iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA	RAID2
Post-translational Modifications (PTMs)
dbPAF	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.20e-53	181.9	109	429

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrellle..kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflafl 99
           Gl N gN CY+NS LQ+ +n+pe+r+l+ +    ++ ++ e+p  + ++ + +lq++f  l+   ++ ++ ++ ++ l+k+ +   ++eqqD+qEf   +
   Q: 109  GLINGGNFCYVNSFLQVWFNVPEFRQLIYDfrPSENFVPPEAPRMNVQATMLALQDIFYTLQ---TTPFNETDKTSNLGKLLRL--NSEQQDSQEFGLKF 203
           9*****************************75555667777778888899999999999995...4444444444555555444..567*********** PP
   S: 100  ldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkkeslqdcLesftkeee 199
           +++le+ l                       +  + k++ + ++dlF g++ ++i+c +c+++s+ree+ ++l+l+++g       +l d+L++++ ee+
   Q: 204  FNALERCL----------------------PDHPNGKETLKRLKDLFTGETCTRIVC-KCGQRSEREETAISLTLNIEGYC-----TLLDALDAYFGEEH 275
           ********......................445778888899***************.7*********************9.....9************* PP
   S: 200  legenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqkekkkYeLiavvvHsG.slssGHYvay 298
           l++   ++c+kc+k  +++k+ +  klP+v++++L+R++++++   r+k+++ + +p+e+  + f  ++++     + Y+L+av +H+G ++++GHY+ +
   Q: 276  LDD---FKCSKCNKTGDVSKQSDYVKLPPVIVIQLNRYKYTSK--GRQKLKTPMAYPREIPAKAFQRTNNSIPPPAEMYDLFAVTIHEGnNAECGHYYDL 370
           *97...********************************99886..778******************999999999************************* PP
   S: 299  vknekgk.WllfdDskVtevke.eevleetg...................staYvlfYkr 337
           +k+  ++ W++++D++V+++++    ++                      +  Y l+Y+r
   Q: 371  IKSPLNQkWYRYNDETVEAIPKpPGTEKP-TtakteksrkkdkekyptdqKACYGLLYRR 429
           ***65555***********9752222222.124556777777777777777777777776 PP

Organism

Caenorhabditis elegans

Protein Sequence
(Fasta)

MTKETDKKPK ERPNQRKVAF RNEAINALVN TDEDQVTFSK AMEVAKLDCQ KCLLHDMHSS 60
KSSNCRDNPF CIHRLGLEKF EKLITQEQET KEEAKKDQKR RDLNDQPAGL INGGNFCYVN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAAATGACAA AGGAGACTGA CAAAAAGCCA AAAGAACGTC CGAATCAAAG AAAAGTTGCA 60
TTTCGAAATG AAGCAATAAA TGCATTAGTA AATACAGATG AGGACCAAGT CACATTTTCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-1267--Proteomics identification
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR028134--USP4/12
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

cel:CELE_F30A10.10

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000130	Aegilops tauschii	27.87	6.00e-24	105.00
IUUC-Aml-001357	Ailuropoda melanoleuca	27.65	2.00e-29	123.00
IUUC-Apl-003773	Anas platyrhynchos	29.83	5.00e-29	122.00
IUUC-Aca-004466	Anolis carolinensis	28.08	7.00e-33	133.00
IUUC-Ame-011554	Astyanax mexicanus	29.79	5.00e-31	128.00
IUUC-Bta-012573	Bos taurus	27.65	2.00e-29	124.00
IUUC-Bra-017494	Brassica rapa	29.19	5.00e-30	125.00
IUUC-Cja-019991	Callithrix jacchus	27.03	3.00e-30	126.00
IUUC-Cfa-020294	Canis familiaris	27.65	2.00e-29	123.00
IUUC-Cpo-021706	Cavia porcellus	27.65	2.00e-28	120.00
IUUC-Csa-023931	Chlorocebus sabaeus	28.02	2.00e-29	123.00
IUUC-Csv-026006	Ciona savignyi	26.10	4.00e-29	122.00
IUUC-Cne-027065	Cryptococcus neoformans	31.87	2.00e-29	123.00
IUUC-Dre-027624	Danio rerio	30.13	1.00e-31	130.00
IUUC-Ete-032818	Echinops telfairi	27.22	5.00e-25	108.00
IUUC-Eca-033692	Equus caballus	27.65	1.00e-29	124.00
IUUC-Fca-035676	Felis catus	28.02	2.00e-29	123.00
IUUC-Fal-036913	Ficedula albicollis	28.53	6.00e-32	131.00
IUUC-Gga-041041	Gallus gallus	28.57	2.00e-32	133.00
IUUC-Gac-042570	Gasterosteus aculeatus	28.91	5.00e-31	129.00
IUUC-Gma-043910	Glycine max	30.00	4.00e-22	99.40
IUUC-Ggo-045367	Gorilla gorilla	28.15	7.00e-30	124.00
IUUC-Hsa-046019	Homo sapiens	27.65	2.00e-29	123.00
IUUC-Hvu-047303	Hordeum vulgare	27.29	1.00e-22	100.00
IUUC-Itr-048319	Ictidomys tridecemlineatus	27.73	3.00e-29	122.00
IUUC-Loc-052756	Lepisosteus oculatus	29.64	3.00e-30	126.00
IUUC-Laf-054043	Loxodonta africana	27.65	1.00e-29	124.00
IUUC-Mcc-054986	Macaca mulatta	27.37	4.00e-30	125.00
IUUC-Meu-056228	Macropus eugenii	27.65	4.00e-28	119.00
IUUC-Mga-059896	Meleagris gallopavo	28.99	5.00e-33	135.00
IUUC-Mvi-060269	Microbotryum violaceum	29.60	9.00e-32	131.00
IUUC-Mmr-060887	Microcebus murinus	27.65	2.00e-29	123.00
IUUC-Mdo-062506	Monodelphis domestica	27.94	1.00e-29	124.00
IUUC-Mmu-063642	Mus musculus	26.77	4.00e-30	125.00
IUUC-Mpu-066194	Mustela putorius furo	27.65	2.00e-29	123.00
IUUC-Mlu-067233	Myotis lucifugus	27.35	4.00e-30	125.00
IUUC-Nle-069052	Nomascus leucogenys	27.03	4.00e-30	125.00
IUUC-Ola-086568	Oryzias latipes	31.18	1.00e-33	137.00
IUUC-Oga-088687	Otolemur garnettii	27.11	3.00e-29	122.00
IUUC-Oar-090345	Ovis aries	27.65	6.00e-30	125.00
IUUC-Ptr-090734	Pan troglodytes	27.65	2.00e-29	124.00
IUUC-Pan-091704	Papio anubis	28.02	2.00e-29	123.00
IUUC-Pab-098129	Pongo abelii	27.65	2.00e-29	123.00
IUUC-Pva-102719	Pteropus vampyrus	27.65	1.00e-29	124.00
IUUC-Rno-105363	Rattus norvegicus	28.02	9.00e-30	124.00
IUUC-Sha-107620	Sarcophilus harrisii	27.94	6.00e-29	122.00
IUUC-Sit-110683	Setaria italica	30.18	2.00e-24	106.00
IUUC-Sbi-113833	Sorghum bicolor	31.49	1.00e-23	102.00
IUUC-Tgu-117519	Taeniopygia guttata	28.53	2.00e-29	123.00
IUUC-Tru-117651	Takifugu rubripes	30.38	7.00e-32	131.00
IUUC-Tsy-119201	Tarsius syrichta	25.37	4.00e-22	99.40
IUUC-Tni-120840	Tetraodon nigroviridis	29.43	6.00e-31	128.00
IUUC-Tca-121674	Theobroma cacao	28.73	6.00e-33	135.00
IUUC-Tae-125247	Triticum aestivum	27.87	6.00e-24	105.00
IUUC-Tur-126599	Triticum urartu	28.24	1.00e-22	100.00
IUUC-Ttr-128312	Tursiops truncatus	26.76	3.00e-26	112.00
IUUC-Vpa-130348	Vicugna pacos	27.65	1.00e-28	120.00
IUUC-Xma-133263	Xiphophorus maculatus	27.34	1.00e-26	114.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence