iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-054426

UUCD1 version

UUC-LoA-01108

Ensembl Protein ID

ENSLAFP00000010704.3

UniProt Accession

G3TA40; G3TA40_LOXAF

Protein Name

Uncharacterized protein

Gene Name

USP25

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000012798.3	ENSLAFT00000012801.3	ENSLAFP00000010704.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	5.00e-64	217.0	81	567

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle....kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs 85
           +GlkN+gNtC++ +v+Q+L+n+ e+r+l+l+    ++ ++l+++++++++ +++++l+ lf+ l+ +k+k+v+p++ +++lk++ ++ +
   Q: 81   VGLKNVGNTCWFSAVIQSLFNLLEFRRLVLNykppSNAQDLPRNQKEHRNLPFMRELRYLFALLVGTKRKYVDPSRAVEILKDAFKS-N 168
           6******************************99988889999999999999*******************************99997.9 PP
   S: 86   gyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlsl 174
            ++qqD++Ef++ lld le+++++                  + +ee +++k k+++++lF g++    + +  +++ + +e f +++l
   Q: 169  DSQQQDVSEFTHKLLDWLEDAFQM------------------KAEEETDEEKPKNPMVELFYGRFLAVGVLE--GKKFENTEMFGQYPL 237
           **********************33..................123456788999************777664..444556899****** PP
   S: 175  pvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlsp 263
           +v+g +     +l++cLe+ + e e+e+   +++e+  k+    +++++++lP+vL+++L+Rf+f+++ +++eki++k+efp+ L l++
   Q: 238  QVNGFK-----DLHECLEAAMIEGEIES---LHSENSGKS---GQEHWFTELPPVLTFELSRFEFNQALGRPEKIHNKLEFPQVLYLDR 315
           ******.....9**************96...999998865...589******************************************* PP
   S: 264  fcts..................................................................................... 267
           ++++                                                                                     
   Q: 316  YMHRnreitrikreeikrlkdyltvlqqrlerylsygsgpkrfplvdvlqyalefasskpvctspvddidassppsgsipsqtlpstae 404
           ****8888888888888888777777777777777777777777777777777777777777777777777777777776666666666 PP
   S: 268  ..............peekqke.................................................................... 274
                                                                                                    
   Q: 405  pqgapssevpstspA-----Avaaissrsvihkpftqsrippdlpmhpaprhiteeelsvlegclhrwrteiendtrdlqesisrihrt 488
           666655555555550.....055555555555555555555666666666666666666666666666777777777777788888888 PP
   S: 275  ...........kkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetg.....staYvlfYk 336
                      ++ Y+L+av+vH+G+++ GHY+ay+ +++++ W++++D +Vt++++ee ++++      ++aY+l+Y 
   Q: 489  idlmysdksmiQVPYRLHAVLVHEGQANAGHYWAYIFDHHENrWMKYNDITVTKSSWEELVRDSFggyrnASAYCLMYI 567
           88888888888**************************966656***************99997779************6 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

SDVIDLTGDD KDDLQRAIAL SLAESNRAFR ETGITDEEQA ISRVLEASIA ENKACLKKTP 60
TEVWRDSRNP YDRKRQDKAP VGLKNVGNTC WFSAVIQSLF NLLEFRRLVL NYKPPSNAQD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCAGATGTGA TTGATCTCAC TGGAGATGAT AAAGATGATC TTCAGAGGGC AATTGCCTTG 60
AGTTTGGCGG AATCAAACAG GGCGTTCAGG GAGACTGGAA TAACTGATGA GGAGCAAGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR003903--UIM_dom
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50330--UIM
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH
PF02809--UIM

SMART

SM00726--UIM

Gene Ontology

GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:1904293--P:negative regulation of ERAD pathway
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001340	Ailuropoda melanoleuca	93.39	0.00e+00	1824.00
IUUC-Apl-004030	Anas platyrhynchos	82.46	0.00e+00	1669.00
IUUC-Aca-004753	Anolis carolinensis	65.31	0.00e+00	992.00
IUUC-Ani-009503	Aspergillus nidulans	33.96	1.00e-11	65.50
IUUC-Ame-010624	Astyanax mexicanus	70.35	0.00e+00	1077.00
IUUC-Bta-013166	Bos taurus	96.69	0.00e+00	1830.00
IUUC-Cel-018346	Caenorhabditis elegans	27.92	2.00e-29	125.00
IUUC-Cja-019150	Callithrix jacchus	96.67	0.00e+00	1276.00
IUUC-Cfa-020649	Canis familiaris	95.80	0.00e+00	1296.00
IUUC-Cpo-021807	Cavia porcellus	93.09	0.00e+00	1879.00
IUUC-Csa-023388	Chlorocebus sabaeus	96.82	0.00e+00	1285.00
IUUC-Cho-024343	Choloepus hoffmanni	84.05	0.00e+00	972.00
IUUC-Cin-025302	Ciona intestinalis	37.44	1.00e-95	343.00
IUUC-Csv-025911	Ciona savignyi	34.77	9.00e-130	457.00
IUUC-Cgl-026575	Colletotrichum gloeosporioides	34.58	2.00e-11	65.10
IUUC-Dre-028016	Danio rerio	76.98	0.00e+00	1057.00
IUUC-Dno-029495	Dasypus novemcinctus	96.66	0.00e+00	1300.00
IUUC-Dor-030948	Dipodomys ordii	81.69	0.00e+00	1422.00
IUUC-Eca-033214	Equus caballus	95.79	0.00e+00	959.00
IUUC-Fca-035876	Felis catus	96.58	0.00e+00	1866.00
IUUC-Fal-036762	Ficedula albicollis	84.39	0.00e+00	1116.00
IUUC-Gmo-039490	Gadus morhua	71.13	0.00e+00	1399.00
IUUC-Gga-040817	Gallus gallus	77.68	0.00e+00	1585.00
IUUC-Gac-042473	Gasterosteus aculeatus	71.73	0.00e+00	1430.00
IUUC-Ggo-044939	Gorilla gorilla	91.89	0.00e+00	1750.00
IUUC-Hsa-046204	Homo sapiens	96.90	0.00e+00	1816.00
IUUC-Kpa-049349	Komagataella pastoris	28.12	2.00e-10	61.60
IUUC-Lch-049572	Latimeria chalumnae	78.47	0.00e+00	1082.00
IUUC-Loc-052070	Lepisosteus oculatus	79.08	0.00e+00	1084.00
IUUC-Lma-053078	Leptosphaeria maculans	30.89	9.00e-13	69.70
IUUC-Mcc-055858	Macaca mulatta	96.96	0.00e+00	1287.00
IUUC-Mga-059808	Meleagris gallopavo	85.30	0.00e+00	1684.00
IUUC-Mmr-060987	Microcebus murinus	96.96	0.00e+00	1290.00
IUUC-Mmu-064245	Mus musculus	92.45	0.00e+00	1800.00
IUUC-Mpu-066304	Mustela putorius furo	95.80	0.00e+00	1295.00
IUUC-Mlu-067139	Myotis lucifugus	95.86	0.00e+00	1856.00
IUUC-Nfi-068458	Neosartorya fischeri	23.24	4.00e-16	80.90
IUUC-Nle-069075	Nomascus leucogenys	96.90	0.00e+00	1811.00
IUUC-Ont-072150	Oreochromis niloticus	74.86	0.00e+00	1062.00
IUUC-Oan-073054	Ornithorhynchus anatinus	78.72	0.00e+00	1541.00
IUUC-Ocu-074102	Oryctolagus cuniculus	97.53	0.00e+00	1311.00
IUUC-Ola-086529	Oryzias latipes	69.05	0.00e+00	1357.00
IUUC-Oga-088939	Otolemur garnettii	96.17	0.00e+00	1850.00
IUUC-Oar-090266	Ovis aries	96.23	0.00e+00	1296.00
IUUC-Ptr-090546	Pan troglodytes	96.69	0.00e+00	1812.00
IUUC-Pan-092311	Papio anubis	96.82	0.00e+00	1285.00
IUUC-Psi-093459	Pelodiscus sinensis	90.00	0.00e+00	1026.00
IUUC-Pfo-096726	Poecilia formosa	75.59	0.00e+00	1056.00
IUUC-Pab-097608	Pongo abelii	93.79	0.00e+00	1796.00
IUUC-Pca-100718	Procavia capensis	92.32	0.00e+00	1243.00
IUUC-Pva-103150	Pteropus vampyrus	92.47	0.00e+00	1461.00
IUUC-Rno-105727	Rattus norvegicus	93.48	0.00e+00	1773.00
IUUC-Sha-107051	Sarcophilus harrisii	88.61	0.00e+00	1731.00
IUUC-Sar-113097	Sorex araneus	85.97	0.00e+00	1697.00
IUUC-Sre-115145	Sporisorium reilianum	25.73	6.00e-11	63.90
IUUC-Ssc-115877	Sus scrofa	94.40	0.00e+00	1799.00
IUUC-Tgu-117473	Taeniopygia guttata	78.29	0.00e+00	1546.00
IUUC-Tru-118135	Takifugu rubripes	66.67	0.00e+00	1283.00
IUUC-Tsy-119471	Tarsius syrichta	89.09	0.00e+00	1765.00
IUUC-Tni-120139	Tetraodon nigroviridis	68.56	0.00e+00	1248.00
IUUC-Tbe-127549	Tupaia belangeri	89.18	0.00e+00	1730.00
IUUC-Ttr-128896	Tursiops truncatus	89.08	0.00e+00	1742.00
IUUC-Uma-129338	Ustilago maydis	24.60	6.00e-14	73.60
IUUC-Vda-129742	Verticillium dahliae	23.67	2.00e-12	68.90
IUUC-Vpa-130500	Vicugna pacos	91.76	0.00e+00	1171.00
IUUC-Xtr-132896	Xenopus tropicalis	80.31	0.00e+00	1583.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence