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Tag Content
UUCD2 ID IUUC-Nle-069651
UUCD1 version UUC-NoL-01079
Ensembl Protein ID ENSNLEP00000021252.1
UniProt Accession G1S6W3; G1S6W3_NOMLE
Genbank Protein ID ENSNLEP00000021252
Protein Name PAB-dependent poly(A)-specific ribonuclease subunit PAN2; Inactive ubiquitin carboxyl-terminal hydrolase 52; PAB1P-dependent poly(A)-nuclease; PAN deadenylation complex catalytic subunit 2
Genbank Nucleotide ID ADFV01002431
Gene Name PAN2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSNLEG00000017499.1 ENSNLET00000022331.1 ENSNLEP00000021252.1
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 3.20e-19 69.2 525 909
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   DUB/USP
   S: 11   YmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs.............. 85
           Y+N+++Q+L++++++r+l+ +   + +++      + +l+++l  lf+ l  s+    + +++l+a++++ e                 
   Q: 525  YCNCMIQVLYFLEPVRCLIQN---HLCQK------EFCLACELGFLFHMLDLSRGDPCQGNNFLRAFRTIPEASAlgliladsdeasgk 604
           9********************...55654......57*************99***************9999886677777776666666 PP
   S: 86   gyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlsl 174
           g+     q   +f+l ql++++++        +e  +  +      ++  ++++s+i +lF  ++++   c +c+++++r ++ l ++l
   Q: 605  GNLARLIQRWNRFILTQLHQDMQE--------LEVPQ--AYRGAGGSSFCSSGDSVIGQLFSCEMENCSLC-RCGSETVRASSTLLFTL 682
           666666777888888888888833........22222..3344467899*****************99999.8**************** PP
   S: 175  pvpgkeetkkeslqdcLesftkeee.legenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdls 262
           + p+ ++++k+  +  +++  k+   l+++ + +c++c+k+q + ++  +++lP++L+++    s +e+     +i+ +v f+  + ++
   Q: 683  SYPDGSKSDKTGKNYDFAQVLKRSIcLDQNTQAWCDTCEKYQPTIQTRNIRHLPDILVINCEVNSSKEADFW--RIQAEVAFK--MAVK 767
           ***88888887655556665555542677778*****************************99977776555..588888887..5666 PP
   S: 263  pfcts........peekqke..............................................................kkkYeLi 281
           ++  +                                                                              + Y+L+
   Q: 768  KHGGEisknkefaL-----AdwkelgspegvlvcpsieelknvwlpfsirmkmtknkgldvcnwtdgdemqwgparaeeehgVYVYDLM 851
           66655333444550.....0555555555555555555555555555555555555566666666666666666666666669****** PP
   S: 282  avvvHsG.slssGHYvayvkn...........ekgkWllfdDskVtevkeeevleetg 327
           a vvH   s  +G  va++k            ++++W+lf+D  +++++++e +++  
   Q: 852  ATVVHILdSRTGGSLVAHIKVgetyhqrkegvTHQQWYLFNDFFIEPIDKHEAVQFDM 909
           *******9*************999988877777888************9999888654 PP
   
Organism Nomascus leucogenys
Functional Description
(View)

Functional Description


     Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.
 Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.
Protein Sequence
(Fasta)
MNFEGLDPGL AEYAPAMHSA LDPVLDAHLN PSLLQNVELD PEGVALEALP VQESVHIMEV 60
YSELHSVVAE VGVPVSVSHF DLHEEMLWVG SHGGHATSFF GPALERYSSF QVNGSDDIRQ 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Nle-069651|DUB,USP|Nomascus leucogenys
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGAACTTTG AGGGTCTGGA CCCTGGACTG GCAGAGTATG CCCCAGCCAT GCATTCTGCC 60
CTGGACCCTG TCCTGGATGC CCACCTGAAC CCAAGTCTGC TACAGAATGT GGAGCTGGAC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Nle-069651|DUB,USP|Nomascus leucogenys
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0269--Exonuclease
KW-0378--Hydrolase
KW-0507--mRNA processing
KW-0540--Nuclease
KW-0539--Nucleus
KW-1185--Reference proteome
Interpro

IPR013520--Exonuclease_RNaseT/DNA_pol3
IPR030843--PAN2
IPR028881--PAN2_dom
IPR012337--RNaseH-like_dom
IPR028889--USP_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR017986--WD40_repeat_dom
PROSITE

PS50235--USP_3
Pfam

PF00929--RNase_T
PF13423--UCH_1
SMART

SM00479--EXOIII
Gene Ontology

GO:0005634--C:nucleus
GO:0000932--C:P-body
GO:0031251--C:PAN complex
GO:0003676--F:nucleic acid binding
GO:0004535--F:poly(A)-specific ribonuclease activity
GO:0006397--P:mRNA processing
GO:0000289--P:nuclear-transcribed mRNA poly(A) tail shortening
GO:0010606--P:positive regulation of cytoplasmic mRNA processing body assembly
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001273 Ailuropoda melanoleuca 93.93 0.00e+00 2226.00
IUUC-Apl-003500 Anas platyrhynchos 81.54 0.00e+00 1763.00
IUUC-Aca-004930 Anolis carolinensis 80.17 0.00e+00 1894.00
IUUC-Acl-008214 Aspergillus clavatus 30.12 1.00e-144 507.00
IUUC-Afu-009112 Aspergillus fumigatus 30.90 2.00e-141 496.00
IUUC-Ang-009531 Aspergillus niger 30.10 9.00e-139 488.00
IUUC-Ame-011259 Astyanax mexicanus 73.33 0.00e+00 1726.00
IUUC-Bta-012371 Bos taurus 93.68 0.00e+00 2214.00
IUUC-Bci-013684 Botrytis cinerea 30.14 1.00e-124 441.00
IUUC-Cja-019297 Callithrix jacchus 92.07 0.00e+00 2184.00
IUUC-Cfa-020489 Canis familiaris 93.27 0.00e+00 2199.00
IUUC-Cpo-022392 Cavia porcellus 92.85 0.00e+00 2222.00
IUUC-Csa-023220 Chlorocebus sabaeus 95.01 0.00e+00 2248.00
IUUC-Csv-025841 Ciona savignyi 43.23 0.00e+00 828.00
IUUC-Cgl-026534 Colletotrichum gloeosporioides 31.61 2.00e-151 530.00
IUUC-Cne-026932 Cryptococcus neoformans 42.65 1.00e-72 268.00
IUUC-Dre-028482 Danio rerio 70.65 0.00e+00 1672.00
IUUC-Dno-029398 Dasypus novemcinctus 92.77 0.00e+00 2185.00
IUUC-Dor-030307 Dipodomys ordii 88.15 0.00e+00 1281.00
IUUC-Dme-032111 Drosophila melanogaster 40.49 0.00e+00 838.00
IUUC-Eca-033985 Equus caballus 94.01 0.00e+00 2224.00
IUUC-Eeu-034928 Erinaceus europaeus 82.47 0.00e+00 700.00
IUUC-Fca-035587 Felis catus 94.10 0.00e+00 2235.00
IUUC-Fal-037587 Ficedula albicollis 80.71 0.00e+00 1867.00
IUUC-Fso-038133 Fusarium solani 29.20 6.00e-127 448.00
IUUC-Gmo-039076 Gadus morhua 70.86 0.00e+00 1640.00
IUUC-Ggr-039957 Gaeumannomyces graminis 31.10 5.00e-128 452.00
IUUC-Gga-040948 Gallus gallus 81.73 0.00e+00 1941.00
IUUC-Gac-042396 Gasterosteus aculeatus 71.38 0.00e+00 1689.00
IUUC-Ggo-045412 Gorilla gorilla 95.43 0.00e+00 2256.00
IUUC-Hsa-046076 Homo sapiens 95.43 0.00e+00 2259.00
IUUC-Itr-048143 Ictidomys tridecemlineatus 86.36 0.00e+00 1988.00
IUUC-Kpa-049178 Komagataella pastoris 40.52 2.00e-66 247.00
IUUC-Lch-050279 Latimeria chalumnae 69.97 0.00e+00 1630.00
IUUC-Loc-052872 Lepisosteus oculatus 73.44 0.00e+00 1732.00
IUUC-Lma-052986 Leptosphaeria maculans 31.34 5.00e-147 515.00
IUUC-Laf-054181 Loxodonta africana 91.56 0.00e+00 2182.00
IUUC-Mcc-054812 Macaca mulatta 95.01 0.00e+00 2237.00
IUUC-Meu-056325 Macropus eugenii 88.61 0.00e+00 2098.00
IUUC-Mor-057246 Magnaporthe oryzae 28.60 3.00e-114 406.00
IUUC-Mpo-057464 Magnaporthe poae 30.57 4.00e-130 459.00
IUUC-Mla-058911 Melampsora laricipopulina 31.02 9.00e-89 322.00
IUUC-Mga-059335 Meleagris gallopavo 82.12 0.00e+00 1896.00
IUUC-Mvi-060461 Microbotryum violaceum 32.55 7.00e-134 472.00
IUUC-Mmr-060636 Microcebus murinus 94.60 0.00e+00 2229.00
IUUC-Mmu-063503 Mus musculus 91.74 0.00e+00 2154.00
IUUC-Mpu-066670 Mustela putorius furo 93.93 0.00e+00 2219.00
IUUC-Mlu-068119 Myotis lucifugus 92.68 0.00e+00 2231.00
IUUC-Nfi-068398 Neosartorya fischeri 31.07 2.00e-144 506.00
IUUC-Ncr-068927 Neurospora crassa 28.83 3.00e-123 436.00
IUUC-Opr-070614 Ochotona princeps 92.87 0.00e+00 2174.00
IUUC-Ont-072433 Oreochromis niloticus 71.73 0.00e+00 1739.00
IUUC-Oan-073283 Ornithorhynchus anatinus 69.56 0.00e+00 1316.00
IUUC-Ocu-074401 Oryctolagus cuniculus 92.57 0.00e+00 2192.00
IUUC-Ola-087522 Oryzias latipes 71.45 0.00e+00 1689.00
IUUC-Oga-088226 Otolemur garnettii 93.08 0.00e+00 2210.00
IUUC-Oar-089241 Ovis aries 94.01 0.00e+00 2251.00
IUUC-Pan-092297 Papio anubis 94.55 0.00e+00 1993.00
IUUC-Psi-094043 Pelodiscus sinensis 78.77 0.00e+00 1810.00
IUUC-Pma-094394 Petromyzon marinus 66.18 0.00e+00 1458.00
IUUC-Pno-095053 Phaeosphaeria nodorum 30.60 5.00e-138 485.00
IUUC-Ppa-095188 Physcomitrella patens 31.38 3.00e-146 513.00
IUUC-Pfo-097517 Poecilia formosa 72.51 0.00e+00 1746.00
IUUC-Pca-100471 Procavia capensis 93.04 0.00e+00 2080.00
IUUC-Pva-102805 Pteropus vampyrus 90.37 0.00e+00 1770.00
IUUC-Pte-104021 Pyrenophora teres 31.12 3.00e-149 522.00
IUUC-Pyt-104682 Pyrenophora triticirepentis 30.94 3.00e-148 519.00
IUUC-Rno-105471 Rattus norvegicus 91.78 0.00e+00 2156.00
IUUC-Sce-106235 Saccharomyces cerevisiae 37.46 8.00e-60 225.00
IUUC-Sha-106883 Sarcophilus harrisii 87.48 0.00e+00 1930.00
IUUC-Spo-108169 Schizosaccharomyces pombe 30.80 6.00e-132 465.00
IUUC-Sar-113323 Sorex araneus 90.40 0.00e+00 1601.00
IUUC-Sre-115075 Sporisorium reilianum 29.33 2.00e-68 254.00
IUUC-Ssc-116363 Sus scrofa 92.73 0.00e+00 2222.00
IUUC-Tru-118427 Takifugu rubripes 71.91 0.00e+00 1756.00
IUUC-Tni-120218 Tetraodon nigroviridis 72.09 0.00e+00 1751.00
IUUC-Tre-122177 Trichoderma reesei 30.62 1.00e-140 494.00
IUUC-Tme-127176 Tuber melanosporum 31.38 1.00e-128 454.00
IUUC-Tbe-127641 Tupaia belangeri 86.96 0.00e+00 727.00
IUUC-Ttr-128888 Tursiops truncatus 93.37 0.00e+00 1376.00
IUUC-Uma-129361 Ustilago maydis 38.12 8.00e-63 236.00
IUUC-Xtr-132811 Xenopus tropicalis 75.62 0.00e+00 1790.00
Created Date 25-Jun-2017

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