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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Cel-018198
Ensembl Protein ID H39E23.1d
UniProt Accession Q9TW45; B1Q266; E0AHE2; E0AHE3; E1B6W1; G5EE60; G5EE76; H2L2K6; H2L2K7; N1NTJ6; Q17346; Q17368; Q1ZXR3; Q9TVG6; PAR1_CAEEL
Genbank Protein ID AAA97437.1; AAA83272.1; CAB54262.2; CAB54262.2; CAB54263.1; CAB54263.1; CAJ85756.1; CAJ85756.1; CAQ16148.2; CAQ16148.2; CBL43447.1; CBL43447.1; CBO24859.1; CBO24859.1; CBW44387.1; CBW44388.1; CBW48399.1; CCE71393.1; CCE71394.1; CCE71394.1; CCW45975.1; CCW45975.1
Protein Name Serine/threonine-protein kinase par-1
Genbank Nucleotide ID U22183; U40858; Z96102; Z81027; Z96102; Z81027; Z96102; Z81027; Z96102; Z81027; Z96102; Z81027; Z96102; Z81027; Z96102; Z96102; Z96102; Z96102; Z96102; Z81027; Z96102; Z81027
Gene Name par-1; H39E23.1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
WBGene00003916 H39E23.1a H39E23.1a
WBGene00003916 H39E23.1b H39E23.1b
WBGene00003916 H39E23.1c H39E23.1c
WBGene00003916 H39E23.1d H39E23.1d
WBGene00003916 H39E23.1e H39E23.1e
WBGene00003916 H39E23.1j H39E23.1j
WBGene00003916 H39E23.1l H39E23.1l
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
circBasemicroRNARAID2
Protein-protein Interaction
IIDiRefIndexMentha
Post-translational Modifications (PTMs)
dbPAFUniProtPHOSIDA
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
UBD/Alpha-Helix/UBA 74.19 6.00e-159 560.00 IUUC-Hsa-046901
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Caenorhabditis elegans
Functional Description
(View)

Functional Description


     Required for cytoplasmic partitioning and asymmetric cell division in early embryogenesis (PubMed:7758115). Phosphorylates and restricts the asymmetry effector mex-5 (and possibly also mex-6) to the anterior cytoplasm of the zygote (PubMed:18842813). Regulates mes-1 expression during early embryogenesis (PubMed:11003841). Critical role in postembryonic vulval morphogenesis (PubMed:12490197). Involved in the establishment of neuronal polarity (PubMed:20023164).
 Required for cytoplasmic partitioning and asymmetric cell division in early embryogenesis (PubMed:7758115). Phosphorylates and restricts the asymmetry effector mex-5 (and possibly also mex-6) to the anterior cytoplasm of the zygote (PubMed:18842813). Regulates mes-1 expression during early embryogenesis (PubMed:11003841). Critical role in postembryonic vulval morphogenesis (PubMed:12490197). Involved in the establishment of neuronal polarity (PubMed:20023164).
Protein Sequence
(Fasta)
MFNAAYSSLL ARFMCQPSSS SVTPIPEEEE SLIPKRKVSE VVTTAPMAPT LTSSGKRRTV 60
KVSPDGDHVT HNRKNSSSHA RSTGQSGMSS RSAARRNDQD VHVGKYKLLK TIGKGNFAKV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Cel-018198|UBD,UBA|Caenorhabditis elegans
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Nucleotide Sequence
(Fasta)
ATGAGCTCGG CGTCAGTCGG CAAAAAACCA GTAAGTACAT AACTTCTCTA TGATTTCTTT 60
TTAGTTTTTT TGGTACAAAA TTATCTTCTA GGCATGCATG ATCCTTCTAT CCTCTCTTCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Cel-018198|UBD,UBA|Caenorhabditis elegans
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0418--Kinase
KW-0460--Magnesium
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
Interpro

IPR028375--KA1/Ssp2_C
IPR001772--KA1_dom
IPR011009--Kinase-like_dom
IPR033624--MARK/par1
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR008271--Ser/Thr_kinase_AS
IPR015940--UBA
PROSITE

PS50032--KA1
PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
PS50030--UBA
Pfam

PF02149--KA1
PF00069--Pkinase
SMART

SM00220--S_TKc
Gene Ontology

GO:0005938--C:cell cortex
GO:0071944--C:cell periphery
GO:0005737--C:cytoplasm
GO:0005524--F:ATP binding
GO:0046872--F:metal ion binding
GO:0032035--F:myosin II tail binding
GO:0004674--F:protein serine/threonine kinase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0055059--P:asymmetric neuroblast division
GO:0045167--P:asymmetric protein localization involved in cell fate determination
GO:0009880--P:embryonic pattern specification
GO:0030010--P:establishment of cell polarity
GO:0007163--P:establishment or maintenance of cell polarity
GO:0000226--P:microtubule cytoskeleton organization
GO:0018105--P:peptidyl-serine phosphorylation
GO:0009949--P:polarity specification of anterior/posterior axis
GO:0006468--P:protein phosphorylation
GO:0040025--P:vulval development
KEGG cel:CELE_H39E23.1
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001559 Ailuropoda melanoleuca 76.78 6.00e-150 523.00
IUUC-Aca-004803 Anolis carolinensis 74.00 1.00e-162 566.00
IUUC-Ame-011854 Astyanax mexicanus 76.90 9.00e-160 556.00
IUUC-Bta-013546 Bos taurus 66.06 4.00e-153 533.00
IUUC-Cja-019475 Callithrix jacchus 73.55 1.00e-161 562.00
IUUC-Cfa-020356 Canis familiaris 73.55 1.00e-161 562.00
IUUC-Cpo-022503 Cavia porcellus 75.74 5.00e-161 560.00
IUUC-Csa-023035 Chlorocebus sabaeus 74.92 2.00e-157 548.00
IUUC-Cho-024317 Choloepus hoffmanni 57.63 2.00e-104 372.00
IUUC-Cin-025762 Ciona intestinalis 50.00 1.00e-96 346.00
IUUC-Csv-026013 Ciona savignyi 55.62 7.00e-106 375.00
IUUC-Cgl-026480 Colletotrichum gloeosporioides 39.02 2.00e-69 256.00
IUUC-Dre-028387 Danio rerio 75.15 7.00e-153 533.00
IUUC-Dno-029653 Dasypus novemcinctus 73.26 4.00e-161 560.00
IUUC-Dor-030743 Dipodomys ordii 73.26 2.00e-161 561.00
IUUC-Dme-031957 Drosophila melanogaster 54.63 2.00e-108 385.00
IUUC-Ete-032528 Echinops telfairi 72.97 7.00e-161 559.00
IUUC-Eca-033799 Equus caballus 73.55 9.00e-162 562.00
IUUC-Eeu-034949 Erinaceus europaeus 73.26 1.00e-160 558.00
IUUC-Fca-035596 Felis catus 73.55 1.00e-161 561.00
IUUC-Fal-037115 Ficedula albicollis 77.27 9.00e-131 459.00
IUUC-Gmo-039460 Gadus morhua 66.58 2.00e-152 531.00
IUUC-Gga-040502 Gallus gallus 73.24 1.00e-162 565.00
IUUC-Gac-042044 Gasterosteus aculeatus 76.28 3.00e-159 554.00
IUUC-Ggo-044770 Gorilla gorilla 68.60 2.00e-153 535.00
IUUC-Hsa-046901 Homo sapiens 74.19 1.00e-161 562.00
IUUC-Itr-049080 Ictidomys tridecemlineatus 66.49 6.00e-154 536.00
IUUC-Lch-049922 Latimeria chalumnae 77.71 3.00e-160 557.00
IUUC-Loc-052896 Lepisosteus oculatus 76.04 6.00e-161 559.00
IUUC-Laf-054590 Loxodonta africana 75.44 3.00e-160 557.00
IUUC-Mcc-055104 Macaca mulatta 74.19 8.00e-162 562.00
IUUC-Meu-056525 Macropus eugenii 73.55 5.00e-161 560.00
IUUC-Mmr-060697 Microcebus murinus 73.55 8.00e-162 562.00
IUUC-Mdo-062445 Monodelphis domestica 73.24 2.00e-162 564.00
IUUC-Mmu-063467 Mus musculus 73.55 1.00e-161 561.00
IUUC-Mpu-066665 Mustela putorius furo 73.55 1.00e-161 561.00
IUUC-Mlu-067700 Myotis lucifugus 70.57 2.00e-150 525.00
IUUC-Nle-069385 Nomascus leucogenys 72.59 8.00e-151 526.00
IUUC-Opr-070302 Ochotona princeps 73.55 8.00e-162 562.00
IUUC-Ont-071386 Oreochromis niloticus 77.11 7.00e-162 563.00
IUUC-Oan-072929 Ornithorhynchus anatinus 73.73 2.00e-162 565.00
IUUC-Ocu-073853 Oryctolagus cuniculus 72.68 3.00e-161 560.00
IUUC-Ola-086790 Oryzias latipes 70.44 3.00e-156 544.00
IUUC-Oga-088194 Otolemur garnettii 67.76 2.00e-153 535.00
IUUC-Oar-090325 Ovis aries 73.16 3.00e-161 560.00
IUUC-Ptr-091413 Pan troglodytes 66.75 6.00e-154 536.00
IUUC-Pan-092847 Papio anubis 74.19 8.00e-162 562.00
IUUC-Psi-092994 Pelodiscus sinensis 72.96 2.00e-161 561.00
IUUC-Pma-094666 Petromyzon marinus 75.37 4.00e-162 563.00
IUUC-Pfo-096944 Poecilia formosa 54.01 1.00e-106 379.00
IUUC-Pab-098232 Pongo abelii 74.92 2.00e-157 548.00
IUUC-Pca-100975 Procavia capensis 68.99 8.00e-127 446.00
IUUC-Pva-103239 Pteropus vampyrus 73.55 9.00e-162 562.00
IUUC-Pgr-103687 Puccinia graminis 45.88 6.00e-71 261.00
IUUC-Ptt-103944 Puccinia triticina 45.79 6.00e-70 258.00
IUUC-Rno-105368 Rattus norvegicus 66.49 9.00e-154 536.00
IUUC-Sha-107115 Sarcophilus harrisii 73.24 5.00e-162 563.00
IUUC-Ssc-116439 Sus scrofa 73.26 1.00e-159 554.00
IUUC-Tgu-116652 Taeniopygia guttata 75.60 2.00e-153 535.00
IUUC-Tru-118387 Takifugu rubripes 72.85 1.00e-162 565.00
IUUC-Tsy-119138 Tarsius syrichta 69.04 3.00e-137 481.00
IUUC-Tni-120412 Tetraodon nigroviridis 75.89 2.00e-144 505.00
IUUC-Tme-127019 Tuber melanosporum 42.61 1.00e-69 256.00
IUUC-Tbe-127841 Tupaia belangeri 76.75 8.00e-125 439.00
IUUC-Ttr-128436 Tursiops truncatus 73.55 1.00e-161 562.00
IUUC-Vpa-130477 Vicugna pacos 75.00 2.00e-149 521.00
IUUC-Xtr-132367 Xenopus tropicalis 72.42 1.00e-152 532.00
Created Date 25-Jun-2017

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