iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Nle-069633

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ADFV01035579

Gene Name

HERC1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSNLEG00000012301.2	ENSNLET00000015750.2	ENSNLEP00000015000.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.20e-93	312.7	4500	4834
E3 adaptor/Cullin RING/DCX/DWD	1.30e-15	56.9	3426	3456

Active Site

Position(s)	Description	Evidence
4803	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 6    kkrle.vefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknp.....ehlklFeflGrllgkalqdgr 86
            +r++ v++vgE + d+gGv+ ++++++++el++  + l+  s+n ++++ +n+d++l np     ehl  F+flG+l+g+a+++++
   Q: 4500 PSRAWkVKLVGEGADDAGGVFDDTITEMCQELETGIVDLLIPSPNATAEVGYNRDRFLFNPsacldEHLMQFKFLGILMGVAIRTKK 4586
           466666********************************************************************************* PP
   S: 87   lldlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeee..LkpgGenipVtneNke 171
           +ldl+l++ ++k+l+ ++l+ledleevd  ++++l++i++ ++s i+e++++ ++  ++ + ++++ ++  ++pgG++ip t +N++
   Q: 4587 PLDLHLAPLVWKQLCCVPLTLEDLEEVDLLYVQTLNSILHIEDSGITEESFHEMIPLDSFVGQSADGKMvpIIPGGNSIPLTFSNRK 4673
           *******************************************************9999887777766666**************** PP
   S: 172  eYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefss 258
           eYv++ +eyrl+e +++qv+a+reG+++++p  llsl+t+++le+++cG++ei+ve lkk  +y++ + e+++ +qwFw++leefs+
   Q: 4674 EYVERAIEYRLHE-MDRQVAAVREGMSWIVPVPLLSLLTAKQLEQMVCGMPEISVEVLKKVVRYRE-VDEQHQLVQWFWHTLEEFSN 4758
           *************.**************************************************88.******************** PP
   S: 259  eerkafLqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           eer  f++Fv+g+srlP+ + a+++ ++f+i k d+  d+lP+s+TCf++L+LP+Yss+ ++ e+L+yAi++++++++
   Q: 4759 EERVLFMRFVSGRSRLPA-NTADIS-QRFQIMKvDRPYDSLPTSQTCFFQLRLPPYSSQLVMAERLRYAINNCRSIDM 4834
           *****************6.899999.679999956666***********************************99987 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 3    tds.vtclaf.sd.tllvsGsdDgtikvWDlr 31
           +++ +tc+ + +  +ll+++++Dgti+vW+++
   Q: 3426 QNRvMTCV-WcNKkGLLATSGNDGTIRVWNVT 3456
           55416677.*9778****************97 PP

Organism

Nomascus leucogenys

Protein Sequence
(Fasta)

MATMIPPVKL KWLEHLNSSW ITEDSESIAT REGVAVLYSK LVSNKEVVPL PQQVLCLKGP 60
QLPDFERESL SSDEQDHYLD ALLSSQLALA KMVCSDSPFA GALRKRLLVL QRVFYALSNK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTCTTTCCCT TTGACAAGTC GCTGCTGCTG CAGCAAAAAT AAAGGACGCG ACCGCCGCAG 60
CCTCTGCGGA GCCGGGCTCG GGTCGCCGGA GCCGCGCCCC ACCCCGCCAG CTCCAGAGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR001870--B30.2/SPRY
IPR013320--ConA-like_dom
IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens
IPR003877--SPRY_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50188--B302_SPRY
PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00632--HECT
PF00415--RCC1
PF00622--SPRY
PF00400--WD40

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc
SM00449--SPRY
SM00320--WD40

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001830	Ailuropoda melanoleuca	97.70	0.00e+00	8789.00
IUUC-Atr-003065	Amborella trichopoda	31.97	6.00e-44	172.00
IUUC-Apl-003461	Anas platyrhynchos	92.44	0.00e+00	8364.00
IUUC-Aca-004452	Anolis carolinensis	84.92	0.00e+00	7382.00
IUUC-Aly-006545	Arabidopsis lyrata	35.48	1.00e-44	174.00
IUUC-Ame-011268	Astyanax mexicanus	59.90	0.00e+00	2194.00
IUUC-Bta-013213	Bos taurus	97.90	0.00e+00	8777.00
IUUC-Bol-015203	Brassica oleracea	34.20	3.00e-46	180.00
IUUC-Bra-017584	Brassica rapa	34.20	2.00e-46	181.00
IUUC-Cja-019298	Callithrix jacchus	98.93	0.00e+00	8894.00
IUUC-Cfa-021213	Canis familiaris	97.84	0.00e+00	8877.00
IUUC-Cpo-021674	Cavia porcellus	96.23	0.00e+00	5922.00
IUUC-Csa-023341	Chlorocebus sabaeus	98.77	0.00e+00	8883.00
IUUC-Cho-024567	Choloepus hoffmanni	96.51	0.00e+00	1817.00
IUUC-Cin-025709	Ciona intestinalis	36.00	5.00e-171	596.00
IUUC-Csv-026336	Ciona savignyi	37.13	2.00e-175	612.00
IUUC-Dre-028289	Danio rerio	78.71	0.00e+00	7073.00
IUUC-Dno-029988	Dasypus novemcinctus	97.14	0.00e+00	8723.00
IUUC-Dor-030636	Dipodomys ordii	85.29	0.00e+00	2135.00
IUUC-Dme-032171	Drosophila melanogaster	39.44	4.00e-156	547.00
IUUC-Ete-032598	Echinops telfairi	84.04	0.00e+00	1350.00
IUUC-Eca-033754	Equus caballus	97.86	0.00e+00	8818.00
IUUC-Eeu-034702	Erinaceus europaeus	92.24	0.00e+00	1518.00
IUUC-Fca-035900	Felis catus	98.17	0.00e+00	8859.00
IUUC-Fal-037034	Ficedula albicollis	90.46	0.00e+00	7182.00
IUUC-Gmo-038634	Gadus morhua	90.87	0.00e+00	1222.00
IUUC-Gga-040321	Gallus gallus	92.50	0.00e+00	8429.00
IUUC-Gac-042444	Gasterosteus aculeatus	56.59	0.00e+00	2189.00
IUUC-Gma-043808	Glycine max	33.16	2.00e-44	174.00
IUUC-Ggo-045134	Gorilla gorilla	94.34	0.00e+00	4836.00
IUUC-Hsa-046516	Homo sapiens	99.09	0.00e+00	8876.00
IUUC-Hvu-047529	Hordeum vulgare	34.50	1.00e-44	175.00
IUUC-Itr-048914	Ictidomys tridecemlineatus	96.75	0.00e+00	2539.00
IUUC-Lch-049903	Latimeria chalumnae	86.80	0.00e+00	7892.00
IUUC-Lpe-051165	Leersia perrieri	33.08	4.00e-46	179.00
IUUC-Loc-052149	Lepisosteus oculatus	84.28	0.00e+00	7532.00
IUUC-Laf-053426	Loxodonta africana	97.28	0.00e+00	8815.00
IUUC-Mcc-055826	Macaca mulatta	99.05	0.00e+00	8935.00
IUUC-Meu-056521	Macropus eugenii	86.17	0.00e+00	2279.00
IUUC-Mga-059567	Meleagris gallopavo	96.02	0.00e+00	2125.00
IUUC-Mmr-061512	Microcebus murinus	97.78	0.00e+00	8757.00
IUUC-Mdo-062177	Monodelphis domestica	92.15	0.00e+00	8293.00
IUUC-Mmu-064373	Mus musculus	97.00	0.00e+00	8750.00
IUUC-Mpu-066148	Mustela putorius furo	97.53	0.00e+00	8784.00
IUUC-Mlu-067680	Myotis lucifugus	97.59	0.00e+00	8747.00
IUUC-Opr-070609	Ochotona princeps	96.24	0.00e+00	1459.00
IUUC-Ont-071249	Oreochromis niloticus	81.14	0.00e+00	7451.00
IUUC-Oan-073157	Ornithorhynchus anatinus	93.33	0.00e+00	8396.00
IUUC-Ocu-074841	Oryctolagus cuniculus	97.49	0.00e+00	8854.00
IUUC-Ola-086889	Oryzias latipes	79.72	0.00e+00	7254.00
IUUC-Oga-088459	Otolemur garnettii	97.02	0.00e+00	8766.00
IUUC-Oar-089888	Ovis aries	97.86	0.00e+00	8734.00
IUUC-Ptr-091114	Pan troglodytes	99.12	0.00e+00	8898.00
IUUC-Pan-092442	Papio anubis	98.93	0.00e+00	8910.00
IUUC-Psi-093833	Pelodiscus sinensis	91.81	0.00e+00	5480.00
IUUC-Pma-094275	Petromyzon marinus	77.56	0.00e+00	1739.00
IUUC-Pfo-097262	Poecilia formosa	79.92	0.00e+00	7137.00
IUUC-Pab-097760	Pongo abelii	98.80	0.00e+00	5048.00
IUUC-Pop-099121	Populus trichocarpa	35.47	3.00e-47	184.00
IUUC-Pca-100465	Procavia capensis	95.97	0.00e+00	4585.00
IUUC-Ppe-101345	Prunus persica	33.25	2.00e-48	187.00
IUUC-Pva-102950	Pteropus vampyrus	97.24	0.00e+00	4147.00
IUUC-Rno-104892	Rattus norvegicus	96.73	0.00e+00	8660.00
IUUC-Sha-106633	Sarcophilus harrisii	93.58	0.00e+00	8302.00
IUUC-Smo-108827	Selaginella moellendorffii	34.63	5.00e-48	186.00
IUUC-Sly-111155	Solanum lycopersicum	36.52	5.00e-50	192.00
IUUC-Stu-112166	Solanum tuberosum	31.46	5.00e-46	179.00
IUUC-Sar-113251	Sorex araneus	88.34	0.00e+00	2531.00
IUUC-Sbi-114352	Sorghum bicolor	31.45	5.00e-43	169.00
IUUC-Ssc-116391	Sus scrofa	97.80	0.00e+00	8811.00
IUUC-Tgu-116554	Taeniopygia guttata	91.93	0.00e+00	8352.00
IUUC-Tru-118695	Takifugu rubripes	80.56	0.00e+00	7402.00
IUUC-Tsy-119647	Tarsius syrichta	91.81	0.00e+00	5688.00
IUUC-Tni-120707	Tetraodon nigroviridis	80.57	0.00e+00	7376.00
IUUC-Tca-121094	Theobroma cacao	34.78	9.00e-47	182.00
IUUC-Tur-126300	Triticum urartu	34.50	7.00e-45	176.00
IUUC-Tbe-127346	Tupaia belangeri	90.08	0.00e+00	2603.00
IUUC-Ttr-128542	Tursiops truncatus	93.67	0.00e+00	5938.00
IUUC-Vpa-130611	Vicugna pacos	97.66	0.00e+00	4026.00
IUUC-Xtr-131933	Xenopus tropicalis	84.60	0.00e+00	7635.00
IUUC-Xma-134216	Xiphophorus maculatus	77.22	0.00e+00	6877.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence