iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Rno-105938

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

E3 ubiquitin-protein ligase TRIM11; RING-type E3 ubiquitin transferase TRIM11; Tripartite motif-containing protein 11

Genbank Nucleotide ID

BC160894

Gene Name

Trim11

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000002915.7	ENSRNOT00000047268.5	ENSRNOP00000039974.5

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC	RAID2
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	1.60e-06	28.5	12	71
E3 activity/RING/RING	3.80e-08	34.1	16	57

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwl..asggk..tcPvtrqplteedlvPnltl 61
           ee  C+I l+ ++dPv++ +G+ + r++I+++    +      cP +r+  ++++l Pn  l
   Q: 12   EEATCAICLDYFTDPVMTDCGHNFCRECIRRCWgqPE--GpyACPECREVSAQRNLRPNRPL 71
           7889***************************995333..346*****************866 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           CaiCl+ f d p+ ++CgH f+++C+  +w     +  +   CP Cr
   Q: 16   CAICLDYFTD-PVMTDCGHNFCRECIrRCW----GQPEGPYACPECR 57
           **********.999************99**....66789999****8 PP

Organism

Rattus norvegicus

Functional Description
(View)

E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway. Mediates MED15 ubiquitination leading to proteasomal degradation. May contribute to the innate restriction of retroviruses.

Protein Sequence
(Fasta)

MAAPDLSTNL QEEATCAICL DYFTDPVMTD CGHNFCRECI RRCWGQPEGP YACPECREVS 60
AQRNLRPNRP LAKMAEMARR LHPPSPVPQG VCAAHREPLT TFCGDDLSLL CPTCERSEHW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCGCTCCTC CTGCGCTCTC TCTGCGGAAT AGCTTGATTG CCCCCCGGCA CCACGAAGAG 60
CCTGATCCAG GCGCAGCCGC TAGCACCATG GCCGCTCCAG ACTTGTCCAC CAACCTCCAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0051--Antiviral defense
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF13765--PRY
PF00622--SPRY
PF00643--zf-B_box

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00336--BBOX
SM00589--PRY
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0051607--P:defense response to virus
GO:0045087--P:innate immune response
GO:0050768--P:negative regulation of neurogenesis
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0046597--P:negative regulation of viral entry into host cell
GO:1902187--P:negative regulation of viral release from host cell
GO:0032897--P:negative regulation of viral transcription
GO:0046598--P:positive regulation of viral entry into host cell

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001800	Ailuropoda melanoleuca	70.73	6.00e-162	563.00
IUUC-Bta-012332	Bos taurus	86.97	0.00e+00	756.00
IUUC-Cja-019969	Callithrix jacchus	77.99	0.00e+00	637.00
IUUC-Cfa-020491	Canis familiaris	86.97	0.00e+00	767.00
IUUC-Cpo-021936	Cavia porcellus	87.82	0.00e+00	748.00
IUUC-Csa-024151	Chlorocebus sabaeus	89.74	0.00e+00	720.00
IUUC-Cho-024990	Choloepus hoffmanni	77.97	6.00e-115	406.00
IUUC-Dno-029580	Dasypus novemcinctus	77.44	6.00e-180	624.00
IUUC-Ete-032556	Echinops telfairi	69.34	8.00e-112	396.00
IUUC-Eca-033612	Equus caballus	75.00	6.00e-137	480.00
IUUC-Fca-035821	Felis catus	86.45	1.00e-147	515.00
IUUC-Ggo-044629	Gorilla gorilla	90.17	0.00e+00	725.00
IUUC-Hsa-046332	Homo sapiens	90.17	0.00e+00	724.00
IUUC-Itr-047946	Ictidomys tridecemlineatus	91.03	0.00e+00	749.00
IUUC-Laf-054350	Loxodonta africana	74.02	4.00e-140	491.00
IUUC-Mcc-055827	Macaca mulatta	88.46	0.00e+00	704.00
IUUC-Meu-056122	Macropus eugenii	72.16	0.00e+00	641.00
IUUC-Mmr-061700	Microcebus murinus	87.37	0.00e+00	745.00
IUUC-Mdo-062921	Monodelphis domestica	62.96	7.00e-162	563.00
IUUC-Mmu-063762	Mus musculus	98.29	0.00e+00	818.00
IUUC-Mpu-065873	Mustela putorius furo	86.54	0.00e+00	763.00
IUUC-Mlu-067379	Myotis lucifugus	68.02	3.00e-166	578.00
IUUC-Nle-069440	Nomascus leucogenys	89.62	0.00e+00	721.00
IUUC-Opr-070901	Ochotona princeps	78.80	5.00e-175	607.00
IUUC-Oan-073401	Ornithorhynchus anatinus	43.76	3.00e-87	315.00
IUUC-Ocu-074038	Oryctolagus cuniculus	73.49	9.00e-156	543.00
IUUC-Oga-088948	Otolemur garnettii	84.85	0.00e+00	724.00
IUUC-Oar-090242	Ovis aries	80.13	0.00e+00	705.00
IUUC-Ptr-090615	Pan troglodytes	90.71	3.00e-100	358.00
IUUC-Pan-092626	Papio anubis	89.96	0.00e+00	722.00
IUUC-Pab-097895	Pongo abelii	83.55	0.00e+00	726.00
IUUC-Pca-100435	Procavia capensis	86.30	0.00e+00	723.00
IUUC-Pva-102288	Pteropus vampyrus	78.21	0.00e+00	647.00
IUUC-Sha-107354	Sarcophilus harrisii	74.41	0.00e+00	664.00
IUUC-Tbe-127733	Tupaia belangeri	91.83	0.00e+00	750.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence