• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-064002
Ensembl Protein ID ENSMUSP00000075167.6
UniProt Accession P00520; P97896; Q61252; Q61253; Q61254; Q61255; Q61256; Q61257; Q61258; Q61259; Q61260; Q61261; Q6PCM5; Q8C1X4; ABL1_MOUSE
Genbank Protein ID AAA88241.1; BAC41088.1; AAH59260.1; AAB60451.1; AAB60451.1; AAB60450.1; AAB60450.1; AAB60448.1; AAB60448.1; AAB60449.1; AAB60449.1; CAA30411.1; CAA30412.1; CAA30413.1; CAA30414.1; AAA37136.1; AAA37137.1; AAA37138.1; AAA37134.1; AAA37135.1
Protein Name Tyrosine-protein kinase ABL1; Abelson murine leukemia viral oncogene homolog 1; Abelson tyrosine-protein kinase 1; Proto-oncogene c-Abl; p150
Genbank Nucleotide ID J02995; AK090095; BC059260; U14721; U14720; U14721; U14720; U14721; U13835; U14721; U13835; X07539; X07539; X07540; X07541; M12263; M12264; M12265; M12266; K03228
Gene Name Abl1; Abl
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000026842.16 ENSMUST00000075759.12 ENSMUSP00000075167.6
ENSMUSG00000026842.16 ENSMUST00000142554.7 ENSMUSP00000142123.1
ENSMUSG00000026842.16 ENSMUST00000123471.1 ENSMUSP00000142297.1
ENSMUSG00000026842.16 ENSMUST00000135233.2 ENSMUSP00000141320.1
ENSMUSG00000026842.16 ENSMUST00000028190.12 ENSMUSP00000028190.6
ENSMUSG00000026842.16 ENSMUST00000124089.1 ENSMUSP00000117748.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
circBasemiRTarBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Protein 3D Structure
PDBMMDB
Drug and target
GRACPDTD
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
Phospho.ELMUniProtPHOSIDAPhosphoBase
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 5.90e-14 52.9 82 139
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
            +++ +lyd+ a+ d++L+++kG++++v+  ++++++W+++  ++++ +G +P+n+++ ++
   Q: 82   PNLFVALYDFVASGDNTLSITKGEKLRVL-GYNHNGEWCEA--QTKNGQGWVPSNYITPVN 139
           68899************************.***********..79999**********997 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9. Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-191' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks.
 Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9. Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-191' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks.
Protein Sequence
(Fasta)
MGQQPGKVLG DQRRPSLPAL HFIKGAGKRD SSRHGGPHCN VFVEHEALQR PVASDFEPQG 60
LSEAARWNSK ENLLAGPSEN DPNLFVALYD FVASGDNTLS ITKGEKLRVL GYNHNGEWCE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064002|UBD,SH3|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ACCTTTAAAA GGTCGTGCGG AGCCGGGTTG TCGCAGGCAG TGAGGCTGGA ACCCGAAGGT 60
GCGGCGGCGT GTGGGAGACC GGCGCCTGTG GTCTATCGGA CCTCGCTCGG GGAATTCCGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064002|UBD,SH3|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0067--ATP-binding
KW-0072--Autophagy
KW-0130--Cell adhesion
KW-0160--Chromosomal rearrangement
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0227--DNA damage
KW-0234--DNA repair
KW-0238--DNA-binding
KW-0254--Endocytosis
KW-0418--Kinase
KW-0449--Lipoprotein
KW-0460--Magnesium
KW-0464--Manganese
KW-0479--Metal-binding
KW-0496--Mitochondrion
KW-0519--Myristate
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0656--Proto-oncogene
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase
KW-0832--Ubl conjugation
Interpro

IPR033221--ABL1
IPR015015--F-actin_binding
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom
PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3
Pfam

PF08919--F_actin_bind
PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1
PRINTS

PR00401--SH2DOMAIN
PR00109--TYRKINASE
SMART

SM00808--FABD
SM00252--SH2
SM00326--SH3
SM00219--TyrKc
Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0031252--C:cell leading edge
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005739--C:mitochondrion
GO:0043005--C:neuron projection
GO:0016604--C:nuclear body
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0051015--F:actin filament binding
GO:0005524--F:ATP binding
GO:0003677--F:DNA binding
GO:0016301--F:kinase activity
GO:0000287--F:magnesium ion binding
GO:0030145--F:manganese ion binding
GO:0051019--F:mitogen-activated protein kinase binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0070064--F:proline-rich region binding
GO:0008022--F:protein C-terminus binding
GO:0019904--F:protein domain specific binding
GO:0004672--F:protein kinase activity
GO:0005080--F:protein kinase C binding
GO:0004713--F:protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0017124--F:SH3 domain binding
GO:0019905--F:syntaxin binding
GO:0030036--P:actin cytoskeleton organization
GO:0090135--P:actin filament branching
GO:0050798--P:activated T cell proliferation
GO:1990051--P:activation of protein kinase C activity
GO:0046632--P:alpha-beta T cell differentiation
GO:0006915--P:apoptotic process
GO:0006914--P:autophagy
GO:0042100--P:B cell proliferation
GO:0002322--P:B cell proliferation involved in immune response
GO:0050853--P:B cell receptor signaling pathway
GO:0001922--P:B-1 B cell homeostasis
GO:0060020--P:Bergmann glial cell differentiation
GO:0007596--P:blood coagulation
GO:0072358--P:cardiovascular system development
GO:0006974--P:cellular response to DNA damage stimulus
GO:0070301--P:cellular response to hydrogen peroxide
GO:0071222--P:cellular response to lipopolysaccharide
GO:0021587--P:cerebellum morphogenesis
GO:0048668--P:collateral sprouting
GO:0006975--P:DNA damage induced protein phosphorylation
GO:0006281--P:DNA repair
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0045184--P:establishment of protein localization
GO:0045087--P:innate immune response
GO:0030035--P:microspike assembly
GO:0030514--P:negative regulation of BMP signaling pathway
GO:0022408--P:negative regulation of cell-cell adhesion
GO:2000773--P:negative regulation of cellular senescence
GO:2000352--P:negative regulation of endothelial cell apoptotic process
GO:0070373--P:negative regulation of ERK1 and ERK2 cascade
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045930--P:negative regulation of mitotic cell cycle
GO:1900275--P:negative regulation of phospholipase C activity
GO:0071901--P:negative regulation of protein serine/threonine kinase activity
GO:0051444--P:negative regulation of ubiquitin-protein transferase activity
GO:0001843--P:neural tube closure
GO:0060563--P:neuroepithelial cell differentiation
GO:0050885--P:neuromuscular process controlling balance
GO:0030182--P:neuron differentiation
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0018108--P:peptidyl-tyrosine phosphorylation
GO:0006909--P:phagocytosis
GO:0048008--P:platelet-derived growth factor receptor signaling pathway
GO:0035791--P:platelet-derived growth factor receptor-beta signaling pathway
GO:1904531--P:positive regulation of actin filament binding
GO:0043065--P:positive regulation of apoptotic process
GO:0007204--P:positive regulation of cytosolic calcium ion concentration
GO:0070374--P:positive regulation of ERK1 and ERK2 cascade
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:1902715--P:positive regulation of interferon-gamma secretion
GO:1900042--P:positive regulation of interleukin-2 secretion
GO:1904528--P:positive regulation of microtubule binding
GO:0045931--P:positive regulation of mitotic cell cycle
GO:0051149--P:positive regulation of muscle cell differentiation
GO:1901216--P:positive regulation of neuron death
GO:0033690--P:positive regulation of osteoblast proliferation
GO:0051353--P:positive regulation of oxidoreductase activity
GO:0050731--P:positive regulation of peptidyl-tyrosine phosphorylation
GO:0001934--P:positive regulation of protein phosphorylation
GO:0051281--P:positive regulation of release of sequestered calcium ion into cytosol
GO:2000096--P:positive regulation of Wnt signaling pathway, planar cell polarity pathway
GO:0009791--P:post-embryonic development
GO:0046777--P:protein autophosphorylation
GO:0032956--P:regulation of actin cytoskeleton organization
GO:0030516--P:regulation of axon extension
GO:0051726--P:regulation of cell cycle
GO:0042127--P:regulation of cell proliferation
GO:2000772--P:regulation of cellular senescence
GO:1903053--P:regulation of extracellular matrix organization
GO:0031113--P:regulation of microtubule polymerization
GO:2001020--P:regulation of response to DNA damage stimulus
GO:0006979--P:response to oxidative stress
GO:0042770--P:signal transduction in response to DNA damage
GO:0048536--P:spleen development
GO:0034446--P:substrate adhesion-dependent cell spreading
GO:0048538--P:thymus development
GO:0002333--P:transitional one stage B cell differentiation
KEGG mmu:11350
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001550 Ailuropoda melanoleuca 85.17 0.00e+00 1778.00
IUUC-Apl-003452 Anas platyrhynchos 79.02 0.00e+00 1578.00
IUUC-Aca-005312 Anolis carolinensis 79.84 0.00e+00 1273.00
IUUC-Ame-011903 Astyanax mexicanus 72.77 0.00e+00 1140.00
IUUC-Bta-012351 Bos taurus 84.38 0.00e+00 1673.00
IUUC-Cja-019491 Callithrix jacchus 86.64 0.00e+00 1847.00
IUUC-Cfa-021256 Canis familiaris 86.20 0.00e+00 1820.00
IUUC-Cpo-022046 Cavia porcellus 87.89 0.00e+00 1589.00
IUUC-Csa-023046 Chlorocebus sabaeus 86.37 0.00e+00 1771.00
IUUC-Dre-028190 Danio rerio 67.47 0.00e+00 1265.00
IUUC-Dno-029853 Dasypus novemcinctus 85.07 0.00e+00 1804.00
IUUC-Dor-030635 Dipodomys ordii 80.23 0.00e+00 1638.00
IUUC-Dme-032098 Drosophila melanogaster 75.11 0.00e+00 778.00
IUUC-Eca-033720 Equus caballus 85.09 0.00e+00 1713.00
IUUC-Eeu-035173 Erinaceus europaeus 84.19 0.00e+00 1413.00
IUUC-Fca-035967 Felis catus 85.68 0.00e+00 1772.00
IUUC-Fal-036723 Ficedula albicollis 78.67 0.00e+00 1579.00
IUUC-Gmo-039550 Gadus morhua 75.54 0.00e+00 1144.00
IUUC-Gga-040481 Gallus gallus 77.79 0.00e+00 1533.00
IUUC-Gac-041643 Gasterosteus aculeatus 75.85 0.00e+00 1189.00
IUUC-Ggo-045299 Gorilla gorilla 86.29 0.00e+00 1860.00
IUUC-Hsa-047033 Homo sapiens 100.00 1.00e-41 160.00
IUUC-Itr-047935 Ictidomys tridecemlineatus 86.81 0.00e+00 1722.00
IUUC-Lch-050530 Latimeria chalumnae 75.15 0.00e+00 1526.00
IUUC-Loc-052430 Lepisosteus oculatus 85.34 0.00e+00 1039.00
IUUC-Laf-053609 Loxodonta africana 84.29 0.00e+00 1746.00
IUUC-Mcc-055654 Macaca mulatta 87.18 0.00e+00 1885.00
IUUC-Meu-056488 Macropus eugenii 75.20 0.00e+00 1544.00
IUUC-Mga-059270 Meleagris gallopavo 77.76 0.00e+00 1572.00
IUUC-Mmr-060593 Microcebus murinus 86.34 0.00e+00 1748.00
IUUC-Mdo-062227 Monodelphis domestica 89.64 0.00e+00 1344.00
IUUC-Mpu-066197 Mustela putorius furo 83.61 0.00e+00 1783.00
IUUC-Mlu-067255 Myotis lucifugus 86.18 0.00e+00 1695.00
IUUC-Nle-069977 Nomascus leucogenys 84.97 0.00e+00 1365.00
IUUC-Opr-070327 Ochotona princeps 79.00 0.00e+00 1495.00
IUUC-Ont-072307 Oreochromis niloticus 65.92 0.00e+00 1295.00
IUUC-Oan-073100 Ornithorhynchus anatinus 80.40 0.00e+00 1634.00
IUUC-Ocu-074892 Oryctolagus cuniculus 80.00 0.00e+00 1534.00
IUUC-Ola-087389 Oryzias latipes 68.71 0.00e+00 1130.00
IUUC-Oga-088145 Otolemur garnettii 87.00 0.00e+00 1735.00
IUUC-Oar-090432 Ovis aries 90.19 0.00e+00 1396.00
IUUC-Ptr-090800 Pan troglodytes 86.64 0.00e+00 1862.00
IUUC-Psi-093078 Pelodiscus sinensis 79.23 0.00e+00 1660.00
IUUC-Pma-094420 Petromyzon marinus 78.34 0.00e+00 900.00
IUUC-Pfo-096979 Poecilia formosa 71.08 0.00e+00 1107.00
IUUC-Pca-100874 Procavia capensis 98.68 0.00e+00 769.00
IUUC-Pva-102415 Pteropus vampyrus 84.38 0.00e+00 1773.00
IUUC-Rno-105682 Rattus norvegicus 96.15 0.00e+00 2051.00
IUUC-Sha-106711 Sarcophilus harrisii 80.11 0.00e+00 1641.00
IUUC-Ssc-115472 Sus scrofa 84.45 0.00e+00 1772.00
IUUC-Tgu-117037 Taeniopygia guttata 79.38 0.00e+00 1683.00
IUUC-Tru-118324 Takifugu rubripes 67.05 0.00e+00 1110.00
IUUC-Tsy-119216 Tarsius syrichta 95.25 0.00e+00 1163.00
IUUC-Tni-119950 Tetraodon nigroviridis 59.09 0.00e+00 1104.00
IUUC-Ttr-128209 Tursiops truncatus 86.11 0.00e+00 1846.00
IUUC-Xtr-132477 Xenopus tropicalis 71.60 0.00e+00 1112.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved