iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cne-026889

Ensembl Protein ID

AAW41320

UniProt Accession

P0CO54; Q55YQ9; Q5KN30; ATG8_CRYNJ

Genbank Protein ID

AAW41320.1

Protein Name

Autophagy-related protein 8; Autophagy-related ubiquitin-like modifier ATG8

Genbank Nucleotide ID

AE017341

Gene Name

ATG8; CNA07930

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
CNA07930	AAW41320	AAW41320

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
ULD/UBL/ATG8	2.10e-48	161.2	14	117

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UBL/ATG8

   S: 1    krkeevekirdkfpdkiPvivekakkekipeldkkkylvPsdltvgqlvkiirkrlqlraedalfllvnnslvsvsatlaeiyeeekdedgflyvayasee 101
           krk+e+e+ir+k++d+iPvi+eka+k++ip++dkkkylvP+dltvgq+v++irkr++l +e+a+f++v++ l++++a +++iy+e+kdedgflyv yase+
   Q: 14   KRKAEAERIRQKYQDRIPVICEKAEKSDIPTIDKKKYLVPADLTVGQFVYVIRKRIKLAPEKAIFIFVDDILPPTAALMSSIYDEHKDEDGFLYVLYASEN 114
           699************************************************************************************************** PP
   S: 102  tfG 104
           tfG
   Q: 115  TFG 117
           **9 PP

Organism

Cryptococcus neoformans

Functional Description
(View)

Ubiquitin-like modifier involved in autophagosomes formation. With ATG4, mediates the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Participates also in membrane fusion events that take place in the early secretory pathway. Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy.

Protein Sequence
(Fasta)

MVRSKFKDEH PFDKRKAEAE RIRQKYQDRI PVICEKAEKS DIPTIDKKKY LVPADLTVGQ 60
FVYVIRKRIK LAPEKAIFIF VDDILPPTAA LMSSIYDEHK DEDGFLYVLY ASENTFGDLE 120

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Nucleotide Sequence
(Fasta)

CTCCTTCAAC TCCTTTTACT ATTACTGCTG TCTAACTACT CCTTATTTAC TCGGCGTGAG 60
TTCCATGATA CTCCGTGGAT GGCAAAGGCG TGCTGACTTC ACCACCAGCA ACAGCAACAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0072--Autophagy
KW-0181--Complete proteome
KW-0968--Cytoplasmic vesicle
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0833--Ubl conjugation pathway
KW-0926--Vacuole

Interpro

IPR004241--Atg8-like
IPR029071--Ubiquitin-rel_dom

Pfam

PF02991--Atg8

Gene Ontology

GO:0000421--C:autophagosome membrane
GO:0031410--C:cytoplasmic vesicle
GO:0006914--P:autophagy
GO:0015031--P:protein transport

KEGG

cne:CNA07930

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000059	Aegilops tauschii	73.50	8.00e-51	189.00
IUUC-Aml-001323	Ailuropoda melanoleuca	58.04	6.00e-38	147.00
IUUC-Atr-002791	Amborella trichopoda	77.31	3.00e-52	194.00
IUUC-Apl-003994	Anas platyrhynchos	54.31	4.00e-37	144.00
IUUC-Aca-005288	Anolis carolinensis	56.25	2.00e-35	138.00
IUUC-Aly-005554	Arabidopsis lyrata	79.49	3.00e-45	171.00
IUUC-Ath-006958	Arabidopsis thaliana	78.63	1.00e-44	169.00
IUUC-Ago-007898	Ashbya gossypii	72.03	2.00e-49	185.00
IUUC-Acl-008314	Aspergillus clavatus	88.14	3.00e-59	217.00
IUUC-Afl-008708	Aspergillus flavus	88.98	7.00e-60	219.00
IUUC-Afu-009097	Aspergillus fumigatus	88.14	3.00e-59	217.00
IUUC-Ani-009196	Aspergillus nidulans	87.29	2.00e-58	215.00
IUUC-Ang-009530	Aspergillus niger	88.14	3.00e-59	217.00
IUUC-Aor-009909	Aspergillus oryzae	88.98	7.00e-60	219.00
IUUC-Ate-010358	Aspergillus terreus	88.14	3.00e-59	217.00
IUUC-Ame-010914	Astyanax mexicanus	55.56	5.00e-38	147.00
IUUC-Bgr-012248	Blumeria graminis	86.44	6.00e-58	213.00
IUUC-Bta-012805	Bos taurus	58.04	6.00e-38	147.00
IUUC-Bci-013959	Botrytis cinerea	87.18	8.00e-59	216.00
IUUC-Bdi-014390	Brachypodium distachyon	78.15	7.00e-52	193.00
IUUC-Bol-016488	Brassica oleracea	78.63	2.00e-52	195.00
IUUC-Bra-016921	Brassica rapa	78.63	4.00e-52	194.00
IUUC-Cel-018200	Caenorhabditis elegans	53.45	2.00e-35	138.00
IUUC-Cja-019369	Callithrix jacchus	58.04	6.00e-38	147.00
IUUC-Cfa-020603	Canis familiaris	58.04	6.00e-38	147.00
IUUC-Cpo-022522	Cavia porcellus	54.31	4.00e-37	144.00
IUUC-Cre-022866	Chlamydomonas reinhardtii	75.59	9.00e-46	173.00
IUUC-Csa-024117	Chlorocebus sabaeus	58.04	6.00e-38	147.00
IUUC-Cho-025008	Choloepus hoffmanni	50.86	2.00e-34	135.00
IUUC-Cin-025297	Ciona intestinalis	56.03	1.00e-38	149.00
IUUC-Csv-026146	Ciona savignyi	39.32	3.00e-22	95.10
IUUC-Cgl-026691	Colletotrichum gloeosporioides	63.80	8.00e-53	197.00
IUUC-Cme-027158	Cyanidioschyzon merolae	31.25	1.80e-01	27.30
IUUC-Dre-027910	Danio rerio	57.89	2.00e-38	148.00
IUUC-Dno-029218	Dasypus novemcinctus	58.18	1.00e-36	144.00
IUUC-Dor-030245	Dipodomys ordii	58.04	6.00e-38	147.00
IUUC-Dse-031428	Dothistroma septosporum	88.03	5.00e-59	217.00
IUUC-Dme-031813	Drosophila melanogaster	57.76	3.00e-39	151.00
IUUC-Ete-032671	Echinops telfairi	58.04	7.00e-38	146.00
IUUC-Eca-033464	Equus caballus	54.31	4.00e-37	144.00
IUUC-Eeu-035131	Erinaceus europaeus	54.65	9.00e-26	105.00
IUUC-Fca-036493	Felis catus	58.04	8.00e-38	147.00
IUUC-Fal-037143	Ficedula albicollis	52.07	1.00e-37	145.00
IUUC-Fox-037846	Fusarium oxysporum	88.89	1.00e-59	218.00
IUUC-Fso-038134	Fusarium solani	88.89	2.00e-59	218.00
IUUC-Gmo-039671	Gadus morhua	53.72	3.00e-38	148.00
IUUC-Ggr-039770	Gaeumannomyces graminis	84.55	2.00e-58	215.00
IUUC-Gga-040257	Gallus gallus	58.93	3.00e-38	147.00
IUUC-Gac-042507	Gasterosteus aculeatus	52.85	3.00e-38	148.00
IUUC-Gma-043726	Glycine max	77.87	2.00e-46	175.00
IUUC-Ggo-044860	Gorilla gorilla	58.04	8.00e-38	146.00
IUUC-Hsa-045905	Homo sapiens	58.04	6.00e-38	147.00
IUUC-Hvu-047588	Hordeum vulgare	76.03	3.00e-52	194.00
IUUC-Itr-048405	Ictidomys tridecemlineatus	58.04	6.00e-38	147.00
IUUC-Kpa-049124	Komagataella pastoris	81.36	5.00e-55	203.00
IUUC-Lch-049798	Latimeria chalumnae	52.59	2.00e-37	145.00
IUUC-Lpe-051292	Leersia perrieri	78.63	3.00e-52	194.00
IUUC-Loc-052290	Lepisosteus oculatus	56.03	7.00e-38	147.00
IUUC-Laf-054203	Loxodonta africana	58.04	6.00e-38	147.00
IUUC-Mcc-055307	Macaca mulatta	58.04	6.00e-38	147.00
IUUC-Meu-056010	Macropus eugenii	54.31	4.00e-37	144.00
IUUC-Mor-057276	Magnaporthe oryzae	88.14	1.00e-58	215.00
IUUC-Mpo-057469	Magnaporthe poae	83.74	1.00e-57	213.00
IUUC-Mtr-058417	Medicago truncatula	78.99	7.00e-46	173.00
IUUC-Mla-059098	Melampsora laricipopulina	87.93	8.00e-59	216.00
IUUC-Mga-060108	Meleagris gallopavo	53.39	2.00e-37	145.00
IUUC-Mvi-060496	Microbotryum violaceum	88.89	3.00e-58	214.00
IUUC-Mmr-061776	Microcebus murinus	58.04	6.00e-38	147.00
IUUC-Mdo-062279	Monodelphis domestica	53.85	4.00e-37	144.00
IUUC-Mmu-064157	Mus musculus	58.04	6.00e-38	147.00
IUUC-Mac-064522	Musa acuminata	75.63	2.00e-45	172.00
IUUC-Mpu-066028	Mustela putorius furo	58.04	1.00e-37	146.00
IUUC-Mlu-067166	Myotis lucifugus	58.04	6.00e-38	147.00
IUUC-Nfi-068367	Neosartorya fischeri	88.14	3.00e-59	217.00
IUUC-Ncr-068894	Neurospora crassa	88.24	4.00e-60	220.00
IUUC-Nle-069220	Nomascus leucogenys	58.04	6.00e-38	147.00
IUUC-Opr-070777	Ochotona princeps	58.04	6.00e-38	147.00
IUUC-Ont-072343	Oreochromis niloticus	54.31	2.00e-35	138.00
IUUC-Oan-073485	Ornithorhynchus anatinus	56.25	5.00e-33	130.00
IUUC-Ocu-074148	Oryctolagus cuniculus	58.04	6.00e-38	147.00
IUUC-Oba-075926	Oryza barthii	77.78	2.00e-51	192.00
IUUC-Obr-076830	Oryza brachyantha	77.78	3.00e-52	194.00
IUUC-Ogl-077457	Oryza glaberrima	77.78	2.00e-51	192.00
IUUC-Ogu-078078	Oryza glumaepatula	77.78	2.00e-51	192.00
IUUC-Oin-079771	Oryza indica	77.78	2.00e-51	192.00
IUUC-Olo-080412	Oryza longistaminata	77.78	2.00e-51	192.00
IUUC-Ome-081791	Oryza meridionalis	77.78	2.00e-51	192.00
IUUC-Oni-082774	Oryza nivara	77.78	2.00e-51	192.00
IUUC-Opu-083501	Oryza punctata	77.31	2.00e-52	194.00
IUUC-Oru-084425	Oryza rufipogon	75.63	5.00e-51	190.00
IUUC-Osa-085439	Oryza sativa	77.78	2.00e-51	192.00
IUUC-Ola-086310	Oryzias latipes	55.17	8.00e-36	139.00
IUUC-Olu-087892	Ostreococcus lucimarinus	79.46	3.00e-52	194.00
IUUC-Oga-088312	Otolemur garnettii	58.04	6.00e-38	147.00
IUUC-Oar-089989	Ovis aries	58.04	6.00e-38	147.00
IUUC-Ptr-091108	Pan troglodytes	58.04	6.00e-38	147.00
IUUC-Pan-092269	Papio anubis	54.31	2.00e-35	138.00
IUUC-Psi-093055	Pelodiscus sinensis	54.31	4.00e-37	144.00
IUUC-Pma-094337	Petromyzon marinus	55.36	9.00e-37	143.00
IUUC-Pno-095035	Phaeosphaeria nodorum	88.03	4.00e-59	217.00
IUUC-Ppa-095786	Physcomitrella patens	80.34	9.00e-53	196.00
IUUC-Pfo-096380	Poecilia formosa	57.14	4.00e-36	140.00
IUUC-Pab-097660	Pongo abelii	58.04	6.00e-38	147.00
IUUC-Pop-100069	Populus trichocarpa	79.49	9.00e-46	172.00
IUUC-Pca-100230	Procavia capensis	58.04	6.00e-38	147.00
IUUC-Ppe-101670	Prunus persica	76.92	3.00e-45	171.00
IUUC-Pva-103103	Pteropus vampyrus	54.31	4.00e-37	144.00
IUUC-Pgr-103531	Puccinia graminis	18.45	1.20e-01	26.20
IUUC-Pte-104230	Pyrenophora teres	88.03	3.00e-59	217.00
IUUC-Rno-105497	Rattus norvegicus	58.04	6.00e-38	147.00
IUUC-Sce-106150	Saccharomyces cerevisiae	78.45	6.00e-52	193.00
IUUC-Sha-106656	Sarcophilus harrisii	58.04	6.00e-38	147.00
IUUC-Sja-107857	Schizosaccharomyces japonicus	80.17	1.00e-53	199.00
IUUC-Spo-108156	Schizosaccharomyces pombe	76.27	3.00e-45	171.00
IUUC-Ssl-108578	Sclerotinia sclerotiorum	87.18	9.00e-59	216.00
IUUC-Smo-109082	Selaginella moellendorffii	79.13	8.00e-52	193.00
IUUC-Sit-109732	Setaria italica	76.92	9.00e-51	189.00
IUUC-Sly-111700	Solanum lycopersicum	78.81	2.00e-52	194.00
IUUC-Stu-112612	Solanum tuberosum	79.17	6.00e-54	200.00
IUUC-Sar-113670	Sorex araneus	52.68	7.00e-34	133.00
IUUC-Sbi-114346	Sorghum bicolor	77.78	2.00e-51	191.00
IUUC-Sre-114964	Sporisorium reilianum	84.48	4.00e-56	207.00
IUUC-Ssc-116182	Sus scrofa	58.04	6.00e-38	147.00
IUUC-Tgu-116669	Taeniopygia guttata	54.31	5.00e-37	144.00
IUUC-Tru-118632	Takifugu rubripes	55.56	5.00e-38	147.00
IUUC-Tsy-118919	Tarsius syrichta	54.31	4.00e-37	144.00
IUUC-Tni-120706	Tetraodon nigroviridis	55.17	8.00e-36	140.00
IUUC-Tca-121335	Theobroma cacao	76.07	6.00e-46	174.00
IUUC-Tre-122077	Trichoderma reesei	88.79	5.00e-59	217.00
IUUC-Tvi-122400	Trichoderma virens	88.79	5.00e-59	217.00
IUUC-Tae-124455	Triticum aestivum	76.47	4.00e-51	191.00
IUUC-Tur-126158	Triticum urartu	72.03	6.00e-50	187.00
IUUC-Tme-126955	Tuber melanosporum	87.18	2.00e-57	212.00
IUUC-Tbe-127765	Tupaia belangeri	59.30	1.00e-27	112.00
IUUC-Ttr-128712	Tursiops truncatus	54.31	4.00e-37	144.00
IUUC-Uma-129435	Ustilago maydis	83.90	2.00e-56	208.00
IUUC-Vda-129807	Verticillium dahliae	88.24	5.00e-60	220.00
IUUC-Vpa-130804	Vicugna pacos	54.31	3.00e-35	138.00
IUUC-Vvi-130830	Vitis vinifera	76.47	1.00e-45	172.00
IUUC-Xtr-132183	Xenopus tropicalis	54.31	4.00e-37	144.00
IUUC-Xma-133400	Xiphophorus maculatus	54.17	6.00e-38	147.00
IUUC-Yli-134327	Yarrowia lipolytica	85.37	4.00e-53	197.00
IUUC-Zma-135270	Zea mays	78.15	3.00e-52	194.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence