iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ssc-115960

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Probable cytosolic iron-sulfur protein assembly protein CIAO1; WD repeat-containing protein 39

Genbank Nucleotide ID

CU896688

Gene Name

CIAO1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSSCG00000008130.2	ENSSSCT00000008907.2	ENSSSCP00000008681.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	6.60e-43	143.1	192	222
UBD/Beta-Prp	1.60e-49	169.0	151	332

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWD 29
           gH++ v++laf ++  +l+s+sdD t+++W+
   Q: 192  GHESTVWSLAFdPSgQRLASCSDDRTVRIWR 222
           8***********6669**************8 PP

UBD/Beta-Prp

   S: 11   svitcvkfspdksllatgsrdgtikvwdvttgkl..lrslsgheaevtavkfspdgkilvtgseDrtikvw..dls............. 82
           + +++v ++p+++lla++s+d+t+k+++ ++ +    ++l+ghe++v+++ f+p+g+ l+++s+Drt+++w                  
   Q: 151  QSMKKVLWHPSQELLASASYDDTVKLYREEEDDWvcCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWrqY-Lpgneqgvacngsd 238
           567899*********************9876544349**********************************861.24556688888889 PP
   S: 83   .tgkcvhtlkg.hedsvlslsfspsgdklvsGshdrtirvwdletgqclee........tlsghdgvvncvvvhpdg.nllvsGslDrt 160
            + kc+ tl+g h+++++++++++ +  l+++  d+ irv++ + g+  ++        + + h++ vncv+++p++  ll+s+s+D+ 
   Q: 239  pSWKCICTLSGfHSRTIYDVAWCQLTGALATACGDDAIRVFEEDPGSDPQQptfsltahLPQAHSQDVNCVAWNPKEqGLLASCSDDGE 327
           9999*****976*****************************999999999999************************************ PP
   S: 161  vrlWd 165
           + +W+
   Q: 328  LAFWK 332
           ****7 PP

Organism

Sus scrofa

Functional Description
(View)

Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.

Protein Sequence
(Fasta)

MKDSLVLLGR IPAHPDSRCW FLAWNPAGTL LASCGGDRSV RIWGREGDSW ICKSVLCEGH 60
QRTVRKVAWS PCGNYLASAS FDATTCIWKK NKDDFECVTT LEGHENEVKS VAWAPSGNLL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGTTTGCGTG GTGGGAGCCG CAGTCGGCAG TGCTGTCTCT GCTCACCACT TTCTGCGCCA 60
GGCCGCCATG AAGGACTCGC TGGTGCTGCT TGGCCGTATC CCGGCGCACC CGGACTCCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0159--Chromosome partition
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR028608--CIAO1/Cia1
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0097361--C:CIA complex
GO:0071817--C:MMXD complex
GO:0007059--P:chromosome segregation
GO:0016226--P:iron-sulfur cluster assembly

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000874	Aegilops tauschii	40.68	4.00e-60	226.00
IUUC-Aml-001317	Ailuropoda melanoleuca	90.21	3.00e-175	607.00
IUUC-Atr-003029	Amborella trichopoda	48.68	4.00e-85	307.00
IUUC-Apl-004042	Anas platyrhynchos	77.27	1.00e-56	211.00
IUUC-Aly-006458	Arabidopsis lyrata	45.22	2.00e-77	282.00
IUUC-Ath-006671	Arabidopsis thaliana	45.06	1.00e-77	282.00
IUUC-Ago-007820	Ashbya gossypii	36.66	6.00e-51	194.00
IUUC-Acl-008042	Aspergillus clavatus	30.23	2.00e-44	173.00
IUUC-Afl-008639	Aspergillus flavus	31.74	1.00e-48	187.00
IUUC-Afu-008899	Aspergillus fumigatus	34.38	3.00e-44	172.00
IUUC-Ani-009453	Aspergillus nidulans	31.01	4.00e-45	175.00
IUUC-Ang-009758	Aspergillus niger	34.16	4.00e-50	191.00
IUUC-Aor-010212	Aspergillus oryzae	31.74	1.00e-48	187.00
IUUC-Ate-010314	Aspergillus terreus	31.41	1.00e-47	183.00
IUUC-Ame-010676	Astyanax mexicanus	72.46	1.00e-146	511.00
IUUC-Bgr-012095	Blumeria graminis	29.02	3.00e-33	135.00
IUUC-Bta-012884	Bos taurus	91.10	2.00e-177	613.00
IUUC-Bci-013622	Botrytis cinerea	30.27	2.00e-34	139.00
IUUC-Bdi-014614	Brachypodium distachyon	45.61	1.00e-77	282.00
IUUC-Bol-016439	Brassica oleracea	44.71	4.00e-76	277.00
IUUC-Bra-016830	Brassica rapa	43.95	7.00e-75	273.00
IUUC-Cel-018709	Caenorhabditis elegans	37.92	5.00e-57	214.00
IUUC-Cja-019822	Callithrix jacchus	88.72	1.00e-172	598.00
IUUC-Cfa-020823	Canis familiaris	90.50	2.00e-175	607.00
IUUC-Cre-022811	Chlamydomonas reinhardtii	45.82	3.00e-74	271.00
IUUC-Csa-023754	Chlorocebus sabaeus	89.61	4.00e-174	603.00
IUUC-Cin-025395	Ciona intestinalis	53.41	1.00e-106	379.00
IUUC-Csv-025943	Ciona savignyi	51.94	3.00e-103	367.00
IUUC-Cgl-026435	Colletotrichum gloeosporioides	28.65	4.00e-31	129.00
IUUC-Cne-026939	Cryptococcus neoformans	30.43	3.00e-39	155.00
IUUC-Cme-027239	Cyanidioschyzon merolae	37.97	1.00e-37	150.00
IUUC-Dre-028172	Danio rerio	70.54	5.00e-144	503.00
IUUC-Dno-029472	Dasypus novemcinctus	88.32	7.00e-146	509.00
IUUC-Dor-031134	Dipodomys ordii	77.15	2.00e-142	498.00
IUUC-Dse-031535	Dothistroma septosporum	28.91	2.00e-41	163.00
IUUC-Dme-032020	Drosophila melanogaster	54.85	3.00e-108	384.00
IUUC-Eca-033700	Equus caballus	90.21	2.00e-174	604.00
IUUC-Eeu-035010	Erinaceus europaeus	87.83	3.00e-168	583.00
IUUC-Fca-036309	Felis catus	87.57	1.00e-168	585.00
IUUC-Fal-037243	Ficedula albicollis	69.30	3.00e-81	294.00
IUUC-Fox-038058	Fusarium oxysporum	31.03	2.00e-37	150.00
IUUC-Fso-038459	Fusarium solani	31.19	8.00e-34	137.00
IUUC-Gmo-039375	Gadus morhua	70.15	1.00e-136	478.00
IUUC-Ggr-040002	Gaeumannomyces graminis	33.99	1.00e-35	144.00
IUUC-Gga-040294	Gallus gallus	72.93	7.00e-122	429.00
IUUC-Gac-042499	Gasterosteus aculeatus	70.03	5.00e-135	473.00
IUUC-Gma-043543	Glycine max	46.61	4.00e-80	291.00
IUUC-Ggo-045181	Gorilla gorilla	89.61	4.00e-174	603.00
IUUC-Hsa-046528	Homo sapiens	89.61	4.00e-174	603.00
IUUC-Hvu-047341	Hordeum vulgare	53.19	4.00e-49	187.00
IUUC-Itr-048790	Ictidomys tridecemlineatus	89.32	7.00e-173	599.00
IUUC-Kpa-049353	Komagataella pastoris	33.90	6.00e-50	190.00
IUUC-Lch-049763	Latimeria chalumnae	73.29	1.00e-151	528.00
IUUC-Lpe-051500	Leersia perrieri	42.32	1.00e-73	269.00
IUUC-Loc-052021	Lepisosteus oculatus	75.75	5.00e-150	523.00
IUUC-Lma-053331	Leptosphaeria maculans	33.25	1.00e-49	191.00
IUUC-Laf-054558	Loxodonta africana	88.13	3.00e-172	597.00
IUUC-Mcc-055374	Macaca mulatta	89.32	3.00e-173	600.00
IUUC-Meu-056042	Macropus eugenii	70.83	6.00e-107	379.00
IUUC-Mor-057187	Magnaporthe oryzae	32.69	4.00e-34	138.00
IUUC-Mtr-058072	Medicago truncatula	45.83	8.00e-79	286.00
IUUC-Mla-059108	Melampsora laricipopulina	29.77	7.00e-47	181.00
IUUC-Mga-059370	Meleagris gallopavo	58.06	9.00e-95	339.00
IUUC-Mvi-060495	Microbotryum violaceum	34.95	3.00e-50	192.00
IUUC-Mmr-060902	Microcebus murinus	90.21	2.00e-175	608.00
IUUC-Mdo-062510	Monodelphis domestica	86.94	6.00e-164	569.00
IUUC-Mmu-063575	Mus musculus	88.13	6.00e-171	592.00
IUUC-Mac-065322	Musa acuminata	47.92	2.00e-83	302.00
IUUC-Mpu-065925	Mustela putorius furo	89.91	5.00e-174	603.00
IUUC-Mlu-067755	Myotis lucifugus	89.61	7.00e-175	605.00
IUUC-Nfi-068327	Neosartorya fischeri	30.77	2.00e-44	173.00
IUUC-Ncr-068845	Neurospora crassa	29.89	2.00e-29	123.00
IUUC-Nle-069406	Nomascus leucogenys	87.24	3.00e-168	583.00
IUUC-Opr-070416	Ochotona princeps	67.36	1.00e-122	432.00
IUUC-Ont-071936	Oreochromis niloticus	70.62	1.00e-137	481.00
IUUC-Oan-073452	Ornithorhynchus anatinus	81.82	1.00e-71	261.00
IUUC-Ocu-074791	Oryctolagus cuniculus	87.24	7.00e-171	592.00
IUUC-Oba-075636	Oryza barthii	46.59	7.00e-81	293.00
IUUC-Obr-076742	Oryza brachyantha	44.76	4.00e-68	251.00
IUUC-Ogl-077766	Oryza glaberrima	46.59	7.00e-81	293.00
IUUC-Ogu-079039	Oryza glumaepatula	46.59	3.00e-81	294.00
IUUC-Oin-079315	Oryza indica	45.21	7.00e-69	253.00
IUUC-Olo-080669	Oryza longistaminata	41.41	6.00e-73	267.00
IUUC-Ome-081490	Oryza meridionalis	46.59	6.00e-81	293.00
IUUC-Oni-082572	Oryza nivara	46.59	7.00e-81	293.00
IUUC-Opu-083732	Oryza punctata	46.73	6.00e-81	293.00
IUUC-Oru-084763	Oryza rufipogon	46.59	7.00e-81	293.00
IUUC-Osa-085372	Oryza sativa	46.59	7.00e-81	293.00
IUUC-Ola-087379	Oryzias latipes	68.96	1.00e-132	465.00
IUUC-Olu-087801	Ostreococcus lucimarinus	34.12	5.00e-39	154.00
IUUC-Oga-089076	Otolemur garnettii	89.32	5.00e-173	599.00
IUUC-Oar-090022	Ovis aries	90.80	3.00e-176	610.00
IUUC-Ptr-090809	Pan troglodytes	89.61	4.00e-174	603.00
IUUC-Pan-091685	Papio anubis	89.61	3.00e-175	608.00
IUUC-Psi-093046	Pelodiscus sinensis	82.20	4.00e-162	563.00
IUUC-Pma-094181	Petromyzon marinus	59.40	6.00e-119	419.00
IUUC-Pno-094882	Phaeosphaeria nodorum	33.09	6.00e-50	191.00
IUUC-Ppa-095172	Physcomitrella patens	43.90	2.00e-76	279.00
IUUC-Pfo-096396	Poecilia formosa	67.95	1.00e-134	471.00
IUUC-Pab-098427	Pongo abelii	89.02	1.00e-171	595.00
IUUC-Pop-100016	Populus trichocarpa	48.51	8.00e-83	300.00
IUUC-Pca-101048	Procavia capensis	89.02	4.00e-173	600.00
IUUC-Ppe-102050	Prunus persica	44.86	5.00e-79	287.00
IUUC-Pva-103117	Pteropus vampyrus	89.91	3.00e-175	607.00
IUUC-Pgr-103307	Puccinia graminis	33.33	4.00e-52	198.00
IUUC-Ptt-103938	Puccinia triticina	35.99	4.00e-44	171.00
IUUC-Pte-104315	Pyrenophora teres	31.65	2.00e-50	192.00
IUUC-Pyt-104825	Pyrenophora triticirepentis	31.65	2.00e-50	192.00
IUUC-Rno-105523	Rattus norvegicus	87.54	2.00e-170	591.00
IUUC-Sce-106297	Saccharomyces cerevisiae	38.17	5.00e-54	204.00
IUUC-Sha-106981	Sarcophilus harrisii	86.25	6.00e-137	479.00
IUUC-Sja-107715	Schizosaccharomyces japonicus	36.36	1.00e-47	184.00
IUUC-Spo-108214	Schizosaccharomyces pombe	38.46	9.00e-50	191.00
IUUC-Smo-109034	Selaginella moellendorffii	44.23	2.00e-77	281.00
IUUC-Sit-110663	Setaria italica	47.21	1.00e-81	296.00
IUUC-Sly-110898	Solanum lycopersicum	44.97	7.00e-75	273.00
IUUC-Stu-112647	Solanum tuberosum	47.39	3.00e-63	234.00
IUUC-Sbi-114288	Sorghum bicolor	45.16	7.00e-78	283.00
IUUC-Sre-115065	Sporisorium reilianum	40.00	6.00e-66	244.00
IUUC-Tru-118382	Takifugu rubripes	67.95	2.00e-137	481.00
IUUC-Tsy-119585	Tarsius syrichta	81.01	2.00e-152	531.00
IUUC-Tni-120133	Tetraodon nigroviridis	70.00	8.00e-135	472.00
IUUC-Tca-121167	Theobroma cacao	47.18	9.00e-75	273.00
IUUC-Tre-122119	Trichoderma reesei	28.31	6.00e-35	141.00
IUUC-Tvi-122407	Trichoderma virens	28.01	4.00e-35	142.00
IUUC-Tae-125748	Triticum aestivum	45.10	3.00e-74	271.00
IUUC-Tur-126682	Triticum urartu	45.49	1.00e-59	223.00
IUUC-Tme-127095	Tuber melanosporum	33.78	2.00e-54	206.00
IUUC-Tbe-128004	Tupaia belangeri	89.61	5.00e-174	602.00
IUUC-Ttr-129284	Tursiops truncatus	88.53	5.00e-170	589.00
IUUC-Uma-129527	Ustilago maydis	40.64	3.00e-66	245.00
IUUC-Vda-129854	Verticillium dahliae	30.26	1.00e-32	133.00
IUUC-Vpa-130681	Vicugna pacos	81.03	2.00e-45	175.00
IUUC-Vvi-131004	Vitis vinifera	50.75	2.00e-80	291.00
IUUC-Xtr-131928	Xenopus tropicalis	75.67	3.00e-150	524.00
IUUC-Xma-134290	Xiphophorus maculatus	67.66	2.00e-131	461.00
IUUC-Yli-134364	Yarrowia lipolytica	40.41	1.00e-57	216.00
IUUC-Zma-135658	Zea mays	46.88	2.00e-80	291.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence