iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	CircNet	miRTarBase
microRNA	TRANSFAC	TargetScan	RepTar
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB	7.20e-19	69.6	63	138
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box	2.30e-10	39.6	170	201

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB

   S: 1    aDvilvv.......g.geeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgkldene 69
           +Dv+++v       g g+ f++ + vLaa++++F+++f++++ es+ +  v+++dv++e+f++l++++Ytg+++++e
   Q: 63   CDVTIEVvtpgsgpGtGRLFPCNRNVLAAACPYFKSMFTGGMYESQ-QASVTMHDVDAESFEVLVDYCYTGRVSLSE 138
           8999999999998867*****************************9.**************************9876 PP

E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box

   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhFk 32
           l Nc++il fAd+++ ++L+++a+++i ++Fk
   Q: 170  LTNCTAILKFADAFGHRKLRSQAQSYIAQNFK 201
           58*****************************7 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MQSREDAPRS RRLASPRGGK RPKKIHKPTV SAFFTGPEEL KDTAHSAALL AQLKSFYDAR 60
LLCDVTIEVV TPGSGPGTGR LFPCNRNVLA AACPYFKSMF TGGMYESQQA SVTMHDVDAE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGAAGGCGA GCAGACGCGG AGAAAGGACG CGGGAGTGAG AGAGGGTGAG TCAGCCACTG 60
TCTAAACGAT AACGGGAGGC GGTTCTGCGG GGTAGGGTTG AATTCAGTAA ATGGGCTCGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0880--Kelch repeat
KW-1185--Reference proteome
KW-0677--Repeat

Interpro

IPR011705--BACK
IPR000210--BTB/POZ_dom
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1

SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch

Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0016567--P:protein ubiquitination

KEGG

hsa:89890

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001587	Ailuropoda melanoleuca	88.70	0.00e+00	1206.00
IUUC-Ang-009864	Aspergillus niger	29.41	9.00e-08	50.40
IUUC-Bta-012917	Bos taurus	89.02	0.00e+00	1132.00
IUUC-Cja-018915	Callithrix jacchus	95.88	0.00e+00	1218.00
IUUC-Cfa-021068	Canis familiaris	91.69	0.00e+00	1214.00
IUUC-Csa-023423	Chlorocebus sabaeus	98.81	0.00e+00	1236.00
IUUC-Eca-034344	Equus caballus	91.69	0.00e+00	1187.00
IUUC-Eeu-034558	Erinaceus europaeus	88.87	0.00e+00	1147.00
IUUC-Mcc-055318	Macaca mulatta	99.41	0.00e+00	1236.00
IUUC-Mpu-065812	Mustela putorius furo	90.23	0.00e+00	1211.00
IUUC-Mlu-067107	Myotis lucifugus	91.39	0.00e+00	1164.00
IUUC-Nle-069209	Nomascus leucogenys	100.00	0.00e+00	1245.00
IUUC-Opr-071109	Ochotona princeps	73.49	0.00e+00	946.00
IUUC-Ptr-090788	Pan troglodytes	100.00	0.00e+00	1245.00
IUUC-Pan-091842	Papio anubis	98.37	0.00e+00	1258.00
IUUC-Pab-098569	Pongo abelii	99.70	0.00e+00	1242.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence