iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mtr-058392

Ensembl Protein ID

AES80982

UniProt Accession

G7L2M4; I3RZM0; G7L2M4_MEDTR

Genbank Protein ID

AES80982.2; AFK33462.1

Protein Name

Presenilin

Genbank Nucleotide ID

CM001223; BT133667

Gene Name

MTR_7g087200

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
MTR_7g087200	AES80982	AES80982

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Alpha-Helix/CUE	29.55	2.00e-32	136.00	IUUC-Cel-018553

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Medicago truncatula

Functional Description
(View)

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.

Protein Sequence
(Fasta)

MESSVLESIG VEIIGVMSPV SICMFLVVLL VYTLSTTSSP ETTFTTAANL VYAENPSDTT 60
AQKLEGALLN AVVFIILIAI VTFLLVLLYY YNCTAFLRNY VRFSAFFVLA TMGGSIFINL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CACTAATCCA GAAAAAAGTA AACAAAAACT CAAGCTTAGT ACTCCCTCAT AGAAGAATTA 60
AACTCATCTC TCTCATAGAG TCCATAGACA TAGTGTTTGA AGAAAGAAGA AGAATGAAAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0472--Membrane
KW-0914--Notch signaling pathway
KW-0645--Protease
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP

Pfam

PF01080--Presenilin

PRINTS

PR01072--PRESENILIN

SMART

SM00730--PSN

Gene Ontology

GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0016021--C:integral component of membrane
GO:0004190--F:aspartic-type endopeptidase activity
GO:0007219--P:Notch signaling pathway
GO:0016485--P:protein processing

KEGG

mtr:MTR_7g087200

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000686	Aegilops tauschii	53.27	2.00e-90	326.00
IUUC-Aml-001648	Ailuropoda melanoleuca	35.31	1.00e-35	143.00
IUUC-Atr-003039	Amborella trichopoda	61.27	2.00e-135	474.00
IUUC-Apl-003959	Anas platyrhynchos	33.17	2.00e-32	132.00
IUUC-Aca-004582	Anolis carolinensis	32.77	6.00e-35	141.00
IUUC-Aly-005455	Arabidopsis lyrata	60.43	3.00e-124	437.00
IUUC-Ath-006730	Arabidopsis thaliana	61.49	3.00e-127	447.00
IUUC-Ame-010686	Astyanax mexicanus	31.40	2.00e-35	142.00
IUUC-Bta-013026	Bos taurus	33.49	1.00e-36	146.00
IUUC-Bdi-014196	Brachypodium distachyon	52.18	1.00e-100	359.00
IUUC-Bol-015841	Brassica oleracea	63.01	3.00e-117	414.00
IUUC-Bra-017580	Brassica rapa	73.46	6.00e-63	234.00
IUUC-Cel-018553	Caenorhabditis elegans	30.68	6.00e-43	167.00
IUUC-Cja-019994	Callithrix jacchus	32.03	8.00e-37	147.00
IUUC-Cfa-020074	Canis familiaris	33.50	2.00e-37	149.00
IUUC-Cpo-022237	Cavia porcellus	33.73	9.00e-39	153.00
IUUC-Cre-022747	Chlamydomonas reinhardtii	43.95	9.00e-51	194.00
IUUC-Csa-023537	Chlorocebus sabaeus	33.98	4.00e-37	148.00
IUUC-Cho-024735	Choloepus hoffmanni	29.20	2.00e-32	132.00
IUUC-Cin-025780	Ciona intestinalis	33.89	4.00e-44	171.00
IUUC-Csv-025967	Ciona savignyi	33.73	5.00e-43	167.00
IUUC-Dre-028526	Danio rerio	32.13	3.00e-39	155.00
IUUC-Dno-029758	Dasypus novemcinctus	32.37	3.00e-36	145.00
IUUC-Dor-030609	Dipodomys ordii	28.08	1.00e-21	97.10
IUUC-Dme-031929	Drosophila melanogaster	31.60	9.00e-42	164.00
IUUC-Ete-032487	Echinops telfairi	38.05	2.00e-18	86.70
IUUC-Eca-034387	Equus caballus	33.19	2.00e-28	119.00
IUUC-Eeu-035134	Erinaceus europaeus	37.33	8.00e-34	136.00
IUUC-Fca-035396	Felis catus	32.33	5.00e-38	151.00
IUUC-Fal-036600	Ficedula albicollis	32.85	3.00e-36	145.00
IUUC-Gmo-039665	Gadus morhua	32.32	1.00e-27	117.00
IUUC-Gga-040706	Gallus gallus	32.15	6.00e-34	137.00
IUUC-Gac-042511	Gasterosteus aculeatus	31.75	7.00e-37	147.00
IUUC-Gma-043822	Glycine max	69.72	9.00e-106	376.00
IUUC-Ggo-045338	Gorilla gorilla	32.31	4.00e-27	115.00
IUUC-Hsa-046822	Homo sapiens	33.98	4.00e-37	148.00
IUUC-Hvu-047141	Hordeum vulgare	54.04	8.00e-97	346.00
IUUC-Itr-048420	Ictidomys tridecemlineatus	34.32	1.00e-37	149.00
IUUC-Lch-049638	Latimeria chalumnae	32.72	6.00e-29	121.00
IUUC-Lpe-051132	Leersia perrieri	51.97	3.00e-94	338.00
IUUC-Loc-052427	Lepisosteus oculatus	33.09	7.00e-41	160.00
IUUC-Laf-053758	Loxodonta africana	34.27	3.00e-42	165.00
IUUC-Mcc-055682	Macaca mulatta	33.98	4.00e-37	148.00
IUUC-Meu-056004	Macropus eugenii	31.80	1.00e-22	100.00
IUUC-Mga-059466	Meleagris gallopavo	32.52	5.00e-36	144.00
IUUC-Mmr-060890	Microcebus murinus	32.88	4.00e-27	115.00
IUUC-Mdo-062197	Monodelphis domestica	33.57	3.00e-38	152.00
IUUC-Mmu-063176	Mus musculus	33.01	5.00e-36	144.00
IUUC-Mac-064858	Musa acuminata	88.51	4.00e-41	160.00
IUUC-Mpu-065927	Mustela putorius furo	32.03	3.00e-37	148.00
IUUC-Mlu-067079	Myotis lucifugus	33.98	9.00e-43	167.00
IUUC-Nle-070180	Nomascus leucogenys	33.98	4.00e-37	148.00
IUUC-Opr-070847	Ochotona princeps	32.52	2.00e-33	136.00
IUUC-Ont-071867	Oreochromis niloticus	31.40	1.00e-34	140.00
IUUC-Oan-072783	Ornithorhynchus anatinus	38.05	6.00e-32	130.00
IUUC-Ocu-074527	Oryctolagus cuniculus	33.74	9.00e-37	147.00
IUUC-Oba-075256	Oryza barthii	52.34	4.00e-84	304.00
IUUC-Obr-076302	Oryza brachyantha	51.76	8.00e-92	330.00
IUUC-Ogl-077097	Oryza glaberrima	52.04	1.00e-95	342.00
IUUC-Ogu-078570	Oryza glumaepatula	53.66	4.00e-92	330.00
IUUC-Oin-079244	Oryza indica	52.04	4.00e-95	341.00
IUUC-Olo-080484	Oryza longistaminata	50.33	2.00e-62	231.00
IUUC-Ome-081814	Oryza meridionalis	52.58	3.00e-97	348.00
IUUC-Oni-082057	Oryza nivara	53.66	1.00e-91	329.00
IUUC-Opu-084176	Oryza punctata	53.64	5.00e-94	337.00
IUUC-Oru-084618	Oryza rufipogon	53.66	4.00e-92	330.00
IUUC-Osa-085602	Oryza sativa	53.75	1.00e-92	332.00
IUUC-Ola-086707	Oryzias latipes	33.02	9.00e-26	109.00
IUUC-Olu-087811	Ostreococcus lucimarinus	39.13	2.00e-46	179.00
IUUC-Oga-088560	Otolemur garnettii	32.31	5.00e-27	114.00
IUUC-Oar-090348	Ovis aries	33.33	3.00e-38	152.00
IUUC-Ptr-091060	Pan troglodytes	33.98	4.00e-37	148.00
IUUC-Pan-091742	Papio anubis	32.88	4.00e-27	115.00
IUUC-Psi-093505	Pelodiscus sinensis	31.78	7.00e-36	144.00
IUUC-Pma-094612	Petromyzon marinus	29.81	3.00e-23	102.00
IUUC-Ppa-095431	Physcomitrella patens	55.02	1.00e-61	229.00
IUUC-Pfo-097396	Poecilia formosa	33.09	1.00e-39	156.00
IUUC-Pab-098591	Pongo abelii	33.98	4.00e-37	148.00
IUUC-Pop-099661	Populus trichocarpa	49.53	2.00e-89	322.00
IUUC-Pca-101029	Procavia capensis	33.01	4.00e-33	135.00
IUUC-Ppe-101495	Prunus persica	63.01	6.00e-140	489.00
IUUC-Pva-102244	Pteropus vampyrus	32.03	5.00e-36	144.00
IUUC-Rno-105861	Rattus norvegicus	32.76	3.00e-34	138.00
IUUC-Sha-107045	Sarcophilus harrisii	33.50	2.00e-37	149.00
IUUC-Smo-109325	Selaginella moellendorffii	46.56	7.00e-72	263.00
IUUC-Sit-110624	Setaria italica	51.73	8.00e-94	336.00
IUUC-Sly-110865	Solanum lycopersicum	91.43	3.00e-34	135.00
IUUC-Stu-112433	Solanum tuberosum	66.05	3.00e-125	441.00
IUUC-Sar-113169	Sorex araneus	35.48	3.00e-31	129.00
IUUC-Sbi-114305	Sorghum bicolor	51.51	7.00e-92	330.00
IUUC-Ssc-115766	Sus scrofa	34.22	5.00e-38	151.00
IUUC-Tgu-117280	Taeniopygia guttata	33.89	9.00e-35	140.00
IUUC-Tru-117732	Takifugu rubripes	33.50	6.00e-35	141.00
IUUC-Tsy-119624	Tarsius syrichta	32.60	4.00e-33	135.00
IUUC-Tni-119852	Tetraodon nigroviridis	32.37	1.00e-32	134.00
IUUC-Tca-121865	Theobroma cacao	65.35	4.00e-129	454.00
IUUC-Tae-125925	Triticum aestivum	52.99	5.00e-98	350.00
IUUC-Tur-126237	Triticum urartu	54.34	4.00e-84	304.00
IUUC-Tbe-127632	Tupaia belangeri	32.31	3.00e-27	115.00
IUUC-Ttr-129008	Tursiops truncatus	32.42	2.00e-26	112.00
IUUC-Vpa-130625	Vicugna pacos	34.21	5.00e-28	118.00
IUUC-Vvi-131312	Vitis vinifera	61.99	3.00e-122	431.00
IUUC-Xtr-132756	Xenopus tropicalis	32.13	6.00e-40	157.00
IUUC-Xma-133377	Xiphophorus maculatus	33.01	2.00e-37	149.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence