iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Mmu-064281

Ensembl Protein ID

ENSMUSP00000042803.5

UniProt Accession

Q80TE3; Q4QQN4; MARH4_MOUSE

Genbank Protein ID

BAC65784.1; AAH98191.1

Protein Name

E3 ubiquitin-protein ligase MARCH4; Membrane-associated RING finger protein 4; Membrane-associated RING-CH protein IV; RING-type E3 ubiquitin transferase MARCH4

Genbank Nucleotide ID

AK122502; BC098191

Gene Name

March4; Kiaa1399

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000039372.5	ENSMUST00000047786.5	ENSMUSP00000042803.5

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
microRNA	TRANSFAC	RepTar	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	90.41	3.00e-165	578.00	IUUC-Hsa-046918

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Mus musculus

Functional Description
(View)

E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.

Protein Sequence
(Fasta)

MLMPLGGLLW WWCCCCGWYS CGLCTPAPQM LRHQGLLKCR CRMLFNDLKV FLLRRPPPAP 60
LPMHGDPQLP GVAANNNTLP ALGAGGWAGW RGPREAVGRE TPPLPPPPPL PPSGDDDWDG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GATTTGTTTC CTTTTCGGCT TTTCTAAGAG ATATATTTAT ATACGGTTCT GGGGAGTCTC 60
CAGGACCAAG CTGGAGCCAA GTGCCGTCTG TCTGACCATC TCGACCACAC CGTCTCTATT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0732--Signal
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR033275--MARCH-like
IPR011016--Znf_RING-CH
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51292--ZF_RING_CH

Pfam

PF12906--RINGv

SMART

SM00744--RINGv

Gene Ontology

GO:0000139--C:Golgi membrane
GO:0005795--C:Golgi stack
GO:0016021--C:integral component of membrane
GO:0005802--C:trans-Golgi network
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding

KEGG

mmu:381270

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001891	Ailuropoda melanoleuca	90.39	2.00e-175	608.00
IUUC-Aca-004387	Anolis carolinensis	79.46	3.00e-77	280.00
IUUC-Bta-012464	Bos taurus	85.77	3.00e-119	420.00
IUUC-Cja-019551	Callithrix jacchus	90.39	1.00e-172	598.00
IUUC-Cfa-020632	Canis familiaris	90.31	0.00e+00	626.00
IUUC-Cpo-021989	Cavia porcellus	91.45	5.00e-168	583.00
IUUC-Csa-023116	Chlorocebus sabaeus	90.67	6.00e-172	596.00
IUUC-Cho-024369	Choloepus hoffmanni	87.95	3.00e-173	600.00
IUUC-Cin-025794	Ciona intestinalis	34.10	9.00e-32	129.00
IUUC-Csv-026342	Ciona savignyi	36.65	9.00e-30	123.00
IUUC-Dre-028502	Danio rerio	55.85	3.00e-108	385.00
IUUC-Dno-028874	Dasypus novemcinctus	90.46	8.00e-169	586.00
IUUC-Dor-030725	Dipodomys ordii	74.81	9.00e-123	433.00
IUUC-Eca-033517	Equus caballus	91.56	1.00e-170	592.00
IUUC-Eeu-034758	Erinaceus europaeus	88.46	7.00e-164	570.00
IUUC-Fca-035463	Felis catus	90.00	3.00e-167	581.00
IUUC-Fal-036690	Ficedula albicollis	75.74	2.00e-119	422.00
IUUC-Gmo-039433	Gadus morhua	65.34	2.00e-98	352.00
IUUC-Gga-040630	Gallus gallus	82.85	3.00e-132	464.00
IUUC-Gac-042616	Gasterosteus aculeatus	68.01	2.00e-102	365.00
IUUC-Ggo-045073	Gorilla gorilla	90.91	5.00e-166	577.00
IUUC-Hsa-046918	Homo sapiens	84.38	7.00e-166	576.00
IUUC-Lch-049497	Latimeria chalumnae	78.51	8.00e-108	382.00
IUUC-Loc-051876	Lepisosteus oculatus	69.50	9.00e-94	337.00
IUUC-Laf-054047	Loxodonta africana	90.79	8.00e-173	599.00
IUUC-Mcc-055218	Macaca mulatta	90.93	6.00e-173	600.00
IUUC-Meu-056883	Macropus eugenii	81.56	3.00e-153	535.00
IUUC-Mga-059842	Meleagris gallopavo	83.26	8.00e-115	405.00
IUUC-Mvi-060405	Microbotryum violaceum	36.84	2.00e-10	60.50
IUUC-Mmr-061536	Microcebus murinus	90.67	3.00e-167	581.00
IUUC-Mdo-062808	Monodelphis domestica	79.80	4.00e-144	504.00
IUUC-Mpu-066588	Mustela putorius furo	90.91	2.00e-169	588.00
IUUC-Mlu-067794	Myotis lucifugus	91.77	2.00e-164	571.00
IUUC-Ncr-068689	Neurospora crassa	35.37	3.00e-08	52.80
IUUC-Nle-069484	Nomascus leucogenys	90.91	5.00e-166	577.00
IUUC-Opr-070536	Ochotona princeps	76.30	3.00e-129	454.00
IUUC-Ont-072656	Oreochromis niloticus	68.75	2.00e-104	372.00
IUUC-Ocu-074169	Oryctolagus cuniculus	89.90	1.00e-177	615.00
IUUC-Ola-086356	Oryzias latipes	64.79	1.00e-98	352.00
IUUC-Olu-087713	Ostreococcus lucimarinus	43.86	3.00e-09	55.80
IUUC-Oga-088785	Otolemur garnettii	87.95	9.00e-122	429.00
IUUC-Oar-089431	Ovis aries	87.01	5.00e-162	563.00
IUUC-Ptr-090885	Pan troglodytes	90.91	5.00e-166	577.00
IUUC-Pan-092062	Papio anubis	91.38	2.00e-173	601.00
IUUC-Psi-093715	Pelodiscus sinensis	72.19	1.00e-148	519.00
IUUC-Pfo-097302	Poecilia formosa	66.55	2.00e-104	372.00
IUUC-Pab-097767	Pongo abelii	84.38	7.00e-166	576.00
IUUC-Pva-102171	Pteropus vampyrus	91.71	4.00e-166	577.00
IUUC-Rno-106010	Rattus norvegicus	97.66	3.00e-176	610.00
IUUC-Sha-106704	Sarcophilus harrisii	85.42	2.00e-169	588.00
IUUC-Sar-113178	Sorex araneus	72.01	4.00e-71	261.00
IUUC-Ssc-115455	Sus scrofa	92.19	6.00e-178	616.00
IUUC-Tgu-116933	Taeniopygia guttata	80.95	3.00e-131	461.00
IUUC-Tru-118477	Takifugu rubripes	70.22	9.00e-104	370.00
IUUC-Tni-120144	Tetraodon nigroviridis	69.43	2.00e-101	361.00
IUUC-Tbe-127850	Tupaia belangeri	90.39	1.00e-158	552.00
IUUC-Ttr-128599	Tursiops truncatus	91.18	8.00e-133	466.00
IUUC-Xtr-131961	Xenopus tropicalis	67.83	4.00e-135	474.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence