iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
RAID2
Post-translational Modifications (PTMs)
CPLM
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.80e-63	215.2	170	656

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle....kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs 85
           +GlkN+gNtC++ +v+Q+L+n+ e+r+l+l+    ++ ++l+++++++++ +++++l+ lf+ l+ +k+k+v+p++ +++lk++ ++ +
   Q: 170  VGLKNVGNTCWFSAVIQSLFNLLEFRRLVLNykppSNAQDLPRNQKEHRNLPFMRELRYLFALLVGTKRKYVDPSRAVEILKDAFKS-N 257
           6******************************99988889999999999999*******************************99997.9 PP
   S: 86   gyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlsl 174
            ++qqD++Ef++ lld le+++++                  + +ee +++k k+++++lF g++    + +   ++ + +e f +++l
   Q: 258  DSQQQDVSEFTHKLLDWLEDAFQM------------------KAEEETDEEKPKNPMVELFYGRFLAMGVLEG--KKFENTEMFGQYPL 326
           **********************33..................123456788999************8888754..44556899****** PP
   S: 175  pvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlsp 263
           +v+g +     +l++cLe+ + e e+e+   +++++  k+    +++++++lP+vL+++L+Rf+f+++ +++eki++k+efp+ L l++
   Q: 327  QVNGFK-----DLHECLEAAMIEGEIES---LHSDNSGKS---GQEHWFTELPPVLTFELSRFEFNQALGRPEKIHNKLEFPQVLYLDR 404
           ******.....9**************96...999998865...589******************************************* PP
   S: 264  fcts..................................................................................... 267
           ++++                                                                                     
   Q: 405  YMHRnreitrikreeikrlkdyltvlqqrlerylsygsgpkrfplvdvlqyalefasskpvctspvddidatsstsgstssqslpstte 493
           ****8888888888888888888888888888888888888888888888888888888777777777777777777666666655555 PP
   S: 268  peekqke.................................................................................. 274
           +     +                                                                                  
   Q: 494  Q-----Qgtpasdlpssspasgaalslrsvihkpftqsrippdlpmhpaprhiteeelsvlesclhrwrteiendtrdlqesisrihrt 577
           0.....15555555555566666666666666666666666666666666666666666777777777777777777777888888888 PP
   S: 275  ...........kkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetg.....staYvlfYk 336
                      ++ Y+L+av+vH+G+++ GHY+ay+ +++++ W++++D  Vt++++ee ++++      ++aY+l+Y 
   Q: 578  ielmysdksmiQVPYRLHAVLVHEGQANAGHYWAYIFDHRESrWMKYNDIAVTKSSWEELVRDSFggyrnASAYCLMYI 656
           88888888888**************************966556***************99997779************6 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MTVEQNVLQQ SAAQKHQQTF LNQLREITGI NDAQILQQAL KDSNGNLELA VAFLTAKNAK 60
TPPQEETAYY QTAALPGSDR YISVGSQADA NVIDLTGDDK DDLQRAIALS LAESNRTFRE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGCCGCGGT GGCGCTCTCC GGCAGCGTCT CGCCGCTTGC CCGCGGGGCC CGCGTTCGCC 60
CGCCGCCATC GCCTTCGCGC CCGGCTGGCG GGGGCGCCGT CCTCCCGGGC CGTCCGCGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1267--Proteomics identification
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR009060--UBA-like
IPR003903--UIM_dom
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50330--UIM
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH
PF02809--UIM

SMART

SM00726--UIM

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

rno:304150

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001340	Ailuropoda melanoleuca	90.88	0.00e+00	1935.00
IUUC-Apl-004030	Anas platyrhynchos	80.90	0.00e+00	1775.00
IUUC-Aca-004753	Anolis carolinensis	63.95	0.00e+00	981.00
IUUC-Ame-010624	Astyanax mexicanus	68.68	0.00e+00	1057.00
IUUC-Bta-013166	Bos taurus	92.88	0.00e+00	1932.00
IUUC-Cel-018346	Caenorhabditis elegans	28.17	2.00e-28	121.00
IUUC-Cja-019150	Callithrix jacchus	93.59	0.00e+00	1410.00
IUUC-Cfa-020649	Canis familiaris	93.20	0.00e+00	1424.00
IUUC-Cpo-021807	Cavia porcellus	90.98	0.00e+00	2011.00
IUUC-Csa-023388	Chlorocebus sabaeus	93.99	0.00e+00	1407.00
IUUC-Cho-024343	Choloepus hoffmanni	80.70	0.00e+00	952.00
IUUC-Cin-025302	Ciona intestinalis	37.90	6.00e-96	344.00
IUUC-Csv-025911	Ciona savignyi	34.91	5.00e-130	458.00
IUUC-Dre-028016	Danio rerio	75.16	0.00e+00	1162.00
IUUC-Dno-029495	Dasypus novemcinctus	89.96	0.00e+00	1413.00
IUUC-Dor-030948	Dipodomys ordii	79.58	0.00e+00	1400.00
IUUC-Fca-035876	Felis catus	93.56	0.00e+00	1947.00
IUUC-Fal-036762	Ficedula albicollis	83.15	0.00e+00	1103.00
IUUC-Gmo-039490	Gadus morhua	70.88	0.00e+00	1504.00
IUUC-Gga-040817	Gallus gallus	83.42	0.00e+00	1321.00
IUUC-Gac-042473	Gasterosteus aculeatus	71.57	0.00e+00	1539.00
IUUC-Ggo-044939	Gorilla gorilla	89.52	0.00e+00	1877.00
IUUC-Hsa-046204	Homo sapiens	93.75	0.00e+00	1940.00
IUUC-Kpa-049349	Komagataella pastoris	28.27	3.00e-10	61.20
IUUC-Lch-049572	Latimeria chalumnae	78.36	0.00e+00	1202.00
IUUC-Loc-052070	Lepisosteus oculatus	74.15	0.00e+00	1194.00
IUUC-Lma-053078	Leptosphaeria maculans	30.56	4.00e-12	67.40
IUUC-Laf-054426	Loxodonta africana	93.48	0.00e+00	1791.00
IUUC-Mcc-055858	Macaca mulatta	94.23	0.00e+00	1437.00
IUUC-Mga-059808	Meleagris gallopavo	83.70	0.00e+00	1791.00
IUUC-Mmr-060987	Microcebus murinus	94.09	0.00e+00	1420.00
IUUC-Mmu-064245	Mus musculus	96.02	0.00e+00	2032.00
IUUC-Mpu-066304	Mustela putorius furo	92.45	0.00e+00	1394.00
IUUC-Mlu-067139	Myotis lucifugus	93.27	0.00e+00	1963.00
IUUC-Nle-069075	Nomascus leucogenys	93.75	0.00e+00	1937.00
IUUC-Ont-072150	Oreochromis niloticus	74.69	0.00e+00	1175.00
IUUC-Oan-073054	Ornithorhynchus anatinus	78.62	0.00e+00	1653.00
IUUC-Ocu-074102	Oryctolagus cuniculus	90.09	0.00e+00	1410.00
IUUC-Ola-086529	Oryzias latipes	68.43	0.00e+00	1466.00
IUUC-Oga-088939	Otolemur garnettii	92.26	0.00e+00	1935.00
IUUC-Oar-090266	Ovis aries	92.81	0.00e+00	1397.00
IUUC-Ptr-090546	Pan troglodytes	93.56	0.00e+00	1937.00
IUUC-Pan-092311	Papio anubis	94.10	0.00e+00	1436.00
IUUC-Psi-093459	Pelodiscus sinensis	88.96	0.00e+00	1147.00
IUUC-Pfo-096726	Poecilia formosa	73.82	0.00e+00	1159.00
IUUC-Pab-097608	Pongo abelii	90.96	0.00e+00	1895.00
IUUC-Pca-100718	Procavia capensis	88.99	0.00e+00	1210.00
IUUC-Pva-103150	Pteropus vampyrus	89.67	0.00e+00	1441.00
IUUC-Sha-107051	Sarcophilus harrisii	86.35	0.00e+00	1818.00
IUUC-Sar-113097	Sorex araneus	83.40	0.00e+00	1767.00
IUUC-Ssc-115877	Sus scrofa	91.45	0.00e+00	1915.00
IUUC-Tgu-117473	Taeniopygia guttata	76.75	0.00e+00	1655.00
IUUC-Tru-118135	Takifugu rubripes	67.00	0.00e+00	1406.00
IUUC-Tsy-119471	Tarsius syrichta	87.09	0.00e+00	1738.00
IUUC-Tni-120139	Tetraodon nigroviridis	66.51	0.00e+00	1314.00
IUUC-Tbe-127549	Tupaia belangeri	87.03	0.00e+00	1826.00
IUUC-Ttr-128896	Tursiops truncatus	86.57	0.00e+00	1847.00
IUUC-Vpa-130500	Vicugna pacos	91.21	0.00e+00	1306.00
IUUC-Xtr-132896	Xenopus tropicalis	79.45	0.00e+00	1696.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence