iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ptr-091069

UUCD1 version

UUC-PaT-01001

Ensembl Protein ID

ENSPTRP00000023301.5

UniProt Accession

H2QKH0; H2QKH0_PANTR

Genbank Protein ID

JAA04048.1; JAA15358.1

Protein Name

Ubiquitin-conjugating enzyme E2C

Genbank Nucleotide ID

AACZ03018248; GABF01006787

Gene Name

LOC736246; UBE2C

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000013564.6	ENSPTRT00000025249.5	ENSPTRP00000023301.5

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	1.50e-45	154.4	34	166

Active Site

Position(s)	Description	Evidence
114	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00388}

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkee 89
           Rl++el++l+ +  +gisa p+++ +l++w  +i G ++t+Ye+  +kl++efp+ YP+++P+vkflt+++hPnv+++G++Cl+ilk  
   Q: 34   RLQQELMTLMMSGDKGISAFPESD-NLFKWVGTIHGAAGTVYEDLRYKLSLEFPSGYPYNAPTVKFLTPCYHPNVDTQGNICLDILK-- 119
           9***********************.9************************************************************9.. PP
   S: 90   ekWspalsvesvllsiqsllaepnpesplneeaaellkknreeykkkv 137
           ekWs+ ++v+++llsiqsll epn++spln++aael+k+   ++kk +
   Q: 120  EKWSALYDVRTILLSIQSLLGEPNIDSPLNTHAAELWKNPT-AFKKYL 166
           ***********************************997655.488765 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MASQNRDPAA TSVAAARKGA EPSGGAARGP VGKRLQQELM TLMMSGDKGI SAFPESDNLF 60
KWVGTIHGAA GTVYEDLRYK LSLEFPSGYP YNAPTVKFLT PCYHPNVDTQ GNICLDILKE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCTTCCC AAAACCGCGA CCCAGCCGCC ACTAGCGTTG CCGCCGCCCG TAAAGGAGCT 60
GAGCCGAGCG GGGGCGCCGC CCGGGGTCCG GTGGGCAAAA GGTGAGTGAT GCGGCTTACC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0000209--P:protein polyubiquitination
GO:0030071--P:regulation of mitotic metaphase/anaphase transition

KEGG

ptr:736246

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001924	Ailuropoda melanoleuca	95.58	1.00e-94	337.00
IUUC-Atr-002885	Amborella trichopoda	60.90	3.00e-53	200.00
IUUC-Aly-006086	Arabidopsis lyrata	58.79	5.00e-53	199.00
IUUC-Ath-006897	Arabidopsis thaliana	58.33	9.00e-52	195.00
IUUC-Acl-008223	Aspergillus clavatus	66.14	5.00e-39	153.00
IUUC-Afl-008675	Aspergillus flavus	54.22	2.00e-38	151.00
IUUC-Afu-008997	Aspergillus fumigatus	65.35	8.00e-38	149.00
IUUC-Ani-009470	Aspergillus nidulans	55.42	7.00e-39	152.00
IUUC-Ang-009648	Aspergillus niger	58.78	2.00e-38	151.00
IUUC-Aor-009977	Aspergillus oryzae	57.25	3.00e-31	127.00
IUUC-Ate-010318	Aspergillus terreus	51.14	4.00e-38	150.00
IUUC-Ame-011302	Astyanax mexicanus	76.47	6.00e-75	272.00
IUUC-Bta-013101	Bos taurus	97.21	1.00e-99	354.00
IUUC-Bci-013787	Botrytis cinerea	56.71	8.00e-45	172.00
IUUC-Bdi-014144	Brachypodium distachyon	68.57	8.00e-57	212.00
IUUC-Bol-015613	Brassica oleracea	57.40	4.00e-53	200.00
IUUC-Bra-017249	Brassica rapa	57.99	5.00e-53	200.00
IUUC-Cfa-020588	Canis familiaris	97.77	8.00e-97	345.00
IUUC-Cpo-021384	Cavia porcellus	97.21	6.00e-100	355.00
IUUC-Csa-023437	Chlorocebus sabaeus	98.88	1.00e-104	371.00
IUUC-Cho-024330	Choloepus hoffmanni	98.29	1.00e-67	247.00
IUUC-Cin-025365	Ciona intestinalis	56.88	1.00e-32	131.00
IUUC-Csv-025933	Ciona savignyi	62.07	1.00e-59	221.00
IUUC-Cgl-026494	Colletotrichum gloeosporioides	57.14	2.00e-44	171.00
IUUC-Cme-027266	Cyanidioschyzon merolae	51.61	1.00e-37	149.00
IUUC-Dre-027375	Danio rerio	76.47	2.00e-74	271.00
IUUC-Dno-029921	Dasypus novemcinctus	94.97	9.00e-94	335.00
IUUC-Dor-030209	Dipodomys ordii	93.85	3.00e-95	340.00
IUUC-Dse-031516	Dothistroma septosporum	54.67	3.00e-38	150.00
IUUC-Dme-031942	Drosophila melanogaster	66.43	2.00e-55	207.00
IUUC-Ete-032827	Echinops telfairi	84.69	4.00e-41	158.00
IUUC-Eca-034073	Equus caballus	98.32	3.00e-97	346.00
IUUC-Eeu-034854	Erinaceus europaeus	74.86	5.00e-68	249.00
IUUC-Fca-035666	Felis catus	98.32	3.00e-97	346.00
IUUC-Fal-037652	Ficedula albicollis	88.57	3.00e-54	202.00
IUUC-Fox-037793	Fusarium oxysporum	55.49	1.00e-43	168.00
IUUC-Fso-038151	Fusarium solani	57.41	7.00e-45	172.00
IUUC-Gmo-038894	Gadus morhua	77.22	8.00e-61	225.00
IUUC-Ggr-039730	Gaeumannomyces graminis	60.29	7.00e-35	139.00
IUUC-Gga-040537	Gallus gallus	88.24	2.00e-71	260.00
IUUC-Gac-041346	Gasterosteus aculeatus	71.59	6.00e-62	229.00
IUUC-Gma-043989	Glycine max	58.08	2.00e-54	204.00
IUUC-Ggo-045594	Gorilla gorilla	98.90	3.00e-104	369.00
IUUC-Hsa-046216	Homo sapiens	100.00	1.00e-105	375.00
IUUC-Hvu-047797	Hordeum vulgare	69.40	5.00e-54	203.00
IUUC-Itr-048402	Ictidomys tridecemlineatus	98.32	3.00e-97	346.00
IUUC-Kpa-049294	Komagataella pastoris	58.64	7.00e-49	186.00
IUUC-Lch-049761	Latimeria chalumnae	70.95	9.00e-73	265.00
IUUC-Lpe-051089	Leersia perrieri	62.82	3.00e-55	207.00
IUUC-Loc-052297	Lepisosteus oculatus	77.65	8.00e-74	270.00
IUUC-Lma-053214	Leptosphaeria maculans	50.32	8.00e-43	165.00
IUUC-Laf-054468	Loxodonta africana	95.58	3.00e-101	360.00
IUUC-Mcc-055338	Macaca mulatta	98.88	1.00e-104	371.00
IUUC-Meu-056147	Macropus eugenii	92.18	1.00e-93	335.00
IUUC-Mor-057239	Magnaporthe oryzae	53.61	2.00e-41	161.00
IUUC-Mpo-057491	Magnaporthe poae	61.76	2.00e-43	168.00
IUUC-Mtr-057687	Medicago truncatula	59.64	3.00e-48	184.00
IUUC-Mla-058880	Melampsora laricipopulina	65.00	7.00e-51	192.00
IUUC-Mga-059929	Meleagris gallopavo	88.78	7.00e-50	187.00
IUUC-Mvi-060528	Microbotryum violaceum	57.06	3.00e-46	177.00
IUUC-Mmr-060747	Microcebus murinus	98.14	5.00e-86	309.00
IUUC-Mdo-062343	Monodelphis domestica	93.89	1.00e-94	338.00
IUUC-Mmu-063563	Mus musculus	95.53	1.00e-97	348.00
IUUC-Mac-064823	Musa acuminata	64.54	1.00e-53	201.00
IUUC-Mpu-065746	Mustela putorius furo	96.69	2.00e-95	340.00
IUUC-Mlu-067388	Myotis lucifugus	95.58	4.00e-94	336.00
IUUC-Nfi-068577	Neosartorya fischeri	62.32	2.00e-38	151.00
IUUC-Ncr-068803	Neurospora crassa	56.96	2.00e-38	151.00
IUUC-Opr-070902	Ochotona princeps	93.33	4.00e-94	336.00
IUUC-Ont-071672	Oreochromis niloticus	69.71	2.00e-64	238.00
IUUC-Oan-073728	Ornithorhynchus anatinus	81.93	3.00e-38	149.00
IUUC-Ocu-074566	Oryctolagus cuniculus	92.78	4.00e-91	326.00
IUUC-Oba-075538	Oryza barthii	67.18	1.00e-51	194.00
IUUC-Obr-076757	Oryza brachyantha	69.57	4.00e-36	142.00
IUUC-Ogu-078467	Oryza glumaepatula	65.75	8.00e-56	209.00
IUUC-Oin-079533	Oryza indica	66.41	5.00e-51	192.00
IUUC-Olo-080673	Oryza longistaminata	67.94	3.00e-52	196.00
IUUC-Ome-081483	Oryza meridionalis	67.14	5.00e-55	206.00
IUUC-Oni-082321	Oryza nivara	65.75	8.00e-56	209.00
IUUC-Opu-083245	Oryza punctata	65.71	9.00e-54	202.00
IUUC-Oru-084641	Oryza rufipogon	62.99	4.00e-54	203.00
IUUC-Osa-085992	Oryza sativa	65.75	8.00e-56	209.00
IUUC-Ola-086807	Oryzias latipes	72.47	5.00e-72	263.00
IUUC-Olu-087834	Ostreococcus lucimarinus	70.80	6.00e-56	208.00
IUUC-Oga-088699	Otolemur garnettii	95.60	6.00e-102	362.00
IUUC-Oar-089542	Ovis aries	96.69	2.00e-95	340.00
IUUC-Pan-092533	Papio anubis	97.79	3.00e-103	367.00
IUUC-Psi-093581	Pelodiscus sinensis	67.47	1.00e-58	218.00
IUUC-Pma-094607	Petromyzon marinus	72.35	4.00e-71	259.00
IUUC-Pno-094829	Phaeosphaeria nodorum	54.05	9.00e-43	165.00
IUUC-Ppa-095861	Physcomitrella patens	66.43	1.00e-55	208.00
IUUC-Pfo-096836	Poecilia formosa	70.11	5.00e-67	246.00
IUUC-Pab-098707	Pongo abelii	100.00	1.00e-105	375.00
IUUC-Pop-099870	Populus trichocarpa	66.43	5.00e-54	203.00
IUUC-Pca-100661	Procavia capensis	97.21	4.00e-99	352.00
IUUC-Ppe-101289	Prunus persica	57.14	2.00e-54	204.00
IUUC-Pva-103235	Pteropus vampyrus	93.30	1.00e-88	318.00
IUUC-Pte-104292	Pyrenophora teres	58.65	4.00e-43	166.00
IUUC-Rno-105501	Rattus norvegicus	96.09	2.00e-98	350.00
IUUC-Sce-106133	Saccharomyces cerevisiae	62.79	1.00e-37	148.00
IUUC-Sha-107205	Sarcophilus harrisii	93.62	3.00e-77	280.00
IUUC-Sja-108009	Schizosaccharomyces japonicus	56.98	5.00e-50	189.00
IUUC-Spo-108136	Schizosaccharomyces pombe	54.97	2.00e-50	191.00
IUUC-Ssl-108394	Sclerotinia sclerotiorum	56.71	1.00e-44	172.00
IUUC-Smo-109459	Selaginella moellendorffii	64.71	3.00e-52	197.00
IUUC-Sit-110754	Setaria italica	66.43	3.00e-55	207.00
IUUC-Sly-111137	Solanum lycopersicum	65.49	2.00e-53	201.00
IUUC-Stu-112305	Solanum tuberosum	65.28	7.00e-54	202.00
IUUC-Sbi-114299	Sorghum bicolor	63.38	1.00e-51	195.00
IUUC-Ssc-115625	Sus scrofa	97.77	3.00e-97	346.00
IUUC-Tru-118289	Takifugu rubripes	75.58	1.00e-36	143.00
IUUC-Tni-120070	Tetraodon nigroviridis	73.28	5.00e-57	212.00
IUUC-Tca-121158	Theobroma cacao	59.28	2.00e-54	204.00
IUUC-Tre-121973	Trichoderma reesei	57.23	1.00e-44	172.00
IUUC-Tvi-122496	Trichoderma virens	56.89	1.00e-44	172.00
IUUC-Tae-123596	Triticum aestivum	65.75	3.00e-56	210.00
IUUC-Tur-126818	Triticum urartu	64.66	2.00e-42	163.00
IUUC-Tme-127044	Tuber melanosporum	65.69	5.00e-42	163.00
IUUC-Ttr-128548	Tursiops truncatus	76.54	3.00e-68	250.00
IUUC-Vda-129840	Verticillium dahliae	55.09	2.00e-43	168.00
IUUC-Vvi-131685	Vitis vinifera	60.84	1.00e-55	208.00
IUUC-Xtr-132953	Xenopus tropicalis	79.33	2.00e-82	297.00
IUUC-Xma-134093	Xiphophorus maculatus	70.11	4.00e-67	246.00
IUUC-Yli-134548	Yarrowia lipolytica	57.23	3.00e-51	194.00
IUUC-Zma-135182	Zea mays	65.71	2.00e-54	204.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence