iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ola-087161

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

BAAF04092472

Gene Name

SMURF2 (1 of many)

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSORLG00000013762.1	ENSORLT00000017261.1	ENSORLP00000017260.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	5.40e-124	414.2	402	733

Active Site

Position(s)	Description	Evidence
702	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl krl+++f+gEegld+gGv+re+l+lls+e+ np++glf+ys +d +tlq+npds + npehl++F+f+Gr++g+a+++g+++d 
   Q: 402  PKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAV-NPEHLSYFHFVGRIMGLAVFHGHYIDG 489
           678999*****************************************************98.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk+llgk+++l+d+e+vdp+l++sl +i+ n   di+   ld tf+v+++ +ge+  +eLkp+G++i+Vt++ k+eYv+l+v+
   Q: 490  GFTLPFYKQLLGKPITLDDMESVDPDLHNSLVWILGN---DITGV-LDHTFCVEHSAYGEIIPHELKPNGKSISVTEDTKKEYVRLYVN 574
           ***********************************99...9***8.******************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+  gi+ q+ a+++Gfnevip++ll++F+e+elel++cG  +id+ d++++t+ k+ +t ds+ ++wFw+++e+f++e r+++LqFv
   Q: 575  WRFLHGIEAQFLALQKGFNEVIPQHLLKAFDEKELELIVCGLGKIDIVDWRSNTRLKH-CTTDSNIVKWFWKAVESFDEERRARLLQFV 662
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tgssr Pl+Gf++l+    prlf+i++ da+ ++lP+++TCfn++++P+Y+s+e+l++kLl+Aieet gF +
   Q: 663  TGSSR-PLQGFKALQgaagPRLFTIHQiDANANNLPKAHTCFNRIDIPPYESYEKLYDKLLTAIEETCGFAV 733
           ****6.9********************99999**************************************76 PP

Organism

Oryzias latipes

Protein Sequence
(Fasta)

VLCAKNLAKK DFFRLPDPFA KVVVDGSGQC HSTDTVRNTL DPKWNQHYDL YIGKADSITI 60
SVWNHKKIHK KQGAGFLGCV RLLSNTINRL KDTGYQRLDL NKLGPNDNDT VRGQIVVSLQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGTTGTGTG CAAAGAACCT GGCAAAGAAA GACTTCTTTC GTAAGTATTT TGTGTTGCAT 60
TTTAATTCAT TGTGACTATT AGGAATGTAT AATACAATTT AGTCCAAATT ATTTCAAAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Csv-026339	Ciona savignyi	61.68	0.00e+00	943.00
IUUC-Gac-041983	Gasterosteus aculeatus	88.56	0.00e+00	1362.00
IUUC-Ont-072243	Oreochromis niloticus	88.07	0.00e+00	1368.00
IUUC-Pfo-096142	Poecilia formosa	88.38	0.00e+00	1366.00
IUUC-Tru-118497	Takifugu rubripes	87.35	0.00e+00	1310.00
IUUC-Tni-120781	Tetraodon nigroviridis	86.52	0.00e+00	1151.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence