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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046420
UUCD1 version UUC-HoS-00772
Ensembl Protein ID ENSP00000293805.5
UniProt Accession Q8N143; Q6PCB4; BCL6B_HUMAN
Genbank Protein ID BAC00962.1; BAC00963.1; AAH59404.1
Protein Name B-cell CLL/lymphoma 6 member B protein; Bcl6-associated zinc finger protein; Zinc finger protein 62
Genbank Nucleotide ID AB076580; AB076581; AC040977
Gene Name BCL6B; BAZF; ZNF62
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000161940.10 ENST00000293805.9 ENSP00000293805.5
ENSG00000161940.10 ENST00000537931.2 ENSP00000445010.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsiteCircNetmiRTarBase
microRNATRANSFACTargetScanRepTar
miRcodeRAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/BCR/BTB_Other BTB_Other 22279058
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB 2.50e-10 42.2 38 104
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_Other: BTB
   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikd.vqpevfrallkFlYtgklden 68
           +Dv+l vgg+  +ahk+vL a+S +Fy+ f +    +   +   + +  ++  f  ll+F+Yt++l+++
   Q: 38   TDVTLLVGGQPLRAHKAVLIACSGFFYSIFRGRAGVG--VDVLSLPGgPEARGFAPLLDFMYTSRLRLS 104
           7*******************************99987..689999966*****************9875 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Acts as a sequence-specific transcriptional repressor in association with BCL6. May function in a narrow stage or be related to some events in the early B-cell development.
 Acts as a sequence-specific transcriptional repressor in association with BCL6. May function in a narrow stage or be related to some events in the early B-cell development.
Protein Sequence
(Fasta)
MGSPAAPEGA LGYVREFTRH SSDVLGNLNE LRLRGILTDV TLLVGGQPLR AHKAVLIACS 60
GFFYSIFRGR AGVGVDVLSL PGGPEARGFA PLLDFMYTSR LRLSPATAPA VLAAATYLQM 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046420|E3,BTB_Other|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGATAAAGGA GCCGAGGCCA AGAGGGGAGA GAGACCCCGC CCCCCTTAAG AAGAGAAGCC 60
GCGGCCCCTG CAGGACGGGG GTAAGAACAA GAGACTGAGG GAGCCAGACT CCTGGGTCCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046420|E3,BTB_Other|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR000210--BTB/POZ_dom
IPR023413--GFP-like
IPR011333--SKP1/BTB/POZ
IPR013087--Znf_C2H2_type
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2
Pfam

PF00651--BTB
SMART

SM00225--BTB
SM00355--ZnF_C2H2
Gene Ontology

GO:0005634--C:nucleus
GO:0046872--F:metal ion binding
GO:0000977--F:RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001227--F:transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0042127--P:regulation of cell proliferation
GO:0050727--P:regulation of inflammatory response
GO:0042092--P:type 2 immune response
KEGG hsa:255877
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002419 Ailuropoda melanoleuca 91.65 0.00e+00 731.00
IUUC-Bta-013175 Bos taurus 90.81 0.00e+00 754.00
IUUC-Cja-018749 Callithrix jacchus 95.42 0.00e+00 839.00
IUUC-Cfa-020386 Canis familiaris 91.00 0.00e+00 733.00
IUUC-Csa-023792 Chlorocebus sabaeus 97.49 0.00e+00 820.00
IUUC-Cho-025094 Choloepus hoffmanni 89.86 7.00e-113 399.00
IUUC-Dno-029013 Dasypus novemcinctus 89.56 0.00e+00 762.00
IUUC-Dor-030873 Dipodomys ordii 92.28 0.00e+00 803.00
IUUC-Ete-033032 Echinops telfairi 87.76 0.00e+00 647.00
IUUC-Eca-034190 Equus caballus 90.38 2.00e-166 578.00
IUUC-Fca-036275 Felis catus 87.18 2.00e-140 492.00
IUUC-Gac-042094 Gasterosteus aculeatus 50.00 7.00e-109 387.00
IUUC-Ggo-045349 Gorilla gorilla 99.79 0.00e+00 862.00
IUUC-Itr-048884 Ictidomys tridecemlineatus 91.02 0.00e+00 815.00
IUUC-Laf-053423 Loxodonta africana 92.69 0.00e+00 799.00
IUUC-Mcc-054929 Macaca mulatta 96.66 0.00e+00 819.00
IUUC-Meu-056583 Macropus eugenii 69.48 4.00e-164 571.00
IUUC-Mdo-062982 Monodelphis domestica 82.27 3.00e-96 345.00
IUUC-Mmu-064402 Mus musculus 90.19 0.00e+00 785.00
IUUC-Mpu-066664 Mustela putorius furo 89.77 0.00e+00 758.00
IUUC-Mlu-067140 Myotis lucifugus 91.44 0.00e+00 748.00
IUUC-Nle-069642 Nomascus leucogenys 98.33 0.00e+00 848.00
IUUC-Opr-070308 Ochotona princeps 89.14 0.00e+00 730.00
IUUC-Ocu-074174 Oryctolagus cuniculus 79.74 1.00e-128 452.00
IUUC-Oga-088996 Otolemur garnettii 55.60 7.00e-129 454.00
IUUC-Oar-090313 Ovis aries 89.35 0.00e+00 754.00
IUUC-Ptr-090601 Pan troglodytes 99.79 0.00e+00 864.00
IUUC-Pan-092651 Papio anubis 96.87 0.00e+00 820.00
IUUC-Pab-098548 Pongo abelii 98.75 0.00e+00 853.00
IUUC-Pca-100214 Procavia capensis 87.27 0.00e+00 725.00
IUUC-Pva-103170 Pteropus vampyrus 79.75 4.00e-173 600.00
IUUC-Rno-105150 Rattus norvegicus 89.98 0.00e+00 771.00
IUUC-Sha-107591 Sarcophilus harrisii 66.53 9.00e-165 573.00
IUUC-Sar-113228 Sorex araneus 83.30 0.00e+00 658.00
IUUC-Ssc-116067 Sus scrofa 93.39 0.00e+00 768.00
IUUC-Tru-117948 Takifugu rubripes 49.70 5.00e-110 391.00
IUUC-Tsy-119245 Tarsius syrichta 90.39 0.00e+00 639.00
IUUC-Tbe-127318 Tupaia belangeri 91.86 0.00e+00 781.00
IUUC-Ttr-128316 Tursiops truncatus 91.10 0.00e+00 647.00
Created Date 25-Jun-2017

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