iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-089325

Ensembl Protein ID

ENSOARP00000011807.1

UniProt Accession

W5PMY2; W5PMY2_SHEEP

Genbank Protein ID

ENSOARP00000011807

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AMGL01027268

Gene Name

USP10

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000011010.1	ENSOART00000011979.1	ENSOARP00000011807.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	6.60e-69	232.8	400	778

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw......kskkk.............avspr 71
           Gl N gN CY+N++LQ+L+++p++ +l++   +   +  +++ +++++++s+ +l++e++      k ++              a++p+
   Q: 400  GLINKGNWCYINATLQALVACPPMYHLMKF-IPLYSK-VQRPCTSTPMIDSFVRLMNEFTnmpvppKPRQAlgdkivrdirpgaAFEPT 486
           9***************************99.333333.334799***************7666654333337777888888888***** PP
   S: 72   ellkalkkeaeefs.gyeqqDaqEflaflldqleeelkk.................eknkpkeeeeeedkselsde............a 130
            +++ l  +++++s + +q+Da+E+l f+l++l+ee+ +                  k+++++e e+e+      e            +
   Q: 487  YIYRLLTVIKSSLSeKGRQEDAEEYLGFILNGLHEEMLNlkkllspnnekltisngPKSHSVNEDEQEEPG----EgsedeweqvgprN 571
           *9999999999966599********************4456678777677775444333333333333333....25555566665551 PP
   S: 131  eekkkkknk...........slisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkkeslqdcLesftkeeelegenkyyc 208
                   k           ++i+ +F+g+++ +++ ++  ++s + +pf++l+l++++++ +   ++qd+Les +++e+++g    y+
   Q: 572  --------KtsvtrqadfvqTPITGIFGGHIR-SVVYQQSSKESATLQPFFTLQLDIQSDKIR---TVQDALESLVARESVQG----YT 644
           ........344444445666***********9.688999999*******************99...****************8....99 PP
   S: 209  ekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqke...kkkYeLiavvvHsG.slssG 293
           +k k+++e +++++l+klP+vL+lhLkRf ++++++++ k+ k++e+p  L++s+ + sp  k+k+   +++Y+L+avv+H+G s+ +G
   Q: 645  TKTKQEVEISRRVTLEKLPPVLVLHLKRFVYEKTGGCQ-KLIKNIEYPVDLEISKELLSPGVKSKNfkcHRTYRLFAVVYHHGsSATGG 732
           999****************************9998886.****************999988888778889******************* PP
   S: 294  HYvayvknekgk.WllfdDskVtevkeeevleetg.staYvlfYkr 337
           HY+++v +   + Wl++dD++V++v++++v++  + +taY+l+Y+r
   Q: 733  HYTTDVFQIGLNgWLRIDDQTVKVVSQQQVVRPAAeRTAYLLYYRR 778
           ********87777*****************997778********98 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

SFFFPQYIFG DFSPDEFNQF FVTPRASVEL PPYGGTVLCG AQAAGDLPDG HDYQRIEFGV 60
NEVIEPSDTL PRTPNYSISS TLNPQAPEFI LSCTTSKKLP DDIELRQLQY PGPALALDGG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCTTTTTTTT TTCCCCAGTA TATTTTTGGA GATTTTAGCC CTGATGAATT CAATCAGTTC 60
TTTGTGACTC CTCGCGCTTC AGTTGAGGTA AGACAAAATT TTGTTTTATT GGGTGCATGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR009818--Ataxin-2_C
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF07145--PAM2
PF00443--UCH

Gene Ontology

GO:0005829--C:cytosol
GO:0005769--C:early endosome
GO:0005654--C:nucleoplasm
GO:0043234--C:protein complex
GO:0004197--F:cysteine-type endopeptidase activity
GO:0003723--F:RNA binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0071347--P:cellular response to interleukin-1
GO:0030330--P:DNA damage response, signal transduction by p53 class mediator
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0016579--P:protein deubiquitination
GO:0010506--P:regulation of autophagy
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000082	Aegilops tauschii	29.80	1.00e-42	168.00
IUUC-Aml-001584	Ailuropoda melanoleuca	86.31	0.00e+00	1237.00
IUUC-Atr-002927	Amborella trichopoda	34.96	5.00e-57	215.00
IUUC-Apl-003988	Anas platyrhynchos	76.38	0.00e+00	1060.00
IUUC-Aca-004461	Anolis carolinensis	88.32	2.00e-157	548.00
IUUC-Aly-006038	Arabidopsis lyrata	34.87	3.00e-53	202.00
IUUC-Ath-007328	Arabidopsis thaliana	34.87	2.00e-52	199.00
IUUC-Ago-007717	Ashbya gossypii	30.34	3.00e-43	170.00
IUUC-Acl-008188	Aspergillus clavatus	35.89	2.00e-61	231.00
IUUC-Afl-008456	Aspergillus flavus	39.44	3.00e-47	182.00
IUUC-Afu-009067	Aspergillus fumigatus	37.34	3.00e-65	243.00
IUUC-Ani-009483	Aspergillus nidulans	33.05	4.00e-59	223.00
IUUC-Ang-009639	Aspergillus niger	36.39	3.00e-58	220.00
IUUC-Aor-010040	Aspergillus oryzae	36.13	4.00e-59	223.00
IUUC-Ate-010310	Aspergillus terreus	35.56	5.00e-60	226.00
IUUC-Ame-011012	Astyanax mexicanus	79.13	2.00e-165	576.00
IUUC-Bgr-012311	Blumeria graminis	35.16	7.00e-44	172.00
IUUC-Bta-013299	Bos taurus	93.58	0.00e+00	1333.00
IUUC-Bci-013783	Botrytis cinerea	38.32	2.00e-57	218.00
IUUC-Bdi-015039	Brachypodium distachyon	31.78	8.00e-47	181.00
IUUC-Bol-015806	Brassica oleracea	36.39	2.00e-61	229.00
IUUC-Bra-017076	Brassica rapa	36.39	4.00e-61	229.00
IUUC-Cja-018715	Callithrix jacchus	83.21	0.00e+00	1196.00
IUUC-Cfa-020194	Canis familiaris	86.43	0.00e+00	1246.00
IUUC-Cpo-022272	Cavia porcellus	73.14	0.00e+00	969.00
IUUC-Cre-022713	Chlamydomonas reinhardtii	34.23	3.00e-34	139.00
IUUC-Csa-023310	Chlorocebus sabaeus	84.34	0.00e+00	1214.00
IUUC-Cho-024966	Choloepus hoffmanni	72.06	0.00e+00	825.00
IUUC-Cin-025616	Ciona intestinalis	48.33	8.00e-103	367.00
IUUC-Csv-026043	Ciona savignyi	46.48	2.00e-97	349.00
IUUC-Cgl-026421	Colletotrichum gloeosporioides	34.70	4.00e-45	176.00
IUUC-Cne-026962	Cryptococcus neoformans	35.97	1.00e-50	195.00
IUUC-Cme-027113	Cyanidioschyzon merolae	32.26	6.00e-36	145.00
IUUC-Dre-028072	Danio rerio	76.56	0.00e+00	684.00
IUUC-Dno-029489	Dasypus novemcinctus	84.30	0.00e+00	1235.00
IUUC-Dor-031068	Dipodomys ordii	71.97	3.00e-133	469.00
IUUC-Dse-031553	Dothistroma septosporum	37.94	1.00e-55	211.00
IUUC-Dme-031759	Drosophila melanogaster	43.27	7.00e-81	296.00
IUUC-Ete-032549	Echinops telfairi	75.12	0.00e+00	800.00
IUUC-Eca-033380	Equus caballus	87.28	0.00e+00	1269.00
IUUC-Eeu-034818	Erinaceus europaeus	81.11	0.00e+00	1155.00
IUUC-Fca-035535	Felis catus	84.59	0.00e+00	1175.00
IUUC-Fal-036627	Ficedula albicollis	75.06	0.00e+00	1021.00
IUUC-Fox-037904	Fusarium oxysporum	37.05	4.00e-54	206.00
IUUC-Fso-038170	Fusarium solani	35.37	1.00e-51	198.00
IUUC-Gmo-039499	Gadus morhua	71.73	1.00e-179	623.00
IUUC-Ggr-040042	Gaeumannomyces graminis	36.12	5.00e-60	226.00
IUUC-Gga-040571	Gallus gallus	75.19	0.00e+00	1064.00
IUUC-Gac-041345	Gasterosteus aculeatus	78.08	0.00e+00	633.00
IUUC-Gma-043436	Glycine max	34.10	3.00e-56	213.00
IUUC-Ggo-044652	Gorilla gorilla	84.24	0.00e+00	1226.00
IUUC-Hsa-045864	Homo sapiens	84.49	0.00e+00	1232.00
IUUC-Hvu-047071	Hordeum vulgare	32.75	3.00e-51	196.00
IUUC-Itr-048216	Ictidomys tridecemlineatus	88.10	0.00e+00	933.00
IUUC-Kpa-049132	Komagataella pastoris	30.94	1.00e-44	174.00
IUUC-Lch-050040	Latimeria chalumnae	68.24	0.00e+00	847.00
IUUC-Loc-052449	Lepisosteus oculatus	77.80	0.00e+00	665.00
IUUC-Lma-053248	Leptosphaeria maculans	37.20	3.00e-58	219.00
IUUC-Laf-054121	Loxodonta africana	83.04	0.00e+00	1205.00
IUUC-Mcc-055514	Macaca mulatta	84.47	0.00e+00	1218.00
IUUC-Meu-056873	Macropus eugenii	69.07	0.00e+00	738.00
IUUC-Mor-057243	Magnaporthe oryzae	34.69	7.00e-57	216.00
IUUC-Mpo-057439	Magnaporthe poae	35.92	2.00e-59	224.00
IUUC-Mtr-058457	Medicago truncatula	33.85	1.00e-55	210.00
IUUC-Mla-058929	Melampsora laricipopulina	31.54	4.00e-54	206.00
IUUC-Mga-060157	Meleagris gallopavo	74.81	0.00e+00	1057.00
IUUC-Mvi-060442	Microbotryum violaceum	36.59	2.00e-51	197.00
IUUC-Mmr-061062	Microcebus murinus	83.31	0.00e+00	1208.00
IUUC-Mdo-062798	Monodelphis domestica	77.64	0.00e+00	1081.00
IUUC-Mmu-064050	Mus musculus	78.35	0.00e+00	1133.00
IUUC-Mac-065619	Musa acuminata	33.08	1.00e-51	197.00
IUUC-Mpu-066554	Mustela putorius furo	86.07	0.00e+00	1239.00
IUUC-Mlu-068003	Myotis lucifugus	85.10	0.00e+00	1228.00
IUUC-Nfi-068612	Neosartorya fischeri	36.82	1.00e-62	234.00
IUUC-Ncr-068878	Neurospora crassa	35.13	2.00e-51	197.00
IUUC-Nle-069661	Nomascus leucogenys	85.50	0.00e+00	1220.00
IUUC-Opr-070944	Ochotona princeps	79.85	6.00e-161	560.00
IUUC-Ont-071266	Oreochromis niloticus	77.61	0.00e+00	646.00
IUUC-Oan-073442	Ornithorhynchus anatinus	76.80	0.00e+00	1036.00
IUUC-Ocu-073788	Oryctolagus cuniculus	77.81	0.00e+00	1018.00
IUUC-Oba-075085	Oryza barthii	33.45	3.00e-36	145.00
IUUC-Obr-076663	Oryza brachyantha	33.16	1.00e-44	174.00
IUUC-Ogl-076937	Oryza glaberrima	29.87	3.00e-47	182.00
IUUC-Ogu-078909	Oryza glumaepatula	30.23	4.00e-45	176.00
IUUC-Oin-079617	Oryza indica	32.03	2.00e-48	187.00
IUUC-Olo-081043	Oryza longistaminata	26.54	9.00e-25	108.00
IUUC-Ome-081646	Oryza meridionalis	24.74	4.00e-22	99.80
IUUC-Oni-082914	Oryza nivara	30.23	3.00e-45	176.00
IUUC-Oru-084878	Oryza rufipogon	30.23	3.00e-45	176.00
IUUC-Osa-085822	Oryza sativa	30.75	2.00e-49	189.00
IUUC-Ola-086931	Oryzias latipes	79.14	2.00e-177	616.00
IUUC-Oga-088443	Otolemur garnettii	82.81	0.00e+00	1213.00
IUUC-Ptr-091584	Pan troglodytes	81.46	0.00e+00	1137.00
IUUC-Pan-092551	Papio anubis	82.60	0.00e+00	1187.00
IUUC-Psi-093366	Pelodiscus sinensis	72.09	9.00e-180	623.00
IUUC-Pno-095136	Phaeosphaeria nodorum	35.26	2.00e-51	197.00
IUUC-Ppa-095574	Physcomitrella patens	35.76	2.00e-56	213.00
IUUC-Pfo-097462	Poecilia formosa	75.75	0.00e+00	651.00
IUUC-Pab-098547	Pongo abelii	84.62	0.00e+00	1219.00
IUUC-Pop-099529	Populus trichocarpa	37.18	1.00e-60	227.00
IUUC-Pca-101066	Procavia capensis	74.24	0.00e+00	1026.00
IUUC-Ppe-102110	Prunus persica	37.53	1.00e-57	217.00
IUUC-Pva-103015	Pteropus vampyrus	81.11	0.00e+00	1151.00
IUUC-Ptt-103998	Puccinia triticina	33.75	6.00e-53	202.00
IUUC-Pte-104417	Pyrenophora teres	34.42	2.00e-54	207.00
IUUC-Pyt-104820	Pyrenophora triticirepentis	35.62	1.00e-54	207.00
IUUC-Rno-105533	Rattus norvegicus	80.15	0.00e+00	1152.00
IUUC-Sce-106160	Saccharomyces cerevisiae	28.02	8.00e-38	152.00
IUUC-Sha-106590	Sarcophilus harrisii	77.67	0.00e+00	1087.00
IUUC-Sja-107669	Schizosaccharomyces japonicus	35.85	3.00e-56	213.00
IUUC-Spo-108353	Schizosaccharomyces pombe	36.90	1.00e-63	237.00
IUUC-Ssl-108599	Sclerotinia sclerotiorum	37.13	7.00e-57	215.00
IUUC-Smo-108842	Selaginella moellendorffii	36.56	4.00e-37	147.00
IUUC-Sit-110781	Setaria italica	31.75	4.00e-53	202.00
IUUC-Sly-111797	Solanum lycopersicum	33.76	6.00e-53	201.00
IUUC-Stu-112188	Solanum tuberosum	34.18	2.00e-53	203.00
IUUC-Sbi-114862	Sorghum bicolor	32.78	2.00e-45	176.00
IUUC-Sre-115162	Sporisorium reilianum	35.45	7.00e-65	242.00
IUUC-Ssc-115505	Sus scrofa	96.12	1.00e-158	551.00
IUUC-Tgu-116535	Taeniopygia guttata	75.03	0.00e+00	1028.00
IUUC-Tru-117542	Takifugu rubripes	70.59	0.00e+00	686.00
IUUC-Tni-120200	Tetraodon nigroviridis	58.47	0.00e+00	773.00
IUUC-Tca-121548	Theobroma cacao	35.24	2.00e-44	173.00
IUUC-Tre-122124	Trichoderma reesei	37.17	7.00e-59	222.00
IUUC-Tvi-122457	Trichoderma virens	35.60	1.00e-52	201.00
IUUC-Tae-125646	Triticum aestivum	33.16	6.00e-53	202.00
IUUC-Tme-127180	Tuber melanosporum	40.56	4.00e-69	256.00
IUUC-Tbe-127530	Tupaia belangeri	70.57	0.00e+00	922.00
IUUC-Ttr-128549	Tursiops truncatus	81.20	0.00e+00	1173.00
IUUC-Uma-129381	Ustilago maydis	34.23	4.00e-65	243.00
IUUC-Vda-129889	Verticillium dahliae	32.89	8.00e-51	195.00
IUUC-Vpa-130100	Vicugna pacos	81.11	0.00e+00	1135.00
IUUC-Vvi-131366	Vitis vinifera	36.64	5.00e-61	228.00
IUUC-Xtr-132048	Xenopus tropicalis	62.55	0.00e+00	861.00
IUUC-Xma-133593	Xiphophorus maculatus	76.61	0.00e+00	645.00
IUUC-Yli-134338	Yarrowia lipolytica	30.42	2.00e-31	131.00
IUUC-Zma-135586	Zea mays	31.31	5.00e-47	182.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence