iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Loc-052231

Ensembl Protein ID

ENSLOCP00000011105.1

UniProt Accession

W5MRU6; W5MRU6_LEPOC

Genbank Protein ID

ENSLOCP00000011105

Protein Name

Histone deacetylase

Genbank Nucleotide ID

AHAT01016292

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLOCG00000009104.1	ENSLOCT00000011121.1	ENSLOCP00000011105.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/Other	80.25	0.00e+00	1456.00	IUUC-Hsa-046925

Active Site

Position(s)	Description	Evidence
772	N/A	{ECO:0000256\|PIRSR:PIRSR037911-1}

Organism

Lepisosteus oculatus

Functional Description
(View)

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

Protein Sequence
(Fasta)

PSAVDVSAAL PLQVSPTAIP MDLRVDHQFS LASADPSLRE QQLQQELIAL KQKQQIQRQL 60
LIAEFQRQHE QLSRQHEAQL QEHVKHQQDM LALKHQQELL EHQRKMEKHR HEQEMEKHQR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCTTCTGCAG TTGATGTGAG CGCAGCACTG CCTCTGCAAG TTTCCCCAAC TGCAATTCCC 60
ATGGACCTGC GGGTGGATCA CCAGTTCTCC CTTGCCTCTG CTGACCCGAG CCTGCGGGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc

Interpro

IPR033660--HDAC4
IPR000286--His_deacetylse
IPR023801--His_deacetylse_dom
IPR024643--Hist_deacetylase_Gln_rich_N
IPR017320--Histone_deAcase_II_euk

Pfam

PF12203--HDAC4_Gln
PF00850--Hist_deacetyl

PRINTS

PR01270--HDASUPER

Gene Ontology

GO:0000118--C:histone deacetylase complex
GO:0046872--F:metal ion binding
GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0048701--P:embryonic cranial skeleton morphogenesis
GO:0001755--P:neural crest cell migration
GO:0090299--P:regulation of neural crest formation
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000749	Aegilops tauschii	45.45	7.00e-62	231.00
IUUC-Aml-002279	Ailuropoda melanoleuca	79.75	0.00e+00	1455.00
IUUC-Atr-002745	Amborella trichopoda	39.47	1.00e-70	260.00
IUUC-Apl-003250	Anas platyrhynchos	80.15	0.00e+00	1449.00
IUUC-Aca-004668	Anolis carolinensis	76.62	0.00e+00	1431.00
IUUC-Aly-006432	Arabidopsis lyrata	44.67	4.00e-67	249.00
IUUC-Ath-007355	Arabidopsis thaliana	42.71	5.00e-73	268.00
IUUC-Ago-007972	Ashbya gossypii	39.49	4.00e-69	256.00
IUUC-Acl-008187	Aspergillus clavatus	39.79	2.00e-71	264.00
IUUC-Afl-008399	Aspergillus flavus	43.30	1.00e-38	154.00
IUUC-Afu-008954	Aspergillus fumigatus	36.36	3.00e-61	229.00
IUUC-Ani-009142	Aspergillus nidulans	38.90	4.00e-68	252.00
IUUC-Ang-009522	Aspergillus niger	33.83	6.00e-22	99.40
IUUC-Aor-010069	Aspergillus oryzae	37.97	8.00e-63	234.00
IUUC-Ate-010291	Aspergillus terreus	40.16	1.00e-71	264.00
IUUC-Ame-010780	Astyanax mexicanus	41.64	8.00e-73	268.00
IUUC-Bta-013215	Bos taurus	79.96	0.00e+00	1442.00
IUUC-Bci-013789	Botrytis cinerea	37.41	8.00e-67	248.00
IUUC-Bdi-014007	Brachypodium distachyon	42.53	1.00e-70	260.00
IUUC-Bol-015468	Brassica oleracea	41.98	8.00e-75	274.00
IUUC-Bra-016680	Brassica rapa	42.24	4.00e-75	275.00
IUUC-Cel-018220	Caenorhabditis elegans	38.95	1.00e-65	244.00
IUUC-Cja-019816	Callithrix jacchus	80.23	0.00e+00	1473.00
IUUC-Cfa-020861	Canis familiaris	79.63	0.00e+00	1428.00
IUUC-Cpo-021562	Cavia porcellus	79.85	0.00e+00	1464.00
IUUC-Cre-022561	Chlamydomonas reinhardtii	50.67	6.00e-55	206.00
IUUC-Csa-023612	Chlorocebus sabaeus	80.04	0.00e+00	1446.00
IUUC-Csv-026359	Ciona savignyi	53.04	3.00e-89	321.00
IUUC-Cgl-026709	Colletotrichum gloeosporioides	36.41	5.00e-65	242.00
IUUC-Cne-026978	Cryptococcus neoformans	38.86	1.00e-69	258.00
IUUC-Dre-028284	Danio rerio	84.30	0.00e+00	1498.00
IUUC-Dno-029951	Dasypus novemcinctus	78.59	0.00e+00	1361.00
IUUC-Dor-030362	Dipodomys ordii	69.94	0.00e+00	1207.00
IUUC-Dse-031186	Dothistroma septosporum	35.46	4.00e-60	226.00
IUUC-Dme-031766	Drosophila melanogaster	58.39	7.00e-156	545.00
IUUC-Ete-032279	Echinops telfairi	37.04	8.00e-56	212.00
IUUC-Eca-033842	Equus caballus	43.88	3.00e-76	280.00
IUUC-Eeu-034487	Erinaceus europaeus	50.82	3.00e-59	223.00
IUUC-Fca-036187	Felis catus	80.58	0.00e+00	1463.00
IUUC-Fox-038067	Fusarium oxysporum	37.92	3.00e-66	246.00
IUUC-Fso-038263	Fusarium solani	38.15	2.00e-66	247.00
IUUC-Gmo-038473	Gadus morhua	79.40	0.00e+00	765.00
IUUC-Ggr-040062	Gaeumannomyces graminis	39.78	2.00e-64	240.00
IUUC-Gga-040501	Gallus gallus	82.67	0.00e+00	1483.00
IUUC-Gac-042335	Gasterosteus aculeatus	74.91	0.00e+00	1392.00
IUUC-Gma-043738	Glycine max	42.41	1.00e-66	247.00
IUUC-Ggo-045380	Gorilla gorilla	80.19	0.00e+00	1449.00
IUUC-Hsa-046925	Homo sapiens	80.25	0.00e+00	1474.00
IUUC-Hvu-047285	Hordeum vulgare	42.23	3.00e-68	251.00
IUUC-Itr-048036	Ictidomys tridecemlineatus	80.63	0.00e+00	1437.00
IUUC-Kpa-049281	Komagataella pastoris	38.38	9.00e-69	254.00
IUUC-Lch-050325	Latimeria chalumnae	82.00	0.00e+00	1432.00
IUUC-Lpe-051214	Leersia perrieri	40.64	3.00e-75	276.00
IUUC-Lma-053263	Leptosphaeria maculans	40.66	2.00e-74	273.00
IUUC-Laf-054490	Loxodonta africana	75.52	0.00e+00	1425.00
IUUC-Mcc-055265	Macaca mulatta	79.68	0.00e+00	1448.00
IUUC-Meu-056676	Macropus eugenii	83.02	0.00e+00	652.00
IUUC-Mor-057095	Magnaporthe oryzae	37.80	2.00e-67	250.00
IUUC-Mpo-057389	Magnaporthe poae	38.96	1.00e-63	238.00
IUUC-Mtr-058463	Medicago truncatula	39.57	5.00e-69	255.00
IUUC-Mla-059143	Melampsora laricipopulina	39.50	9.00e-66	244.00
IUUC-Mmr-061633	Microcebus murinus	73.99	0.00e+00	1276.00
IUUC-Mdo-062198	Monodelphis domestica	44.19	5.00e-76	279.00
IUUC-Mmu-063089	Mus musculus	81.37	0.00e+00	1457.00
IUUC-Mac-064630	Musa acuminata	43.23	5.00e-72	265.00
IUUC-Mpu-065887	Mustela putorius furo	80.34	0.00e+00	1472.00
IUUC-Mlu-067470	Myotis lucifugus	80.84	0.00e+00	1487.00
IUUC-Nfi-068404	Neosartorya fischeri	39.02	1.00e-70	261.00
IUUC-Ncr-068672	Neurospora crassa	38.65	8.00e-67	248.00
IUUC-Nle-069099	Nomascus leucogenys	75.66	0.00e+00	896.00
IUUC-Opr-071074	Ochotona princeps	44.56	1.00e-86	314.00
IUUC-Ont-071613	Oreochromis niloticus	73.33	0.00e+00	1373.00
IUUC-Oan-073275	Ornithorhynchus anatinus	82.39	0.00e+00	1486.00
IUUC-Ocu-074627	Oryctolagus cuniculus	44.78	4.00e-84	306.00
IUUC-Oba-075489	Oryza barthii	40.98	6.00e-73	268.00
IUUC-Obr-076150	Oryza brachyantha	40.64	7.00e-75	275.00
IUUC-Ogl-077437	Oryza glaberrima	40.64	2.00e-74	273.00
IUUC-Ogu-078370	Oryza glumaepatula	40.64	3.00e-74	273.00
IUUC-Oin-079210	Oryza indica	40.64	4.00e-74	272.00
IUUC-Olo-080971	Oryza longistaminata	42.01	4.00e-64	239.00
IUUC-Oni-082031	Oryza nivara	40.64	5.00e-74	272.00
IUUC-Opu-083471	Oryza punctata	40.71	1.00e-73	270.00
IUUC-Oru-084755	Oryza rufipogon	40.64	3.00e-74	273.00
IUUC-Osa-085447	Oryza sativa	40.64	3.00e-74	273.00
IUUC-Ola-087031	Oryzias latipes	71.55	0.00e+00	1296.00
IUUC-Oga-088201	Otolemur garnettii	75.60	0.00e+00	1293.00
IUUC-Oar-089997	Ovis aries	73.76	0.00e+00	1212.00
IUUC-Ptr-091116	Pan troglodytes	80.44	0.00e+00	1479.00
IUUC-Pan-092132	Papio anubis	81.86	0.00e+00	981.00
IUUC-Psi-093734	Pelodiscus sinensis	81.75	0.00e+00	1427.00
IUUC-Pma-094347	Petromyzon marinus	70.08	0.00e+00	712.00
IUUC-Pno-095131	Phaeosphaeria nodorum	45.13	1.00e-63	237.00
IUUC-Ppa-095550	Physcomitrella patens	44.51	3.00e-73	270.00
IUUC-Pfo-096293	Poecilia formosa	70.34	0.00e+00	1330.00
IUUC-Pab-098491	Pongo abelii	77.52	0.00e+00	1382.00
IUUC-Pop-099174	Populus trichocarpa	39.57	1.00e-71	264.00
IUUC-Pca-101004	Procavia capensis	69.35	0.00e+00	760.00
IUUC-Ppe-101644	Prunus persica	41.11	5.00e-72	265.00
IUUC-Pva-102961	Pteropus vampyrus	60.45	0.00e+00	721.00
IUUC-Pgr-103380	Puccinia graminis	35.29	3.90e+00	25.80
IUUC-Ptt-103841	Puccinia triticina	38.64	2.00e-66	247.00
IUUC-Pte-104383	Pyrenophora teres	40.26	8.00e-73	268.00
IUUC-Pyt-104427	Pyrenophora triticirepentis	40.00	3.00e-71	262.00
IUUC-Rno-105005	Rattus norvegicus	81.37	0.00e+00	1428.00
IUUC-Sce-106274	Saccharomyces cerevisiae	37.78	6.00e-62	232.00
IUUC-Sha-107646	Sarcophilus harrisii	61.43	0.00e+00	888.00
IUUC-Sja-107915	Schizosaccharomyces japonicus	38.32	4.00e-70	259.00
IUUC-Spo-108300	Schizosaccharomyces pombe	39.32	3.00e-72	266.00
IUUC-Smo-109615	Selaginella moellendorffii	46.20	4.00e-77	282.00
IUUC-Sit-110160	Setaria italica	41.64	1.00e-69	257.00
IUUC-Sly-111164	Solanum lycopersicum	40.00	9.00e-77	281.00
IUUC-Stu-112685	Solanum tuberosum	39.20	8.00e-61	228.00
IUUC-Sar-113692	Sorex araneus	35.13	2.00e-47	184.00
IUUC-Sbi-114301	Sorghum bicolor	41.81	3.00e-68	253.00
IUUC-Sre-115013	Sporisorium reilianum	40.42	6.00e-67	248.00
IUUC-Ssc-115428	Sus scrofa	81.07	0.00e+00	1440.00
IUUC-Tgu-116776	Taeniopygia guttata	82.72	0.00e+00	1485.00
IUUC-Tru-118180	Takifugu rubripes	86.17	0.00e+00	853.00
IUUC-Tsy-119468	Tarsius syrichta	75.35	0.00e+00	634.00
IUUC-Tni-120196	Tetraodon nigroviridis	73.21	0.00e+00	1338.00
IUUC-Tca-121312	Theobroma cacao	41.01	4.00e-75	276.00
IUUC-Tre-121930	Trichoderma reesei	39.32	2.00e-70	260.00
IUUC-Tvi-122373	Trichoderma virens	39.40	9.00e-69	254.00
IUUC-Tae-123064	Triticum aestivum	39.20	1.00e-67	250.00
IUUC-Tme-127027	Tuber melanosporum	43.48	3.00e-58	219.00
IUUC-Tbe-127675	Tupaia belangeri	40.96	6.00e-19	89.70
IUUC-Ttr-128360	Tursiops truncatus	74.22	0.00e+00	842.00
IUUC-Uma-129408	Ustilago maydis	42.73	2.00e-65	243.00
IUUC-Vda-129994	Verticillium dahliae	42.03	4.00e-60	226.00
IUUC-Vpa-130525	Vicugna pacos	56.14	2.00e-15	77.80
IUUC-Vvi-131038	Vitis vinifera	41.57	2.00e-73	270.00
IUUC-Xtr-132956	Xenopus tropicalis	76.10	0.00e+00	1315.00
IUUC-Xma-134265	Xiphophorus maculatus	72.63	0.00e+00	1348.00
IUUC-Yli-134680	Yarrowia lipolytica	40.10	2.00e-67	250.00
IUUC-Zma-135110	Zea mays	40.98	1.00e-70	260.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence