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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063275
Ensembl Protein ID ENSMUSP00000041819.7
UniProt Accession Q3U1V8; E9QLZ4; Q8BIG8; M3K9_MOUSE
Genbank Protein ID BAC35552.1; BAE33385.1; ENSMUSP00000041819
Protein Name Mitogen-activated protein kinase kinase kinase 9
Genbank Nucleotide ID AK053843; AK155677; AC124595
Gene Name Map3k9
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000042724.7 ENSMUST00000035987.7 ENSMUSP00000041819.7
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarmiRNAMap
RAID2
Protein-protein Interaction
IIDHINT
Drug and target
GRAC
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTM
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 9.90e-16 58.6 51 105
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 7    qvlydyeaqnddeLtlkkGdvvlvi...ekeeqdegWlkgvkelegkrGlfPenFve 60
            + ++yea+ +deLtl+ Gdvv+v+   ++ + degW+ g  +l+++ G+fP+n+v+
   Q: 51   TAVFEYEAAGEDELTLRLGDVVEVLskdSQVSGDEGWWTG--QLNQRVGIFPSNYVT 105
           689**********************76666777*******..8************97 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade through the phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7 which in turn activate the JNKs. The MKK/JNK signaling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors. Plays also a role in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis (By similarity).
 Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade through the phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7 which in turn activate the JNKs. The MKK/JNK signaling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors. Plays also a role in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis (By similarity).
Protein Sequence
(Fasta)
MESSRSLLGC LASATAAPPG DDATGAGAEE EEDEEEAAAE LGSHAALPYW TAVFEYEAAG 60
EDELTLRLGD VVEVLSKDSQ VSGDEGWWTG QLNQRVGIFP SNYVTPRSAF SSRCQPGAED 120
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Protein Fasta Sequence


>IUUC-Mmu-063275|UBD,SH3|Mus musculus
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Nucleotide Sequence
(Fasta)
GGGGAGGGAG CGGCCAGCGG GCGGCGGGCA CGGGCGGCAC GAGCAGGTGG GAGCCGCCGA 60
GGGGCGAGGC CGCCCGCGGG GGCGCCAGGC GGCCGGGACT GCGCCGCGCC CCTGTCCGCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063275|UBD,SH3|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0053--Apoptosis
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0723--Serine/threonine-protein kinase
KW-0728--SH3 domain
KW-0346--Stress response
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
Interpro

IPR011009--Kinase-like_dom
IPR016231--MLK1/MLK2/MLK4
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR008271--Ser/Thr_kinase_AS
IPR001452--SH3_domain
PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
PS50002--SH3
Pfam

PF00069--Pkinase
PF14604--SH3_9
PRINTS

PR00452--SH3DOMAIN
PR00109--TYRKINASE
SMART

SM00220--S_TKc
SM00326--SH3
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005524--F:ATP binding
GO:0004706--F:JUN kinase kinase kinase activity
GO:0004674--F:protein serine/threonine kinase activity
GO:0007257--P:activation of JUN kinase activity
GO:0006915--P:apoptotic process
GO:0043065--P:positive regulation of apoptotic process
GO:0046777--P:protein autophosphorylation
GO:0006468--P:protein phosphorylation
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
KEGG mmu:338372
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001439 Ailuropoda melanoleuca 90.79 0.00e+00 1740.00
IUUC-Aca-004389 Anolis carolinensis 74.30 0.00e+00 1333.00
IUUC-Ame-011769 Astyanax mexicanus 52.15 0.00e+00 851.00
IUUC-Bta-012675 Bos taurus 91.97 0.00e+00 1712.00
IUUC-Cel-018266 Caenorhabditis elegans 31.66 7.00e-52 199.00
IUUC-Cja-018922 Callithrix jacchus 90.97 0.00e+00 1757.00
IUUC-Cpo-021603 Cavia porcellus 91.48 0.00e+00 1693.00
IUUC-Csa-023806 Chlorocebus sabaeus 90.18 0.00e+00 1121.00
IUUC-Cho-025023 Choloepus hoffmanni 84.76 3.00e-94 339.00
IUUC-Csv-026102 Ciona savignyi 59.06 8.00e-165 573.00
IUUC-Dre-028642 Danio rerio 59.85 0.00e+00 995.00
IUUC-Dno-029040 Dasypus novemcinctus 90.16 0.00e+00 1735.00
IUUC-Dme-032210 Drosophila melanogaster 46.69 9.00e-143 501.00
IUUC-Fal-036753 Ficedula albicollis 81.68 0.00e+00 1346.00
IUUC-Gga-040283 Gallus gallus 81.00 0.00e+00 1439.00
IUUC-Gac-041536 Gasterosteus aculeatus 59.03 0.00e+00 946.00
IUUC-Ggo-045285 Gorilla gorilla 88.95 0.00e+00 902.00
IUUC-Hsa-045938 Homo sapiens 92.71 0.00e+00 1717.00
IUUC-Lch-049935 Latimeria chalumnae 61.72 0.00e+00 1007.00
IUUC-Loc-051860 Lepisosteus oculatus 65.03 0.00e+00 1033.00
IUUC-Laf-053926 Loxodonta africana 92.88 0.00e+00 1747.00
IUUC-Mcc-055636 Macaca mulatta 90.45 0.00e+00 1725.00
IUUC-Mmr-061210 Microcebus murinus 92.44 0.00e+00 1663.00
IUUC-Mdo-062056 Monodelphis domestica 88.99 0.00e+00 1645.00
IUUC-Mlu-067856 Myotis lucifugus 94.12 0.00e+00 1644.00
IUUC-Nle-068969 Nomascus leucogenys 88.83 0.00e+00 1673.00
IUUC-Ont-071908 Oreochromis niloticus 72.83 0.00e+00 832.00
IUUC-Ome-081788 Oryza meridionalis 29.77 5.00e-31 129.00
IUUC-Ola-087339 Oryzias latipes 59.83 0.00e+00 939.00
IUUC-Oga-088123 Otolemur garnettii 83.79 0.00e+00 1636.00
IUUC-Ptr-091156 Pan troglodytes 88.77 0.00e+00 1699.00
IUUC-Pan-091971 Papio anubis 91.95 0.00e+00 1729.00
IUUC-Pma-094398 Petromyzon marinus 71.67 0.00e+00 697.00
IUUC-Pfo-096513 Poecilia formosa 57.83 0.00e+00 940.00
IUUC-Pab-097753 Pongo abelii 91.78 0.00e+00 1723.00
IUUC-Pca-100945 Procavia capensis 84.26 0.00e+00 1591.00
IUUC-Pva-102748 Pteropus vampyrus 93.31 0.00e+00 1058.00
IUUC-Rno-105729 Rattus norvegicus 95.91 0.00e+00 1761.00
IUUC-Tru-117541 Takifugu rubripes 58.44 0.00e+00 920.00
IUUC-Tni-119938 Tetraodon nigroviridis 70.83 0.00e+00 788.00
IUUC-Tbe-128153 Tupaia belangeri 85.37 0.00e+00 1583.00
IUUC-Ttr-128341 Tursiops truncatus 87.30 0.00e+00 1555.00
IUUC-Xtr-131880 Xenopus tropicalis 69.81 0.00e+00 1229.00
Created Date 25-Jun-2017

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