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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046991
Ensembl Protein ID ENSP00000295797.4
UniProt Accession P41743; D3DNQ4; Q8WW06; KPCI_HUMAN
Genbank Protein ID AAA60171.1; AAB17011.1; EAW78513.1; EAW78515.1; AAH22016.3
Protein Name Protein kinase C iota type; Atypical protein kinase C-lambda/iota; nPKC-iota
Genbank Nucleotide ID L18964; L33881; CH471052; CH471052; BC022016
Gene Name PRKCI; DXS1179E
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000163558.12 ENST00000295797.4 ENSP00000295797.4
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRWalkTargetScanRepTarSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Drug and target
TTDDrugBankGRAC
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
MethyCancerTCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
ULD/UDP/UFD/PB1 PB1 16949360
Classification
Family E-value Score Start End
ULD/UDP/UFD/PB1 3.00e-21 77.1 25 106
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   ULD/UDP/UFD/PB1
   S: 1    tvrvkvsykgeirsfaldlekpgkfedLlkavrtltelkn.sevalkYeDedGDlvtlksDedldkavslla.skksllrlliq 82
           +vrvk++y+g+i  + +++e++++fe L+++vr++++++n + +++k+ De+GD +t++s+ +l++a++l++ +k+s l ++++
   Q: 25   QVRVKAYYRGDI--MITHFEPSISFEGLCNEVRDMCSFDNeQLFTMKWIDEEGDPCTVSSQLELEEAFRLYElNKDSELLIHVF 106
           69**********..88******************************************************************98 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process at a very early step. In glioblastoma cells, may function downstream of phosphatidylinositol 3-kinase (PI(3)K) and PDPK1 in the promotion of cell survival by phosphorylating and inhibiting the pro-apoptotic factor BAD. Can form a protein complex in non-small cell lung cancer (NSCLC) cells with PARD6A and ECT2 and regulate ECT2 oncogenic activity by phosphorylation, which in turn promotes transformed growth and invasion. In response to nerve growth factor (NGF), acts downstream of SRC to phosphorylate and activate IRAK1, allowing the subsequent activation of NF-kappa-B and neuronal cell survival. Functions in the organization of the apical domain in epithelial cells by phosphorylating EZR. This step is crucial for activation and normal distribution of EZR at the early stages of intestinal epithelial cell differentiation. Forms a protein complex with LLGL1 and PARD6B independently of PARD3 to regulate epithelial cell polarity. Plays a role in microtubule dynamics in the early secretory pathway through interaction with RAB2A and GAPDH and recruitment to vesicular tubular clusters (VTCs). In human coronary artery endothelial cells (HCAEC), is activated by saturated fatty acids and mediates lipid-induced apoptosis.
 Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process at a very early step. In glioblastoma cells, may function downstream of phosphatidylinositol 3-kinase (PI(3)K) and PDPK1 in the promotion of cell survival by phosphorylating and inhibiting the pro-apoptotic factor BAD. Can form a protein complex in non-small cell lung cancer (NSCLC) cells with PARD6A and ECT2 and regulate ECT2 oncogenic activity by phosphorylation, which in turn promotes transformed growth and invasion. In response to nerve growth factor (NGF), acts downstream of SRC to phosphorylate and activate IRAK1, allowing the subsequent activation of NF-kappa-B and neuronal cell survival. Functions in the organization of the apical domain in epithelial cells by phosphorylating EZR. This step is crucial for activation and normal distribution of EZR at the early stages of intestinal epithelial cell differentiation. Forms a protein complex with LLGL1 and PARD6B independently of PARD3 to regulate epithelial cell polarity. Plays a role in microtubule dynamics in the early secretory pathway through interaction with RAB2A and GAPDH and recruitment to vesicular tubular clusters (VTCs). In human coronary artery endothelial cells (HCAEC), is activated by saturated fatty acids and mediates lipid-induced apoptosis.
Protein Sequence
(Fasta)
MPTQRDSSTM SHTVAGGGSG DHSHQVRVKA YYRGDIMITH FEPSISFEGL CNEVRDMCSF 60
DNEQLFTMKW IDEEGDPCTV SSQLELEEAF RLYELNKDSE LLIHVFPCVP ERPGMPCPGE 120
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Protein Fasta Sequence


>IUUC-Hsa-046991|ULD,PB1|Homo sapiens
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Nucleotide Sequence
(Fasta)
GGTTGCGCCC GCCCTACCCC GGAATGTGGG CCTTTGGAGC GAGCGAAGTG GGAGGGACCG 60
ACGCAGGAGG TGTCTTGGGC CCGGGCGGCT GTAGAGGCGG CGGCGCCTAC GGGCAGTGGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046991|ULD,PB1|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0967--Endosome
KW-0418--Kinase
KW-0472--Membrane
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0656--Proto-oncogene
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
KW-0043--Tumor suppressor
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR000961--AGC-kinase_C
IPR034661--aPKC_iota
IPR020454--DAG/PE-bd
IPR011009--Kinase-like_dom
IPR000270--PB1_dom
IPR002219--PE/DAG-bd
IPR012233--PKC
IPR017892--Pkinase_C
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR008271--Ser/Thr_kinase_AS
PROSITE

PS51285--AGC_KINASE_CTER
PS51745--PB1
PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
PS00479--ZF_DAG_PE_1
PS50081--ZF_DAG_PE_2
Pfam

PF00130--C1_1
PF00564--PB1
PF00069--Pkinase
PF00433--Pkinase_C
PRINTS

PR00008--DAGPEDOMAIN
SMART

SM00109--C1
SM00666--PB1
SM00133--S_TK_X
SM00220--S_TKc
Gene Ontology

GO:0016324--C:apical plasma membrane
GO:0005923--C:bicellular tight junction
GO:0031252--C:cell leading edge
GO:0005829--C:cytosol
GO:0005768--C:endosome
GO:0070062--C:extracellular exosome
GO:0000139--C:Golgi membrane
GO:0045171--C:intercellular bridge
GO:0015630--C:microtubule cytoskeleton
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0043234--C:protein complex
GO:0043220--C:Schmidt-Lanterman incisure
GO:0005524--F:ATP binding
GO:0046872--F:metal ion binding
GO:0005543--F:phospholipid binding
GO:0004672--F:protein kinase activity
GO:0004697--F:protein kinase C activity
GO:0004674--F:protein serine/threonine kinase activity
GO:0007015--P:actin filament organization
GO:0070830--P:bicellular tight junction assembly
GO:0016477--P:cell migration
GO:0045216--P:cell-cell junction organization
GO:0032869--P:cellular response to insulin stimulus
GO:0007010--P:cytoskeleton organization
GO:0035089--P:establishment of apical/basal cell polarity
GO:0045197--P:establishment or maintenance of epithelial cell apical/basal polarity
GO:0042462--P:eye photoreceptor cell development
GO:0048194--P:Golgi vesicle budding
GO:0035556--P:intracellular signal transduction
GO:0061024--P:membrane organization
GO:0043066--P:negative regulation of apoptotic process
GO:0034351--P:negative regulation of glial cell apoptotic process
GO:0043524--P:negative regulation of neuron apoptotic process
GO:0018105--P:peptidyl-serine phosphorylation
GO:2000353--P:positive regulation of endothelial cell apoptotic process
GO:0090004--P:positive regulation of establishment of protein localization to plasma membrane
GO:0060252--P:positive regulation of glial cell proliferation
GO:0046326--P:positive regulation of glucose import
GO:0010976--P:positive regulation of neuron projection development
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0006468--P:protein phosphorylation
GO:0006612--P:protein targeting to membrane
GO:0070555--P:response to interleukin-1
GO:0046903--P:secretion
GO:0016192--P:vesicle-mediated transport
KEGG hsa:5584
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001764 Ailuropoda melanoleuca 99.05 0.00e+00 1047.00
IUUC-Apl-003711 Anas platyrhynchos 95.74 0.00e+00 1095.00
IUUC-Aca-005142 Anolis carolinensis 94.95 0.00e+00 1109.00
IUUC-Ame-010977 Astyanax mexicanus 87.42 0.00e+00 1012.00
IUUC-Bta-013414 Bos taurus 99.16 0.00e+00 1207.00
IUUC-Bol-015169 Brassica oleracea 35.29 6.00e-51 196.00
IUUC-Cel-018340 Caenorhabditis elegans 58.43 0.00e+00 705.00
IUUC-Cja-019802 Callithrix jacchus 99.47 0.00e+00 1137.00
IUUC-Cfa-021236 Canis familiaris 98.49 0.00e+00 1166.00
IUUC-Cpo-022127 Cavia porcellus 97.35 0.00e+00 1087.00
IUUC-Csa-023332 Chlorocebus sabaeus 99.79 0.00e+00 976.00
IUUC-Cho-025054 Choloepus hoffmanni 67.66 3.00e-131 462.00
IUUC-Cin-025740 Ciona intestinalis 59.50 0.00e+00 704.00
IUUC-Csv-026145 Ciona savignyi 60.80 0.00e+00 706.00
IUUC-Dre-028444 Danio rerio 88.42 0.00e+00 1035.00
IUUC-Dno-029228 Dasypus novemcinctus 100.00 0.00e+00 649.00
IUUC-Dme-031630 Drosophila melanogaster 66.45 0.00e+00 802.00
IUUC-Ete-032633 Echinops telfairi 73.52 0.00e+00 653.00
IUUC-Eca-033572 Equus caballus 99.47 0.00e+00 1140.00
IUUC-Eeu-035110 Erinaceus europaeus 98.13 0.00e+00 1174.00
IUUC-Fca-035559 Felis catus 98.83 0.00e+00 1206.00
IUUC-Fal-036953 Ficedula albicollis 96.44 0.00e+00 1104.00
IUUC-Gmo-039334 Gadus morhua 87.92 0.00e+00 1053.00
IUUC-Gga-040223 Gallus gallus 93.82 0.00e+00 1132.00
IUUC-Gac-042113 Gasterosteus aculeatus 88.42 0.00e+00 1061.00
IUUC-Ggo-044520 Gorilla gorilla 93.21 0.00e+00 1083.00
IUUC-Lch-050263 Latimeria chalumnae 88.76 0.00e+00 1075.00
IUUC-Loc-052221 Lepisosteus oculatus 89.43 0.00e+00 1046.00
IUUC-Laf-053591 Loxodonta africana 98.83 0.00e+00 1205.00
IUUC-Mcc-055118 Macaca mulatta 96.98 0.00e+00 1166.00
IUUC-Mga-059886 Meleagris gallopavo 95.57 0.00e+00 1093.00
IUUC-Mmr-060926 Microcebus murinus 99.66 0.00e+00 1214.00
IUUC-Mdo-062698 Monodelphis domestica 93.54 0.00e+00 1131.00
IUUC-Mmu-063689 Mus musculus 98.32 0.00e+00 1191.00
IUUC-Mpu-066630 Mustela putorius furo 99.14 0.00e+00 1179.00
IUUC-Mlu-067416 Myotis lucifugus 95.31 0.00e+00 1118.00
IUUC-Nle-069811 Nomascus leucogenys 99.50 0.00e+00 1211.00
IUUC-Opr-070466 Ochotona princeps 86.55 0.00e+00 750.00
IUUC-Ont-072278 Oreochromis niloticus 86.70 0.00e+00 992.00
IUUC-Oan-073651 Ornithorhynchus anatinus 98.62 0.00e+00 746.00
IUUC-Ocu-074383 Oryctolagus cuniculus 99.16 0.00e+00 1208.00
IUUC-Ola-087283 Oryzias latipes 82.00 0.00e+00 806.00
IUUC-Oga-088337 Otolemur garnettii 90.52 0.00e+00 1073.00
IUUC-Oar-089954 Ovis aries 99.64 0.00e+00 1147.00
IUUC-Ptr-091673 Pan troglodytes 100.00 0.00e+00 1217.00
IUUC-Pan-092494 Papio anubis 99.83 0.00e+00 1212.00
IUUC-Psi-094044 Pelodiscus sinensis 93.57 0.00e+00 1129.00
IUUC-Pfo-096661 Poecilia formosa 86.88 0.00e+00 1016.00
IUUC-Pab-097659 Pongo abelii 99.33 0.00e+00 1209.00
IUUC-Pca-101107 Procavia capensis 98.50 0.00e+00 809.00
IUUC-Rno-105790 Rattus norvegicus 98.66 0.00e+00 1198.00
IUUC-Sha-106895 Sarcophilus harrisii 97.17 0.00e+00 1100.00
IUUC-Sar-113513 Sorex araneus 99.07 0.00e+00 635.00
IUUC-Ssc-115835 Sus scrofa 99.04 0.00e+00 1050.00
IUUC-Tgu-116874 Taeniopygia guttata 93.68 0.00e+00 1134.00
IUUC-Tru-117823 Takifugu rubripes 88.21 0.00e+00 1025.00
IUUC-Tsy-119154 Tarsius syrichta 99.11 0.00e+00 1135.00
IUUC-Tni-119968 Tetraodon nigroviridis 85.55 0.00e+00 1008.00
IUUC-Tbe-127238 Tupaia belangeri 79.60 0.00e+00 758.00
IUUC-Ttr-129208 Tursiops truncatus 98.99 0.00e+00 1203.00
IUUC-Vpa-130363 Vicugna pacos 88.63 0.00e+00 1037.00
IUUC-Xtr-132652 Xenopus tropicalis 87.60 0.00e+00 1062.00
Created Date 25-Jun-2017

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