iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-053648

UUCD1 version

UUC-LoA-00505

Ensembl Protein ID

ENSLAFP00000012177.3

UniProt Accession

G3TDF5; G3TDF5_LOXAF

Protein Name

Breast cancer type 1 susceptibility protein homolog

Gene Name

BRCA1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000021784.2	ENSLAFT00000014535.3	ENSLAFP00000012177.3
ENSLAFG00000021784.2	ENSLAFT00000022382.2	ENSLAFP00000016250.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	3.30e-07	31.1	24	65

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iCle +k+ p+++ C H+f++ C  k+    n++++  +CPlC+
   Q: 24   CPICLELIKE-PVSTKCDHIFCKFCMLKL---LNQKKGPSQCPLCK 65
           ********99.**************9666...68899********7 PP

Organism

Loxodonta africana

Functional Description
(View)

E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to mitosis. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator.

Protein Sequence
(Fasta)

MDFSVAHIEE VQNVLNAMQK ILECPICLEL IKEPVSTKCD HIFCKFCMLK LLNQKKGPSQ 60
CPLCKNHITK RSLQESTRFS QLVEELLKII RAFELDTGLQ FANSYNFAKK ENNSPEHVKE 120

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Nucleotide Sequence
(Fasta)

ATGGATTTTT CTGTGGCTCA CATTGAAGAA GTACAAAATG TCCTTAATGC TATGCAGAAA 60
ATCTTGGAGT GTCCAATCTG GTAAGTCAAC AGAGGAGTTT TTTGATTTAA GATTCTTCCT 120

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Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0158--Chromosome
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0233--DNA recombination
KW-0234--DNA repair
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR011364--BRCA1
IPR031099--BRCA1-associated
IPR025994--BRCA1_serine_dom
IPR001357--BRCT_dom
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50172--BRCT
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00533--BRCT
PF12820--BRCT_assoc
PF00097--zf-C3HC4

PRINTS

PR00493--BRSTCANCERI

SMART

SM00292--BRCT
SM00184--RING

Gene Ontology

GO:0070531--C:BRCA1-A complex
GO:0031436--C:BRCA1-BARD1 complex
GO:0005737--C:cytoplasm
GO:0030529--C:intracellular ribonucleoprotein complex
GO:0000800--C:lateral element
GO:0005886--C:plasma membrane
GO:0003684--F:damaged DNA binding
GO:0003723--F:RNA binding
GO:0044212--F:transcription regulatory region DNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0071681--P:cellular response to indole-3-methanol
GO:0071356--P:cellular response to tumor necrosis factor
GO:0007098--P:centrosome cycle
GO:0043009--P:chordate embryonic development
GO:0007059--P:chromosome segregation
GO:0006260--P:DNA replication
GO:0009048--P:dosage compensation by inactivation of X chromosome
GO:0000724--P:double-strand break repair via homologous recombination
GO:0031572--P:G2 DNA damage checkpoint
GO:0008630--P:intrinsic apoptotic signaling pathway in response to DNA damage
GO:1902042--P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0045717--P:negative regulation of fatty acid biosynthetic process
GO:0035067--P:negative regulation of histone acetylation
GO:0051572--P:negative regulation of histone H3-K4 methylation
GO:0051573--P:negative regulation of histone H3-K9 methylation
GO:0033147--P:negative regulation of intracellular estrogen receptor signaling pathway
GO:2000378--P:negative regulation of reactive oxygen species metabolic process
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0045766--P:positive regulation of angiogenesis
GO:0071158--P:positive regulation of cell cycle arrest
GO:0045739--P:positive regulation of DNA repair
GO:0051571--P:positive regulation of histone H3-K4 methylation
GO:2000617--P:positive regulation of histone H3-K9 acetylation
GO:0051574--P:positive regulation of histone H3-K9 methylation
GO:2000620--P:positive regulation of histone H4-K16 acetylation
GO:0070512--P:positive regulation of histone H4-K20 methylation
GO:0031398--P:positive regulation of protein ubiquitination
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0010575--P:positive regulation of vascular endothelial growth factor production
GO:0006301--P:postreplication repair
GO:0051865--P:protein autoubiquitination
GO:0085020--P:protein K6-linked ubiquitination
GO:0044030--P:regulation of DNA methylation
GO:0006349--P:regulation of gene expression by genetic imprinting
GO:0043627--P:response to estrogen
GO:0010212--P:response to ionizing radiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002388	Ailuropoda melanoleuca	72.62	0.00e+00	2565.00
IUUC-Apl-003252	Anas platyrhynchos	36.00	4.00e-128	453.00
IUUC-Aca-004526	Anolis carolinensis	57.26	3.00e-79	289.00
IUUC-Ame-011720	Astyanax mexicanus	50.74	5.00e-57	216.00
IUUC-Bta-013433	Bos taurus	69.56	0.00e+00	2400.00
IUUC-Cel-018208	Caenorhabditis elegans	35.44	2.00e-10	60.80
IUUC-Cja-019149	Callithrix jacchus	72.34	0.00e+00	2490.00
IUUC-Cfa-020322	Canis familiaris	71.07	0.00e+00	2472.00
IUUC-Cpo-021583	Cavia porcellus	46.33	0.00e+00	1292.00
IUUC-Cre-022955	Chlamydomonas reinhardtii	30.22	6.00e-09	57.00
IUUC-Csa-024227	Chlorocebus sabaeus	73.99	8.00e-149	520.00
IUUC-Cho-024530	Choloepus hoffmanni	69.54	0.00e+00	1223.00
IUUC-Cin-025364	Ciona intestinalis	43.68	9.00e-16	77.40
IUUC-Csv-026245	Ciona savignyi	36.36	2.00e-13	69.30
IUUC-Dno-029247	Dasypus novemcinctus	72.94	0.00e+00	2135.00
IUUC-Dme-032032	Drosophila melanogaster	54.35	3.00e-11	59.70
IUUC-Ete-032472	Echinops telfairi	59.63	0.00e+00	1862.00
IUUC-Eca-033446	Equus caballus	75.60	0.00e+00	2696.00
IUUC-Eeu-034858	Erinaceus europaeus	60.20	0.00e+00	971.00
IUUC-Fca-035991	Felis catus	73.42	0.00e+00	2620.00
IUUC-Fal-036803	Ficedula albicollis	29.82	2.00e-87	318.00
IUUC-Gmo-038782	Gadus morhua	50.00	1.00e-49	191.00
IUUC-Ggr-039833	Gaeumannomyces graminis	36.73	9.00e-08	51.60
IUUC-Gga-040969	Gallus gallus	53.19	4.00e-79	290.00
IUUC-Gac-042296	Gasterosteus aculeatus	47.89	1.00e-54	208.00
IUUC-Ggo-044740	Gorilla gorilla	70.80	0.00e+00	2382.00
IUUC-Hsa-046086	Homo sapiens	74.08	0.00e+00	2487.00
IUUC-Itr-048512	Ictidomys tridecemlineatus	70.02	0.00e+00	2487.00
IUUC-Lch-049789	Latimeria chalumnae	52.24	3.00e-76	281.00
IUUC-Loc-051952	Lepisosteus oculatus	54.09	9.00e-70	259.00
IUUC-Mcc-055210	Macaca mulatta	72.87	0.00e+00	2553.00
IUUC-Meu-056342	Macropus eugenii	39.72	1.00e-132	468.00
IUUC-Mga-060163	Meleagris gallopavo	56.27	4.00e-83	303.00
IUUC-Mmr-061402	Microcebus murinus	69.89	0.00e+00	803.00
IUUC-Mdo-062209	Monodelphis domestica	45.94	0.00e+00	1315.00
IUUC-Mmu-064003	Mus musculus	54.17	0.00e+00	1657.00
IUUC-Mpu-065825	Mustela putorius furo	72.41	0.00e+00	795.00
IUUC-Mlu-068176	Myotis lucifugus	70.65	0.00e+00	2373.00
IUUC-Nle-069178	Nomascus leucogenys	73.49	0.00e+00	2518.00
IUUC-Opr-070574	Ochotona princeps	58.42	0.00e+00	1862.00
IUUC-Ont-072380	Oreochromis niloticus	51.72	2.00e-59	224.00
IUUC-Oan-073243	Ornithorhynchus anatinus	72.62	1.00e-33	135.00
IUUC-Ocu-074424	Oryctolagus cuniculus	67.22	0.00e+00	2281.00
IUUC-Ola-086863	Oryzias latipes	48.82	5.00e-56	213.00
IUUC-Oar-089938	Ovis aries	69.54	0.00e+00	2452.00
IUUC-Ptr-090960	Pan troglodytes	74.18	0.00e+00	2521.00
IUUC-Pan-092609	Papio anubis	71.57	0.00e+00	2190.00
IUUC-Psi-093889	Pelodiscus sinensis	29.12	2.00e-56	214.00
IUUC-Pfo-096328	Poecilia formosa	51.64	3.00e-60	227.00
IUUC-Pab-097982	Pongo abelii	74.18	0.00e+00	2531.00
IUUC-Pca-100698	Procavia capensis	72.59	0.00e+00	772.00
IUUC-Pva-102631	Pteropus vampyrus	75.29	0.00e+00	1149.00
IUUC-Rno-105879	Rattus norvegicus	54.65	0.00e+00	1676.00
IUUC-Sha-106701	Sarcophilus harrisii	38.58	0.00e+00	696.00
IUUC-Spo-108335	Schizosaccharomyces pombe	34.83	5.00e-10	58.90
IUUC-Sar-113047	Sorex araneus	61.50	0.00e+00	1437.00
IUUC-Ssc-115846	Sus scrofa	71.87	0.00e+00	2514.00
IUUC-Tgu-116785	Taeniopygia guttata	30.76	9.00e-98	352.00
IUUC-Tru-117895	Takifugu rubripes	47.42	3.00e-55	210.00
IUUC-Tsy-118885	Tarsius syrichta	55.65	3.00e-176	613.00
IUUC-Tni-119654	Tetraodon nigroviridis	46.01	4.00e-50	193.00
IUUC-Tbe-127421	Tupaia belangeri	59.45	1.00e-147	518.00
IUUC-Ttr-128685	Tursiops truncatus	73.19	0.00e+00	2429.00
IUUC-Vpa-130216	Vicugna pacos	68.30	0.00e+00	850.00
IUUC-Xtr-132398	Xenopus tropicalis	54.34	8.00e-59	223.00
IUUC-Xma-133651	Xiphophorus maculatus	52.94	1.00e-46	182.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence