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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Sce-106352
UUCD1 version UUC-SaC-00029
Ensembl Protein ID YIL030C
UniProt Accession P40318; D6VVQ1; DOA10_YEAST
Genbank Protein ID CAA54133.1; CAA86961.1; CAA86921.1; DAA08517.1
Protein Name ERAD-associated E3 ubiquitin-protein ligase DOA10; RING-type E3 ubiquitin transferase DOA10
Genbank Nucleotide ID X76715; Z46881; Z46861; BK006942
Gene Name SSM4; DOA10; YIL030C; YI3299.01C; YI9905.18C
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YIL030C YIL030C YIL030C
Annotation
mRNA Expression
GEOFFGED
Protein-protein Interaction
IIDiRefIndexHINTMentha
Protein 3D Structure
PDB
Post-translational Modifications (PTMs)
CPLMdbPAFdbPTMUniProt
PHOSIDABioGRID
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 15252059; 21467040; 17065559; 20159987; 20110468
Classification
Family E-value Score Start End
E3 activity/RING/RING 0.71 8.9 39 77
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledf.kdgplvlpCgHv.....fhadClqkwpglk 33
           C iC+ +  +d pl+ pC+       +h++Cl  w+ +k
   Q: 39   CRICRGEAtEDNPLFHPCKCRgsikyMHESCLLEWVASK 77
           ****99998555999***865678879********3333 PP
   
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC6 and UBC7 E2 ligases, and transfers it to substrates promoting their degradation. Mediates the degradation of a broad range of substrates, including endoplasmic reticulum membrane proteins (ERQC), soluble nuclear proteins and soluble cytoplasmic proteins (CytoQC). Component of the DOA10 ubiquitin ligase complex, which is part of the ERAD-C pathway responsible for the rapid degradation of membrane proteins with misfolded cytoplasmic domains. ERAD-C substrates are ubiquitinated through DOA10 in conjunction with the E2 ubiquitin-conjugating enzymes UBC6 and UBC7-CUE1. Ubiquitinated substrates are then removed to the cytosol via the action of the UFD1-NPL4-CDC48/p97 (UNC) AAA ATPase complex and targeted to the proteasome. Also recognizes the N-terminally acetylated residue of proteins as degradation signal (degron). N-terminally acetylated target proteins include MATALPHA2, TBF1, SLK19, YMR090W, HIS3, HSP104, UBP6 and ARO8.
 E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC6 and UBC7 E2 ligases, and transfers it to substrates promoting their degradation. Mediates the degradation of a broad range of substrates, including endoplasmic reticulum membrane proteins (ERQC), soluble nuclear proteins and soluble cytoplasmic proteins (CytoQC). Component of the DOA10 ubiquitin ligase complex, which is part of the ERAD-C pathway responsible for the rapid degradation of membrane proteins with misfolded cytoplasmic domains. ERAD-C substrates are ubiquitinated through DOA10 in conjunction with the E2 ubiquitin-conjugating enzymes UBC6 and UBC7-CUE1. Ubiquitinated substrates are then removed to the cytosol via the action of the UFD1-NPL4-CDC48/p97 (UNC) AAA ATPase complex and targeted to the proteasome. Also recognizes the N-terminally acetylated residue of proteins as degradation signal (degron). N-terminally acetylated target proteins include MATALPHA2, TBF1, SLK19, YMR090W, HIS3, HSP104, UBP6 and ARO8.
Protein Sequence
(Fasta)
MDVDSDVNVS RLRDELHKVA NEETDTATFN DDAPSGATCR ICRGEATEDN PLFHPCKCRG 60
SIKYMHESCL LEWVASKNID ISKPGADVKC DICHYPIQFK TIYAENMPEK IPFSLLLSKS 120
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Protein Fasta Sequence


>IUUC-Sce-106352|E3,RING|Saccharomyces cerevisiae
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Nucleotide Sequence
(Fasta)
ATGGATGTTG ATTCTGACGT TAATGTCTCC AGGTTAAGAG ATGAACTGCA TAAGGTGGCA 60
AACGAGGAAA CAGATACCGC CACTTTCAAT GATGATGCGC CATCCGGCGC CACCTGCCGT 120
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Nucleotide Fasta Sequence


>IUUC-Sce-106352|E3,RING|Saccharomyces cerevisiae
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Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR011016--Znf_RING-CH
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS51292--ZF_RING_CH
Pfam

PF12906--RINGv
SMART

SM00744--RINGv
Gene Ontology

GO:0000837--C:Doa10p ubiquitin ligase complex
GO:0030176--C:integral component of endoplasmic reticulum membrane
GO:0016021--C:integral component of membrane
GO:0005635--C:nuclear envelope
GO:0005637--C:nuclear inner membrane
GO:0061630--F:ubiquitin protein ligase activity
GO:1904264--F:ubiquitin protein ligase activity involved in ERAD pathway
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0030433--P:ubiquitin-dependent ERAD pathway
KEGG sce:YIL030C
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000922 Aegilops tauschii 39.47 8.00e-16 77.00
IUUC-Aml-002317 Ailuropoda melanoleuca 29.60 8.00e-17 80.50
IUUC-Atr-002732 Amborella trichopoda 34.23 3.00e-18 85.90
IUUC-Apl-003346 Anas platyrhynchos 29.46 5.00e-17 81.30
IUUC-Aca-004674 Anolis carolinensis 29.60 9.00e-17 80.50
IUUC-Aly-005919 Arabidopsis lyrata 34.23 3.00e-19 89.00
IUUC-Ath-007662 Arabidopsis thaliana 34.23 3.00e-19 89.40
IUUC-Ago-007857 Ashbya gossypii 33.17 4.00e-147 513.00
IUUC-Acl-008114 Aspergillus clavatus 28.31 1.00e-34 140.00
IUUC-Afl-008703 Aspergillus flavus 27.20 1.00e-29 123.00
IUUC-Afu-008872 Aspergillus fumigatus 29.44 3.00e-33 136.00
IUUC-Ani-009237 Aspergillus nidulans 27.02 9.00e-26 111.00
IUUC-Ang-009656 Aspergillus niger 27.93 9.00e-30 124.00
IUUC-Aor-010019 Aspergillus oryzae 27.20 8.00e-30 124.00
IUUC-Ate-010367 Aspergillus terreus 28.36 7.00e-28 118.00
IUUC-Ame-011557 Astyanax mexicanus 30.08 2.00e-17 82.80
IUUC-Bgr-011974 Blumeria graminis 27.03 3.00e-21 96.30
IUUC-Bta-013572 Bos taurus 29.60 1.00e-16 80.50
IUUC-Bci-013727 Botrytis cinerea 27.34 2.00e-27 117.00
IUUC-Bdi-014478 Brachypodium distachyon 37.50 7.00e-17 81.30
IUUC-Bol-015765 Brassica oleracea 35.14 1.00e-19 90.50
IUUC-Bra-017013 Brassica rapa 35.14 1.00e-19 90.50
IUUC-Cel-018256 Caenorhabditis elegans 33.33 6.00e-14 71.20
IUUC-Cja-019361 Callithrix jacchus 28.79 8.00e-17 80.50
IUUC-Cfa-021059 Canis familiaris 29.60 9.00e-17 80.50
IUUC-Cpo-022259 Cavia porcellus 29.60 9.00e-17 80.50
IUUC-Cre-022957 Chlamydomonas reinhardtii 35.63 2.00e-13 67.40
IUUC-Csa-024132 Chlorocebus sabaeus 28.79 7.00e-17 80.90
IUUC-Cho-024752 Choloepus hoffmanni 39.34 1.00e-11 63.50
IUUC-Cin-025673 Ciona intestinalis 32.00 4.00e-17 81.60
IUUC-Csv-026342 Ciona savignyi 37.18 3.00e-09 53.10
IUUC-Cgl-026714 Colletotrichum gloeosporioides 26.67 1.00e-27 117.00
IUUC-Cne-026977 Cryptococcus neoformans 23.70 1.00e-16 80.90
IUUC-Cme-027283 Cyanidioschyzon merolae 32.88 1.00e-10 60.10
IUUC-Dre-027968 Danio rerio 30.83 2.00e-18 86.30
IUUC-Dno-029848 Dasypus novemcinctus 28.79 6.00e-17 80.90
IUUC-Dor-031149 Dipodomys ordii 37.70 9.00e-12 63.50
IUUC-Dse-031295 Dothistroma septosporum 27.65 4.00e-27 115.00
IUUC-Dme-031749 Drosophila melanogaster 37.61 1.00e-19 90.50
IUUC-Ete-032230 Echinops telfairi 37.70 1.00e-11 63.50
IUUC-Eca-034268 Equus caballus 29.60 8.00e-17 80.50
IUUC-Eeu-034731 Erinaceus europaeus 37.70 1.00e-11 63.20
IUUC-Fca-036434 Felis catus 29.60 8.00e-17 80.50
IUUC-Fal-036963 Ficedula albicollis 29.60 8.00e-17 80.50
IUUC-Fox-038040 Fusarium oxysporum 32.06 3.00e-21 95.90
IUUC-Fso-038260 Fusarium solani 34.35 3.00e-22 99.40
IUUC-Gmo-038761 Gadus morhua 30.40 4.00e-17 81.60
IUUC-Ggr-039905 Gaeumannomyces graminis 26.40 1.00e-24 107.00
IUUC-Gga-041150 Gallus gallus 29.60 9.00e-17 80.50
IUUC-Gac-042399 Gasterosteus aculeatus 31.58 2.00e-19 89.00
IUUC-Gma-042674 Glycine max 33.33 5.00e-18 85.10
IUUC-Ggo-045093 Gorilla gorilla 28.79 7.00e-17 80.90
IUUC-Hsa-046275 Homo sapiens 28.79 7.00e-17 80.90
IUUC-Hvu-047562 Hordeum vulgare 35.64 3.00e-16 78.60
IUUC-Itr-048106 Ictidomys tridecemlineatus 30.40 1.00e-17 81.60
IUUC-Kpa-049197 Komagataella pastoris 36.29 8.00e-63 233.00
IUUC-Lch-050358 Latimeria chalumnae 30.23 2.00e-09 55.80
IUUC-Lpe-051172 Leersia perrieri 29.20 3.00e-17 82.40
IUUC-Loc-051866 Lepisosteus oculatus 30.08 5.00e-18 84.70
IUUC-Lma-053314 Leptosphaeria maculans 25.94 8.00e-25 107.00
IUUC-Laf-054000 Loxodonta africana 29.60 7.00e-17 80.90
IUUC-Mcc-055595 Macaca mulatta 29.69 3.00e-17 82.00
IUUC-Meu-056883 Macropus eugenii 28.70 3.00e-09 54.30
IUUC-Mor-057197 Magnaporthe oryzae 25.66 8.00e-24 105.00
IUUC-Mpo-057582 Magnaporthe poae 40.83 3.00e-23 102.00
IUUC-Mtr-057848 Medicago truncatula 35.14 1.00e-19 90.10
IUUC-Mla-058855 Melampsora laricipopulina 25.08 2.00e-10 58.90
IUUC-Mga-059985 Meleagris gallopavo 29.46 7.00e-17 80.90
IUUC-Mvi-060425 Microbotryum violaceum 25.41 1.00e-19 90.50
IUUC-Mmr-061236 Microcebus murinus 28.79 1.00e-16 80.10
IUUC-Mdo-062693 Monodelphis domestica 28.79 7.00e-17 80.90
IUUC-Mmu-064221 Mus musculus 28.79 7.00e-17 80.90
IUUC-Mac-064930 Musa acuminata 50.00 2.00e-14 68.90
IUUC-Mpu-066231 Mustela putorius furo 29.60 9.00e-17 80.50
IUUC-Mlu-067461 Myotis lucifugus 29.60 9.00e-17 80.50
IUUC-Nfi-068608 Neosartorya fischeri 30.26 3.00e-33 135.00
IUUC-Ncr-068743 Neurospora crassa 25.43 8.00e-25 108.00
IUUC-Nle-069646 Nomascus leucogenys 28.79 7.00e-17 80.90
IUUC-Opr-070365 Ochotona princeps 30.30 2.00e-17 82.40
IUUC-Ont-071418 Oreochromis niloticus 31.58 7.00e-19 87.40
IUUC-Oan-073648 Ornithorhynchus anatinus 34.33 7.00e-11 59.30
IUUC-Ocu-074853 Oryctolagus cuniculus 29.60 7.00e-17 80.90
IUUC-Oba-075890 Oryza barthii 29.20 2.00e-17 83.20
IUUC-Obr-076659 Oryza brachyantha 28.99 8.00e-11 60.80
IUUC-Ogl-077236 Oryza glaberrima 29.20 2.00e-17 82.80
IUUC-Ogu-078167 Oryza glumaepatula 29.20 2.00e-17 83.20
IUUC-Oin-079695 Oryza indica 29.20 3.00e-17 82.80
IUUC-Olo-080281 Oryza longistaminata 40.79 1.00e-15 76.60
IUUC-Ome-081221 Oryza meridionalis 39.71 2.00e-09 54.30
IUUC-Oni-083058 Oryza nivara 29.20 2.00e-17 83.20
IUUC-Opu-083911 Oryza punctata 29.20 2.00e-17 83.20
IUUC-Oru-084882 Oryza rufipogon 29.20 2.00e-17 83.20
IUUC-Osa-085984 Oryza sativa 29.20 2.00e-17 82.80
IUUC-Ola-087523 Oryzias latipes 31.06 3.00e-18 85.10
IUUC-Olu-087805 Ostreococcus lucimarinus 44.90 2.00e-08 52.00
IUUC-Oga-088607 Otolemur garnettii 29.60 1.00e-16 80.10
IUUC-Oar-089601 Ovis aries 29.60 1.00e-16 80.50
IUUC-Ptr-091477 Pan troglodytes 28.79 7.00e-17 80.90
IUUC-Pan-092525 Papio anubis 28.79 9.00e-17 80.10
IUUC-Psi-094098 Pelodiscus sinensis 29.60 8.00e-17 80.50
IUUC-Pma-094706 Petromyzon marinus 35.40 2.00e-20 88.60
IUUC-Pno-094876 Phaeosphaeria nodorum 36.36 2.00e-21 97.10
IUUC-Ppa-095692 Physcomitrella patens 30.63 2.00e-17 82.80
IUUC-Pfo-096116 Poecilia formosa 30.08 2.00e-18 85.90
IUUC-Pab-098038 Pongo abelii 28.79 7.00e-17 80.90
IUUC-Pop-099523 Populus trichocarpa 30.67 2.00e-19 89.40
IUUC-Pca-101000 Procavia capensis 28.79 7.00e-17 80.90
IUUC-Ppe-101729 Prunus persica 34.23 9.00e-19 87.40
IUUC-Pva-102450 Pteropus vampyrus 28.79 8.00e-17 80.50
IUUC-Pgr-103425 Puccinia graminis 24.33 1.00e-15 78.20
IUUC-Ptt-103985 Puccinia triticina 24.81 1.00e-13 71.20
IUUC-Pte-104148 Pyrenophora teres 23.99 1.00e-24 107.00
IUUC-Pyt-104663 Pyrenophora triticirepentis 23.74 9.00e-25 107.00
IUUC-Rno-105989 Rattus norvegicus 28.79 7.00e-17 80.90
IUUC-Sha-107014 Sarcophilus harrisii 39.34 3.00e-11 60.80
IUUC-Sja-107820 Schizosaccharomyces japonicus 28.41 4.00e-26 112.00
IUUC-Spo-108307 Schizosaccharomyces pombe 28.90 6.00e-27 114.00
IUUC-Ssl-108455 Sclerotinia sclerotiorum 28.21 2.00e-05 40.80
IUUC-Smo-109022 Selaginella moellendorffii 37.50 3.00e-17 82.00
IUUC-Sit-110338 Setaria italica 40.00 1.00e-17 84.00
IUUC-Sly-111874 Solanum lycopersicum 33.09 9.00e-21 94.00
IUUC-Stu-112495 Solanum tuberosum 33.09 1.00e-20 94.00
IUUC-Sar-113497 Sorex araneus 31.19 2.00e-16 79.70
IUUC-Sbi-114728 Sorghum bicolor 28.99 7.00e-11 60.50
IUUC-Sre-115100 Sporisorium reilianum 34.85 5.00e-15 75.50
IUUC-Ssc-115407 Sus scrofa 29.60 9.00e-17 80.50
IUUC-Tgu-117016 Taeniopygia guttata 29.60 7.00e-17 80.90
IUUC-Tru-118345 Takifugu rubripes 30.83 3.00e-18 85.50
IUUC-Tsy-119470 Tarsius syrichta 29.60 9.00e-17 80.50
IUUC-Tni-119846 Tetraodon nigroviridis 32.48 3.00e-18 85.10
IUUC-Tca-121135 Theobroma cacao 33.33 3.00e-18 85.50
IUUC-Tre-121940 Trichoderma reesei 28.53 8.00e-29 121.00
IUUC-Tvi-122339 Trichoderma virens 27.32 4.00e-27 115.00
IUUC-Tae-122752 Triticum aestivum 37.80 2.00e-17 82.80
IUUC-Tur-125992 Triticum urartu 39.47 2.00e-14 72.40
IUUC-Tme-127133 Tuber melanosporum 29.82 8.00e-29 121.00
IUUC-Tbe-127567 Tupaia belangeri 34.92 3.00e-11 60.10
IUUC-Ttr-129098 Tursiops truncatus 33.33 2.00e-10 57.80
IUUC-Uma-129384 Ustilago maydis 27.30 1.00e-25 110.00
IUUC-Vda-130026 Verticillium dahliae 26.30 7.00e-26 111.00
IUUC-Vpa-130798 Vicugna pacos 29.60 1.00e-16 80.50
IUUC-Vvi-130911 Vitis vinifera 31.97 7.00e-20 91.30
IUUC-Xtr-132891 Xenopus tropicalis 30.40 2.00e-16 79.00
IUUC-Xma-133659 Xiphophorus maculatus 30.08 8.00e-18 84.00
IUUC-Yli-134628 Yarrowia lipolytica 25.50 7.00e-26 110.00
IUUC-Zma-135318 Zea mays 40.00 6.00e-18 84.70
Created Date 25-Jun-2017

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