iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mtr-058572

Ensembl Protein ID

AES98760

UniProt Accession

G7KEA9; G7KEA9_MEDTR

Genbank Protein ID

AES98760.1

Protein Name

Ubiquitin-activating enzyme E1 1

Genbank Nucleotide ID

CM001221

Gene Name

MTR_5g072480

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
MTR_5g072480	AES98759	AES98759
MTR_5g072480	KEH28189	KEH28189
MTR_5g072480	AES98760	AES98760

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	1.30e-168	562.9	575	1062

Active Site

Position(s)	Description	Evidence
756	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU10132}

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGv.....gsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvnveahe 94
           YD Qi ++G++ q+k++ akv++vG g+lGcE+lKnL+l+Gv     g++tv+D+d +e+snl+rqFLfr++++g+ K+ vaa a++ +np+ n+ea +
   Q: 575  YDAQISVFGQKLQKKFEDAKVFVVGSGALGCEFLKNLALMGVscggqGKLTVTDDDVIEKSNLSRQFLFRDWNIGQAKSTVAASAAASINPQLNIEALQ 673
           *************************************************************************************************** PP
   S: 95   esiteleeeiv...FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsddppqktiPfctlketpnaaehtiewa 190
           ++++ ++e+++   F +++++V++aldn+ ar++v+++cl+ ++pl+esgtlG + +++ +i++lte y +s+dpp+k++P+ct+ ++p +++h+++wa
   Q: 674  NRVSSETENVFhdtFWENLSIVINALDNVNARLYVDQRCLYFQKPLLESGTLGAKCNTQMVIPHLTENYGASRDPPEKQAPMCTVHSFPHNIDHCLTWA 772
           *********98999************************************************************************************* PP
   S: 191  ............vlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakttinsikqllksfecdivtkskspfwv... 274
                       + +n +l++ ++ ++  ++   ++ ++ +++v + l +e+ e fe++i +a+ +f+ ++ n +kql   f+ d  t+ ++pfw+   
   Q: 773  rsefegllektpAEVNAYLSNPSEYTNAMKNAGDAQARDNLERVLECLDKEKCEAFEDCIIWARLKFEDYFANRVKQLAYTFPEDAATSTGAPFWSapk 871
           ************999************************************************************************************ PP
   S: 275  ......................................................sfcsnaealqvpekvekdeevvkasap..lylllralerfekk.. 315
                                                                  f + ++a+ v +  + +  + +++++  +  l+ +ler++++  
   Q: 872  rfprplqfsssdpshlqflmaasilraetfgiptpdwvknptklavvvdrmivpDFQPKKDAKIVTDEKATSLSTASVDDAvvIDDLIVKLERLRSNlp 970
           *************************************************99999888888888777777777777777777785555555655555433 PP
   S: 316  kgrkpgelsfekddds..avdlvtaaanlraeslgiepkldddlikeiagniipaiattnavvgGlaaqEviKvvsg..kfeplknfflfdae 404
           +g  ++ ++fekddd   ++d+++ +an+ra +++i++ +d+ + k iag+iipaiat +a+  Gl+++E++K+++g  k e ++n+f ++a+
   Q: 971  PGFRMKPIQFEKDDDTnyHMDVIAGLANMRARNYSIPE-VDKLKAKFIAGRIIPAIATSTAMATGLVCLELYKALDGghKLEDYRNTFANLAL 1062
           9999**********************************.*************************************************99875 PP

Organism

Medicago truncatula

Protein Sequence
(Fasta)

MAPSWPEKGN HPHYNSGNNK HVILYYDKKS NTRRTPTQTH FRAKFQKYPY LSRFITKSNQ 60
TLLHSLHNSK PNRRNTISLS FPIRFHFFLP YRRLFHHMLP RKRLSEGEVV VEEPINNNNG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCTCCAT CTTGGCCAGA AAAAGGAAAT CATCCACATT ACAATAGTGG TAACAATAAG 60
CATGTTATCT TGTATTATGA TAAGGTAAAC AATATTTAAT CAATAAGTAT AAAGAAGCAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR032420--E1_4HB
IPR032418--E1_FCCH
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR018965--Ub-activating_enz_E1_C
IPR019572--UBA_E1_Cys
IPR018075--UBQ-activ_enz_E1
IPR018074--UBQ-activ_enz_E1_CS
IPR033127--UBQ-activ_enz_E1_Cys_AS
IPR000011--UBQ/SUMO-activ_enz_E1-like

PROSITE

PS00536--UBIQUITIN_ACTIVAT_1
PS00865--UBIQUITIN_ACTIVAT_2

Pfam

PF16191--E1_4HB
PF16190--E1_FCCH
PF09358--E1_UFD
PF00899--ThiF
PF10585--UBA_e1_thiolCys

PRINTS

PR01849--UBIQUITINACT

SMART

SM00985--UBA_e1_C

Gene Ontology

GO:0005524--F:ATP binding
GO:0008641--F:small protein activating enzyme activity
GO:0006464--P:cellular protein modification process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000456	Aegilops tauschii	80.63	0.00e+00	1683.00
IUUC-Aml-001311	Ailuropoda melanoleuca	44.17	0.00e+00	856.00
IUUC-Atr-002684	Amborella trichopoda	74.03	0.00e+00	1685.00
IUUC-Apl-004158	Anas platyrhynchos	38.15	0.00e+00	649.00
IUUC-Aca-004620	Anolis carolinensis	43.70	0.00e+00	836.00
IUUC-Aly-005418	Arabidopsis lyrata	83.69	0.00e+00	1786.00
IUUC-Ath-006992	Arabidopsis thaliana	83.20	0.00e+00	1736.00
IUUC-Ago-007873	Ashbya gossypii	44.95	0.00e+00	822.00
IUUC-Acl-008181	Aspergillus clavatus	44.95	0.00e+00	807.00
IUUC-Afl-008455	Aspergillus flavus	45.53	0.00e+00	800.00
IUUC-Afu-009065	Aspergillus fumigatus	45.63	0.00e+00	837.00
IUUC-Ani-009371	Aspergillus nidulans	45.85	0.00e+00	803.00
IUUC-Ang-009737	Aspergillus niger	45.07	0.00e+00	804.00
IUUC-Aor-010007	Aspergillus oryzae	45.53	0.00e+00	800.00
IUUC-Ate-010466	Aspergillus terreus	45.07	0.00e+00	833.00
IUUC-Ame-010933	Astyanax mexicanus	44.59	0.00e+00	818.00
IUUC-Bgr-012281	Blumeria graminis	44.48	0.00e+00	820.00
IUUC-Bta-012767	Bos taurus	44.52	0.00e+00	868.00
IUUC-Bci-013721	Botrytis cinerea	45.96	0.00e+00	803.00
IUUC-Bdi-014843	Brachypodium distachyon	80.25	0.00e+00	1636.00
IUUC-Bol-015880	Brassica oleracea	84.28	0.00e+00	1792.00
IUUC-Bra-017252	Brassica rapa	84.48	0.00e+00	1794.00
IUUC-Cel-018260	Caenorhabditis elegans	38.04	0.00e+00	635.00
IUUC-Cja-019152	Callithrix jacchus	44.54	0.00e+00	862.00
IUUC-Cfa-020622	Canis familiaris	43.18	0.00e+00	810.00
IUUC-Cpo-022526	Cavia porcellus	44.23	0.00e+00	851.00
IUUC-Cre-022702	Chlamydomonas reinhardtii	59.81	0.00e+00	1168.00
IUUC-Csa-023780	Chlorocebus sabaeus	44.42	0.00e+00	863.00
IUUC-Cho-024682	Choloepus hoffmanni	34.18	4.00e-94	339.00
IUUC-Cin-025790	Ciona intestinalis	44.34	0.00e+00	853.00
IUUC-Csv-026084	Ciona savignyi	42.72	0.00e+00	838.00
IUUC-Cgl-026512	Colletotrichum gloeosporioides	45.82	0.00e+00	861.00
IUUC-Cne-026960	Cryptococcus neoformans	45.59	0.00e+00	847.00
IUUC-Cme-027290	Cyanidioschyzon merolae	38.83	0.00e+00	688.00
IUUC-Dre-028149	Danio rerio	45.18	0.00e+00	834.00
IUUC-Dno-028884	Dasypus novemcinctus	44.23	0.00e+00	863.00
IUUC-Dor-030229	Dipodomys ordii	42.22	0.00e+00	805.00
IUUC-Dse-031524	Dothistroma septosporum	43.65	0.00e+00	805.00
IUUC-Dme-032045	Drosophila melanogaster	43.88	0.00e+00	827.00
IUUC-Ete-033124	Echinops telfairi	38.64	1.00e-122	433.00
IUUC-Eca-033330	Equus caballus	44.03	0.00e+00	855.00
IUUC-Eeu-035323	Erinaceus europaeus	38.56	9.00e-142	497.00
IUUC-Fca-036255	Felis catus	44.23	0.00e+00	853.00
IUUC-Fal-036848	Ficedula albicollis	38.39	0.00e+00	657.00
IUUC-Fox-038007	Fusarium oxysporum	47.96	4.00e-136	477.00
IUUC-Fso-038339	Fusarium solani	47.05	0.00e+00	829.00
IUUC-Gmo-039338	Gadus morhua	43.80	0.00e+00	816.00
IUUC-Ggr-039823	Gaeumannomyces graminis	45.06	0.00e+00	855.00
IUUC-Gga-040747	Gallus gallus	38.49	0.00e+00	645.00
IUUC-Gac-041773	Gasterosteus aculeatus	43.69	0.00e+00	813.00
IUUC-Gma-043198	Glycine max	87.66	0.00e+00	1905.00
IUUC-Ggo-045336	Gorilla gorilla	44.23	0.00e+00	845.00
IUUC-Hsa-045982	Homo sapiens	44.23	0.00e+00	844.00
IUUC-Hvu-047418	Hordeum vulgare	80.30	0.00e+00	1649.00
IUUC-Itr-048460	Ictidomys tridecemlineatus	44.52	0.00e+00	866.00
IUUC-Kpa-049112	Komagataella pastoris	45.90	0.00e+00	858.00
IUUC-Lch-050371	Latimeria chalumnae	45.40	0.00e+00	859.00
IUUC-Lpe-051299	Leersia perrieri	77.04	0.00e+00	1609.00
IUUC-Loc-052936	Lepisosteus oculatus	45.85	0.00e+00	848.00
IUUC-Lma-053315	Leptosphaeria maculans	45.18	0.00e+00	867.00
IUUC-Laf-053948	Loxodonta africana	45.43	0.00e+00	851.00
IUUC-Mcc-055843	Macaca mulatta	44.42	0.00e+00	865.00
IUUC-Meu-056258	Macropus eugenii	45.73	0.00e+00	855.00
IUUC-Mor-057269	Magnaporthe oryzae	45.23	0.00e+00	842.00
IUUC-Mpo-057435	Magnaporthe poae	45.33	0.00e+00	830.00
IUUC-Mla-059176	Melampsora laricipopulina	47.18	0.00e+00	867.00
IUUC-Mga-059721	Meleagris gallopavo	38.19	0.00e+00	635.00
IUUC-Mvi-060437	Microbotryum violaceum	43.24	0.00e+00	800.00
IUUC-Mmr-061405	Microcebus murinus	43.46	0.00e+00	825.00
IUUC-Mdo-062032	Monodelphis domestica	44.36	0.00e+00	832.00
IUUC-Mmu-063721	Mus musculus	44.01	0.00e+00	850.00
IUUC-Mac-065505	Musa acuminata	76.94	0.00e+00	1665.00
IUUC-Mpu-066409	Mustela putorius furo	44.23	0.00e+00	865.00
IUUC-Mlu-067217	Myotis lucifugus	44.23	0.00e+00	854.00
IUUC-Nfi-068407	Neosartorya fischeri	45.53	0.00e+00	815.00
IUUC-Ncr-068698	Neurospora crassa	45.92	0.00e+00	835.00
IUUC-Nle-070072	Nomascus leucogenys	41.27	0.00e+00	765.00
IUUC-Opr-070715	Ochotona princeps	36.28	4.00e-147	514.00
IUUC-Ont-071671	Oreochromis niloticus	44.69	0.00e+00	835.00
IUUC-Oan-073268	Ornithorhynchus anatinus	40.35	7.00e-177	613.00
IUUC-Ocu-074544	Oryctolagus cuniculus	44.62	0.00e+00	867.00
IUUC-Oba-075120	Oryza barthii	80.61	0.00e+00	1632.00
IUUC-Obr-076557	Oryza brachyantha	81.17	0.00e+00	1650.00
IUUC-Ogl-077887	Oryza glaberrima	80.61	0.00e+00	1634.00
IUUC-Ogu-078305	Oryza glumaepatula	78.00	0.00e+00	1609.00
IUUC-Oin-079370	Oryza indica	78.40	0.00e+00	1616.00
IUUC-Olo-081089	Oryza longistaminata	78.10	0.00e+00	1613.00
IUUC-Ome-081942	Oryza meridionalis	81.11	0.00e+00	1644.00
IUUC-Oni-082365	Oryza nivara	81.01	0.00e+00	1642.00
IUUC-Opu-083301	Oryza punctata	81.01	0.00e+00	1642.00
IUUC-Oru-084469	Oryza rufipogon	78.20	0.00e+00	1612.00
IUUC-Osa-085949	Oryza sativa	80.61	0.00e+00	1661.00
IUUC-Ola-087002	Oryzias latipes	45.19	0.00e+00	845.00
IUUC-Olu-087687	Ostreococcus lucimarinus	59.01	0.00e+00	1132.00
IUUC-Oga-088594	Otolemur garnettii	44.53	0.00e+00	847.00
IUUC-Oar-090068	Ovis aries	44.09	0.00e+00	857.00
IUUC-Ptr-090609	Pan troglodytes	37.86	0.00e+00	648.00
IUUC-Pan-092114	Papio anubis	44.42	0.00e+00	864.00
IUUC-Psi-093489	Pelodiscus sinensis	37.80	0.00e+00	650.00
IUUC-Pma-094214	Petromyzon marinus	48.54	5.00e-35	139.00
IUUC-Pno-095154	Phaeosphaeria nodorum	43.94	0.00e+00	834.00
IUUC-Ppa-095227	Physcomitrella patens	71.83	0.00e+00	1513.00
IUUC-Pfo-097184	Poecilia formosa	44.59	0.00e+00	833.00
IUUC-Pab-097861	Pongo abelii	44.33	0.00e+00	837.00
IUUC-Pop-098934	Populus trichocarpa	80.64	0.00e+00	1775.00
IUUC-Pca-100347	Procavia capensis	41.53	0.00e+00	684.00
IUUC-Ppe-102012	Prunus persica	83.79	0.00e+00	1791.00
IUUC-Pva-102584	Pteropus vampyrus	44.62	0.00e+00	890.00
IUUC-Pgr-103336	Puccinia graminis	46.42	0.00e+00	827.00
IUUC-Ptt-103939	Puccinia triticina	47.03	0.00e+00	824.00
IUUC-Pte-104200	Pyrenophora teres	45.58	0.00e+00	875.00
IUUC-Pyt-104441	Pyrenophora triticirepentis	44.98	0.00e+00	867.00
IUUC-Rno-105462	Rattus norvegicus	43.94	0.00e+00	839.00
IUUC-Sce-106245	Saccharomyces cerevisiae	45.24	0.00e+00	862.00
IUUC-Sha-107142	Sarcophilus harrisii	45.09	0.00e+00	869.00
IUUC-Sja-107841	Schizosaccharomyces japonicus	44.95	0.00e+00	846.00
IUUC-Spo-108034	Schizosaccharomyces pombe	44.34	0.00e+00	825.00
IUUC-Ssl-108497	Sclerotinia sclerotiorum	44.79	0.00e+00	792.00
IUUC-Smo-108912	Selaginella moellendorffii	73.47	0.00e+00	1526.00
IUUC-Sit-110281	Setaria italica	81.74	0.00e+00	1678.00
IUUC-Sly-111237	Solanum lycopersicum	84.20	0.00e+00	1715.00
IUUC-Stu-112001	Solanum tuberosum	80.95	0.00e+00	1736.00
IUUC-Sar-113737	Sorex araneus	44.24	0.00e+00	852.00
IUUC-Sbi-114089	Sorghum bicolor	81.44	0.00e+00	1677.00
IUUC-Sre-115148	Sporisorium reilianum	45.64	0.00e+00	813.00
IUUC-Ssc-115777	Sus scrofa	43.94	0.00e+00	853.00
IUUC-Tgu-116565	Taeniopygia guttata	38.19	0.00e+00	650.00
IUUC-Tru-118742	Takifugu rubripes	45.35	0.00e+00	803.00
IUUC-Tsy-119436	Tarsius syrichta	33.87	5.00e-152	531.00
IUUC-Tni-120401	Tetraodon nigroviridis	45.55	0.00e+00	813.00
IUUC-Tca-121436	Theobroma cacao	82.16	0.00e+00	1823.00
IUUC-Tre-122009	Trichoderma reesei	46.73	0.00e+00	811.00
IUUC-Tvi-122259	Trichoderma virens	46.87	0.00e+00	820.00
IUUC-Tae-125113	Triticum aestivum	80.40	0.00e+00	1614.00
IUUC-Tur-126330	Triticum urartu	80.43	0.00e+00	1680.00
IUUC-Tme-127055	Tuber melanosporum	44.31	0.00e+00	793.00
IUUC-Tbe-127714	Tupaia belangeri	35.56	2.00e-131	462.00
IUUC-Ttr-128331	Tursiops truncatus	44.23	0.00e+00	847.00
IUUC-Uma-129387	Ustilago maydis	45.80	0.00e+00	817.00
IUUC-Vda-129977	Verticillium dahliae	46.52	0.00e+00	806.00
IUUC-Vpa-130716	Vicugna pacos	36.66	3.00e-179	621.00
IUUC-Vvi-130857	Vitis vinifera	82.95	0.00e+00	1814.00
IUUC-Xtr-132947	Xenopus tropicalis	36.28	4.00e-171	594.00
IUUC-Xma-133805	Xiphophorus maculatus	44.39	0.00e+00	817.00
IUUC-Yli-134547	Yarrowia lipolytica	45.29	0.00e+00	845.00
IUUC-Zma-135758	Zea mays	80.18	0.00e+00	1645.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence