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Basic Information Integrated Annotations

Tag Content
iUUCD ID IUUC-Hsa-046690
UUCD1 version UUC-HoS-00214
Ensembl Protein ID ENSP00000252050.4
UniProt Accession Q8IWT3; O75188; Q5TCY3; Q68CP2; Q68D92; Q8N3W9; Q9BU56; CUL9_HUMAN
Genbank Protein ID AAN61516.1; CAC85756.1; CAH18328.1; CAH18696.1; CAI20204.1; EAX04163.1; BAC86090.1; BAC85207.1; BAA31683.3; AAH02879.2
Protein Name Cullin-9; UbcH7-associated protein 1; p53-associated parkin-like cytoplasmic protein
Genbank Nucleotide ID AY145132; AJ318215; CR749511; CR749841; AL133375; CH471081; AK125228; AK129649; AB014608; BC002879
Gene Name CUL9; H7AP1; KIAA0708; PARC
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000112659.13 ENST00000252050.8 ENSP00000252050.4
ENSG00000112659.13 ENST00000372647.6 ENSP00000361730.2
ENSG00000112659.13 ENST00000502719.5 ENSP00000421116.1
ENSG00000112659.13 ENST00000506830.5 ENSP00000425649.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarmiRNAMapSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtBioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RBR RBR 17367545
E3 adaptor/Cullin RING/Cullin Cullin_N_terminal 17367545
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/Cullin 6.50e-138 462.8 1296 1819
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/Cullin

   S: 66   LktynreWekfreqlkvlrkifayldrtyvkkskkvsevrkLaldlwrkeivedikkrllelllklieaeRkgeavdrrllsgvveslve 155
    L ++W+ freql++ +++f y+ + +++w+++i+ed ++rll+l+ +l++ +R+++++++r+l++++++
   Q: 1296 LGPKPTFWPLFREQLCRRTCLF------YTIR-----------AQAWSRDIAED-HRRLLQLCPRLNRVLRHEQNFADRFLPDDEAA--- 1364
    5555689***************......9999...........***********.********************************... PP
   S: 156 LslnklaiykesFEakfleatqefykaesaeflqe.nevdeYlkkvearlneeeeraaryleestetkLlevvekeliakhlesllaelv 244
    +a++k+++Ea++++ +q++++++++ +++ + +d+Yl+++e++ n+ +++a+++++++++++Ll++ve+ + ++ +
   Q: 1365 -----QALGKTCWEALVSPLVQNITSPDAEGVSALgWLLDQYLEQRETSRNPLSRAASFASRVRRLCHLLVHVEPPPGP-------SPEP 1442
    .....**************************************************************************.......**** PP
   S: 245 allrdkktedlsrmykLlsrvln..gleellkeleshikeqgkaaltaeekekdpkkyVerllelknklqklvseaFnndakFlkaldka 332
    ++ +k+++ ++ + s vl+ +l+++++++ s+++eq++++l+a++++ d +V+r+++l+++lq++ se+F+++a+F+ al+++
   Q: 1443 STRPFSKNSKGRDRSPAPSPVLPssSLRNITQCWLSVVQEQVSRFLAAAWRAPD---FVPRYCKLYEHLQRAGSELFGPRAAFMLALRSG 1529
    ***********************99*****************************...********************************* PP
   S: 333 fetfvnknsvlkaakspEllAryiDqlLrks.skglteeeleaqldkvllvfkyisekdv...FekyYkkhLakRLlsgksasseaEesv 418
    f+ +++++s+l+aa+++E++AryiDq+++++ ++g+ + e++ ql+++l+ ++++s++++ Fe++Y++++a+RLls + ss++E++v
   Q: 1530 FSGALLQQSFLTAAHMSEQFARYIDQQIQGGlIGGAPGVEMLGQLQRHLEPIMVLSGLELattFEHFYQHYMADRLLS--FGSSWLEGAV 1617
    ******************************************************************************..********** PP
   S: 419 iekLkeecgaeftskL.erMfqdlkvSedlnrqFk.................................eekenteesesvelsvlvLsag 474
    +e++ g++f+++L + M+q+l++Se+l+rqF+ +eke e++s+++s+lvLs++
   Q: 1618 LEQI----GLCFPNRLpQLMLQSLSTSEELQRQFHlfqlqrldklfleqedeeekrleeeeeeeeeeeAEKELFIEDPSPAISILVLSPR 1703
    ****....*********************************************************9999999999*************** PP
   S: 475 aWpta..set..ekvsLPaelektiekfeefY........lekhsgRkLqWqhtlgraelkaelkkgkyelqVstfQmavLLafnnsekv 552
    +Wp++ + ++ +LP+e+++++++f++fY l+++++R+LqW++ lgrael++ gk++l+Vst+Qm++LL+fn++e+v
   Q: 1704 CWPVSplCYLyhPRKCLPTEFCDALDRFSSFYsqsqnhpvLDMGPHRRLQWTW-LGRAELQF----GKQILHVSTVQMWLLLKFNQTEEV 1788
    *****9866567*****************************************.********....************************ PP
   S: 553 sveelkkatelpeeeLrrtlqsLvssk..kq 581
    sve+l k+++l++e+L ++l +L+s++ +
   Q: 1789 SVETLLKDSDLSPELLLQALVPLTSGNgpLT 1819
    *************************983333 PP
   

Organism Homo sapiens
Functional Description
(View)

Functional Description



     Core component of a Cul9-RING ubiquitin-protein ligase complex, a complex that mediates ubiquitination and subsequent degradation of BIRC5 and is required to maintain microtubule dynamics and genome integrity. Acts downstream of the 3M complex, which inhibits CUL9 activity, leading to prevent ubiquitination of BIRC5 (PubMed:24793696). Cytoplasmic anchor protein in p53/TP53-associated protein complex. Regulates the subcellular localization of p53/TP53 and subsequent function (PubMed:12526791, PubMed:17332328).
Core component of a Cul9-RING ubiquitin-protein ligase complex, a complex that mediates ubiquitination and subsequent degradation of BIRC5 and is required to maintain microtubule dynamics and genome integrity. Acts downstream of the 3M complex, which inhibits CUL9 activity, leading to prevent ubiquitination of BIRC5 (PubMed:24793696). Cytoplasmic anchor protein in p53/TP53-associated protein complex. Regulates the subcellular localization of p53/TP53 and subsequent function (PubMed:12526791, PubMed:17332328).
Protein Sequence
(Fasta)
MVGERHAGDL MVPLGPRLQA YPEELIRQRP GHDGHPEYLI RWSVLKCGEV GKVGVEEGKA 60
EHILMWLSAP EVYANCPGLL GERALSKGLQ HEPAGVSGSF PRDPGGLDEV AMGEMEADVQ 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Hsa-046690|E3,RBR;E3,Cullin|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGCTCTGAGG AGGCGGGGCC AGGACGGCGG GACCGGCCGC TGGGTCCCAG CGAGGGCTGA 60
GCCGGGCGGT GGGAGGTGAG AGGAGAGTTC TGCGCCGACC CAATCCCTCC CCTTCTCCTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Hsa-046690|E3,RBR;E3,Cullin|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR004939--APC_su10/DOC_dom
IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR016150--Casein_kin_II_reg-sub_b-sht
IPR021097--CPH_domain
IPR031222--CUL9
IPR016157--Cullin_CS
IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR019559--Cullin_neddylation_domain
IPR008979--Galactose-bd-like
IPR002867--IBR_dom
IPR014722--Rib_L2_dom2
IPR011991--WHTH_DNA-bd_dom
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS01256--CULLIN_1
PS50069--CULLIN_2
PS51284--DOC
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF03256--ANAPC10
PF11515--Cul7
PF00888--Cullin
PF10557--Cullin_Nedd8
PF01485--IBR

SMART

SM01337--APC10
SM00884--Cullin_Nedd8
SM00647--IBR

Gene Ontology

GO:0031461--C:cullin-RING ubiquitin ligase complex
GO:0005829--C:cytosol
GO:0005524--F:ATP binding
GO:0008270--F:zinc ion binding
GO:0000226--P:microtubule cytoskeleton organization
GO:0016567--P:protein ubiquitination
GO:0007088--P:regulation of mitotic nuclear division
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG hsa:23113
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001405 Ailuropoda melanoleuca 90.93 0.00e+00 4330.00
IUUC-Apl-003458 Anas platyrhynchos 64.99 0.00e+00 758.00
IUUC-Aca-004815 Anolis carolinensis 56.95 0.00e+00 2573.00
IUUC-Ame-010611 Astyanax mexicanus 50.85 0.00e+00 2271.00
IUUC-Bta-012877 Bos taurus 88.19 0.00e+00 4055.00
IUUC-Cja-019255 Callithrix jacchus 96.59 0.00e+00 4543.00
IUUC-Cfa-020119 Canis familiaris 91.46 0.00e+00 4276.00
IUUC-Cpo-022473 Cavia porcellus 84.59 0.00e+00 3812.00
IUUC-Csa-024157 Chlorocebus sabaeus 98.29 0.00e+00 4555.00
IUUC-Cho-024879 Choloepus hoffmanni 85.94 0.00e+00 917.00
IUUC-Cin-025402 Ciona intestinalis 32.03 0.00e+00 725.00
IUUC-Dno-028904 Dasypus novemcinctus 88.91 0.00e+00 4121.00
IUUC-Dor-030112 Dipodomys ordii 88.12 0.00e+00 1357.00
IUUC-Ete-032516 Echinops telfairi 80.79 0.00e+00 1340.00
IUUC-Eca-034394 Equus caballus 90.91 0.00e+00 4157.00
IUUC-Eeu-035166 Erinaceus europaeus 88.75 0.00e+00 2187.00
IUUC-Fca-035740 Felis catus 91.30 0.00e+00 4246.00
IUUC-Fal-036672 Ficedula albicollis 50.73 0.00e+00 1556.00
IUUC-Gmo-038795 Gadus morhua 50.10 0.00e+00 869.00
IUUC-Gga-040154 Gallus gallus 60.76 0.00e+00 899.00
IUUC-Ggo-045570 Gorilla gorilla 99.17 0.00e+00 4557.00
IUUC-Itr-048680 Ictidomys tridecemlineatus 90.56 0.00e+00 4266.00
IUUC-Loc-052706 Lepisosteus oculatus 52.19 0.00e+00 2352.00
IUUC-Mcc-055727 Macaca mulatta 98.25 0.00e+00 4593.00
IUUC-Meu-056074 Macropus eugenii 75.63 0.00e+00 1499.00
IUUC-Mga-059683 Meleagris gallopavo 53.35 3.00e-101 362.00
IUUC-Mmr-060869 Microcebus murinus 92.74 0.00e+00 4312.00
IUUC-Mdo-062902 Monodelphis domestica 73.56 0.00e+00 3306.00
IUUC-Mmu-063991 Mus musculus 85.65 0.00e+00 3987.00
IUUC-Mpu-065974 Mustela putorius furo 91.05 0.00e+00 4226.00
IUUC-Nle-069292 Nomascus leucogenys 98.74 0.00e+00 2900.00
IUUC-Opr-071020 Ochotona princeps 85.96 0.00e+00 2149.00
IUUC-Ont-071953 Oreochromis niloticus 51.27 0.00e+00 2216.00
IUUC-Oan-073534 Ornithorhynchus anatinus 58.90 0.00e+00 2079.00
IUUC-Ocu-074244 Oryctolagus cuniculus 89.28 0.00e+00 4139.00
IUUC-Ola-087072 Oryzias latipes 52.42 0.00e+00 1744.00
IUUC-Oga-088310 Otolemur garnettii 89.81 0.00e+00 4238.00
IUUC-Oar-090174 Ovis aries 88.50 0.00e+00 4004.00
IUUC-Ptr-091410 Pan troglodytes 99.28 0.00e+00 4532.00
IUUC-Pan-091856 Papio anubis 97.93 0.00e+00 2890.00
IUUC-Pma-094192 Petromyzon marinus 45.87 0.00e+00 1432.00
IUUC-Pfo-096773 Poecilia formosa 55.12 0.00e+00 962.00
IUUC-Pab-098635 Pongo abelii 98.55 0.00e+00 3108.00
IUUC-Pca-100539 Procavia capensis 88.75 0.00e+00 1335.00
IUUC-Pva-102813 Pteropus vampyrus 87.38 0.00e+00 1655.00
IUUC-Rno-106105 Rattus norvegicus 86.03 0.00e+00 3995.00
IUUC-Sha-106896 Sarcophilus harrisii 76.68 0.00e+00 1162.00
IUUC-Sar-113132 Sorex araneus 80.77 0.00e+00 1276.00
IUUC-Ssc-116000 Sus scrofa 90.20 0.00e+00 4140.00
IUUC-Tgu-116915 Taeniopygia guttata 63.45 1.00e-144 506.00
IUUC-Tru-118013 Takifugu rubripes 46.85 0.00e+00 2081.00
IUUC-Tsy-119037 Tarsius syrichta 82.45 0.00e+00 1141.00
IUUC-Tni-120062 Tetraodon nigroviridis 50.91 0.00e+00 2258.00
IUUC-Ttr-128780 Tursiops truncatus 86.44 0.00e+00 2667.00
IUUC-Vpa-130086 Vicugna pacos 86.36 0.00e+00 684.00
IUUC-Xtr-132882 Xenopus tropicalis 49.95 0.00e+00 1843.00
Created Date 25-Jun-2017

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