iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ggo-044480

UUCD1 version

UUC-GoG-01036

Ensembl Protein ID

ENSGGOP00000011923.2

UniProt Accession

G3R946; G3R946_GORGO

Protein Name

Uncharacterized protein

Gene Name

UBA7

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGGOG00000012204.2	ENSGGOT00000012264.2	ENSGGOP00000011923.2
ENSGGOG00000012204.2	ENSGGOT00000029258.1	ENSGGOP00000028165.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	7.30e-219	727.4	415	890

Active Site

Position(s)	Description	Evidence
599	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU10132}

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGv.....gsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkel 84
           YD+Qi+++G+  qekl+ +++llvGag++GcEllK ++l+G+     g +tvvDmd++e snl+rqFLfr +dvg++KAevaa+a++ l
   Q: 415  YDGQIAVFGAGFQEKLRCQHYLLVGAGAIGCELLKVFALVGLgagnsGGLTVVDMDHIERSNLSRQFLFRSQDVGRPKAEVAAAAARGL 503
           ***************************************************************************************** PP
   S: 85   npdvnveaheesiteleeeiv...FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd...dpp 167
           npd +v + ++++++++e+i+   Ff+++d+V++ald+++ar +v+ +c+++ +pl+e+gt G++G ++v+++++te+y+++     ++
   Q: 504  NPDLQVIPLTYPLDPTTEHIYgdnFFSRVDGVAAALDSFQARHYVAARCTHYLKPLLEAGTSGTWGSATVFMPHVTEAYRAPAsaaASE 592
           ************************************************************************************999** PP
   S: 168  qktiPfctlketpnaaehtiewa........vlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakt 248
           +  +P+ct++ +p++aeht++wa        +l ++++++++++++ l+++d+ ++++ +++v   l+  +++n+++++++a+ +++ +
   Q: 593  DAPYPVCTVRYFPSTAEHTLQWArhefeelfRLSAETINHHQQAHTSLADMDEPQTLTLLKPVLGVLRV-RPQNWQDCVAWALGHWKLC 680
           *******************************9*******************************888777.6****************** PP
   S: 249  tinsikqllksfecdivtkskspfwv................................................sfcsnaealqvpekv 289
           ++++ikqll++f++++v ++++pfw+                                                ++ ++ + +q+ +  
   Q: 681  FHYGIKQLLRHFPPNKVLEDGTPFWSgpkqcpqplefdtnqdthllyvlaaanlyaqmhglpgsqdwtalrellKLLPQPDPQQMAPIF 769
           ***************************************************************************************** PP
   S: 290  ekdeevvkasap.....lylllralerfekkkgrkpgelsfekddds..avdlvtaaanlraeslgiepkldddlikeiagniipaiat 371
           +++ e  +asa+     ++ l +ale ++  + +kp  l+fekddds  +vd+v+aaa+lr++++gi+p +++ + k+i+g+iipaiat
   Q: 770  ASNLELASASAEfgpeqQKELNKALEVWSVGPPLKP--LMFEKDDDSnfHVDFVAAAASLRCQNYGIPP-VNRAQSKRIVGQIIPAIAT 855
           ***********9***********************9..*******************************.******************* PP
   S: 372  tnavvgGlaaqEviKvvsg..kfeplknfflfdae 404
           t+a+v+Gl+ +E++Kvv g  + +++++ +l++ae
   Q: 856  TTAAVAGLLGLELYKVVGGprPRSAFRHSYLHLAE 890
           *******************7777789988888765 PP

Organism

Gorilla gorilla

Protein Sequence
(Fasta)

MDALDASKLL DEELYSRQLY VLGSPAMQRI QGARVLVSGL QGLGAEVAKN LVLMGVGSLT 60
LHDPHPTCWS DLAAQFLLSE RDLERSRAEA SQELLAQLNR AVQVVVHTGD ITEDLLLDFQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTTTCTTTT CTCCAGAGGA GCCAGAAGAG AGCTGTGACT AGCAGCGTCC CTTATTCCCT 60
TGGCCTTTGT TCCTGTTTGC ACTGGCTACA GCAGGGCACT GGCCCCTACT GTCACCGCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR032420--E1_4HB
IPR032418--E1_FCCH
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR018965--Ub-activating_enz_E1_C
IPR019572--UBA_E1_Cys
IPR018075--UBQ-activ_enz_E1
IPR033127--UBQ-activ_enz_E1_Cys_AS
IPR000011--UBQ/SUMO-activ_enz_E1-like

PROSITE

PS00865--UBIQUITIN_ACTIVAT_2

Pfam

PF16191--E1_4HB
PF16190--E1_FCCH
PF09358--E1_UFD
PF00899--ThiF
PF10585--UBA_e1_thiolCys

PRINTS

PR01849--UBIQUITINACT

SMART

SM00985--UBA_e1_C

Gene Ontology

GO:0005524--F:ATP binding
GO:0019782--F:ISG15 activating enzyme activity
GO:0032020--P:ISG15-protein conjugation
GO:0019941--P:modification-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001816	Ailuropoda melanoleuca	79.98	0.00e+00	1485.00
IUUC-Bta-012665	Bos taurus	76.76	0.00e+00	1366.00
IUUC-Cja-019047	Callithrix jacchus	91.13	0.00e+00	1721.00
IUUC-Cfa-021225	Canis familiaris	81.04	0.00e+00	1533.00
IUUC-Cpo-022336	Cavia porcellus	71.43	0.00e+00	1324.00
IUUC-Csa-023462	Chlorocebus sabaeus	96.21	0.00e+00	1748.00
IUUC-Cho-024436	Choloepus hoffmanni	75.95	1.00e-96	347.00
IUUC-Dno-029347	Dasypus novemcinctus	79.94	0.00e+00	1475.00
IUUC-Dor-030997	Dipodomys ordii	75.32	0.00e+00	1363.00
IUUC-Ete-033124	Echinops telfairi	73.82	0.00e+00	938.00
IUUC-Eca-033929	Equus caballus	82.27	0.00e+00	1574.00
IUUC-Eeu-034717	Erinaceus europaeus	69.12	0.00e+00	956.00
IUUC-Fca-036564	Felis catus	81.77	0.00e+00	1507.00
IUUC-Hsa-046498	Homo sapiens	98.50	0.00e+00	1791.00
IUUC-Itr-048657	Ictidomys tridecemlineatus	78.54	0.00e+00	1445.00
IUUC-Laf-054119	Loxodonta africana	79.14	0.00e+00	1502.00
IUUC-Mcc-055597	Macaca mulatta	94.12	0.00e+00	1682.00
IUUC-Meu-056534	Macropus eugenii	54.13	0.00e+00	835.00
IUUC-Mdo-063058	Monodelphis domestica	56.45	0.00e+00	1003.00
IUUC-Mmu-063578	Mus musculus	73.57	0.00e+00	1389.00
IUUC-Mpu-066255	Mustela putorius furo	79.82	0.00e+00	1509.00
IUUC-Mlu-067814	Myotis lucifugus	76.85	0.00e+00	1365.00
IUUC-Nle-069193	Nomascus leucogenys	96.51	0.00e+00	1771.00
IUUC-Opr-070715	Ochotona princeps	73.45	0.00e+00	1364.00
IUUC-Ocu-074162	Oryctolagus cuniculus	77.77	0.00e+00	1438.00
IUUC-Oga-088895	Otolemur garnettii	81.01	0.00e+00	1506.00
IUUC-Oar-089579	Ovis aries	76.35	0.00e+00	1358.00
IUUC-Ptr-090581	Pan troglodytes	98.58	0.00e+00	1755.00
IUUC-Pan-092458	Papio anubis	96.31	0.00e+00	1743.00
IUUC-Pab-098653	Pongo abelii	91.32	0.00e+00	1661.00
IUUC-Pca-100578	Procavia capensis	76.11	0.00e+00	857.00
IUUC-Pva-102914	Pteropus vampyrus	79.67	0.00e+00	1202.00
IUUC-Rno-106066	Rattus norvegicus	73.44	0.00e+00	1408.00
IUUC-Sha-107368	Sarcophilus harrisii	59.34	0.00e+00	1095.00
IUUC-Ssc-115743	Sus scrofa	82.05	0.00e+00	1521.00
IUUC-Tbe-127587	Tupaia belangeri	74.48	0.00e+00	1219.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence