iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLACG00000012137.1	ENSLACT00000013883.1	ENSLACP00000013786.1
ENSLACG00000012137.1	ENSLACT00000013884.1	ENSLACP00000013787.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.10e-77	261.0	2463	2786

Active Site

Position(s)	Description	Evidence
2756	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 16   EegldlgGvtreflallskelqnpd..lglflysen.dketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsksfykl 99
           +e+ + +G++r ++++ ++++ + d  ++lf +  + + ++ +p +++      +l++F+ +Gr+lg++l +++l++++l+++++k 
   Q: 2463 QENRKRHGSSRSVVDMELDDVDDGDdnAPLFYQPGKrGFYSPRPGKNTE----ARLNCFRNIGRILGLCLLQNELCPITLNRHVIKV 2545
           56678889********9****9999778888333333666666666654....89******************************** PP
   S: 100  llgkklsledleevdpelyks.lkeikena..esdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlk 183
           llg+k++++d++ +dp +y+s  + i++++  +++   +++dl+f ++ ++ +   ++eL++g+ nipVt +N +eYv++++e+r+ 
   Q: 2546 LLGRKVNWHDFAFFDPVMYESlRQLILASQstDAEAVFAAMDLAFAIDLCKEEGGGQVELVTGSVNIPVTPQNVYEYVRKYAEHRML 2632
           *********************5566666664455777889*********************************************** PP
   S: 184  egikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspai....qwFwevleefsseerkafLq 266
              ++ ++a+r+G+ +v+p+++l+ +t+e+++ll++G+ e++v++l ++t+++++  e+ +++    +wFw+++e++s++er++++ 
   Q: 2633 VVTEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLlqfkRWFWSIVEKMSMTERQDLVY 2719
           ****************************************************9999999999989999******************* PP
   S: 267  FvTgssrlPl..gGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           F+T+s++lP+  +Gf++++  +++ir   +d++lP++nTC+++L +P Yssk+ilk+kLl+Ai++ k+F++
   Q: 2720 FWTSSPSLPAseEGFQPMP--SITIRP-PDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIKT-KNFGF 2786
           **********999******..799999.99**********************************9.99875 PP

Organism

Latimeria chalumnae

Protein Sequence
(Fasta)

LSYRLREVSE KLNKYNLNSH PPLNVLEQAT IKQCVVGPNH AAFLLEDGRI CRIVFAVQPD 60
RLEFGKPDNS DGSKLSSGSG TGRTSRPGRT SDSPWFLSGS DTLGRLAGNT LGSRWSCGVG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTGGCTGAA GCAAGATGGC GGTTTCTCAT TAAACGGGAT TCATACTTGA TCTCCTTTCC 60
TCTGTTTATT TAGTCCTGTT GGAGTCTGTT ATTTAATTAA AATTTACACG TAAATCTTCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR024725--E3_UbLigase_EDD_UBA
IPR000569--HECT_dom
IPR002004--PABP_HYD
IPR009091--RCC1/BLIP-II
IPR003126--Znf_UBR

PROSITE

PS50237--HECT
PS51309--PABC
PS51157--ZF_UBR

Pfam

PF11547--E3_UbLigase_EDD
PF00632--HECT
PF00658--PABP

SMART

SM00119--HECTc
SM00517--PolyA
SM00396--ZnF_UBR1

Gene Ontology

GO:0003723--F:RNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002217	Ailuropoda melanoleuca	94.40	0.00e+00	4404.00
IUUC-Apl-004165	Anas platyrhynchos	94.15	0.00e+00	4381.00
IUUC-Aca-004577	Anolis carolinensis	94.22	0.00e+00	3840.00
IUUC-Ame-010702	Astyanax mexicanus	84.51	0.00e+00	2484.00
IUUC-Bta-012313	Bos taurus	94.40	0.00e+00	4417.00
IUUC-Cel-018165	Caenorhabditis elegans	35.11	6.00e-67	250.00
IUUC-Cja-019858	Callithrix jacchus	94.40	0.00e+00	4435.00
IUUC-Cfa-020973	Canis familiaris	94.44	0.00e+00	4417.00
IUUC-Cpo-022108	Cavia porcellus	93.83	0.00e+00	1877.00
IUUC-Csa-023985	Chlorocebus sabaeus	94.26	0.00e+00	4446.00
IUUC-Cho-025034	Choloepus hoffmanni	87.89	0.00e+00	933.00
IUUC-Cin-025715	Ciona intestinalis	39.79	0.00e+00	912.00
IUUC-Csv-026088	Ciona savignyi	39.76	2.00e-156	546.00
IUUC-Dre-027730	Danio rerio	88.03	0.00e+00	4028.00
IUUC-Dno-029123	Dasypus novemcinctus	92.05	0.00e+00	4266.00
IUUC-Dor-030757	Dipodomys ordii	89.97	0.00e+00	2773.00
IUUC-Dme-032192	Drosophila melanogaster	51.04	7.00e-173	602.00
IUUC-Ete-032292	Echinops telfairi	91.68	0.00e+00	2094.00
IUUC-Eca-034347	Equus caballus	94.25	0.00e+00	4370.00
IUUC-Eeu-034873	Erinaceus europaeus	90.34	0.00e+00	4205.00
IUUC-Fca-036485	Felis catus	93.22	0.00e+00	4309.00
IUUC-Fal-037071	Ficedula albicollis	94.62	0.00e+00	4393.00
IUUC-Gmo-039589	Gadus morhua	88.48	0.00e+00	3985.00
IUUC-Gga-041195	Gallus gallus	93.29	0.00e+00	4284.00
IUUC-Gac-042538	Gasterosteus aculeatus	88.62	0.00e+00	4010.00
IUUC-Ggo-045351	Gorilla gorilla	93.87	0.00e+00	4487.00
IUUC-Hsa-045941	Homo sapiens	94.51	0.00e+00	4467.00
IUUC-Itr-048635	Ictidomys tridecemlineatus	94.22	0.00e+00	4403.00
IUUC-Loc-052664	Lepisosteus oculatus	89.12	0.00e+00	4116.00
IUUC-Laf-053935	Loxodonta africana	94.18	0.00e+00	1550.00
IUUC-Mcc-054703	Macaca mulatta	94.26	0.00e+00	4447.00
IUUC-Meu-056431	Macropus eugenii	86.98	0.00e+00	788.00
IUUC-Mga-059289	Meleagris gallopavo	95.16	0.00e+00	3532.00
IUUC-Mmr-061737	Microcebus murinus	93.97	0.00e+00	4355.00
IUUC-Mdo-062499	Monodelphis domestica	94.19	0.00e+00	4372.00
IUUC-Mmu-063273	Mus musculus	93.54	0.00e+00	4323.00
IUUC-Mpu-066907	Mustela putorius furo	94.59	0.00e+00	4071.00
IUUC-Mlu-067942	Myotis lucifugus	94.05	0.00e+00	4430.00
IUUC-Nle-069527	Nomascus leucogenys	94.47	0.00e+00	4467.00
IUUC-Opr-070626	Ochotona princeps	82.82	0.00e+00	1392.00
IUUC-Ont-071951	Oreochromis niloticus	87.99	0.00e+00	3956.00
IUUC-Oan-072958	Ornithorhynchus anatinus	94.87	0.00e+00	4048.00
IUUC-Ocu-074503	Oryctolagus cuniculus	92.01	0.00e+00	4327.00
IUUC-Ola-086757	Oryzias latipes	88.60	0.00e+00	4028.00
IUUC-Oga-088781	Otolemur garnettii	93.94	0.00e+00	4403.00
IUUC-Oar-089274	Ovis aries	94.25	0.00e+00	4396.00
IUUC-Ptr-090669	Pan troglodytes	94.96	0.00e+00	3905.00
IUUC-Pan-092226	Papio anubis	94.37	0.00e+00	4434.00
IUUC-Psi-093502	Pelodiscus sinensis	94.69	0.00e+00	4385.00
IUUC-Pma-094454	Petromyzon marinus	82.12	0.00e+00	729.00
IUUC-Pfo-096173	Poecilia formosa	88.43	0.00e+00	3749.00
IUUC-Pab-098355	Pongo abelii	95.06	0.00e+00	3083.00
IUUC-Pca-100570	Procavia capensis	94.19	0.00e+00	1123.00
IUUC-Pva-102572	Pteropus vampyrus	91.13	0.00e+00	1311.00
IUUC-Rno-104916	Rattus norvegicus	92.24	0.00e+00	3828.00
IUUC-Sha-106653	Sarcophilus harrisii	94.62	0.00e+00	4385.00
IUUC-Sar-113517	Sorex araneus	86.10	0.00e+00	1238.00
IUUC-Ssc-115470	Sus scrofa	95.88	0.00e+00	2467.00
IUUC-Tgu-116932	Taeniopygia guttata	94.51	0.00e+00	4371.00
IUUC-Tru-117682	Takifugu rubripes	88.17	0.00e+00	2581.00
IUUC-Tsy-119417	Tarsius syrichta	91.49	0.00e+00	2414.00
IUUC-Tni-120442	Tetraodon nigroviridis	84.67	0.00e+00	3672.00
IUUC-Tbe-127456	Tupaia belangeri	82.08	0.00e+00	2007.00
IUUC-Ttr-128606	Tursiops truncatus	90.07	0.00e+00	1496.00
IUUC-Vpa-130112	Vicugna pacos	91.86	0.00e+00	3619.00
IUUC-Xtr-131929	Xenopus tropicalis	91.76	0.00e+00	4330.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence