iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-062499

UUCD1 version

UUC-MoD-00331

Ensembl Protein ID

ENSMODP00000007389.3

UniProt Accession

F6VZ48; F6VZ48_MONDO

Protein Name

Uncharacterized protein

Gene Name

UBR5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000005976.3	ENSMODT00000007538.3	ENSMODP00000007389.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.70e-77	260.6	2458	2778

Active Site

Position(s)	Description	Evidence
2748	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 19   ldlgGvtreflallskelqnpd..lglf.lysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsksfyklllg 102
            + +G++r ++++ ++++ + d  ++lf +  +++ +t +p +++      +l++F+ +Gr+lg++l +++l++++l+++++k llg
   Q: 2458 RKRHGSSRSVVDMELDDTDDGDdnAPLFyQPGKRGFYTPRPGKNTE----ARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLG 2540
           5567889999998888888888777888234444777777777765....89*********************************** PP
   S: 103  kklsledleevdpelyks.lkeikena..esdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegi 186
           +k++++d++ +dp +y+s  + i++++  ++d   +++dl+f ++ ++ +   ++eL+p+G nipVt +N +eYv++++e+r+    
   Q: 2541 RKVNWHDFAFFDPVMYESlRQLILASQstDADAVFAAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVA 2627
           ******************5555666655566889999************************************************** PP
   S: 187  keqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspai....qwFwevleefsseerkafLqFvT 269
           ++ ++a+r+G+ +v+p+++l+ +t+e+++ll++G+ e++v++l ++t+++++  e+ +++    ++Fw+++e++s++er+  + F+T
   Q: 2628 EQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLlqfkRRFWSIVEKMSMTERQXXVYFWT 2714
           *************************************************99999999999888999********************* PP
   S: 270  gssrlPl..gGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           +s++lP+  +Gf++++  +++ir   +d++lP++nTC+++L +P Yssk+ilk+kLl+Ai++ k+F++
   Q: 2715 SSPSLPAseEGFQPMP--SITIRP-PDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIKT-KNFGF 2778
           *******999******..799999.99**********************************9.99875 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

RLREVSEKLN KYNLNSHPPL NVLEQATIKQ CVVGPNHAAF LLEDGRVCRI GFSVQPDRLE 60
LGKPDNNDGS KLSSGSGAGR TSRPGRTSDS PWFLSGSETL GRLAGNTLGS RWSSGVGGSG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGTTACGAG AAGTGTCAGA GAAACTCAAC AAGTATAATT TAAACAGGTA AAATTTTTTA 60
GATTTTTTTT TCTAGAATAA TATTTCATTG TTCCATGATC AAAAAGGCCA AAGTAGCATG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR024725--E3_UbLigase_EDD_UBA
IPR000569--HECT_dom
IPR002004--PABP_HYD
IPR009091--RCC1/BLIP-II
IPR003126--Znf_UBR

PROSITE

PS50237--HECT
PS51309--PABC
PS51157--ZF_UBR

Pfam

PF11547--E3_UbLigase_EDD
PF00632--HECT
PF00658--PABP

SMART

SM00119--HECTc
SM00517--PolyA
SM00396--ZnF_UBR1

Gene Ontology

GO:0005829--C:cytosol
GO:0016020--C:membrane
GO:0005654--C:nucleoplasm
GO:0048471--C:perinuclear region of cytoplasm
GO:0043234--C:protein complex
GO:0003723--F:RNA binding
GO:0034450--F:ubiquitin-ubiquitin ligase activity
GO:0008270--F:zinc ion binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:2000780--P:negative regulation of double-strand break repair
GO:1901315--P:negative regulation of histone H2A K63-linked ubiquitination
GO:0090263--P:positive regulation of canonical Wnt signaling pathway
GO:0035413--P:positive regulation of catenin import into nucleus
GO:0010628--P:positive regulation of gene expression
GO:0033160--P:positive regulation of protein import into nucleus, translocation
GO:0050847--P:progesterone receptor signaling pathway
GO:0000209--P:protein polyubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002217	Ailuropoda melanoleuca	97.91	0.00e+00	4498.00
IUUC-Apl-004165	Anas platyrhynchos	97.48	0.00e+00	4489.00
IUUC-Aca-004577	Anolis carolinensis	95.94	0.00e+00	3909.00
IUUC-Ame-010702	Astyanax mexicanus	84.33	0.00e+00	2472.00
IUUC-Bta-012313	Bos taurus	98.06	0.00e+00	4519.00
IUUC-Cel-018165	Caenorhabditis elegans	35.10	2.00e-66	249.00
IUUC-Cja-019858	Callithrix jacchus	97.98	0.00e+00	4544.00
IUUC-Cfa-020973	Canis familiaris	98.20	0.00e+00	4524.00
IUUC-Cpo-022108	Cavia porcellus	96.68	0.00e+00	1894.00
IUUC-Csa-023985	Chlorocebus sabaeus	97.95	0.00e+00	4553.00
IUUC-Cho-025034	Choloepus hoffmanni	88.59	0.00e+00	975.00
IUUC-Cin-025715	Ciona intestinalis	40.31	0.00e+00	917.00
IUUC-Csv-026088	Ciona savignyi	39.82	4.00e-156	545.00
IUUC-Dre-027730	Danio rerio	88.05	0.00e+00	3979.00
IUUC-Dno-029123	Dasypus novemcinctus	95.55	0.00e+00	4348.00
IUUC-Dor-030757	Dipodomys ordii	93.50	0.00e+00	2842.00
IUUC-Dme-032192	Drosophila melanogaster	51.27	1.00e-170	595.00
IUUC-Ete-032292	Echinops telfairi	94.45	0.00e+00	2152.00
IUUC-Eca-034347	Equus caballus	97.88	0.00e+00	4475.00
IUUC-Eeu-034873	Erinaceus europaeus	93.52	0.00e+00	4290.00
IUUC-Fca-036485	Felis catus	96.77	0.00e+00	4422.00
IUUC-Fal-037071	Ficedula albicollis	98.09	0.00e+00	4509.00
IUUC-Gmo-039589	Gadus morhua	88.58	0.00e+00	3960.00
IUUC-Gga-041195	Gallus gallus	96.76	0.00e+00	4403.00
IUUC-Gac-042538	Gasterosteus aculeatus	88.66	0.00e+00	3984.00
IUUC-Ggo-045351	Gorilla gorilla	97.16	0.00e+00	4571.00
IUUC-Hsa-045941	Homo sapiens	98.02	0.00e+00	4571.00
IUUC-Itr-048635	Ictidomys tridecemlineatus	97.88	0.00e+00	4511.00
IUUC-Lch-050480	Latimeria chalumnae	94.19	0.00e+00	4300.00
IUUC-Loc-052664	Lepisosteus oculatus	89.63	0.00e+00	4091.00
IUUC-Laf-053935	Loxodonta africana	97.54	0.00e+00	1570.00
IUUC-Mcc-054703	Macaca mulatta	97.91	0.00e+00	4547.00
IUUC-Meu-056431	Macropus eugenii	88.75	0.00e+00	803.00
IUUC-Mga-059289	Meleagris gallopavo	97.47	0.00e+00	3600.00
IUUC-Mmr-061737	Microcebus murinus	97.63	0.00e+00	4447.00
IUUC-Mmu-063273	Mus musculus	97.01	0.00e+00	4429.00
IUUC-Mpu-066907	Mustela putorius furo	97.84	0.00e+00	4163.00
IUUC-Mlu-067942	Myotis lucifugus	97.60	0.00e+00	4527.00
IUUC-Nle-069527	Nomascus leucogenys	98.02	0.00e+00	4574.00
IUUC-Opr-070626	Ochotona princeps	85.59	0.00e+00	1405.00
IUUC-Ont-071951	Oreochromis niloticus	87.41	0.00e+00	3915.00
IUUC-Oan-072958	Ornithorhynchus anatinus	98.55	0.00e+00	4182.00
IUUC-Ocu-074503	Oryctolagus cuniculus	95.22	0.00e+00	4398.00
IUUC-Ola-086757	Oryzias latipes	88.81	0.00e+00	4018.00
IUUC-Oga-088781	Otolemur garnettii	97.98	0.00e+00	4511.00
IUUC-Oar-089274	Ovis aries	97.80	0.00e+00	4503.00
IUUC-Ptr-090669	Pan troglodytes	97.73	0.00e+00	3973.00
IUUC-Pan-092226	Papio anubis	97.88	0.00e+00	4528.00
IUUC-Psi-093502	Pelodiscus sinensis	98.38	0.00e+00	4510.00
IUUC-Pma-094454	Petromyzon marinus	76.91	0.00e+00	729.00
IUUC-Pfo-096173	Poecilia formosa	88.22	0.00e+00	3731.00
IUUC-Pab-098355	Pongo abelii	98.09	0.00e+00	3147.00
IUUC-Pca-100570	Procavia capensis	97.31	0.00e+00	1148.00
IUUC-Pva-102572	Pteropus vampyrus	93.20	0.00e+00	1330.00
IUUC-Rno-104916	Rattus norvegicus	95.15	0.00e+00	3904.00
IUUC-Sha-106653	Sarcophilus harrisii	99.46	0.00e+00	4558.00
IUUC-Sar-113517	Sorex araneus	90.36	0.00e+00	1271.00
IUUC-Ssc-115470	Sus scrofa	98.16	0.00e+00	2496.00
IUUC-Tgu-116932	Taeniopygia guttata	97.81	0.00e+00	4487.00
IUUC-Tru-117682	Takifugu rubripes	87.63	0.00e+00	2565.00
IUUC-Tsy-119417	Tarsius syrichta	93.58	0.00e+00	2431.00
IUUC-Tni-120442	Tetraodon nigroviridis	84.32	0.00e+00	3628.00
IUUC-Tbe-127456	Tupaia belangeri	85.13	0.00e+00	2087.00
IUUC-Ttr-128606	Tursiops truncatus	94.63	0.00e+00	1538.00
IUUC-Vpa-130112	Vicugna pacos	95.39	0.00e+00	3712.00
IUUC-Xtr-131929	Xenopus tropicalis	94.18	0.00e+00	4378.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence