GCGAGGGCTA CGCGCGCTCC GGCCGGGGCG CGGGCGCGCT CTCAGGCGGG 60
CTCCGGCGGC AGCGACGCGA GCGCGGCGAT GGGGAGCGGC GGCGGTGAGT GCGGGGCGAT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046867|E3,F-box|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0195--Cyclin
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0498--Mitosis
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
Interpro

IPR028857--CCNF_metazoan
IPR013763--Cyclin-like
IPR004367--Cyclin_C-dom
IPR006671--Cyclin_N
IPR001810--F-box_dom
IPR013780--Glyco_hydro_b
PROSITE

PS00292--CYCLINS
PS50181--FBOX
Pfam

PF02984--Cyclin_C
PF00134--Cyclin_N
PF00646--F-box
SMART

SM00385--CYCLIN
SM01332--Cyclin_C
SM00256--FBOX
Gene Ontology

GO:0030054--C:cell junction
GO:0005814--C:centriole
GO:0005813--C:centrosome
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0051301--P:cell division
GO:0007067--P:mitotic nuclear division
GO:0010826--P:negative regulation of centrosome duplication
GO:0001890--P:placenta development
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0000320--P:re-entry into mitotic cell cycle
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
KEGG hsa:899
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001520 Ailuropoda melanoleuca 86.25 0.00e+00 1237.00
IUUC-Apl-003215 Anas platyrhynchos 69.66 0.00e+00 1077.00
IUUC-Ame-011700 Astyanax mexicanus 60.12 0.00e+00 716.00
IUUC-Bta-013230 Bos taurus 86.57 0.00e+00 1247.00
IUUC-Cja-019256 Callithrix jacchus 94.01 0.00e+00 1400.00
IUUC-Cfa-020123 Canis familiaris 87.02 0.00e+00 1254.00
IUUC-Cpo-021599 Cavia porcellus 85.62 0.00e+00 1276.00
IUUC-Csa-023518 Chlorocebus sabaeus 91.98 0.00e+00 1323.00
IUUC-Dre-028186 Danio rerio 55.16 0.00e+00 691.00
IUUC-Dno-029401 Dasypus novemcinctus 80.96 0.00e+00 1142.00
IUUC-Dor-031087 Dipodomys ordii 80.03 0.00e+00 1137.00
IUUC-Ete-032869 Echinops telfairi 84.91 1.00e-74 273.00
IUUC-Eca-033473 Equus caballus 89.27 0.00e+00 1286.00
IUUC-Eeu-034533 Erinaceus europaeus 70.88 3.00e-177 615.00
IUUC-Fca-035961 Felis catus 85.70 0.00e+00 1216.00
IUUC-Fal-036659 Ficedula albicollis 66.41 0.00e+00 1003.00
IUUC-Gmo-039557 Gadus morhua 58.59 0.00e+00 637.00
IUUC-Gga-040389 Gallus gallus 66.04 0.00e+00 872.00
IUUC-Gac-042059 Gasterosteus aculeatus 60.69 0.00e+00 676.00
IUUC-Ggo-044497 Gorilla gorilla 99.24 0.00e+00 1441.00
IUUC-Itr-047922 Ictidomys tridecemlineatus 87.84 0.00e+00 1298.00
IUUC-Lch-050143 Latimeria chalumnae 65.08 0.00e+00 858.00
IUUC-Loc-052538 Lepisosteus oculatus 65.91 4.00e-47 180.00
IUUC-Laf-054481 Loxodonta africana 81.68 0.00e+00 1101.00
IUUC-Mcc-055426 Macaca mulatta 97.46 0.00e+00 1417.00
IUUC-Meu-056150 Macropus eugenii 71.28 0.00e+00 932.00
IUUC-Mga-059822 Meleagris gallopavo 65.25 0.00e+00 782.00
IUUC-Mmr-061785 Microcebus murinus 90.97 0.00e+00 1305.00
IUUC-Mdo-062763 Monodelphis domestica 73.94 0.00e+00 1076.00
IUUC-Mmu-064391 Mus musculus 83.89 0.00e+00 1193.00
IUUC-Mpu-065756 Mustela putorius furo 86.07 0.00e+00 1222.00
IUUC-Mlu-067607 Myotis lucifugus 86.02 0.00e+00 1229.00
IUUC-Nle-069147 Nomascus leucogenys 97.33 0.00e+00 1378.00
IUUC-Opr-071129 Ochotona princeps 84.30 0.00e+00 1254.00
IUUC-Ont-072031 Oreochromis niloticus 60.39 0.00e+00 707.00
IUUC-Oan-073514 Ornithorhynchus anatinus 66.48 9.00e-173 600.00
IUUC-Ocu-074914 Oryctolagus cuniculus 86.06 0.00e+00 1200.00
IUUC-Ola-086606 Oryzias latipes 58.59 0.00e+00 662.00
IUUC-Oga-088632 Otolemur garnettii 89.86 0.00e+00 1291.00
IUUC-Oar-090320 Ovis aries 82.28 0.00e+00 1189.00
IUUC-Ptr-091175 Pan troglodytes 99.87 0.00e+00 1439.00
IUUC-Pan-092003 Papio anubis 97.07 0.00e+00 1399.00
IUUC-Psi-093719 Pelodiscus sinensis 68.65 0.00e+00 1018.00
IUUC-Pma-094390 Petromyzon marinus 56.48 4.00e-125 441.00
IUUC-Pfo-096911 Poecilia formosa 60.39 0.00e+00 723.00
IUUC-Pab-097562 Pongo abelii 98.22 0.00e+00 1433.00
IUUC-Pca-100748 Procavia capensis 68.32 4.00e-111 395.00
IUUC-Pva-102168 Pteropus vampyrus 84.24 0.00e+00 1222.00
IUUC-Rno-105157 Rattus norvegicus 84.86 0.00e+00 1212.00
IUUC-Sha-107184 Sarcophilus harrisii 72.73 0.00e+00 1082.00
IUUC-Sar-113086 Sorex araneus 70.68 9.00e-88 318.00
IUUC-Ssc-116347 Sus scrofa 86.82 0.00e+00 1224.00
IUUC-Tgu-117463 Taeniopygia guttata 66.24 0.00e+00 993.00
IUUC-Tru-118348 Takifugu rubripes 59.94 0.00e+00 724.00
IUUC-Tsy-119459 Tarsius syrichta 85.84 3.00e-100 359.00
IUUC-Tni-120853 Tetraodon nigroviridis 62.00 0.00e+00 677.00
IUUC-Tbe-127361 Tupaia belangeri 75.51 0.00e+00 689.00
IUUC-Ttr-128214 Tursiops truncatus 77.19 0.00e+00 1028.00
IUUC-Xtr-132479 Xenopus tropicalis 67.58 0.00e+00 810.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved