iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Apl-003232

Ensembl Protein ID

ENSAPLP00000004806.1

UniProt Accession

U3IC34; U3IC34_ANAPL

Genbank Protein ID

ENSAPLP00000004806

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ADON01047156

Gene Name

TBL1X

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAPLG00000005235.1	ENSAPLT00000005427.1	ENSAPLP00000004806.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.50e-54	178.5	450	488
UBD/Beta-Prp	8.60e-65	218.5	320	522

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllks 38
           H+++v+++af +d ++l+sGs D+ +++W++ +g+l++s
   Q: 450  HQEPVYSVAFsPDgKYLASGSFDKCVHIWNTQSGTLVHS 488
           9**********999*******************999876 PP

UBD/Beta-Prp

   S: 13   itcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlsls 101
             +v++ ++++ +a+ s+d +i v +++    +++++gh++ev+a+k++p+g +l+++s+D+t+k+w++++ +cvh l++h++++++++
   Q: 320  ALDVDW-QNNTTFASCSTDMCIHVCRLSCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDTCVHDLQAHSKEIYTIK 407
           444555.6666677777777777777777777777777777777777777777777777777777777777777777777777777777 PP
   S: 102  fsp.........sgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtd 181
           +sp         s+  l+s+s d+t+r+wd++ g c++ tl++h++ v +v+++pdg++l+sGs D++v +W+ ++g+l++  +g  t+
   Q: 408  WSPtgpgtsnpnSNIMLASASFDSTVRLWDVDRGVCIH-TLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGTLVHSYRG--TG 493
           77766555555333567777777777777777777777.7777777777777777777777777777777777777777777776..77 PP
   S: 182  svyslsfdsngkelvsgsldgtvklwdlq 210
            +  + ++  g  + + + dg+v + dl+
   Q: 494  GIFEVCWNARGDKVGASASDGSVCVLDLR 522
           77777777777777777777777776665 PP

Organism

Anas platyrhynchos

Protein Sequence
(Fasta)

MSITSDEVNF LVYRYLQESG FSHSAFTFGI ESHISQSNIN GTLVPPAALI SILQKGLQYV 60
EAEISINEDG TVFDGRPIES LSLIDAVMPD VVQTRQQAFR EKLAQQQASA AAAAAATAAT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGAAACTGG GGAGCTTGAC TGTACTTGCA CGTGAGTAAG TGAACATTTA GCCGGAAATC 60
AGCTTTGCAA AATGTTGAAA CTGTTGACTG TTTTTCAGCA TCTTCTCGCC TACTTGCGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR024977--Apc4_WD40_dom
IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12894--ANAPC4_WD40
PF08513--LisH
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00667--LisH
SM00320--WD40

Gene Ontology

GO:0005667--C:transcription factor complex
GO:0003682--F:chromatin binding
GO:0003714--F:transcription corepressor activity
GO:0044212--F:transcription regulatory region DNA binding
GO:0045444--P:fat cell differentiation
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043627--P:response to estrogen
GO:0048545--P:response to steroid hormone

KEGG

apla:101794927

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001450	Ailuropoda melanoleuca	92.73	0.00e+00	993.00
IUUC-Aca-005035	Anolis carolinensis	95.64	0.00e+00	1009.00
IUUC-Bta-013202	Bos taurus	95.83	0.00e+00	1005.00
IUUC-Cja-019281	Callithrix jacchus	91.97	0.00e+00	976.00
IUUC-Cfa-020929	Canis familiaris	95.44	0.00e+00	999.00
IUUC-Cre-022979	Chlamydomonas reinhardtii	60.88	6.00e-131	460.00
IUUC-Csa-023943	Chlorocebus sabaeus	93.69	0.00e+00	973.00
IUUC-Cho-024872	Choloepus hoffmanni	81.07	6.00e-100	357.00
IUUC-Cin-025704	Ciona intestinalis	72.49	0.00e+00	794.00
IUUC-Csv-026257	Ciona savignyi	70.46	0.00e+00	763.00
IUUC-Cne-026946	Cryptococcus neoformans	38.91	7.00e-31	128.00
IUUC-Cme-027258	Cyanidioschyzon merolae	39.38	8.00e-104	370.00
IUUC-Dno-028926	Dasypus novemcinctus	93.93	0.00e+00	983.00
IUUC-Dme-031939	Drosophila melanogaster	81.47	2.00e-175	608.00
IUUC-Ete-032822	Echinops telfairi	84.70	0.00e+00	846.00
IUUC-Eca-033897	Equus caballus	96.39	0.00e+00	1003.00
IUUC-Fca-036462	Felis catus	96.02	0.00e+00	1001.00
IUUC-Fal-037388	Ficedula albicollis	99.62	0.00e+00	1027.00
IUUC-Gga-040671	Gallus gallus	99.62	0.00e+00	1027.00
IUUC-Gac-041851	Gasterosteus aculeatus	90.44	0.00e+00	938.00
IUUC-Gma-044208	Glycine max	48.43	4.00e-152	531.00
IUUC-Ggo-045373	Gorilla gorilla	92.98	0.00e+00	982.00
IUUC-Hsa-045841	Homo sapiens	93.54	0.00e+00	983.00
IUUC-Itr-048236	Ictidomys tridecemlineatus	98.39	0.00e+00	774.00
IUUC-Kpa-049338	Komagataella pastoris	28.00	1.00e-31	130.00
IUUC-Lch-050535	Latimeria chalumnae	92.35	0.00e+00	985.00
IUUC-Laf-054071	Loxodonta africana	94.52	0.00e+00	1007.00
IUUC-Mcc-055233	Macaca mulatta	92.83	0.00e+00	957.00
IUUC-Mga-059895	Meleagris gallopavo	98.28	0.00e+00	1022.00
IUUC-Mvi-060557	Microbotryum violaceum	37.04	2.00e-70	260.00
IUUC-Mmr-061286	Microcebus murinus	96.42	0.00e+00	1010.00
IUUC-Mmu-063447	Mus musculus	95.64	0.00e+00	999.00
IUUC-Nle-069151	Nomascus leucogenys	93.70	0.00e+00	978.00
IUUC-Ont-072252	Oreochromis niloticus	90.06	0.00e+00	959.00
IUUC-Oan-073562	Ornithorhynchus anatinus	96.77	0.00e+00	1011.00
IUUC-Oba-075618	Oryza barthii	47.75	8.00e-141	493.00
IUUC-Ogl-077302	Oryza glaberrima	50.36	4.00e-154	537.00
IUUC-Ogu-078718	Oryza glumaepatula	50.36	4.00e-154	537.00
IUUC-Oin-079515	Oryza indica	44.02	1.00e-92	333.00
IUUC-Ome-081696	Oryza meridionalis	49.28	7.00e-149	520.00
IUUC-Oni-082137	Oryza nivara	50.36	4.00e-154	537.00
IUUC-Opu-083505	Oryza punctata	47.75	4.00e-142	497.00
IUUC-Oru-085276	Oryza rufipogon	50.36	2.00e-154	538.00
IUUC-Osa-085791	Oryza sativa	50.36	4.00e-154	537.00
IUUC-Olu-087589	Ostreococcus lucimarinus	51.56	2.00e-154	538.00
IUUC-Oar-089506	Ovis aries	94.46	0.00e+00	1001.00
IUUC-Ptr-090793	Pan troglodytes	92.18	0.00e+00	951.00
IUUC-Pan-091909	Papio anubis	93.16	0.00e+00	983.00
IUUC-Psi-093358	Pelodiscus sinensis	91.01	0.00e+00	960.00
IUUC-Pma-094105	Petromyzon marinus	61.97	1.00e-98	352.00
IUUC-Pfo-097214	Poecilia formosa	89.10	0.00e+00	927.00
IUUC-Pab-098317	Pongo abelii	93.22	0.00e+00	961.00
IUUC-Rno-105857	Rattus norvegicus	95.64	0.00e+00	999.00
IUUC-Sce-106132	Saccharomyces cerevisiae	24.30	4.00e-40	159.00
IUUC-Sha-107326	Sarcophilus harrisii	95.41	0.00e+00	1017.00
IUUC-Sly-111042	Solanum lycopersicum	50.19	1.00e-149	522.00
IUUC-Stu-112786	Solanum tuberosum	48.02	7.00e-141	493.00
IUUC-Ssc-115646	Sus scrofa	95.46	0.00e+00	1012.00
IUUC-Tgu-116898	Taeniopygia guttata	99.81	0.00e+00	1018.00
IUUC-Tru-117862	Takifugu rubripes	90.63	0.00e+00	951.00
IUUC-Tni-119656	Tetraodon nigroviridis	91.20	0.00e+00	949.00
IUUC-Ttr-128826	Tursiops truncatus	96.67	0.00e+00	922.00
IUUC-Uma-129469	Ustilago maydis	43.53	3.00e-58	219.00
IUUC-Xma-133591	Xiphophorus maculatus	88.91	0.00e+00	927.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence