iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Eca-034289

UUCD1 version

UUC-EqC-00420

Ensembl Protein ID

ENSECAP00000002769.1

UniProt Accession

F6WXE8; F6WXE8_HORSE

Protein Name

Uncharacterized protein

Gene Name

SOCS4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000004043.1	ENSECAT00000004001.1	ENSECAP00000002769.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	6.70e-16	58.1	379	426

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 3    klwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedyq 53
           +++l+r+ p+SLqh+CR +I++c++++++   d+LP P+++k YL++++y+
   Q: 379  STPLIRTFPFSLQHICRTVICNCTTYDGI---DALPVPSAMKLYLKEYHYK 426
           678899***********************...****************985 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

MAENSENNSK NVDVRPKTSR SRSADRKDGY VWSGKKLSWS KKSESCSDAE TVNSIEKTEV 60
PLRSQERKHS CSSIELDLDH SCGHRFLGRS LKQKLQDAMG QCFPIKNCSS RHPSGLSSKR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGATACGTCC AGAAAGTGCC CAGAAGAAAC TTCCTGCCAG AAAAACTGAA AAAACAATAT 60
TCATAATACT GGAATTTGTG GATAATTTGT TAAAATGGCG GAAAATAGTG AAAATAATAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000980--SH2
IPR028416--SOCS4
IPR022252--SOCS4/SOCS5_dom
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF12610--SOCS
PF07525--SOCS_box

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0004860--F:protein kinase inhibitor activity
GO:0019221--P:cytokine-mediated signaling pathway
GO:0035556--P:intracellular signal transduction
GO:0042059--P:negative regulation of epidermal growth factor receptor signaling pathway
GO:0007175--P:negative regulation of epidermal growth factor-activated receptor activity
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0006469--P:negative regulation of protein kinase activity
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0016567--P:protein ubiquitination

KEGG

ecb:100050301

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001789	Ailuropoda melanoleuca	94.76	0.00e+00	797.00
IUUC-Apl-003839	Anas platyrhynchos	79.77	0.00e+00	647.00
IUUC-Aca-004840	Anolis carolinensis	79.55	0.00e+00	701.00
IUUC-Bta-012503	Bos taurus	94.56	0.00e+00	796.00
IUUC-Bol-016597	Brassica oleracea	29.11	1.10e-01	31.60
IUUC-Cja-019284	Callithrix jacchus	94.33	0.00e+00	795.00
IUUC-Cfa-020890	Canis familiaris	94.56	0.00e+00	799.00
IUUC-Cpo-022081	Cavia porcellus	77.85	0.00e+00	677.00
IUUC-Csa-023076	Chlorocebus sabaeus	93.65	0.00e+00	791.00
IUUC-Cho-024700	Choloepus hoffmanni	94.33	0.00e+00	843.00
IUUC-Dno-029961	Dasypus novemcinctus	94.78	0.00e+00	839.00
IUUC-Dor-030273	Dipodomys ordii	93.65	0.00e+00	804.00
IUUC-Ete-032972	Echinops telfairi	92.65	2.00e-170	590.00
IUUC-Eeu-035208	Erinaceus europaeus	91.03	0.00e+00	751.00
IUUC-Fal-036829	Ficedula albicollis	79.55	0.00e+00	640.00
IUUC-Gga-040725	Gallus gallus	79.32	0.00e+00	669.00
IUUC-Ggo-044886	Gorilla gorilla	94.10	0.00e+00	796.00
IUUC-Hsa-046322	Homo sapiens	93.88	0.00e+00	795.00
IUUC-Itr-048585	Ictidomys tridecemlineatus	94.04	0.00e+00	791.00
IUUC-Lch-049459	Latimeria chalumnae	57.50	1.00e-138	486.00
IUUC-Laf-053484	Loxodonta africana	94.94	0.00e+00	798.00
IUUC-Mcc-054890	Macaca mulatta	93.42	0.00e+00	790.00
IUUC-Meu-056532	Macropus eugenii	84.40	0.00e+00	646.00
IUUC-Mtr-057670	Medicago truncatula	36.67	2.20e+00	26.60
IUUC-Mvi-060418	Microbotryum violaceum	32.10	1.40e-02	32.70
IUUC-Mmr-061714	Microcebus murinus	95.24	0.00e+00	803.00
IUUC-Mmu-063161	Mus musculus	87.39	0.00e+00	738.00
IUUC-Mac-064598	Musa acuminata	33.33	1.90e-01	28.90
IUUC-Mpu-066499	Mustela putorius furo	95.00	0.00e+00	831.00
IUUC-Mlu-066945	Myotis lucifugus	93.88	0.00e+00	793.00
IUUC-Nle-069976	Nomascus leucogenys	93.88	0.00e+00	793.00
IUUC-Opr-070255	Ochotona princeps	87.76	0.00e+00	754.00
IUUC-Ocu-074764	Oryctolagus cuniculus	94.10	0.00e+00	801.00
IUUC-Oga-088910	Otolemur garnettii	87.78	0.00e+00	770.00
IUUC-Oar-090330	Ovis aries	94.33	0.00e+00	792.00
IUUC-Ptr-090709	Pan troglodytes	94.10	0.00e+00	796.00
IUUC-Pan-092540	Papio anubis	93.65	0.00e+00	791.00
IUUC-Psi-093678	Pelodiscus sinensis	81.36	0.00e+00	725.00
IUUC-Pab-097970	Pongo abelii	92.51	0.00e+00	652.00
IUUC-Pop-098820	Populus trichocarpa	41.18	1.40e-01	30.80
IUUC-Pca-100211	Procavia capensis	83.45	0.00e+00	676.00
IUUC-Rno-106014	Rattus norvegicus	85.32	0.00e+00	733.00
IUUC-Sha-106822	Sarcophilus harrisii	83.68	0.00e+00	719.00
IUUC-Ssc-115821	Sus scrofa	95.01	0.00e+00	803.00
IUUC-Tgu-117117	Taeniopygia guttata	80.00	0.00e+00	643.00
IUUC-Tsy-118979	Tarsius syrichta	96.61	8.00e-128	449.00
IUUC-Tca-121131	Theobroma cacao	30.77	2.00e-03	36.60
IUUC-Vpa-130626	Vicugna pacos	94.33	0.00e+00	805.00
IUUC-Vvi-131327	Vitis vinifera	43.24	1.00e-01	31.20

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence