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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046209
UUCD1 version UUC-HoS-00997
Ensembl Protein ID ENSP00000265742.3
UniProt Accession Q9P2G1; Q6GMS4; Q6P3S9; Q9NTD7; Q9NW49; AKIB1_HUMAN
Genbank Protein ID BAA92624.1; AAH63861.1; AAH73893.1; BAA91537.1; CAB70704.1
Protein Name Ankyrin repeat and IBR domain-containing protein 1
Genbank Nucleotide ID AB037807; AC000118; BC073893; AK001179; AL137349
Gene Name ANKIB1; KIAA1386
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000001629.9 ENST00000265742.7 ENSP00000265742.3
ENSG00000001629.9 ENST00000439883.1 ENSP00000407913.1
ENSG00000001629.9 ENST00000413588.1 ENSP00000406644.1
ENSG00000001629.9 ENST00000422095.1 ENSP00000396406.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanmiRecordsRepTarmiRNAMap
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexMentha
Disease-associated Information
GWASdb
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Alpha-Helix/UIM UIM 11406394; 15155768
Classification
Family E-value Score Start End
E3 activity/RBR 3.50e-58 197.4 333 548
UBD/Alpha-Helix/UIM 0.29 13.0 851 868
Active Site
Position(s) Description Evidence
532 N/A {ECO:0000250|UniProtKB:Q9Y4X5}
Domain Profile

   E3 activity/RBR
   S: 1    CkvCllelsveeltvlleCehtfCkeClkqylelkikegqvteiscpaaecpekleeseikellveeelykryekllleevveadaalkw 90
           C++C++++sv e++v + C h+fC+ C++++l+lki+eg++++i+cpa++c++ ++ + i++ +v++e+ kry +++++++ve+++a+kw
   Q: 333  CDICMCSISVFEDPVDMPCGHDFCRGCWESFLNLKIQEGEAHNIFCPAYDCFQLVPVDIIES-VVSKEMDKRYLQFDIKAFVENNPAIKW 421
           **************************************************************.79************************* PP
   S: 91   cpapdCslvvllekea..............eklevecekcgkefCveCkeewHeglsCkelkeklakteeek...........eeaeske 155
           cp+p+C+++v+l+k++              ++  v+c ++g+ fC+eC  e+He+++C+++k++l+k +e+k           e+a+++ 
   Q: 422  CPTPGCDRAVRLTKQGsntsgsdtlsfpllRAPAVDC-GKGHLFCWECLGEAHEPCDCQTWKNWLQKITEMKpeelvgvseayEDAANCL 510
           **************98999999888885544444447.7789*****************************9****************** PP
   S: 156  lleanskkCpkCkvyieknegCnhmtCakCkaefCwlC 193
           +l +nsk+C++Ck++i+knegCnhm+CakCk++fCw+C
   Q: 511  WLLTNSKPCANCKSPIQKNEGCNHMQCAKCKYDFCWIC 548
           ************************************** PP
   

   UBD/Alpha-Helix/UIM
   S: 1    dEdeeLqlAlalSlqEee 18
           ++d+ + lA++lSlqE +
   Q: 851  EDDPNILLAIQLSLQESG 868
           69999***********86 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
 Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
Protein Sequence
(Fasta)
MGNTTTKFRK ALINGDENLA CQIYENNPQL KESLDPNTSY GEPYQHNTPL HYAARHGMNK 60
ILGTFLGRDG NPNKRNVHNE TSMHLLCMGP QIMISEGALH PRLARPTEDD FRRADCLQMI 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046209|UBD,UIM;E3,RBR|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CGCAGCGGCC GGAGAGGGAT GGGGGGCGCC CACCCAGTCT GAGCCTCGCC GCGGGCGCCT 60
TCGGCTCACG CAGCGCTTCC CGCGGGCCGC CAGTGCGCAC CCTCGGCCAC ATCAGCCTCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046209|UBD,UIM;E3,RBR|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0040--ANK repeat
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0449--Lipoprotein
KW-0479--Metal-binding
KW-0519--Myristate
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR016150--Casein_kin_II_reg-sub_b-sht
IPR031127--E3_UB_ligase_RBR
IPR002867--IBR_dom
IPR003903--UIM_dom
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50330--UIM
PS50089--ZF_RING_2
Pfam

PF00023--Ank
PF01485--IBR
SMART

SM00248--ANK
SM00647--IBR
SM00184--RING
Gene Ontology

GO:0005737--C:cytoplasm
GO:0000151--C:ubiquitin ligase complex
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
KEGG hsa:54467
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002145 Ailuropoda melanoleuca 96.34 0.00e+00 2033.00
IUUC-Apl-003749 Anas platyrhynchos 87.36 0.00e+00 1842.00
IUUC-Aca-004337 Anolis carolinensis 83.08 0.00e+00 1757.00
IUUC-Aly-006224 Arabidopsis lyrata 30.42 2.00e-59 223.00
IUUC-Ame-011136 Astyanax mexicanus 77.61 0.00e+00 1533.00
IUUC-Bta-012896 Bos taurus 95.24 0.00e+00 1953.00
IUUC-Bol-015971 Brassica oleracea 30.35 4.00e-59 222.00
IUUC-Cja-019418 Callithrix jacchus 98.44 0.00e+00 2010.00
IUUC-Cfa-021139 Canis familiaris 96.07 0.00e+00 1996.00
IUUC-Cpo-022432 Cavia porcellus 93.49 0.00e+00 1970.00
IUUC-Cre-022815 Chlamydomonas reinhardtii 28.84 5.00e-56 211.00
IUUC-Csa-023239 Chlorocebus sabaeus 99.27 0.00e+00 2070.00
IUUC-Cho-024329 Choloepus hoffmanni 85.87 0.00e+00 1182.00
IUUC-Dre-028543 Danio rerio 78.86 0.00e+00 1532.00
IUUC-Dno-028949 Dasypus novemcinctus 93.87 0.00e+00 1957.00
IUUC-Dor-031083 Dipodomys ordii 84.46 0.00e+00 972.00
IUUC-Ete-032919 Echinops telfairi 93.06 0.00e+00 758.00
IUUC-Eca-033459 Equus caballus 95.52 0.00e+00 1919.00
IUUC-Eeu-034726 Erinaceus europaeus 74.75 0.00e+00 721.00
IUUC-Fca-036063 Felis catus 96.07 0.00e+00 1986.00
IUUC-Fal-036854 Ficedula albicollis 85.11 0.00e+00 1792.00
IUUC-Gmo-039629 Gadus morhua 64.78 0.00e+00 1189.00
IUUC-Gga-040616 Gallus gallus 87.95 0.00e+00 1860.00
IUUC-Gac-042034 Gasterosteus aculeatus 71.63 0.00e+00 1466.00
IUUC-Ggo-045104 Gorilla gorilla 99.63 0.00e+00 2057.00
IUUC-Hvu-047440 Hordeum vulgare 33.14 2.00e-53 203.00
IUUC-Itr-047991 Ictidomys tridecemlineatus 93.90 0.00e+00 1070.00
IUUC-Lch-050129 Latimeria chalumnae 80.62 0.00e+00 1552.00
IUUC-Loc-052381 Lepisosteus oculatus 77.82 0.00e+00 1576.00
IUUC-Laf-053411 Loxodonta africana 94.97 0.00e+00 1969.00
IUUC-Mcc-055098 Macaca mulatta 99.11 0.00e+00 1890.00
IUUC-Mga-059352 Meleagris gallopavo 87.69 0.00e+00 1855.00
IUUC-Mmr-061763 Microcebus murinus 94.39 0.00e+00 1994.00
IUUC-Mdo-062522 Monodelphis domestica 94.94 0.00e+00 1608.00
IUUC-Mmu-063322 Mus musculus 92.85 0.00e+00 1957.00
IUUC-Mac-065184 Musa acuminata 31.33 1.00e-58 221.00
IUUC-Mpu-065807 Mustela putorius furo 96.25 0.00e+00 1997.00
IUUC-Mlu-067421 Myotis lucifugus 92.05 0.00e+00 1875.00
IUUC-Nle-069468 Nomascus leucogenys 99.82 0.00e+00 2061.00
IUUC-Opr-070381 Ochotona princeps 87.95 0.00e+00 1842.00
IUUC-Ont-072092 Oreochromis niloticus 72.74 0.00e+00 1504.00
IUUC-Oan-072962 Ornithorhynchus anatinus 83.92 0.00e+00 701.00
IUUC-Ocu-074462 Oryctolagus cuniculus 92.85 0.00e+00 1860.00
IUUC-Oba-075918 Oryza barthii 34.09 2.00e-55 210.00
IUUC-Olo-080626 Oryza longistaminata 33.85 7.00e-48 185.00
IUUC-Ome-081812 Oryza meridionalis 34.09 2.00e-55 211.00
IUUC-Ola-086873 Oryzias latipes 76.68 0.00e+00 1465.00
IUUC-Oga-088058 Otolemur garnettii 97.34 0.00e+00 2026.00
IUUC-Oar-089724 Ovis aries 94.98 0.00e+00 1941.00
IUUC-Ptr-090646 Pan troglodytes 99.82 0.00e+00 2062.00
IUUC-Pan-092334 Papio anubis 99.17 0.00e+00 2060.00
IUUC-Psi-093827 Pelodiscus sinensis 88.22 0.00e+00 1827.00
IUUC-Pma-094243 Petromyzon marinus 62.20 0.00e+00 909.00
IUUC-Pfo-097370 Poecilia formosa 69.68 0.00e+00 1462.00
IUUC-Pab-098757 Pongo abelii 99.72 0.00e+00 2091.00
IUUC-Pca-101017 Procavia capensis 89.58 0.00e+00 959.00
IUUC-Ppe-101451 Prunus persica 35.41 6.00e-57 215.00
IUUC-Pva-102797 Pteropus vampyrus 93.43 0.00e+00 1920.00
IUUC-Rno-106046 Rattus norvegicus 93.13 0.00e+00 1964.00
IUUC-Sha-107341 Sarcophilus harrisii 87.99 0.00e+00 1854.00
IUUC-Sar-113328 Sorex araneus 86.98 0.00e+00 1517.00
IUUC-Ssc-115681 Sus scrofa 94.07 0.00e+00 1923.00
IUUC-Tgu-116830 Taeniopygia guttata 87.67 0.00e+00 1846.00
IUUC-Tru-117711 Takifugu rubripes 75.20 0.00e+00 1432.00
IUUC-Tsy-119501 Tarsius syrichta 86.26 0.00e+00 926.00
IUUC-Tni-119911 Tetraodon nigroviridis 65.31 0.00e+00 1223.00
IUUC-Tur-126178 Triticum urartu 30.23 1.00e-43 171.00
IUUC-Tbe-127647 Tupaia belangeri 84.78 0.00e+00 1243.00
IUUC-Ttr-129218 Tursiops truncatus 95.88 0.00e+00 2004.00
IUUC-Vpa-130603 Vicugna pacos 95.33 0.00e+00 1964.00
IUUC-Xtr-132250 Xenopus tropicalis 78.71 0.00e+00 1017.00
Created Date 25-Jun-2017

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