iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000020614.1	ENSOART00000022458.1	ENSOARP00000022153.1
ENSOARG00000020614.1	ENSOART00000022459.1	ENSOARP00000022154.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.30e-96	324.1	1647	2026

Active Site

Position(s)	Description	Evidence
1993	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 6    kkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlq..pnpdsglknp.....................ehlk 69
           ++ le+++++E g++l G+t+ef+al+s+elq++dlgl++ +e   ++ +   + +++                         ++  
   Q: 1647 RAMLEIQYENEVGTGL-GPTLEFYALVSQELQRADLGLWRGEEVTLSNPKgsQEGTKY---IqnlqglfalpfgrtakpahiaKVKM 1729
           56899***********.**********************6665533332200222333...14458888999**********9999* PP
   S: 70   lFeflGrllgkalqdgrlldlplsksfyklllgkklsl..edleevdpelykslkeikena......es.................. 130
            F+flG+l++ka++d rl+dlpl  +fyk +l+++ sl  +dl ++dp +++s+  +++ +      e+                  
   Q: 1730 KFRFLGKLMAKAIMDFRLVDLPLGLPFYKWMLRQETSLtsHDLFDIDPVVARSVYHLEDIVrqkkrlEQdksqtkeslqyaletltm 1816
           **********************************654444**************999999855555511555666666554444444 PP
   S: 131  ...dieelgldltfsvseei.....lgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfneviplellslF 209
              ++e+            +     l+   + eLk gG++ipVt+ N+eeY +lv+ + l+eg+ +q+++fr+Gf++v+pl++l++F
   Q: 1817 ngcSVED------------LgldftLPGFPNIELKKGGKDIPVTIHNLEEYLRLVIFWALNEGVSRQFDSFRDGFESVFPLSHLQYF 1891
           4444444............25555578999********************************************************* PP
   S: 210  teeelellicGe..eeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelkprlfvirk... 291
            +eel++l+cG+  +++d+++l + ++ ++gyt+ds+a+++++e+l++f++e+++ fLqFvTgs+rlP+gGf++l+p l+++rk   
   Q: 1892 YPEELDQLLCGSkaDTWDAKTLMECCRPDHGYTHDSRAVKFLFEILSSFDNEQQRLFLQFVTGSPRLPVGGFRSLNPPLTIVRKtfe 1978
           ************7778999999999999*********************************************************** PP
   S: 292  ..dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFels 336
             ++ dd lPs++TC+nyLkLP+Yss ei++ekLl+A +e+ ++F+ls
   Q: 1979 stENPDDFLPSVMTCVNYLKLPDYSSLEIMREKLLMAAREGqQSFHLS 2026
           988888***************************************985 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

MSNRPNNNPG GSLRRSQRNT AGAQPQDDSI GGRSCSSSSV VIVPQPEDPD RANTSEKQKT 60
GQVPKKDNSR GVKRSASPDY NRTNSPSSAK KPKALQHTES PSETSKPHSK SKKRHLDQEP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGAATGGTAG TGTCTAGAAA GGGTATGTCC CTTCAAGAGA GAGGTGCCAA TGTCCAACCG 60
GCCTAATAAC AATCCAGGGG GGTCACTGCG ACGTTCACAG AGGAACACTG CCGGGGCCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR000569--HECT_dom
IPR004170--WWE-dom
IPR018123--WWE-dom_subgr

PROSITE

PS50237--HECT
PS50918--WWE

Pfam

PF00632--HECT
PF02825--WWE

SMART

SM00119--HECTc
SM00678--WWE

Gene Ontology

GO:0016607--C:nuclear speck
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0009790--P:embryo development
GO:2000780--P:negative regulation of double-strand break repair
GO:1901315--P:negative regulation of histone H2A K63-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000750	Aegilops tauschii	38.69	1.00e-126	448.00
IUUC-Aml-001502	Ailuropoda melanoleuca	94.29	0.00e+00	3529.00
IUUC-Atr-002821	Amborella trichopoda	37.45	4.00e-117	417.00
IUUC-Apl-003531	Anas platyrhynchos	91.09	0.00e+00	3304.00
IUUC-Aly-005962	Arabidopsis lyrata	38.80	3.00e-114	407.00
IUUC-Ath-006636	Arabidopsis thaliana	38.66	4.00e-114	407.00
IUUC-Ago-007875	Ashbya gossypii	36.20	4.00e-82	300.00
IUUC-Acl-008242	Aspergillus clavatus	35.85	7.00e-114	405.00
IUUC-Afl-008736	Aspergillus flavus	39.01	2.00e-110	394.00
IUUC-Afu-008812	Aspergillus fumigatus	35.25	1.00e-114	408.00
IUUC-Ani-009407	Aspergillus nidulans	37.58	2.00e-110	395.00
IUUC-Ang-009763	Aspergillus niger	40.18	3.00e-106	380.00
IUUC-Aor-009941	Aspergillus oryzae	30.77	1.00e-112	401.00
IUUC-Ate-010459	Aspergillus terreus	36.42	1.00e-85	312.00
IUUC-Ame-011761	Astyanax mexicanus	87.75	0.00e+00	2972.00
IUUC-Bgr-012265	Blumeria graminis	35.01	2.00e-104	374.00
IUUC-Bta-013070	Bos taurus	96.99	0.00e+00	3643.00
IUUC-Bci-013890	Botrytis cinerea	39.92	7.00e-103	369.00
IUUC-Bdi-014046	Brachypodium distachyon	38.47	5.00e-122	433.00
IUUC-Bol-015942	Brassica oleracea	44.23	2.00e-114	408.00
IUUC-Bra-016849	Brassica rapa	44.23	4.00e-114	407.00
IUUC-Cja-019046	Callithrix jacchus	93.00	0.00e+00	3481.00
IUUC-Cfa-020521	Canis familiaris	92.46	0.00e+00	3391.00
IUUC-Cpo-021639	Cavia porcellus	90.54	0.00e+00	3420.00
IUUC-Cre-022767	Chlamydomonas reinhardtii	39.88	1.00e-89	323.00
IUUC-Csa-023231	Chlorocebus sabaeus	95.45	0.00e+00	3565.00
IUUC-Cho-024380	Choloepus hoffmanni	92.72	0.00e+00	2151.00
IUUC-Cin-025482	Ciona intestinalis	51.21	4.00e-160	557.00
IUUC-Csv-026121	Ciona savignyi	48.20	0.00e+00	1538.00
IUUC-Cgl-026716	Colletotrichum gloeosporioides	34.79	2.00e-110	394.00
IUUC-Cne-026857	Cryptococcus neoformans	39.89	1.00e-94	342.00
IUUC-Cme-027226	Cyanidioschyzon merolae	35.14	2.00e-74	275.00
IUUC-Dre-028174	Danio rerio	87.70	0.00e+00	3014.00
IUUC-Dor-030939	Dipodomys ordii	86.49	0.00e+00	2762.00
IUUC-Dse-031444	Dothistroma septosporum	39.52	2.00e-105	378.00
IUUC-Dme-032162	Drosophila melanogaster	67.73	2.00e-174	607.00
IUUC-Ete-032345	Echinops telfairi	90.12	0.00e+00	2288.00
IUUC-Eca-033229	Equus caballus	96.57	0.00e+00	3454.00
IUUC-Eeu-035205	Erinaceus europaeus	85.64	0.00e+00	3066.00
IUUC-Fca-036444	Felis catus	93.62	0.00e+00	3479.00
IUUC-Fal-037131	Ficedula albicollis	91.88	0.00e+00	3430.00
IUUC-Fox-038035	Fusarium oxysporum	36.16	2.00e-109	390.00
IUUC-Fso-038320	Fusarium solani	37.07	2.00e-109	391.00
IUUC-Gmo-039497	Gadus morhua	81.07	0.00e+00	3037.00
IUUC-Ggr-040057	Gaeumannomyces graminis	34.75	6.00e-108	386.00
IUUC-Gga-041021	Gallus gallus	91.92	0.00e+00	3448.00
IUUC-Gac-042474	Gasterosteus aculeatus	81.53	0.00e+00	3019.00
IUUC-Gma-043060	Glycine max	38.92	6.00e-122	432.00
IUUC-Ggo-044855	Gorilla gorilla	95.72	0.00e+00	3476.00
IUUC-Hsa-046147	Homo sapiens	95.56	0.00e+00	3531.00
IUUC-Hvu-047775	Hordeum vulgare	38.69	8.00e-125	442.00
IUUC-Itr-048131	Ictidomys tridecemlineatus	98.03	0.00e+00	3527.00
IUUC-Kpa-049098	Komagataella pastoris	38.10	2.00e-86	315.00
IUUC-Lch-049818	Latimeria chalumnae	86.47	0.00e+00	3102.00
IUUC-Lpe-051017	Leersia perrieri	38.44	1.00e-118	422.00
IUUC-Loc-051777	Lepisosteus oculatus	85.70	0.00e+00	3244.00
IUUC-Lma-052990	Leptosphaeria maculans	39.74	2.00e-111	398.00
IUUC-Laf-053727	Loxodonta africana	96.82	0.00e+00	3482.00
IUUC-Mcc-055799	Macaca mulatta	94.00	0.00e+00	3470.00
IUUC-Meu-056065	Macropus eugenii	93.79	0.00e+00	2098.00
IUUC-Mor-057054	Magnaporthe oryzae	38.67	8.00e-107	382.00
IUUC-Mpo-057417	Magnaporthe poae	39.36	4.00e-109	390.00
IUUC-Mtr-057849	Medicago truncatula	37.36	1.00e-113	405.00
IUUC-Mla-058870	Melampsora laricipopulina	42.37	3.00e-106	380.00
IUUC-Mga-059580	Meleagris gallopavo	89.86	0.00e+00	2912.00
IUUC-Mvi-060507	Microbotryum violaceum	40.19	8.00e-113	402.00
IUUC-Mmr-060816	Microcebus murinus	95.36	0.00e+00	3550.00
IUUC-Mdo-062866	Monodelphis domestica	90.93	0.00e+00	3273.00
IUUC-Mmu-063906	Mus musculus	97.29	0.00e+00	3585.00
IUUC-Mac-064675	Musa acuminata	38.76	1.00e-111	397.00
IUUC-Mpu-066199	Mustela putorius furo	93.91	0.00e+00	3457.00
IUUC-Mlu-067110	Myotis lucifugus	97.78	0.00e+00	3584.00
IUUC-Nfi-068482	Neosartorya fischeri	35.40	3.00e-114	407.00
IUUC-Ncr-068906	Neurospora crassa	38.94	8.00e-109	389.00
IUUC-Nle-069410	Nomascus leucogenys	93.76	0.00e+00	3475.00
IUUC-Opr-070401	Ochotona princeps	86.18	0.00e+00	1946.00
IUUC-Ont-072100	Oreochromis niloticus	81.81	0.00e+00	3082.00
IUUC-Oan-073121	Ornithorhynchus anatinus	92.13	0.00e+00	3533.00
IUUC-Ocu-074623	Oryctolagus cuniculus	93.62	0.00e+00	3474.00
IUUC-Oba-075380	Oryza barthii	36.51	1.00e-113	404.00
IUUC-Obr-076915	Oryza brachyantha	37.77	8.00e-119	422.00
IUUC-Ogl-077055	Oryza glaberrima	38.42	3.00e-118	420.00
IUUC-Ogu-078892	Oryza glumaepatula	40.36	9.00e-113	402.00
IUUC-Oin-079256	Oryza indica	38.38	1.00e-117	418.00
IUUC-Olo-080343	Oryza longistaminata	38.38	6.00e-118	419.00
IUUC-Ome-081422	Oryza meridionalis	38.10	2.00e-117	417.00
IUUC-Oni-083047	Oryza nivara	36.66	8.00e-115	408.00
IUUC-Opu-083641	Oryza punctata	36.44	2.00e-111	397.00
IUUC-Oru-084439	Oryza rufipogon	40.36	3.00e-113	403.00
IUUC-Osa-085972	Oryza sativa	38.16	1.00e-116	414.00
IUUC-Ola-087173	Oryzias latipes	82.56	0.00e+00	3064.00
IUUC-Olu-087871	Ostreococcus lucimarinus	36.89	4.00e-89	322.00
IUUC-Oga-087908	Otolemur garnettii	92.90	0.00e+00	3481.00
IUUC-Ptr-091543	Pan troglodytes	96.35	0.00e+00	3534.00
IUUC-Pan-092243	Papio anubis	93.96	0.00e+00	3471.00
IUUC-Psi-093150	Pelodiscus sinensis	91.44	0.00e+00	3463.00
IUUC-Pno-094891	Phaeosphaeria nodorum	41.09	1.00e-112	401.00
IUUC-Ppa-095181	Physcomitrella patens	42.14	2.00e-107	383.00
IUUC-Pfo-096267	Poecilia formosa	83.41	0.00e+00	3040.00
IUUC-Pab-098072	Pongo abelii	96.77	0.00e+00	3477.00
IUUC-Pop-099190	Populus trichocarpa	41.34	5.00e-116	413.00
IUUC-Pca-100311	Procavia capensis	90.12	0.00e+00	3252.00
IUUC-Ppe-101284	Prunus persica	37.37	1.00e-115	412.00
IUUC-Pva-102215	Pteropus vampyrus	88.34	0.00e+00	1239.00
IUUC-Pgr-103694	Puccinia graminis	40.48	5.00e-104	373.00
IUUC-Ptt-103916	Puccinia triticina	38.80	4.00e-98	353.00
IUUC-Pte-104346	Pyrenophora teres	39.41	1.00e-109	392.00
IUUC-Pyt-104508	Pyrenophora triticirepentis	39.48	7.00e-110	392.00
IUUC-Rno-105315	Rattus norvegicus	96.17	0.00e+00	3407.00
IUUC-Sce-106273	Saccharomyces cerevisiae	35.00	2.00e-71	265.00
IUUC-Sha-106835	Sarcophilus harrisii	93.33	0.00e+00	3548.00
IUUC-Sja-107943	Schizosaccharomyces japonicus	37.58	9.00e-95	342.00
IUUC-Spo-108081	Schizosaccharomyces pombe	37.26	8.00e-95	342.00
IUUC-Ssl-108560	Sclerotinia sclerotiorum	40.12	2.00e-106	381.00
IUUC-Smo-108776	Selaginella moellendorffii	43.28	2.00e-112	401.00
IUUC-Sit-110717	Setaria italica	37.94	2.00e-120	427.00
IUUC-Sly-111469	Solanum lycopersicum	38.97	6.00e-122	432.00
IUUC-Stu-112896	Solanum tuberosum	38.22	8.00e-106	378.00
IUUC-Sar-113224	Sorex araneus	87.90	0.00e+00	1878.00
IUUC-Sbi-114313	Sorghum bicolor	38.02	1.00e-123	438.00
IUUC-Sre-114993	Sporisorium reilianum	34.09	1.00e-100	362.00
IUUC-Ssc-115535	Sus scrofa	94.39	0.00e+00	3476.00
IUUC-Tgu-117493	Taeniopygia guttata	89.59	0.00e+00	2631.00
IUUC-Tru-118669	Takifugu rubripes	79.60	0.00e+00	2968.00
IUUC-Tsy-119373	Tarsius syrichta	94.18	0.00e+00	1860.00
IUUC-Tni-120049	Tetraodon nigroviridis	77.25	0.00e+00	860.00
IUUC-Tca-121779	Theobroma cacao	38.76	1.00e-115	412.00
IUUC-Tre-122195	Trichoderma reesei	35.95	1.00e-105	378.00
IUUC-Tvi-122650	Trichoderma virens	36.17	4.00e-109	390.00
IUUC-Tae-123580	Triticum aestivum	38.58	1.00e-124	441.00
IUUC-Tur-126295	Triticum urartu	38.54	1.00e-125	444.00
IUUC-Tme-126964	Tuber melanosporum	40.28	2.00e-105	377.00
IUUC-Tbe-128149	Tupaia belangeri	81.74	0.00e+00	1463.00
IUUC-Ttr-128165	Tursiops truncatus	94.78	0.00e+00	3056.00
IUUC-Uma-129365	Ustilago maydis	36.07	6.00e-89	323.00
IUUC-Vda-129725	Verticillium dahliae	41.48	7.00e-110	392.00
IUUC-Vpa-130678	Vicugna pacos	97.08	0.00e+00	2680.00
IUUC-Vvi-131147	Vitis vinifera	39.09	1.00e-121	431.00
IUUC-Xtr-132636	Xenopus tropicalis	88.23	0.00e+00	3242.00
IUUC-Xma-133458	Xiphophorus maculatus	83.92	0.00e+00	3076.00
IUUC-Yli-134481	Yarrowia lipolytica	39.56	4.00e-98	353.00
IUUC-Zma-135782	Zea mays	37.16	8.00e-118	419.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence