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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Spo-108304
UUCD1 version UUC-ScP-00028
Ensembl Protein ID SPCC970.10c.1:pep
UniProt Accession O74563; BRL2_SCHPO
Genbank Protein ID CAA20703.1
Protein Name E3 ubiquitin-protein ligase brl2; BRE1-like protein 2; RING finger protein 1; RING-type E3 ubiquitin transferase brl2
Genbank Nucleotide ID CU329672
Gene Name brl2; rfp1; SPCC970.10c
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
SPCC970.10c SPCC970.10c.1 SPCC970.10c.1:pep
Annotation
mRNA Expression
GEO
Protein-protein Interaction
iRefIndexMentha
Protein Expression/Proteomics
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 17363370
Classification
Family E-value Score Start End
E3 activity/RING/RING 0.00072 18.2 627 666
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledf...kdgplvlpCgHvfhadCl.qkwpglknssskefrCPlC 45
           C++C   f   kd   +  CgH f+ +C+ +++      + ++ rCP+C
   Q: 627  CSVC--NFerwKDRI-ISLCGHGFCYQCIqKRI------ETRQRRCPIC 666
           8888..553335523.355**********8888......********** PP
   
Organism Schizosaccharomyces pombe
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase which belongs to the histone H2B ubiquitin ligase complex (HULC) which mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation.
 E3 ubiquitin-protein ligase which belongs to the histone H2B ubiquitin ligase complex (HULC) which mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation.
Protein Sequence
(Fasta)
MYQNGKPDAP TILGQKRELE DVEIQDDDIQ EVSKEDLLKD VRVRSIQFDE LESKIEGLQN 60
LAEEKLKVLA TLVSWWPEIL QQFSVVFQGN ELKDFESEGV FSILEKFPEL SYFNDAVKNN 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Spo-108304|E3,RING|Schizosaccharomyces pombe
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATTCGCTTCG AATTGCATAT TTTCAATACG GCAAGTTTCA ACTAAGAAGG AGAATTTGAA 60
ATAGATCTGT AAAGACGCGT ATCTATAACT TGCTTATTCA TTACGCGTTA TTACGTTTAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Spo-108304|E3,RING|Schizosaccharomyces pombe
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR013956--E3_ubiquit_lig_BRE1
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF08647--BRE1
SMART

SM00184--RING
Gene Ontology

GO:0033503--C:HULC complex
GO:0031618--C:nuclear pericentric heterochromatin
GO:0005634--C:nucleus
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0031497--P:chromatin assembly
GO:0006336--P:DNA replication-independent nucleosome assembly
GO:0071894--P:histone H2B conserved C-terminal lysine ubiquitination
GO:0051569--P:regulation of histone H3-K4 methylation
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
KEGG spo:SPCC970.10c
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001976 Ailuropoda melanoleuca 43.08 2.00e-15 75.90
IUUC-Apl-003407 Anas platyrhynchos 43.08 2.00e-15 75.90
IUUC-Aca-004850 Anolis carolinensis 43.08 2.00e-14 73.20
IUUC-Aly-006469 Arabidopsis lyrata 50.00 9.00e-15 73.90
IUUC-Ath-006615 Arabidopsis thaliana 50.00 1.00e-14 73.60
IUUC-Ago-007988 Ashbya gossypii 27.61 8.00e-31 126.00
IUUC-Acl-008319 Aspergillus clavatus 27.78 5.00e-28 117.00
IUUC-Ang-009601 Aspergillus niger 27.78 2.00e-28 119.00
IUUC-Aor-010142 Aspergillus oryzae 25.11 3.00e-28 118.00
IUUC-Ate-010547 Aspergillus terreus 26.72 2.00e-26 112.00
IUUC-Ame-011745 Astyanax mexicanus 41.54 1.00e-14 73.60
IUUC-Bgr-012245 Blumeria graminis 24.44 4.00e-23 101.00
IUUC-Bta-012357 Bos taurus 43.08 3.00e-15 75.90
IUUC-Bdi-014799 Brachypodium distachyon 50.77 3.00e-16 79.00
IUUC-Bol-016588 Brassica oleracea 51.67 4.00e-15 75.10
IUUC-Bra-017335 Brassica rapa 51.67 4.00e-15 74.70
IUUC-Cel-018659 Caenorhabditis elegans 44.44 5.00e-09 54.70
IUUC-Cja-019042 Callithrix jacchus 40.00 7.00e-12 64.30
IUUC-Cfa-020320 Canis familiaris 43.08 2.00e-15 75.90
IUUC-Cpo-021617 Cavia porcellus 43.08 2.00e-15 76.30
IUUC-Csa-023509 Chlorocebus sabaeus 43.08 3.00e-15 75.50
IUUC-Cho-024616 Choloepus hoffmanni 43.08 5.00e-15 74.70
IUUC-Cgl-026569 Colletotrichum gloeosporioides 26.77 5.00e-20 90.90
IUUC-Cne-026878 Cryptococcus neoformans 25.53 8.00e-15 73.90
IUUC-Cme-027134 Cyanidioschyzon merolae 41.27 5.00e-11 60.80
IUUC-Dre-028171 Danio rerio 38.14 2.00e-14 73.20
IUUC-Dno-029537 Dasypus novemcinctus 43.08 3.00e-15 75.50
IUUC-Dor-030250 Dipodomys ordii 43.08 2.00e-15 76.30
IUUC-Dse-031300 Dothistroma septosporum 26.83 3.00e-22 98.20
IUUC-Dme-032034 Drosophila melanogaster 43.08 1.00e-14 73.20
IUUC-Ete-033164 Echinops telfairi 43.08 3.00e-15 75.90
IUUC-Eca-033347 Equus caballus 43.08 2.00e-15 75.90
IUUC-Eeu-034801 Erinaceus europaeus 43.08 9.00e-15 73.60
IUUC-Fca-036024 Felis catus 43.08 2.00e-15 76.30
IUUC-Fal-037622 Ficedula albicollis 43.08 3.00e-15 75.90
IUUC-Fso-038414 Fusarium solani 28.41 2.00e-24 105.00
IUUC-Gmo-039446 Gadus morhua 41.54 4.00e-14 71.60
IUUC-Gga-040412 Gallus gallus 43.08 2.00e-15 76.30
IUUC-Gac-042205 Gasterosteus aculeatus 41.54 2.00e-14 72.80
IUUC-Gma-042797 Glycine max 31.75 4.00e-16 78.60
IUUC-Ggo-044703 Gorilla gorilla 43.08 3.00e-15 75.50
IUUC-Hsa-046462 Homo sapiens 43.08 3.00e-15 75.50
IUUC-Hvu-047689 Hordeum vulgare 47.69 2.00e-15 76.30
IUUC-Itr-048298 Ictidomys tridecemlineatus 43.08 2.00e-15 75.90
IUUC-Kpa-049345 Komagataella pastoris 27.85 9.00e-17 80.10
IUUC-Lch-049429 Latimeria chalumnae 43.08 6.00e-15 74.30
IUUC-Lpe-051253 Leersia perrieri 27.14 5.00e-17 81.30
IUUC-Loc-052847 Lepisosteus oculatus 41.54 1.00e-13 68.60
IUUC-Lma-053312 Leptosphaeria maculans 28.96 1.00e-25 109.00
IUUC-Laf-054122 Loxodonta africana 43.08 3.00e-15 75.90
IUUC-Mcc-054647 Macaca mulatta 43.08 3.00e-15 75.50
IUUC-Meu-056559 Macropus eugenii 43.08 4.00e-15 75.10
IUUC-Mor-057068 Magnaporthe oryzae 24.85 2.00e-22 99.40
IUUC-Mpo-057568 Magnaporthe poae 25.38 4.00e-21 94.40
IUUC-Mtr-057632 Medicago truncatula 32.76 2.00e-16 79.30
IUUC-Mla-059072 Melampsora laricipopulina 27.24 1.00e-17 83.60
IUUC-Mga-059731 Meleagris gallopavo 43.08 8.00e-15 74.30
IUUC-Mvi-060341 Microbotryum violaceum 27.31 4.00e-18 85.10
IUUC-Mmr-061495 Microcebus murinus 43.08 2.00e-15 76.30
IUUC-Mdo-062599 Monodelphis domestica 43.08 2.00e-15 75.90
IUUC-Mmu-063278 Mus musculus 43.08 3.00e-15 75.50
IUUC-Mac-065103 Musa acuminata 47.69 3.00e-17 82.00
IUUC-Mpu-065910 Mustela putorius furo 43.08 2.00e-15 76.30
IUUC-Mlu-067040 Myotis lucifugus 43.08 3.00e-15 75.50
IUUC-Ncr-068695 Neurospora crassa 27.11 8.00e-27 113.00
IUUC-Nle-069058 Nomascus leucogenys 43.08 3.00e-15 75.90
IUUC-Opr-071149 Ochotona princeps 43.08 3.00e-15 75.50
IUUC-Ont-071299 Oreochromis niloticus 41.54 3.00e-14 72.40
IUUC-Oan-072996 Ornithorhynchus anatinus 43.08 2.00e-15 75.50
IUUC-Ocu-074773 Oryctolagus cuniculus 43.08 3.00e-15 75.90
IUUC-Oba-075000 Oryza barthii 28.76 8.00e-19 87.40
IUUC-Obr-076532 Oryza brachyantha 28.33 2.00e-19 89.00
IUUC-Ogl-077200 Oryza glaberrima 28.76 9.00e-19 87.00
IUUC-Ogu-078279 Oryza glumaepatula 28.76 7.00e-19 87.40
IUUC-Oin-079097 Oryza indica 28.76 9.00e-19 87.00
IUUC-Olo-080612 Oryza longistaminata 50.00 3.00e-14 72.40
IUUC-Ome-081304 Oryza meridionalis 27.95 4.00e-17 81.60
IUUC-Oni-082162 Oryza nivara 28.76 9.00e-19 87.00
IUUC-Opu-083683 Oryza punctata 50.00 3.00e-15 75.10
IUUC-Oru-084382 Oryza rufipogon 28.76 9.00e-19 87.00
IUUC-Osa-085839 Oryza sativa 50.00 4.00e-15 75.10
IUUC-Ola-087287 Oryzias latipes 41.54 2.00e-14 73.20
IUUC-Olu-087683 Ostreococcus lucimarinus 40.26 4.00e-13 64.70
IUUC-Oga-088961 Otolemur garnettii 43.08 2.00e-15 76.30
IUUC-Oar-089755 Ovis aries 43.08 3.00e-15 75.50
IUUC-Ptr-091602 Pan troglodytes 43.08 3.00e-15 75.50
IUUC-Pan-092263 Papio anubis 43.08 3.00e-15 75.50
IUUC-Psi-093554 Pelodiscus sinensis 43.08 3.00e-15 75.90
IUUC-Pno-095079 Phaeosphaeria nodorum 28.96 8.00e-25 106.00
IUUC-Ppa-095651 Physcomitrella patens 51.67 6.00e-16 77.80
IUUC-Pfo-097527 Poecilia formosa 41.54 2.00e-14 72.40
IUUC-Pab-098598 Pongo abelii 43.08 3.00e-15 75.50
IUUC-Pca-100544 Procavia capensis 41.54 3.00e-14 72.40
IUUC-Ppe-102065 Prunus persica 44.62 4.00e-14 71.60
IUUC-Pva-102720 Pteropus vampyrus 43.08 3.00e-15 75.90
IUUC-Pgr-103536 Puccinia graminis 27.73 6.00e-16 77.80
IUUC-Pte-104415 Pyrenophora teres 27.20 2.00e-22 99.00
IUUC-Pyt-104762 Pyrenophora triticirepentis 22.73 5.00e-23 100.00
IUUC-Rno-104996 Rattus norvegicus 43.08 3.00e-15 75.90
IUUC-Sce-106384 Saccharomyces cerevisiae 32.57 7.00e-30 123.00
IUUC-Sha-107000 Sarcophilus harrisii 43.08 3.00e-15 75.50
IUUC-Sja-107993 Schizosaccharomyces japonicus 29.72 1.00e-74 272.00
IUUC-Smo-109416 Selaginella moellendorffii 49.23 1.00e-16 79.70
IUUC-Sit-110382 Setaria italica 30.38 3.00e-20 91.70
IUUC-Sly-111490 Solanum lycopersicum 41.54 3.00e-15 75.10
IUUC-Sar-113349 Sorex araneus 43.08 4.00e-15 75.10
IUUC-Sbi-114734 Sorghum bicolor 28.88 9.00e-19 84.70
IUUC-Sre-115087 Sporisorium reilianum 25.90 6.00e-19 87.80
IUUC-Ssc-115723 Sus scrofa 43.08 2.00e-15 75.90
IUUC-Tgu-116549 Taeniopygia guttata 43.08 2.00e-15 75.90
IUUC-Tru-118776 Takifugu rubripes 41.54 2.00e-14 72.80
IUUC-Tsy-118808 Tarsius syrichta 43.08 2.00e-15 76.30
IUUC-Tni-120790 Tetraodon nigroviridis 41.54 3.00e-14 72.00
IUUC-Tca-121060 Theobroma cacao 43.08 3.00e-16 79.00
IUUC-Tre-122150 Trichoderma reesei 22.55 4.00e-22 97.80
IUUC-Tvi-122431 Trichoderma virens 21.00 2.00e-24 105.00
IUUC-Tae-124308 Triticum aestivum 28.38 3.00e-17 81.60
IUUC-Tur-126160 Triticum urartu 47.62 1.00e-14 73.20
IUUC-Tme-127177 Tuber melanosporum 27.20 1.00e-27 116.00
IUUC-Tbe-127886 Tupaia belangeri 43.08 6.00e-15 74.30
IUUC-Ttr-128266 Tursiops truncatus 43.08 3.00e-15 75.50
IUUC-Uma-129488 Ustilago maydis 28.73 1.00e-20 92.80
IUUC-Vda-129815 Verticillium dahliae 25.78 1.00e-21 96.30
IUUC-Vpa-130237 Vicugna pacos 43.08 2.00e-15 75.90
IUUC-Vvi-131316 Vitis vinifera 43.08 9.00e-16 77.00
IUUC-Xtr-132906 Xenopus tropicalis 44.62 2.00e-15 75.90
IUUC-Xma-133365 Xiphophorus maculatus 41.54 2.00e-14 72.80
IUUC-Yli-134445 Yarrowia lipolytica 22.82 8.00e-23 100.00
IUUC-Zma-135805 Zea mays 27.98 6.00e-18 84.30
Created Date 25-Jun-2017

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