iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ocu-074590

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin carboxyl-terminal hydrolase

Genbank Nucleotide ID

AAGW02010693

Gene Name

UCHL1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOCUG00000001353.3	ENSOCUT00000030750.2	ENSOCUP00000016914.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	9.00e-64	216.0	2	222

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/UCH

   S: 7    ewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktiffakqvi 95
           ++ ++e +P++++++++++gv +++++ ++ +L++e+lg+++ p ++llllF+++ ++e++rk+q++    e +++++  +++f+kq+i
   Q: 2    QLKPMEINPEMLNKVLSRLGVAGQYRFADVLGLEEETLGTVPAPACALLLLFPLTAQHENFRKKQIE----ELKGQEVSPKVYFMKQTI 86
           5789*************************************************************99....99**************** PP
   S: 96   gNsCatyAllsvllncedkl.ldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeafhfvsy 183
           gNsC+t +l+++++n++dkl ++ G+ l++++++t+++spe++a++++++++++++h+++a++++++ +          +k +fhf+++
   Q: 87   GNSCGTVGLIHAVANNQDKLqFEDGSVLKQFLSETEKMSPEDRAKCFEKNEAIQAAHDAVAQEGQCRVD----------DKVNFHFILF 165
           *******************************************************************99..........5679****** PP
   S: 184  vningrlyeldglkpfPldlgkkketeelkdklkvvraflerikllesdeirfnllaivad 244
            n++g+lyeldg++pfP+++g+++e+  l+d++kv+r+f+er    e++e+rf+++a++++
   Q: 166  NNVDGHLYELDGRMPFPVNHGASSEDSLLQDAAKVCREFTER----EQGEVRFSAVALCKA 222
           ******************************************....************987 PP

Organism

Oryctolagus cuniculus

Protein Sequence
(Fasta)

MQLKPMEINP EMLNKVLSRL GVAGQYRFAD VLGLEEETLG TVPAPACALL LLFPLTAQHE 60
NFRKKQIEEL KGQEVSPKVY FMKQTIGNSC GTVGLIHAVA NNQDKLQFED GSVLKQFLSE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGGGGTGGG GGTGGGGGAC ACGTATTTAT ATCCATATTA AATGTATACC TGTTGAGGAG 60
TCTGTGCTTT CTCTCAATGC TTCAGAGACC CCAAGCTTTC GGGTGATTGG GATGGCACAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH
IPR030297--UCHL1

PROSITE

PS00140--UCH_1

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:1904115--C:axon cytoplasm
GO:0005829--C:cytosol
GO:0043209--C:myelin sheath
GO:0044306--C:neuron projection terminus
GO:0043025--C:neuronal cell body
GO:0016874--F:ligase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0007628--P:adult walking behavior
GO:0007412--P:axon target recognition
GO:0019896--P:axonal transport of mitochondrion
GO:0008283--P:cell proliferation
GO:0042755--P:eating behavior
GO:0048747--P:muscle fiber development
GO:0050905--P:neuromuscular process
GO:0016579--P:protein deubiquitination
GO:0002931--P:response to ischemia
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

