iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Eca-033913

UUCD1 version

UUC-EqC-01052

Ensembl Protein ID

ENSECAP00000018716.1

UniProt Accession

F6TFK4; F6TFK4_HORSE

Protein Name

Uncharacterized protein

Gene Name

USP47

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000020838.1	ENSECAT00000022637.1	ENSECAP00000018716.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.10e-75	255.1	175	549

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeq 89
           +Gl N+  tCY+NS+LQ+L+++pe+r++l +    +++e++ ++p +++  +lq+lf  l++skk+a++++++++++++ ++e    +q
   Q: 175  VGLVNQAMTCYLNSLLQTLFMTPEFRNALYK---WEFEESE-EDPVTSIPYQLQRLFVLLQTSKKRAIETTDVTRSFGWDSSE--AWQQ 257
           6******************************...5555443.5899*********************************9998..9*** PP
   S: 90   qDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpg 178
           +D+qE++++++d+le++                           k++++ +li++l+qg+lk+ ++clec+ +  r ++ ld++l ++ 
   Q: 258  HDVQELCRVMFDALEQKW--------------------------KQTEQADLINELYQGKLKDYVRCLECGYEGWRIDTYLDIPLVIRP 320
           ******************..........................678999*************************************95 PP
   S: 179  ke.etkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfct 266
              +++  s++++L++f ++e l+g n+y+ce+ckkk++a+k l++ ++P  L+l+LkRf f+ ++++r+k+n++++fp+eLd+s f  
   Q: 321  YGsSQAFASVEEALHAFIQPEILDGPNQYFCERCKKKCDARKGLRFLHFPYLLTLQLKRFDFDYTTMHRIKLNDRMTFPEELDMSTFID 409
           54045678******************************************************************************999 PP
   S: 267  speekqke.....................................................kkkYeLiavvvHsGslssGHYvayvkne 302
            ++ek+ +                                                     + +YeL++v+vHsGs+ +GHY+a++k+ 
   Q: 410  VEDEKSPQtesctdsgaenegschsdqmsndfsnddgvdegiclennsgtekiskpgleknSLIYELFSVMVHSGSAAGGHYYACIKSF 498
           9777766678888888899999999999999999999999999999999999999999999***************************6 PP
   S: 303  kgk.WllfdDskVtevkeeevleetg................staYvlfYk 336
           +++ W+ f+D++V+ +++e++++++g                ++aY+l+Y+
   Q: 499  SDEqWYSFNDQHVSRITQEDIKKTHGgssgsrgyyssafassTNAYMLIYR 549
           5555*******************888************************8 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

DVFWRCRQNI FDEMKKKFLQ IENAAEEPRV LCIIQDTTNS KTVNERITLN LPASTPLRKL 60
FEDVANKVGY INGTFDLVWG NGINTADTAP LDHTSDKSLL DANFEPGKKN FLHLTDKDGE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATAGGATGTG TTTTGGAGAT GCAGACAAAA TATCTTTGAT GAAATGAAGA AGAAATTTTT 60
ACAGGTAGAC TGCTGATGTA CTTGCTTTAG TGTAGTAATC AGCAGAGCCA GTAACAGCAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0005737--C:cytoplasm
GO:0019005--C:SCF ubiquitin ligase complex
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0006284--P:base-excision repair
GO:0034644--P:cellular response to UV
GO:0035520--P:monoubiquitinated protein deubiquitination
GO:0043154--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0010972--P:negative regulation of G2/M transition of mitotic cell cycle
GO:1902230--P:negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0030307--P:positive regulation of cell growth
GO:0042981--P:regulation of apoptotic process
GO:0042493--P:response to drug
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002228	Ailuropoda melanoleuca	97.00	0.00e+00	2539.00
IUUC-Apl-003486	Anas platyrhynchos	90.17	0.00e+00	2356.00
IUUC-Aca-005061	Anolis carolinensis	87.76	0.00e+00	2374.00
IUUC-Ame-011206	Astyanax mexicanus	80.36	0.00e+00	2107.00
IUUC-Bta-012942	Bos taurus	97.80	0.00e+00	2575.00
IUUC-Cel-018600	Caenorhabditis elegans	37.18	2.00e-120	427.00
IUUC-Cja-018950	Callithrix jacchus	98.20	0.00e+00	2383.00
IUUC-Cfa-020299	Canis familiaris	98.52	0.00e+00	2558.00
IUUC-Cpo-021943	Cavia porcellus	97.36	0.00e+00	2543.00
IUUC-Csa-023285	Chlorocebus sabaeus	98.07	0.00e+00	2521.00
IUUC-Cho-025006	Choloepus hoffmanni	89.05	0.00e+00	2189.00
IUUC-Cin-025145	Ciona intestinalis	41.78	0.00e+00	725.00
IUUC-Csv-025839	Ciona savignyi	41.55	0.00e+00	790.00
IUUC-Dre-027959	Danio rerio	80.82	0.00e+00	2052.00
IUUC-Dno-030023	Dasypus novemcinctus	95.10	0.00e+00	2431.00
IUUC-Dor-030994	Dipodomys ordii	97.15	0.00e+00	961.00
IUUC-Dme-031604	Drosophila melanogaster	48.87	2.00e-145	510.00
IUUC-Ete-032596	Echinops telfairi	80.65	0.00e+00	1304.00
IUUC-Eeu-034518	Erinaceus europaeus	89.73	0.00e+00	2138.00
IUUC-Fca-035997	Felis catus	98.31	0.00e+00	2580.00
IUUC-Fal-037088	Ficedula albicollis	89.18	0.00e+00	2089.00
IUUC-Gmo-038920	Gadus morhua	76.92	0.00e+00	1985.00
IUUC-Gga-040953	Gallus gallus	89.00	0.00e+00	2341.00
IUUC-Gac-042400	Gasterosteus aculeatus	79.22	0.00e+00	2028.00
IUUC-Ggo-044820	Gorilla gorilla	95.39	0.00e+00	2472.00
IUUC-Hsa-046634	Homo sapiens	98.02	0.00e+00	2555.00
IUUC-Lch-050440	Latimeria chalumnae	86.12	0.00e+00	2278.00
IUUC-Loc-051904	Lepisosteus oculatus	84.49	0.00e+00	2219.00
IUUC-Laf-053760	Loxodonta africana	96.99	0.00e+00	2578.00
IUUC-Mcc-054637	Macaca mulatta	98.17	0.00e+00	2563.00
IUUC-Meu-056904	Macropus eugenii	95.17	0.00e+00	1692.00
IUUC-Mga-059556	Meleagris gallopavo	88.42	0.00e+00	2327.00
IUUC-Mmr-061192	Microcebus murinus	98.31	0.00e+00	2565.00
IUUC-Mdo-061929	Monodelphis domestica	95.30	0.00e+00	2510.00
IUUC-Mmu-063726	Mus musculus	94.21	0.00e+00	2516.00
IUUC-Mpu-066014	Mustela putorius furo	98.44	0.00e+00	2546.00
IUUC-Mlu-067232	Myotis lucifugus	97.58	0.00e+00	2549.00
IUUC-Nle-069619	Nomascus leucogenys	97.92	0.00e+00	2517.00
IUUC-Opr-070224	Ochotona princeps	92.52	0.00e+00	1136.00
IUUC-Ont-071384	Oreochromis niloticus	80.48	0.00e+00	2070.00
IUUC-Oan-073208	Ornithorhynchus anatinus	88.82	0.00e+00	2382.00
IUUC-Ocu-074285	Oryctolagus cuniculus	97.95	0.00e+00	2555.00
IUUC-Ola-087051	Oryzias latipes	78.97	0.00e+00	1982.00
IUUC-Oga-088928	Otolemur garnettii	97.73	0.00e+00	2557.00
IUUC-Oar-090215	Ovis aries	98.02	0.00e+00	2581.00
IUUC-Ptr-091035	Pan troglodytes	98.02	0.00e+00	2559.00
IUUC-Pan-092377	Papio anubis	97.65	0.00e+00	2539.00
IUUC-Pfo-096722	Poecilia formosa	79.77	0.00e+00	2044.00
IUUC-Pab-098723	Pongo abelii	97.95	0.00e+00	2557.00
IUUC-Pca-100105	Procavia capensis	92.59	0.00e+00	2354.00
IUUC-Pva-102514	Pteropus vampyrus	99.17	0.00e+00	965.00
IUUC-Rno-105384	Rattus norvegicus	95.45	0.00e+00	2483.00
IUUC-Sha-106982	Sarcophilus harrisii	93.15	0.00e+00	2472.00
IUUC-Sar-113723	Sorex araneus	86.75	0.00e+00	934.00
IUUC-Ssc-115671	Sus scrofa	97.88	0.00e+00	2043.00
IUUC-Tgu-116722	Taeniopygia guttata	88.06	0.00e+00	2309.00
IUUC-Tru-118380	Takifugu rubripes	77.53	0.00e+00	2049.00
IUUC-Tsy-119646	Tarsius syrichta	91.42	0.00e+00	2343.00
IUUC-Tni-120762	Tetraodon nigroviridis	77.87	0.00e+00	2060.00
IUUC-Tbe-127861	Tupaia belangeri	95.24	0.00e+00	2362.00
IUUC-Ttr-129254	Tursiops truncatus	92.29	0.00e+00	1457.00
IUUC-Vpa-130141	Vicugna pacos	99.05	0.00e+00	1196.00
IUUC-Xtr-132700	Xenopus tropicalis	81.61	0.00e+00	2190.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence