iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ani-009137

Ensembl Protein ID

CADANIAP00005157

UniProt Accession

Q96V54; C8V4E2; Q5B793; CREB_EMENI

Genbank Protein ID

AAL04454.1; EAA59795.1; CBF75829.1

Protein Name

Ubiquitin carboxyl-terminal hydrolase creB; Carbon catabolite repression protein B; Deubiquitinating enzyme creB; Ubiquitin thioesterase creB; Ubiquitin-hydrolyzing enzyme creB; Ubiquitin-specific-processing protease creB

Genbank Nucleotide ID

AF327414; AACD01000061; BN001302

Gene Name

ANIA_03587; creB; molB; AN3587

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
CADANIAG00005157	CADANIAT00005157	CADANIAP00005157

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.50e-94	315.3	56	465

Active Site

Position(s)	Description	Evidence
64	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
417	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenp.................................................... 42
           G++N+gNtCY+NS+LQcL+   ++re++l+ ++++++ e+                                                     
   Q: 56   GMENFGNTCYCNSILQCLYYSVPFREAVLN-YPKRTPIEDLeaalakalryqdpnarleaealaekqkaansprpgqppnpqqkpedkdspey 147
           9*****************************.77777766657788888888888999999999999999999999999999988888888777 PP
   S: 43   ....................kepkgellkslqklfeelw..kskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkk...e 110
                                +  ++l +sl+++fe+++  +s+ + + p+++l++l++e+e+f++ ++qDa+Efl+ ll+++  +++k   +
   Q: 148  kkklalqtlpllettdnsvsYGIPESLFSSLKDMFESIVgsQSRIGIIRPQHFLEVLRRENEMFRTAMHQDAHEFLNLLLNEVVVDVEKaaaK 240
           7777777777776665555555555**************9999999*****************************************884442 PP
   S: 111  knkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkkeslqdcLesftkeeelege 203
             ++ + +++ ++s  +++++ + +  ++ ++++lF+g l+s+++cl+c++ s+r+e fldls+++++++     s+++cL++f++ee+l+++
   Q: 241  LLESPQPASDVSDSVIPSSSSGSRTPNTTRWVHELFEGLLTSETQCLTCEKASQRDEVFLDLSVDLEQHS-----SVTSCLRKFSAEEMLCER 328
           22333333333444455558888888889*****************************************.....9***************** PP
   S: 204  nkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqkekkkYeLiavvvHsG.slssGHY 295
           nk++c++c ++qeaek++k+k+lP++L lhLkRf+++e+ ++ +k++ +v +p +L l  f+t+++ ++  ++ YeL+avvvH G ++ +GHY
   Q: 329  NKFHCDNCGGLQEAEKRMKIKRLPRILALHLKRFKYTEDLQRLQKLFHRVVYPYHLRL--FNTTDDAED-PDRLYELYAVVVHIGgGPYHGHY 418
           *****************************************************88887..566645544.49********************* PP
   S: 296  vayvknekgkWllfdDskVtevkeeevleetg.....staYvlfYkr 337
           v+++k ++++WllfdD+ V++v+++ v ++ g     + aYvlfY++
   Q: 419  VSIIKTQDRGWLLFDDEMVEPVDKNYVRNFFGdkpglACAYVLFYQE 465
           *****************************999*************97 PP

Organism

Aspergillus nidulans

Functional Description
(View)

Ubiquitin thioesterase component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Deubiquitinates the creA catabolic repressor and the quinate permease qutD. Plays also a role in response to carbon starvation and the control of extracellular proteases activity.

Protein Sequence
(Fasta)

MGSFLKSFRK DVGSAAPSVG APPAKKEPQP LPMTPLEKML TELGPIRGDG SDKFYGMENF 60
GNTCYCNSIL QCLYYSVPFR EAVLNYPKRT PIEDLEAALA KALRYQDPNA RLEAEALAEK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGGTCGT TTCTGAAAAG TTTCCGAAAA GATGTGGTGA GTGCATGTTC TATGCCCTGG 60
CCGCCCTCGA GGTCTACCCT GATTTTACCT CAACCGGTCC TTGGTTCACT GTTGCCCGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0045013--P:carbon catabolite repression of transcription
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

ani:AN3587.2

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000193	Aegilops tauschii	47.52	2.00e-82	297.00
IUUC-Aml-001964	Ailuropoda melanoleuca	49.34	4.00e-82	296.00
IUUC-Atr-002650	Amborella trichopoda	47.48	2.00e-80	290.00
IUUC-Apl-003411	Anas platyrhynchos	48.36	1.00e-81	294.00
IUUC-Aca-005212	Anolis carolinensis	50.00	4.00e-82	296.00
IUUC-Aly-005830	Arabidopsis lyrata	45.95	1.00e-76	278.00
IUUC-Ath-006663	Arabidopsis thaliana	47.52	4.00e-79	286.00
IUUC-Ago-007871	Ashbya gossypii	41.59	1.00e-62	233.00
IUUC-Acl-008239	Aspergillus clavatus	80.00	0.00e+00	828.00
IUUC-Afl-008602	Aspergillus flavus	69.63	0.00e+00	856.00
IUUC-Afu-008816	Aspergillus fumigatus	82.69	0.00e+00	853.00
IUUC-Ang-009703	Aspergillus niger	67.42	0.00e+00	829.00
IUUC-Aor-009901	Aspergillus oryzae	66.67	0.00e+00	744.00
IUUC-Ate-010431	Aspergillus terreus	65.21	0.00e+00	814.00
IUUC-Ame-011015	Astyanax mexicanus	49.49	6.00e-83	299.00
IUUC-Bgr-012071	Blumeria graminis	57.26	2.00e-159	553.00
IUUC-Bta-012981	Bos taurus	49.83	7.00e-83	298.00
IUUC-Bci-013837	Botrytis cinerea	57.04	2.00e-173	601.00
IUUC-Bdi-014008	Brachypodium distachyon	46.98	2.00e-80	290.00
IUUC-Bol-015138	Brassica oleracea	47.35	1.00e-76	278.00
IUUC-Bra-016956	Brassica rapa	47.54	1.00e-78	284.00
IUUC-Cel-018379	Caenorhabditis elegans	41.07	9.00e-73	265.00
IUUC-Cja-018831	Callithrix jacchus	49.67	2.00e-82	297.00
IUUC-Cfa-020534	Canis familiaris	49.01	1.00e-81	294.00
IUUC-Cpo-021703	Cavia porcellus	49.34	4.00e-82	296.00
IUUC-Cre-022711	Chlamydomonas reinhardtii	47.35	5.00e-66	243.00
IUUC-Csa-023841	Chlorocebus sabaeus	47.14	8.00e-79	285.00
IUUC-Cho-024902	Choloepus hoffmanni	38.49	7.00e-54	202.00
IUUC-Cin-025659	Ciona intestinalis	53.20	3.00e-61	227.00
IUUC-Csv-025828	Ciona savignyi	54.31	2.00e-62	231.00
IUUC-Cgl-026611	Colletotrichum gloeosporioides	54.48	1.00e-170	591.00
IUUC-Cne-026900	Cryptococcus neoformans	40.49	2.00e-64	238.00
IUUC-Cme-027339	Cyanidioschyzon merolae	32.41	5.00e-38	150.00
IUUC-Dre-027845	Danio rerio	50.17	1.00e-83	301.00
IUUC-Dno-029460	Dasypus novemcinctus	49.01	2.00e-81	293.00
IUUC-Dor-030972	Dipodomys ordii	50.38	1.00e-71	261.00
IUUC-Dse-031470	Dothistroma septosporum	50.62	1.00e-176	611.00
IUUC-Dme-032038	Drosophila melanogaster	56.57	4.00e-68	249.00
IUUC-Ete-032659	Echinops telfairi	53.67	2.00e-54	204.00
IUUC-Eca-033439	Equus caballus	49.34	4.00e-82	296.00
IUUC-Eeu-034916	Erinaceus europaeus	48.95	4.00e-64	236.00
IUUC-Fca-035524	Felis catus	48.82	7.00e-82	295.00
IUUC-Fal-036833	Ficedula albicollis	48.68	1.00e-81	294.00
IUUC-Fox-037682	Fusarium oxysporum	60.13	8.00e-165	572.00
IUUC-Fso-038299	Fusarium solani	53.85	2.00e-159	553.00
IUUC-Gmo-038763	Gadus morhua	49.17	7.00e-82	295.00
IUUC-Ggr-039806	Gaeumannomyces graminis	58.05	3.00e-172	597.00
IUUC-Gga-041151	Gallus gallus	48.36	1.00e-81	295.00
IUUC-Gac-041967	Gasterosteus aculeatus	50.17	7.00e-82	295.00
IUUC-Gma-042927	Glycine max	49.50	7.00e-81	292.00
IUUC-Ggo-044659	Gorilla gorilla	47.14	1.00e-78	285.00
IUUC-Hsa-045700	Homo sapiens	49.67	2.00e-82	297.00
IUUC-Hvu-047692	Hordeum vulgare	47.00	2.00e-79	287.00
IUUC-Itr-049082	Ictidomys tridecemlineatus	49.34	5.00e-82	295.00
IUUC-Kpa-049250	Komagataella pastoris	51.25	2.00e-93	334.00
IUUC-Lch-050435	Latimeria chalumnae	49.16	8.00e-81	291.00
IUUC-Lpe-051368	Leersia perrieri	45.89	1.00e-78	284.00
IUUC-Loc-051968	Lepisosteus oculatus	49.50	6.00e-82	295.00
IUUC-Lma-053300	Leptosphaeria maculans	58.05	0.00e+00	635.00
IUUC-Laf-053887	Loxodonta africana	49.34	4.00e-82	296.00
IUUC-Mcc-055701	Macaca mulatta	49.67	2.00e-82	297.00
IUUC-Mor-057072	Magnaporthe oryzae	62.72	9.00e-169	585.00
IUUC-Mpo-057424	Magnaporthe poae	57.30	5.00e-171	592.00
IUUC-Mtr-057715	Medicago truncatula	48.25	2.00e-81	294.00
IUUC-Mla-059142	Melampsora laricipopulina	55.89	2.00e-100	358.00
IUUC-Mga-059195	Meleagris gallopavo	48.36	2.00e-81	293.00
IUUC-Mvi-060357	Microbotryum violaceum	54.17	1.00e-83	303.00
IUUC-Mmr-060751	Microcebus murinus	49.34	4.00e-82	296.00
IUUC-Mdo-062735	Monodelphis domestica	49.34	5.00e-82	296.00
IUUC-Mmu-063263	Mus musculus	49.01	4.00e-82	296.00
IUUC-Mac-065323	Musa acuminata	47.44	9.00e-80	288.00
IUUC-Mpu-066038	Mustela putorius furo	47.47	4.00e-79	286.00
IUUC-Mlu-068128	Myotis lucifugus	49.34	4.00e-82	296.00
IUUC-Nfi-068611	Neosartorya fischeri	83.95	0.00e+00	823.00
IUUC-Ncr-068699	Neurospora crassa	58.80	2.00e-170	590.00
IUUC-Nle-069767	Nomascus leucogenys	49.67	2.00e-82	296.00
IUUC-Opr-070980	Ochotona princeps	47.81	1.00e-78	285.00
IUUC-Ont-072658	Oreochromis niloticus	49.35	3.00e-82	296.00
IUUC-Oan-073372	Ornithorhynchus anatinus	48.82	3.00e-81	293.00
IUUC-Ocu-074322	Oryctolagus cuniculus	49.67	6.00e-82	295.00
IUUC-Oba-075220	Oryza barthii	45.57	2.00e-78	284.00
IUUC-Obr-076208	Oryza brachyantha	46.82	1.00e-73	268.00
IUUC-Ogl-077216	Oryza glaberrima	45.57	2.00e-78	284.00
IUUC-Ogu-078836	Oryza glumaepatula	45.57	2.00e-78	284.00
IUUC-Oin-079522	Oryza indica	45.57	2.00e-78	284.00
IUUC-Olo-080882	Oryza longistaminata	45.57	2.00e-78	284.00
IUUC-Ome-081549	Oryza meridionalis	45.57	2.00e-78	284.00
IUUC-Oni-082982	Oryza nivara	45.57	2.00e-78	284.00
IUUC-Opu-083532	Oryza punctata	46.03	4.00e-78	283.00
IUUC-Oru-084568	Oryza rufipogon	45.57	2.00e-78	284.00
IUUC-Osa-085299	Oryza sativa	45.57	2.00e-78	284.00
IUUC-Ola-087418	Oryzias latipes	49.35	3.00e-82	296.00
IUUC-Olu-087809	Ostreococcus lucimarinus	43.96	2.00e-65	241.00
IUUC-Oga-088298	Otolemur garnettii	49.34	8.00e-82	295.00
IUUC-Oar-090269	Ovis aries	49.83	3.00e-82	297.00
IUUC-Ptr-090467	Pan troglodytes	49.67	2.00e-82	297.00
IUUC-Pan-092437	Papio anubis	49.51	3.00e-81	293.00
IUUC-Psi-093379	Pelodiscus sinensis	48.48	1.00e-79	288.00
IUUC-Pma-094388	Petromyzon marinus	47.16	7.00e-79	285.00
IUUC-Pno-095044	Phaeosphaeria nodorum	58.18	7.00e-177	612.00
IUUC-Ppa-095275	Physcomitrella patens	49.34	8.00e-84	301.00
IUUC-Pfo-097052	Poecilia formosa	49.35	3.00e-82	296.00
IUUC-Pab-097797	Pongo abelii	49.67	2.00e-82	297.00
IUUC-Pop-099016	Populus trichocarpa	48.10	2.00e-81	293.00
IUUC-Pca-100835	Procavia capensis	51.05	7.00e-67	245.00
IUUC-Ppe-101474	Prunus persica	47.63	5.00e-81	292.00
IUUC-Pva-102878	Pteropus vampyrus	46.89	1.00e-80	291.00
IUUC-Pgr-103306	Puccinia graminis	54.90	2.00e-102	365.00
IUUC-Pte-104356	Pyrenophora teres	52.04	0.00e+00	629.00
IUUC-Pyt-104709	Pyrenophora triticirepentis	49.93	2.00e-161	561.00
IUUC-Rno-106060	Rattus norvegicus	49.34	9.00e-83	298.00
IUUC-Sce-106367	Saccharomyces cerevisiae	42.31	5.00e-73	267.00
IUUC-Sha-107087	Sarcophilus harrisii	49.34	4.00e-82	296.00
IUUC-Sja-107684	Schizosaccharomyces japonicus	44.21	7.00e-95	339.00
IUUC-Spo-108095	Schizosaccharomyces pombe	44.79	1.00e-106	378.00
IUUC-Smo-109064	Selaginella moellendorffii	50.16	1.00e-76	278.00
IUUC-Sit-110819	Setaria italica	47.17	3.00e-80	290.00
IUUC-Sly-111210	Solanum lycopersicum	48.33	6.00e-80	289.00
IUUC-Stu-112398	Solanum tuberosum	48.49	4.00e-80	289.00
IUUC-Sar-113216	Sorex araneus	48.68	2.00e-79	287.00
IUUC-Sbi-114724	Sorghum bicolor	47.77	3.00e-79	286.00
IUUC-Sre-115197	Sporisorium reilianum	56.07	3.00e-94	338.00
IUUC-Ssc-116321	Sus scrofa	49.67	1.00e-82	298.00
IUUC-Tgu-117482	Taeniopygia guttata	47.08	4.00e-81	293.00
IUUC-Tru-118613	Takifugu rubripes	49.35	3.00e-82	296.00
IUUC-Tsy-119520	Tarsius syrichta	52.88	2.00e-56	210.00
IUUC-Tni-120293	Tetraodon nigroviridis	49.35	3.00e-82	296.00
IUUC-Tca-121329	Theobroma cacao	48.33	3.00e-80	290.00
IUUC-Tre-122226	Trichoderma reesei	52.66	2.00e-160	557.00
IUUC-Tvi-122330	Trichoderma virens	51.03	1.00e-158	551.00
IUUC-Tae-125280	Triticum aestivum	48.00	3.00e-82	296.00
IUUC-Tur-126563	Triticum urartu	48.33	3.00e-81	293.00
IUUC-Tme-126890	Tuber melanosporum	66.16	2.00e-133	468.00
IUUC-Tbe-127783	Tupaia belangeri	49.34	4.00e-82	296.00
IUUC-Ttr-129083	Tursiops truncatus	49.67	2.00e-82	297.00
IUUC-Uma-129409	Ustilago maydis	55.44	2.00e-94	338.00
IUUC-Vda-129736	Verticillium dahliae	47.50	7.00e-145	506.00
IUUC-Vpa-130391	Vicugna pacos	47.14	4.00e-73	266.00
IUUC-Vvi-131371	Vitis vinifera	48.50	3.00e-81	293.00
IUUC-Xtr-132082	Xenopus tropicalis	48.54	6.00e-82	295.00
IUUC-Xma-133475	Xiphophorus maculatus	49.35	3.00e-82	296.00
IUUC-Yli-134632	Yarrowia lipolytica	57.63	3.00e-124	437.00
IUUC-Zma-134951	Zea mays	47.17	4.00e-80	289.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence