iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oan-073249

UUCD1 version

UUC-OrA-00356

Ensembl Protein ID

ENSOANP00000017261.1

UniProt Accession

F6ZMJ9; F6ZMJ9_ORNAN

Protein Name

Uncharacterized protein

Gene Name

SOCS3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOANG00000010894.1	ENSOANT00000017264.1	ENSOANP00000017261.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	74.67	1.00e-92	336.00	IUUC-Hsa-046909

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Ornithorhynchus anatinus

Protein Sequence
(Fasta)

MVTYSKFPAI GMSHRLDSSL RLKAFSSKSE YQLVMNAVHK LQQCGFYWST VTGGEANLLL 60
SAEPAGTFLI RDSSDQRHFF TLSVKTQAGT KNLRIQCEGG CFSLQSDPRN TQPIPRFDCV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGTCACGT ACAGCAAATT CCCCGCCATA GGGATGAGCC ACCGTCTGGA CTCAAGCCTG 60
CGCCTCAAGG CCTTCAGCTC CAAAAGCGAG TACCAGCTGG TGATGAACGC CGTCCACAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000980--SH2
IPR028414--SOCS3
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF07525--SOCS_box

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0004860--F:protein kinase inhibitor activity
GO:0019221--P:cytokine-mediated signaling pathway
GO:0007259--P:JAK-STAT cascade
GO:0043066--P:negative regulation of apoptotic process
GO:0050728--P:negative regulation of inflammatory response
GO:0046627--P:negative regulation of insulin receptor signaling pathway
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0006469--P:negative regulation of protein kinase activity
GO:0042512--P:negative regulation of tyrosine phosphorylation of Stat1 protein
GO:0042518--P:negative regulation of tyrosine phosphorylation of Stat3 protein
GO:0045597--P:positive regulation of cell differentiation
GO:0016567--P:protein ubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001529	Ailuropoda melanoleuca	76.00	4.00e-96	343.00
IUUC-Apl-003607	Anas platyrhynchos	83.08	5.00e-91	325.00
IUUC-Aca-005063	Anolis carolinensis	78.20	5.00e-95	339.00
IUUC-Ame-010859	Astyanax mexicanus	53.12	8.00e-64	235.00
IUUC-Bta-012817	Bos taurus	75.11	2.00e-97	347.00
IUUC-Cja-019605	Callithrix jacchus	76.44	1.00e-97	347.00
IUUC-Cfa-021231	Canis familiaris	76.00	6.00e-96	342.00
IUUC-Cpo-022003	Cavia porcellus	75.44	1.00e-95	341.00
IUUC-Csa-023511	Chlorocebus sabaeus	76.99	3.00e-97	347.00
IUUC-Dre-028536	Danio rerio	58.57	4.00e-69	253.00
IUUC-Dno-029003	Dasypus novemcinctus	75.45	2.00e-96	344.00
IUUC-Eca-034205	Equus caballus	68.16	4.00e-63	233.00
IUUC-Fca-036317	Felis catus	75.34	1.00e-93	334.00
IUUC-Gmo-038777	Gadus morhua	60.19	6.00e-34	135.00
IUUC-Gga-041258	Gallus gallus	80.38	6.00e-90	322.00
IUUC-Gac-041837	Gasterosteus aculeatus	57.07	6.00e-65	239.00
IUUC-Ggo-045620	Gorilla gorilla	76.99	3.00e-97	347.00
IUUC-Hsa-046909	Homo sapiens	76.99	3.00e-97	347.00
IUUC-Itr-048023	Ictidomys tridecemlineatus	73.50	2.00e-96	343.00
IUUC-Lch-049510	Latimeria chalumnae	67.15	6.00e-77	279.00
IUUC-Loc-052863	Lepisosteus oculatus	63.94	5.00e-75	272.00
IUUC-Laf-054136	Loxodonta africana	74.35	2.00e-95	340.00
IUUC-Mcc-055383	Macaca mulatta	76.99	3.00e-97	347.00
IUUC-Meu-056153	Macropus eugenii	76.99	3.00e-99	353.00
IUUC-Mmr-061185	Microcebus murinus	75.66	8.00e-96	342.00
IUUC-Mdo-061819	Monodelphis domestica	77.33	9.00e-99	352.00
IUUC-Mmu-064231	Mus musculus	76.89	6.00e-98	349.00
IUUC-Mpu-066691	Mustela putorius furo	76.00	6.00e-96	342.00
IUUC-Mlu-067673	Myotis lucifugus	75.22	1.00e-96	345.00
IUUC-Ont-072406	Oreochromis niloticus	57.07	5.00e-66	243.00
IUUC-Ocu-074935	Oryctolagus cuniculus	77.14	2.00e-27	112.00
IUUC-Ola-087373	Oryzias latipes	50.27	7.00e-50	189.00
IUUC-Oga-088041	Otolemur garnettii	76.34	1.00e-96	344.00
IUUC-Oar-089646	Ovis aries	73.36	4.00e-93	333.00
IUUC-Ptr-091502	Pan troglodytes	76.99	3.00e-97	347.00
IUUC-Pan-091934	Papio anubis	76.99	3.00e-97	347.00
IUUC-Pfo-096412	Poecilia formosa	43.90	4.00e-48	183.00
IUUC-Pab-098554	Pongo abelii	76.99	3.00e-97	347.00
IUUC-Rno-105874	Rattus norvegicus	76.65	2.00e-97	347.00
IUUC-Sha-107151	Sarcophilus harrisii	76.32	7.00e-99	352.00
IUUC-Ssc-115722	Sus scrofa	70.76	3.00e-61	226.00
IUUC-Tgu-117151	Taeniopygia guttata	80.38	1.00e-89	321.00
IUUC-Tru-118428	Takifugu rubripes	56.59	2.00e-66	244.00
IUUC-Tni-120590	Tetraodon nigroviridis	58.05	6.00e-67	246.00
IUUC-Ttr-129065	Tursiops truncatus	75.22	8.00e-97	345.00
IUUC-Xtr-132167	Xenopus tropicalis	70.15	3.00e-81	293.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence