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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046362
UUCD1 version UUC-HoS-00570
Ensembl Protein ID ENSP00000353793.3
UniProt Accession O75717; C9JW18; F6W0U7; WDHD1_HUMAN
Genbank Protein ID CAA06932.1; AAH00622.1; AAH43349.1; AAH63041.1
Protein Name WD repeat and HMG-box DNA-binding protein 1; Acidic nucleoplasmic DNA-binding protein 1
Genbank Nucleotide ID AJ006266; AL160471; BC043349; BC063041
Gene Name WDHD1; AND1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000198554.11 ENST00000360586.7 ENSP00000353793.3
ENSG00000198554.11 ENST00000567693.1 ENSP00000456806.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarmiRNAMapSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosSNPPhosphositePlus
dbPTMHPRDPhospho.ELMUniProt
PHOSIDABioGRIDmUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.10e-13 52.5 134 170
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf.sdtl.lvsGsdDgtikvWDlrtgvl 35
           gH ++v +l+f + ++ l+s+s Dg+++vW ++++++
   Q: 134  GHDAPVLSLSFdPKDIfLASASCDGSVRVWQISDQTC 170
           8**********7444447************9998887 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication.
 Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication.
Protein Sequence
(Fasta)
MPATRKPMRY GHTEGHTEVC FDDSGSFIVT CGSDGDVRIW EDLDDDDPKF INVGEKAYSC 60
ALKSGKLVTA VSNNTIQVHT FPEGVPDGIL TRFTTNANHV VFNGDGTKIA AGSSDFLVKI 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046362|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGGCGCAGTG TGGTGAGCGA GCCGAAGCGC GGGAAGCAGC TCTTGTGGAT CCTCAGTGGC 60
GGAGGCTCGG TCACCCGGGT GAGTCCCCAC TCCGGCTGCC CGCGTCCACC AAGGAGATGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046362|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation
KW-0853--WD repeat
Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR024977--Apc4_WD40_dom
IPR009071--HMG_box_dom
IPR022100--Mcl1_mid
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS50118--HMG_BOX_2
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF12894--ANAPC4_WD40
PF12341--Mcl1_mid
PF00400--WD40
SMART

SM00398--HMG
SM00320--WD40
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0003677--F:DNA binding
KEGG hsa:11169
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000357 Aegilops tauschii 29.07 9.00e-72 265.00
IUUC-Aml-001369 Ailuropoda melanoleuca 89.29 0.00e+00 1956.00
IUUC-Atr-002987 Amborella trichopoda 28.61 3.00e-78 286.00
IUUC-Apl-003331 Anas platyrhynchos 69.10 0.00e+00 1517.00
IUUC-Aca-004285 Anolis carolinensis 65.24 0.00e+00 1459.00
IUUC-Aly-005907 Arabidopsis lyrata 29.88 1.00e-67 251.00
IUUC-Ath-007037 Arabidopsis thaliana 29.02 7.00e-66 246.00
IUUC-Acl-008185 Aspergillus clavatus 25.29 4.00e-30 127.00
IUUC-Afl-008630 Aspergillus flavus 22.43 4.00e-55 209.00
IUUC-Afu-008921 Aspergillus fumigatus 23.58 2.00e-54 207.00
IUUC-Ani-009243 Aspergillus nidulans 22.05 4.00e-52 199.00
IUUC-Ang-009860 Aspergillus niger 25.54 2.00e-31 130.00
IUUC-Aor-010029 Aspergillus oryzae 22.43 4.00e-55 209.00
IUUC-Ate-010570 Aspergillus terreus 25.67 5.00e-33 136.00
IUUC-Bgr-012205 Blumeria graminis 25.65 3.00e-31 130.00
IUUC-Bta-012495 Bos taurus 87.18 0.00e+00 1933.00
IUUC-Bci-013848 Botrytis cinerea 23.33 2.00e-24 108.00
IUUC-Bdi-014162 Brachypodium distachyon 27.56 6.00e-73 269.00
IUUC-Bol-015828 Brassica oleracea 27.51 9.00e-64 238.00
IUUC-Bra-016792 Brassica rapa 29.31 1.00e-60 228.00
IUUC-Cja-018995 Callithrix jacchus 94.96 0.00e+00 2119.00
IUUC-Cfa-020713 Canis familiaris 89.58 0.00e+00 1797.00
IUUC-Cpo-021596 Cavia porcellus 76.41 0.00e+00 1630.00
IUUC-Cre-022785 Chlamydomonas reinhardtii 27.61 2.00e-19 92.00
IUUC-Csa-024080 Chlorocebus sabaeus 97.20 0.00e+00 2058.00
IUUC-Cho-024295 Choloepus hoffmanni 82.14 0.00e+00 709.00
IUUC-Cin-025123 Ciona intestinalis 48.56 3.00e-116 412.00
IUUC-Csv-025859 Ciona savignyi 46.94 2.00e-114 407.00
IUUC-Cgl-026546 Colletotrichum gloeosporioides 24.65 1.00e-26 115.00
IUUC-Cne-026873 Cryptococcus neoformans 28.57 4.00e-42 167.00
IUUC-Dre-028752 Danio rerio 57.71 0.00e+00 1216.00
IUUC-Dno-029844 Dasypus novemcinctus 80.41 0.00e+00 1722.00
IUUC-Dse-031515 Dothistroma septosporum 23.63 4.00e-54 206.00
IUUC-Dme-031614 Drosophila melanogaster 33.25 2.00e-56 214.00
IUUC-Ete-032291 Echinops telfairi 84.77 4.00e-154 539.00
IUUC-Eca-033665 Equus caballus 88.43 0.00e+00 1978.00
IUUC-Eeu-035036 Erinaceus europaeus 75.35 0.00e+00 823.00
IUUC-Fca-036209 Felis catus 89.12 0.00e+00 1969.00
IUUC-Fal-037229 Ficedula albicollis 67.28 0.00e+00 1486.00
IUUC-Fox-037686 Fusarium oxysporum 25.66 3.00e-28 119.00
IUUC-Fso-038120 Fusarium solani 26.51 1.00e-28 122.00
IUUC-Gmo-039627 Gadus morhua 60.16 5.00e-174 605.00
IUUC-Ggr-040058 Gaeumannomyces graminis 28.80 7.00e-25 109.00
IUUC-Gga-040825 Gallus gallus 69.61 0.00e+00 1501.00
IUUC-Gac-042000 Gasterosteus aculeatus 49.09 0.00e+00 979.00
IUUC-Gma-042961 Glycine max 29.95 5.00e-38 153.00
IUUC-Ggo-044531 Gorilla gorilla 99.20 0.00e+00 2223.00
IUUC-Hvu-047719 Hordeum vulgare 28.95 6.00e-72 266.00
IUUC-Itr-048089 Ictidomys tridecemlineatus 89.26 0.00e+00 811.00
IUUC-Lch-050106 Latimeria chalumnae 62.32 0.00e+00 1341.00
IUUC-Lpe-050996 Leersia perrieri 27.52 8.00e-71 262.00
IUUC-Loc-051766 Lepisosteus oculatus 58.76 0.00e+00 1304.00
IUUC-Lma-053144 Leptosphaeria maculans 23.13 5.00e-19 90.10
IUUC-Laf-054285 Loxodonta africana 86.72 0.00e+00 1868.00
IUUC-Mcc-054702 Macaca mulatta 97.79 0.00e+00 2121.00
IUUC-Meu-056634 Macropus eugenii 67.65 0.00e+00 688.00
IUUC-Mor-057040 Magnaporthe oryzae 23.16 1.00e-50 195.00
IUUC-Mpo-057395 Magnaporthe poae 27.83 2.00e-24 108.00
IUUC-Mtr-057830 Medicago truncatula 26.71 7.00e-71 262.00
IUUC-Mla-059152 Melampsora laricipopulina 23.90 3.00e-25 111.00
IUUC-Mga-059492 Meleagris gallopavo 69.55 0.00e+00 1528.00
IUUC-Mvi-060303 Microbotryum violaceum 27.74 2.00e-38 155.00
IUUC-Mmr-061066 Microcebus murinus 90.64 0.00e+00 2008.00
IUUC-Mdo-062039 Monodelphis domestica 74.43 0.00e+00 1618.00
IUUC-Mmu-063620 Mus musculus 83.27 0.00e+00 1828.00
IUUC-Mac-065638 Musa acuminata 27.38 3.00e-74 273.00
IUUC-Mpu-066212 Mustela putorius furo 84.01 0.00e+00 1867.00
IUUC-Mlu-068167 Myotis lucifugus 88.15 0.00e+00 1891.00
IUUC-Nfi-068338 Neosartorya fischeri 23.95 2.00e-53 204.00
IUUC-Ncr-068798 Neurospora crassa 23.45 9.00e-22 99.40
IUUC-Nle-069987 Nomascus leucogenys 97.70 0.00e+00 2148.00
IUUC-Opr-070369 Ochotona princeps 83.14 2.00e-127 450.00
IUUC-Ont-072317 Oreochromis niloticus 59.12 0.00e+00 1253.00
IUUC-Oan-073516 Ornithorhynchus anatinus 83.52 3.00e-140 491.00
IUUC-Ocu-074529 Oryctolagus cuniculus 87.10 0.00e+00 1954.00
IUUC-Oba-075044 Oryza barthii 28.02 5.00e-66 246.00
IUUC-Obr-076499 Oryza brachyantha 28.77 4.00e-64 240.00
IUUC-Ogl-077757 Oryza glaberrima 27.51 6.00e-66 246.00
IUUC-Ogu-078878 Oryza glumaepatula 28.28 1.00e-66 248.00
IUUC-Oin-079900 Oryza indica 28.77 1.00e-66 248.00
IUUC-Olo-080741 Oryza longistaminata 28.75 3.00e-66 247.00
IUUC-Ome-081734 Oryza meridionalis 28.41 2.00e-66 248.00
IUUC-Oni-082656 Oryza nivara 29.28 2.00e-66 247.00
IUUC-Opu-083312 Oryza punctata 27.30 8.00e-65 242.00
IUUC-Oru-084507 Oryza rufipogon 27.74 2.00e-66 247.00
IUUC-Osa-085329 Oryza sativa 27.36 1.00e-58 221.00
IUUC-Ola-086433 Oryzias latipes 64.68 0.00e+00 1083.00
IUUC-Olu-087690 Ostreococcus lucimarinus 27.18 3.00e-35 143.00
IUUC-Oga-088410 Otolemur garnettii 83.82 0.00e+00 1792.00
IUUC-Oar-089993 Ovis aries 86.47 0.00e+00 1903.00
IUUC-Ptr-091145 Pan troglodytes 99.47 0.00e+00 2196.00
IUUC-Pan-092500 Papio anubis 97.61 0.00e+00 2118.00
IUUC-Psi-093984 Pelodiscus sinensis 72.94 0.00e+00 1604.00
IUUC-Pma-094567 Petromyzon marinus 50.43 0.00e+00 669.00
IUUC-Pno-095002 Phaeosphaeria nodorum 25.34 6.00e-19 89.70
IUUC-Pfo-097387 Poecilia formosa 55.61 0.00e+00 1009.00
IUUC-Pab-097803 Pongo abelii 98.67 0.00e+00 2145.00
IUUC-Pop-099165 Populus trichocarpa 28.04 2.00e-68 254.00
IUUC-Pca-100989 Procavia capensis 68.75 2.00e-167 583.00
IUUC-Ppe-102022 Prunus persica 28.18 8.00e-70 259.00
IUUC-Pva-102389 Pteropus vampyrus 83.20 0.00e+00 1835.00
IUUC-Pgr-103635 Puccinia graminis 25.84 9.00e-31 129.00
IUUC-Ptt-103730 Puccinia triticina 27.35 1.00e-29 125.00
IUUC-Pte-104320 Pyrenophora teres 24.51 2.00e-39 157.00
IUUC-Pyt-104622 Pyrenophora triticirepentis 23.57 9.00e-36 145.00
IUUC-Rno-105689 Rattus norvegicus 81.50 0.00e+00 1803.00
IUUC-Sha-107448 Sarcophilus harrisii 75.50 0.00e+00 1598.00
IUUC-Sja-107702 Schizosaccharomyces japonicus 25.43 2.00e-49 191.00
IUUC-Spo-108360 Schizosaccharomyces pombe 25.83 2.00e-53 204.00
IUUC-Ssl-108529 Sclerotinia sclerotiorum 22.90 3.00e-43 170.00
IUUC-Smo-109337 Selaginella moellendorffii 27.25 1.00e-64 241.00
IUUC-Sit-110790 Setaria italica 29.03 2.00e-36 147.00
IUUC-Sly-111470 Solanum lycopersicum 27.31 4.00e-68 253.00
IUUC-Stu-111945 Solanum tuberosum 26.99 4.00e-70 259.00
IUUC-Sar-113075 Sorex araneus 74.82 0.00e+00 1368.00
IUUC-Sbi-114822 Sorghum bicolor 29.33 5.00e-63 236.00
IUUC-Sre-114913 Sporisorium reilianum 23.58 1.00e-36 149.00
IUUC-Ssc-116073 Sus scrofa 85.59 0.00e+00 1675.00
IUUC-Tgu-117253 Taeniopygia guttata 73.49 0.00e+00 1260.00
IUUC-Tru-117741 Takifugu rubripes 57.76 0.00e+00 1173.00
IUUC-Tsy-118834 Tarsius syrichta 93.51 0.00e+00 764.00
IUUC-Tni-120726 Tetraodon nigroviridis 56.66 0.00e+00 1192.00
IUUC-Tca-121655 Theobroma cacao 27.20 6.00e-74 272.00
IUUC-Tre-121921 Trichoderma reesei 24.01 6.00e-27 116.00
IUUC-Tvi-122540 Trichoderma virens 23.60 2.00e-25 111.00
IUUC-Tae-123225 Triticum aestivum 28.52 5.00e-72 266.00
IUUC-Tur-126398 Triticum urartu 28.81 6.00e-70 259.00
IUUC-Tme-127075 Tuber melanosporum 23.97 3.00e-57 216.00
IUUC-Tbe-128002 Tupaia belangeri 85.67 2.00e-162 566.00
IUUC-Ttr-129101 Tursiops truncatus 84.19 0.00e+00 1793.00
IUUC-Uma-129374 Ustilago maydis 23.87 2.00e-24 108.00
IUUC-Vda-129719 Verticillium dahliae 25.08 3.00e-24 107.00
IUUC-Vpa-130039 Vicugna pacos 87.36 0.00e+00 1917.00
IUUC-Vvi-131442 Vitis vinifera 27.91 4.00e-58 220.00
IUUC-Xtr-132599 Xenopus tropicalis 63.68 0.00e+00 1419.00
IUUC-Xma-132991 Xiphophorus maculatus 58.43 0.00e+00 1226.00
IUUC-Zma-135846 Zea mays 28.33 1.00e-69 258.00
Created Date 25-Jun-2017

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