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Tag Content
iUUCD ID IUUC-Mcc-054845
Ensembl Protein ID ENSMMUP00000048866.1
UniProt Accession A0A1D5QLE1; A0A1D5QLE1_MACMU
Genbank Protein ID ENSMMUP00000048866
Protein Name Ubiquitin-related modifier 1
Genbank Nucleotide ID JSUE03014103
Gene Name URM1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMMUG00000018612.3 ENSMMUT00000065843.1 ENSMMUP00000048866.1
ENSMMUG00000018612.3 ENSMMUT00000026165.3 ENSMMUP00000024487.3
ENSMMUG00000018612.3 ENSMMUT00000066074.1 ENSMMUP00000047477.1
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
ULD/UDP/UBQ/UBQ_Other 40.22 3.00e-14 70.90 IUUC-Sce-106366
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Macaca mulatta
Functional Description
(View)

Functional Description


     Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
 Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Protein Sequence
(Fasta)
NPLSKNTKFS GAELLFDGIK KHQVTLPGQE EPWDIRNLLV WIKKNLLKER PELFIQGDSV 60
RPGILVLIND ADWELLGELD YQLQDQDSVL FISTLHGG 98
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Protein Fasta Sequence


>IUUC-Mcc-054845|ULD,UBQ_Other|Macaca mulatta
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Nucleotide Sequence
(Fasta)
ATGGCAGCGC CCTTGTCAGT GGAGGTGGAG TTCGGGTGAG TCACAGAGCT GGGGCACCAT 60
GGGGATAGAT TGAAGTCGTC GGGCTCGGAA TTCCTTTCCT TCTGCCATGG GGCCTGACAC 120
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Nucleotide Fasta Sequence


>IUUC-Mcc-054845|ULD,UBQ_Other|Macaca mulatta
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Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-1185--Reference proteome
KW-0819--tRNA processing
KW-0833--Ubl conjugation pathway
Interpro

IPR012675--Beta-grasp_dom
IPR016155--Mopterin_synth/thiamin_S_b
IPR015221--Urm1
Pfam

PF09138--Urm1
Gene Ontology

GO:0005829--C:cytosol
GO:0032447--P:protein urmylation
GO:0034227--P:tRNA thio-modification
GO:0002098--P:tRNA wobble uridine modification
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002254 Ailuropoda melanoleuca 92.86 1.00e-47 180.00
IUUC-Atr-003089 Amborella trichopoda 57.14 4.00e-27 112.00
IUUC-Apl-003382 Anas platyrhynchos 87.64 4.00e-42 162.00
IUUC-Aca-004981 Anolis carolinensis 80.61 2.00e-42 163.00
IUUC-Aly-005517 Arabidopsis lyrata 53.33 1.00e-26 110.00
IUUC-Ath-006718 Arabidopsis thaliana 53.57 7.00e-24 101.00
IUUC-Ago-007917 Ashbya gossypii 42.22 2.00e-17 80.10
IUUC-Acl-008054 Aspergillus clavatus 66.00 4.00e-15 72.40
IUUC-Afl-008704 Aspergillus flavus 55.06 2.00e-20 90.10
IUUC-Aor-009890 Aspergillus oryzae 53.47 4.00e-22 96.30
IUUC-Bta-012448 Bos taurus 90.82 5.00e-47 178.00
IUUC-Bci-013865 Botrytis cinerea 42.72 2.00e-18 84.00
IUUC-Bdi-014980 Brachypodium distachyon 63.64 2.00e-24 103.00
IUUC-Bol-016055 Brassica oleracea 55.00 6.00e-24 101.00
IUUC-Bra-016845 Brassica rapa 55.00 6.00e-24 101.00
IUUC-Cel-018485 Caenorhabditis elegans 34.78 3.00e-09 52.80
IUUC-Cja-019587 Callithrix jacchus 92.86 1.00e-47 180.00
IUUC-Cfa-020653 Canis familiaris 89.80 7.00e-47 177.00
IUUC-Cpo-021622 Cavia porcellus 92.86 1.00e-47 180.00
IUUC-Cre-023015 Chlamydomonas reinhardtii 53.76 6.00e-23 98.60
IUUC-Csa-023756 Chlorocebus sabaeus 92.11 1.00e-34 138.00
IUUC-Cgl-026518 Colletotrichum gloeosporioides 44.33 3.00e-18 83.20
IUUC-Cne-026953 Cryptococcus neoformans 55.79 1.00e-24 105.00
IUUC-Cme-027314 Cyanidioschyzon merolae 50.77 2.00e-16 77.00
IUUC-Dre-027884 Danio rerio 73.47 3.00e-39 152.00
IUUC-Dno-029262 Dasypus novemcinctus 88.31 2.00e-33 134.00
IUUC-Dor-030601 Dipodomys ordii 86.15 3.00e-24 102.00
IUUC-Dme-031893 Drosophila melanogaster 68.54 8.00e-31 124.00
IUUC-Ete-032773 Echinops telfairi 94.32 9.00e-45 171.00
IUUC-Eca-034187 Equus caballus 91.84 2.00e-47 179.00
IUUC-Eeu-034808 Erinaceus europaeus 88.78 5.00e-46 175.00
IUUC-Fca-036107 Felis catus 90.82 6.00e-47 178.00
IUUC-Fal-036607 Ficedula albicollis 86.52 1.00e-41 160.00
IUUC-Fox-037698 Fusarium oxysporum 45.54 8.00e-20 88.60
IUUC-Gmo-039492 Gadus morhua 72.45 4.00e-39 152.00
IUUC-Ggr-039965 Gaeumannomyces graminis 47.42 8.00e-18 82.80
IUUC-Gga-041268 Gallus gallus 82.65 6.00e-43 164.00
IUUC-Gac-042111 Gasterosteus aculeatus 75.51 6.00e-41 158.00
IUUC-Gma-043240 Glycine max 53.57 9.00e-23 97.80
IUUC-Ggo-045176 Gorilla gorilla 89.47 5.00e-26 109.00
IUUC-Hsa-046077 Homo sapiens 91.84 3.00e-39 152.00
IUUC-Itr-048111 Ictidomys tridecemlineatus 95.51 6.00e-38 148.00
IUUC-Kpa-049157 Komagataella pastoris 45.45 1.00e-17 80.90
IUUC-Lch-049889 Latimeria chalumnae 76.53 4.00e-40 155.00
IUUC-Lpe-050783 Leersia perrieri 59.76 3.00e-23 99.80
IUUC-Loc-052400 Lepisosteus oculatus 74.49 9.00e-40 154.00
IUUC-Lma-053259 Leptosphaeria maculans 46.88 2.00e-18 84.00
IUUC-Laf-053596 Loxodonta africana 90.00 1.00e-45 173.00
IUUC-Meu-055968 Macropus eugenii 85.71 5.00e-45 171.00
IUUC-Mor-057126 Magnaporthe oryzae 45.36 2.00e-16 77.80
IUUC-Mpo-057311 Magnaporthe poae 47.52 8.00e-19 85.90
IUUC-Mtr-058266 Medicago truncatula 51.16 2.00e-22 97.10
IUUC-Mla-058847 Melampsora laricipopulina 40.43 1.00e-09 55.10
IUUC-Mga-059468 Meleagris gallopavo 87.64 3.00e-42 162.00
IUUC-Mvi-060235 Microbotryum violaceum 56.16 2.00e-17 81.30
IUUC-Mdo-061948 Monodelphis domestica 84.69 7.00e-45 171.00
IUUC-Mmu-063946 Mus musculus 89.80 1.00e-46 177.00
IUUC-Mac-064812 Musa acuminata 65.28 6.00e-25 105.00
IUUC-Mpu-066763 Mustela putorius furo 89.80 5.00e-46 175.00
IUUC-Mlu-066970 Myotis lucifugus 90.79 1.00e-34 137.00
IUUC-Ncr-068824 Neurospora crassa 46.32 2.00e-17 80.10
IUUC-Nle-069849 Nomascus leucogenys 90.79 4.00e-34 136.00
IUUC-Opr-070227 Ochotona princeps 92.86 1.00e-47 180.00
IUUC-Ont-072530 Oreochromis niloticus 84.09 3.00e-41 159.00
IUUC-Oan-073191 Ornithorhynchus anatinus 85.39 4.00e-41 159.00
IUUC-Ocu-074460 Oryctolagus cuniculus 89.80 1.00e-46 176.00
IUUC-Oba-075499 Oryza barthii 67.19 8.00e-23 99.40
IUUC-Obr-076896 Oryza brachyantha 56.79 4.00e-22 97.80
IUUC-Ogl-077834 Oryza glaberrima 67.19 2.00e-23 99.80
IUUC-Ogu-078622 Oryza glumaepatula 67.19 2.00e-23 99.80
IUUC-Oin-079358 Oryza indica 67.19 8.00e-23 100.00
IUUC-Olo-081035 Oryza longistaminata 67.19 4.00e-23 100.00
IUUC-Oni-082425 Oryza nivara 67.19 2.00e-23 99.80
IUUC-Opu-083461 Oryza punctata 66.67 2.00e-22 98.60
IUUC-Oru-084875 Oryza rufipogon 60.56 3.00e-21 92.80
IUUC-Oga-089128 Otolemur garnettii 90.82 4.00e-47 179.00
IUUC-Oar-089896 Ovis aries 90.82 5.00e-47 178.00
IUUC-Ptr-091618 Pan troglodytes 89.47 5.00e-26 109.00
IUUC-Pan-092238 Papio anubis 92.11 1.00e-34 138.00
IUUC-Psi-093879 Pelodiscus sinensis 82.65 1.00e-42 164.00
IUUC-Pma-094484 Petromyzon marinus 81.01 4.00e-34 135.00
IUUC-Ppa-095801 Physcomitrella patens 58.02 2.00e-22 97.10
IUUC-Pfo-097192 Poecilia formosa 74.49 1.00e-40 157.00
IUUC-Pab-098203 Pongo abelii 91.84 2.00e-39 153.00
IUUC-Pop-099614 Populus trichocarpa 55.95 9.00e-24 101.00
IUUC-Pca-100507 Procavia capensis 89.47 2.00e-34 136.00
IUUC-Ppe-101174 Prunus persica 54.44 4.00e-25 105.00
IUUC-Pva-102735 Pteropus vampyrus 90.82 9.00e-44 167.00
IUUC-Pgr-103510 Puccinia graminis 38.30 1.00e-08 51.60
IUUC-Ptt-103918 Puccinia triticina 56.10 2.00e-07 47.80
IUUC-Pte-104173 Pyrenophora teres 48.96 4.00e-20 89.40
IUUC-Pyt-104806 Pyrenophora triticirepentis 48.96 5.00e-20 89.00
IUUC-Rno-105820 Rattus norvegicus 89.80 2.00e-46 176.00
IUUC-Sce-106366 Saccharomyces cerevisiae 40.22 1.00e-14 70.90
IUUC-Sja-107727 Schizosaccharomyces japonicus 41.38 1.00e-13 68.20
IUUC-Spo-108074 Schizosaccharomyces pombe 56.60 1.00e-07 47.80
IUUC-Smo-108944 Selaginella moellendorffii 60.23 8.00e-26 107.00
IUUC-Sit-110277 Setaria italica 59.26 5.00e-24 102.00
IUUC-Sly-111505 Solanum lycopersicum 53.57 3.00e-24 102.00
IUUC-Stu-112076 Solanum tuberosum 54.76 1.00e-24 103.00
IUUC-Sbi-114274 Sorghum bicolor 51.06 2.00e-24 103.00
IUUC-Sre-114953 Sporisorium reilianum 62.20 2.00e-24 103.00
IUUC-Ssc-115418 Sus scrofa 89.80 7.00e-47 177.00
IUUC-Tgu-117311 Taeniopygia guttata 86.52 1.00e-41 160.00
IUUC-Tru-118598 Takifugu rubripes 80.90 4.00e-40 155.00
IUUC-Tni-120109 Tetraodon nigroviridis 72.73 8.00e-38 147.00
IUUC-Tca-120942 Theobroma cacao 54.22 4.00e-23 99.00
IUUC-Tre-122099 Trichoderma reesei 47.83 4.00e-15 72.40
IUUC-Tvi-122285 Trichoderma virens 49.50 6.00e-17 79.00
IUUC-Tae-125193 Triticum aestivum 65.22 2.00e-23 100.00
IUUC-Tur-126677 Triticum urartu 55.56 8.00e-21 92.00
IUUC-Tme-127120 Tuber melanosporum 49.02 7.00e-22 95.50
IUUC-Tbe-128050 Tupaia belangeri 64.29 1.00e-27 114.00
IUUC-Ttr-129019 Tursiops truncatus 88.78 4.00e-44 168.00
IUUC-Uma-129483 Ustilago maydis 60.98 2.00e-22 97.10
IUUC-Vda-129690 Verticillium dahliae 41.07 1.00e-16 77.80
IUUC-Vvi-131174 Vitis vinifera 55.42 5.00e-24 102.00
IUUC-Xma-133862 Xiphophorus maculatus 74.49 1.00e-40 157.00
IUUC-Yli-134398 Yarrowia lipolytica 45.83 1.00e-16 77.80
IUUC-Zma-134964 Zea mays 58.54 9.00e-23 98.20
Created Date 25-Jun-2017

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