ocu:100357806

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001376	Ailuropoda melanoleuca	80.08	6.00e-113	399.00
IUUC-Apl-003693	Anas platyrhynchos	67.86	1.00e-89	322.00
IUUC-Aca-004716	Anolis carolinensis	75.00	8.00e-101	359.00
IUUC-Ame-011806	Astyanax mexicanus	67.26	1.00e-84	305.00
IUUC-Bta-013521	Bos taurus	80.95	2.00e-114	404.00
IUUC-Cja-018752	Callithrix jacchus	95.98	3.00e-117	413.00
IUUC-Cfa-020442	Canis familiaris	95.54	7.00e-117	412.00
IUUC-Cpo-021723	Cavia porcellus	97.59	2.00e-95	340.00
IUUC-Csa-023626	Chlorocebus sabaeus	96.41	5.00e-118	416.00
IUUC-Cho-024548	Choloepus hoffmanni	83.33	2.00e-39	155.00
IUUC-Dre-027854	Danio rerio	65.62	7.00e-84	302.00
IUUC-Dno-029325	Dasypus novemcinctus	96.86	1.00e-118	418.00
IUUC-Dor-030114	Dipodomys ordii	95.07	2.00e-127	447.00
IUUC-Ete-033092	Echinops telfairi	78.03	1.00e-97	348.00
IUUC-Eca-033854	Equus caballus	96.48	6.00e-80	288.00
IUUC-Eeu-034493	Erinaceus europaeus	91.93	8.00e-113	399.00
IUUC-Fal-036693	Ficedula albicollis	72.38	1.00e-90	325.00
IUUC-Gmo-038848	Gadus morhua	62.26	3.00e-75	274.00
IUUC-Gga-041078	Gallus gallus	73.21	6.00e-100	356.00
IUUC-Gac-042064	Gasterosteus aculeatus	61.82	8.00e-78	282.00
IUUC-Ggo-044827	Gorilla gorilla	96.41	2.00e-118	417.00
IUUC-Hsa-045820	Homo sapiens	96.41	2.00e-118	417.00
IUUC-Itr-048496	Ictidomys tridecemlineatus	95.96	7.00e-118	416.00
IUUC-Lch-050121	Latimeria chalumnae	72.97	3.00e-97	347.00
IUUC-Loc-052342	Lepisosteus oculatus	69.91	3.00e-92	330.00
IUUC-Laf-053916	Loxodonta africana	94.67	4.00e-116	410.00
IUUC-Mcc-054838	Macaca mulatta	96.41	5.00e-118	416.00
IUUC-Meu-056478	Macropus eugenii	87.00	2.00e-119	421.00
IUUC-Mga-059878	Meleagris gallopavo	71.89	1.00e-93	335.00
IUUC-Mdo-062544	Monodelphis domestica	87.00	4.00e-109	387.00
IUUC-Mmu-063300	Mus musculus	95.96	2.00e-128	451.00
IUUC-Mpu-066128	Mustela putorius furo	95.00	8.00e-104	369.00
IUUC-Mlu-067778	Myotis lucifugus	93.27	4.00e-125	439.00
IUUC-Nle-069686	Nomascus leucogenys	95.96	4.00e-118	416.00
IUUC-Opr-070535	Ochotona princeps	78.92	3.00e-100	357.00
IUUC-Ont-071510	Oreochromis niloticus	61.26	9.00e-79	285.00
IUUC-Oga-089013	Otolemur garnettii	81.35	1.00e-113	402.00
IUUC-Oar-089861	Ovis aries	80.95	1.00e-114	405.00
IUUC-Ptr-091536	Pan troglodytes	94.62	5.00e-116	409.00
IUUC-Pan-092909	Papio anubis	96.41	5.00e-118	416.00
IUUC-Psi-093818	Pelodiscus sinensis	77.68	4.00e-103	367.00
IUUC-Pfo-097335	Poecilia formosa	58.67	2.00e-77	281.00
IUUC-Pab-098048	Pongo abelii	96.41	2.00e-118	417.00
IUUC-Pca-100818	Procavia capensis	71.79	2.00e-66	244.00
IUUC-Pva-102954	Pteropus vampyrus	93.72	2.00e-112	397.00
IUUC-Pyt-104587	Pyrenophora triticirepentis	37.50	2.00e-31	129.00
IUUC-Rno-105966	Rattus norvegicus	95.96	2.00e-128	451.00
IUUC-Sha-107111	Sarcophilus harrisii	87.88	1.00e-87	314.00
IUUC-Sar-113190	Sorex araneus	75.44	1.00e-38	150.00
IUUC-Ssc-115908	Sus scrofa	78.22	2.00e-99	355.00
IUUC-Tgu-117465	Taeniopygia guttata	68.25	3.00e-84	304.00
IUUC-Tru-118565	Takifugu rubripes	59.80	1.00e-68	252.00
IUUC-Tsy-119561	Tarsius syrichta	78.03	1.00e-97	348.00
IUUC-Tbe-128048	Tupaia belangeri	96.36	7.00e-94	335.00
IUUC-Ttr-128494	Tursiops truncatus	94.14	3.00e-114	404.00
IUUC-Vda-129850	Verticillium dahliae	33.91	2.00e-29	121.00
IUUC-Xtr-132286	Xenopus tropicalis	68.16	1.00e-90	325.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence