iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Tru-118004

Ensembl Protein ID

ENSTRUP00000004299.1

UniProt Accession

H2RVY0; H2RVY0_TAKRU

Protein Name

E3 ubiquitin-protein ligase

Gene Name

siah2l; LOC101077377

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000001867.1	ENSTRUT00000004323.1	ENSTRUP00000004299.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	87.35	2.00e-133	473.00	IUUC-Hsa-046179
E3 activity/RING/RING	87.35	8.00e-134	473.00	IUUC-Mmu-063206
E3 activity/RING/RING	87.35	6.00e-134	473.00	IUUC-Rno-105477

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Takifugu rubripes

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Protein Sequence
(Fasta)

MSRPSSAGAG GGGLGTGKAS GGKHGGGSGA AAAVAAAAAA AASVGSVAGS VSAAPSSAVS 60
LTTASLPGQT PELTALFECP VCFDYVLPPI LQCPGGHLIC NSCHQKLSCC RTCRGPLTPS 120

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Nucleotide Sequence
(Fasta)

ATGAGCCGTC CATCCTCAGC GGGAGCCGGA GGTGGAGGAC TCGGAACGGG GAAAGCAAGT 60
GGAGGAAAGC ACGGAGGAGG AAGTGGCGCT GCCGCGGCAG TGGCCGCCGC GGCCGCTGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR018121--7-in-absentia-prot_TRAF-dom
IPR001370--BIR_rpt
IPR004162--SINA-like
IPR008974--TRAF-like
IPR013083--Znf_RING/FYVE/PHD
IPR013010--Znf_SIAH

PROSITE

PS51081--ZF_SIAH

Pfam

PF03145--Sina

Gene Ontology

GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007275--P:multicellular organism development
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

tru:101077377

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001409	Ailuropoda melanoleuca	87.35	1.00e-135	475.00
IUUC-Ame-011678	Astyanax mexicanus	92.91	8.00e-144	503.00
IUUC-Bta-012750	Bos taurus	86.96	2.00e-135	474.00
IUUC-Cja-019800	Callithrix jacchus	87.35	1.00e-135	475.00
IUUC-Cfa-020505	Canis familiaris	86.96	2.00e-135	474.00
IUUC-Cpo-021394	Cavia porcellus	87.35	7.00e-136	476.00
IUUC-Csa-023374	Chlorocebus sabaeus	87.35	1.00e-135	475.00
IUUC-Cho-024933	Choloepus hoffmanni	87.35	8.00e-136	476.00
IUUC-Dre-027711	Danio rerio	93.70	6.00e-145	506.00
IUUC-Dno-029260	Dasypus novemcinctus	88.07	4.00e-132	464.00
IUUC-Dor-030489	Dipodomys ordii	88.52	5.00e-99	352.00
IUUC-Ete-032946	Echinops telfairi	87.35	2.00e-135	475.00
IUUC-Eca-033546	Equus caballus	82.96	2.00e-136	478.00
IUUC-Eeu-034861	Erinaceus europaeus	84.98	3.00e-131	461.00
IUUC-Gmo-039091	Gadus morhua	91.98	1.00e-145	508.00
IUUC-Gga-040252	Gallus gallus	86.17	4.00e-133	467.00
IUUC-Gac-041673	Gasterosteus aculeatus	95.26	9.00e-146	509.00
IUUC-Ggo-044618	Gorilla gorilla	87.35	1.00e-135	475.00
IUUC-Hsa-046179	Homo sapiens	87.35	1.00e-135	475.00
IUUC-Itr-048976	Ictidomys tridecemlineatus	86.56	1.00e-134	472.00
IUUC-Lch-049496	Latimeria chalumnae	83.83	4.00e-137	480.00
IUUC-Loc-052107	Lepisosteus oculatus	93.60	7.00e-143	499.00
IUUC-Laf-054257	Loxodonta africana	86.96	8.00e-134	469.00
IUUC-Mcc-055023	Macaca mulatta	87.35	1.00e-135	475.00
IUUC-Meu-055922	Macropus eugenii	86.17	7.00e-133	466.00
IUUC-Mga-060070	Meleagris gallopavo	83.59	9.00e-130	456.00
IUUC-Mmr-061494	Microcebus murinus	87.35	1.00e-135	475.00
IUUC-Mdo-061971	Monodelphis domestica	87.35	2.00e-135	474.00
IUUC-Mmu-063206	Mus musculus	87.35	7.00e-136	476.00
IUUC-Mpu-066597	Mustela putorius furo	87.35	1.00e-135	475.00
IUUC-Mlu-067199	Myotis lucifugus	86.96	4.00e-135	473.00
IUUC-Nle-069342	Nomascus leucogenys	87.35	1.00e-135	475.00
IUUC-Opr-070341	Ochotona princeps	56.86	6.00e-50	190.00
IUUC-Ont-071906	Oreochromis niloticus	92.88	6.00e-150	523.00
IUUC-Oan-073701	Ornithorhynchus anatinus	53.85	1.00e-49	189.00
IUUC-Ocu-073950	Oryctolagus cuniculus	86.96	3.00e-135	474.00
IUUC-Oga-089154	Otolemur garnettii	87.35	1.00e-135	475.00
IUUC-Oar-089446	Ovis aries	86.96	4.00e-135	473.00
IUUC-Ptr-091088	Pan troglodytes	87.35	1.00e-135	475.00
IUUC-Psi-093079	Pelodiscus sinensis	87.35	2.00e-135	474.00
IUUC-Pfo-097007	Poecilia formosa	91.30	2.00e-140	491.00
IUUC-Pab-098092	Pongo abelii	87.35	1.00e-135	475.00
IUUC-Pca-100328	Procavia capensis	84.98	1.00e-131	462.00
IUUC-Pva-102368	Pteropus vampyrus	96.36	8.00e-61	227.00
IUUC-Rno-105477	Rattus norvegicus	87.35	7.00e-136	476.00
IUUC-Sha-107630	Sarcophilus harrisii	86.96	5.00e-135	473.00
IUUC-Ssc-116441	Sus scrofa	86.96	3.00e-135	474.00
IUUC-Tsy-119548	Tarsius syrichta	85.50	2.00e-63	234.00
IUUC-Tni-120846	Tetraodon nigroviridis	95.65	1.00e-146	512.00
IUUC-Vpa-130799	Vicugna pacos	91.23	1.00e-95	341.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence